Phomopsin B (BioDeep_00000023359)

   

human metabolite


代谢物信息卡片


(2E)-2-[(2E)-2-{[(2S)-1-[(3R,4S,7S,10S,11S)-3-ethyl-11,15-dihydroxy-3-methyl-10-(methylamino)-6,9-dioxo-7-(prop-1-en-2-yl)-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-4-carbonyl]-2,5-dihydro-1H-pyrrol-2-yl]formamido}-3-methylpent-2-enamido]but-2-enedioic acid

化学式: C36H46N6O12 (754.3174)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: C=C(C)C1NC(=O)C(NC)C(O)c2ccc(O)c(c2)OC(C)(CC)C(C(=O)N2CC=CC2C(=O)NC(C(=O)NC(=CC(=O)O)C(=O)O)=C(C)CC)NC1=O
InChI: InChI=1S/C36H46N6O12/c1-8-18(5)26(32(49)38-20(35(52)53)16-24(44)45)40-30(47)21-11-10-14-42(21)34(51)29-36(6,9-2)54-23-15-19(12-13-22(23)43)28(46)27(37-7)33(50)39-25(17(3)4)31(48)41-29/h10-13,15-16,21,25,27-29,37,43,46H,3,8-9,14H2,1-2,4-7H3,(H,38,49)(H,39,50)(H,40,47)(H,41,48)(H,44,45)(H,52,53)/b20-16+,26-18+/t21-,25-,27-,28-,29+,36+/m0/s1

描述信息

D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
Phomopsin B is a mycotoxin from Phomopsis leptostromiformis.
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

3 个代谢物同义名

(2E)-2-[(2E)-2-{[(2S)-1-[(3R,4S,7S,10S,11S)-3-ethyl-11,15-dihydroxy-3-methyl-10-(methylamino)-6,9-dioxo-7-(prop-1-en-2-yl)-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-4-carbonyl]-2,5-dihydro-1H-pyrrol-2-yl]formamido}-3-methylpent-2-enamido]but-2-enedioic acid; (2E)-2-[(2E)-2-{[(2S)-1-[(3R,4S,7S,10S,11S)-3-ethyl-11,15-dihydroxy-3-methyl-10-(methylamino)-6,9-dioxo-7-(prop-1-en-2-yl)-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-4-carbonyl]-2,5-dihydropyrrol-2-yl]formamido}-3-methylpent-2-enamido]but-2-enedioic acid; Phomopsin B



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Svenja Schloß, Matthias Koch, Sascha Rohn, Ronald Maul. Development of a SIDA-LC-MS/MS Method for the Determination of Phomopsin A in Legumes. Journal of agricultural and food chemistry. 2015 Dec; 63(48):10543-9. doi: 10.1021/acs.jafc.5b04792. [PMID: 26567714]
  • Yiwen Tao, Chengbo Mou, Xianjian Zeng, Fang Xu, Jiwen Cai, Zhigang She, Shining Zhou, Yongcheng Lin. 1H and 13C NMR assignments of two new diaryl ethers phomopsides A and B from the mangrove endophytic fungus (ZZF08). Magnetic resonance in chemistry : MRC. 2008 Aug; 46(8):761-4. doi: 10.1002/mrc.2236. [PMID: 18449854]
  • Meng Yu, Khin Than, Steve Colegate, Brian Shiell, Wojtek P Michalski, Stephen Prowse, Lin-Fa Wang. Peptide mimotopes of phomopsins: identification, characterization and application in an immunoassay. Molecular diversity. 2005; 9(1-3):233-40. doi: 10.1007/s11030-005-3126-4. [PMID: 15789570]
  • W el-Sayed, K Hurle. Efficacy of Phomopsis convolvulus as a mycoherbicide for Convolvulus arvensis. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2001; 66(2b):775-89. doi: ". [PMID: 12425103]
  • Y Li, Y Koiso, H Kobayashi, Y Hashimoto, S Iwasaki. Ustiloxins, new antimitotic cyclic peptides: interaction with porcine brain tubulin. Biochemical pharmacology. 1995 May; 49(10):1367-72. doi: 10.1016/0006-2952(95)00072-8. [PMID: 7763278]
  • J G Allen, A G Randall. The clinical biochemistry of experimentally produced lupinosis in the sheep. Australian veterinary journal. 1993 Aug; 70(8):283-8. doi: 10.1111/j.1751-0813.1993.tb07975.x. [PMID: 8216093]
  • J T Mackie, R S Rahaley, R Bennett. Lupinosis in yearling cattle. Australian veterinary journal. 1992 Jul; 69(7):172-3. doi: 10.1111/j.1751-0813.1992.tb07507.x. [PMID: 1445085]
  • J E Peterson. Biliary hyperplasia and carcinogenesis in chronic liver damage induced in rats by phomopsin. Pathology. 1990 Oct; 22(4):213-22. doi: 10.3109/00313029009086665. [PMID: 1982562]
  • C H van Aswegen, W M Lewko, J L Wittliff. Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells. Journal of toxicology and environmental health. 1985; 16(1):13-23. doi: 10.1080/15287398509530715. [PMID: 4068051]
  • M V Jago, J E Peterson, A L Payne, D G Campbell. Lupinosis: response of sheep to different doses of phomopsin. The Australian journal of experimental biology and medical science. 1982 Jun; 60(3):239-51. doi: 10.1038/icb.1982.29. [PMID: 7138414]