Ebelactone B (BioDeep_00000232712)
代谢物信息卡片
(-)-Ebelactone B
化学式: C21H36O4 (352.2613)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(OC1=O)C(C)CC(=CC(C)C(=O)C(C)C(C(C)CC)O)C
InChI: InChI=1S/C21H36O4/c1-8-13(4)18(22)16(7)19(23)14(5)10-12(3)11-15(6)20-17(9-2)21(24)25-20/h10,13-18,20,22H,8-9,11H2,1-7H3/b12-10+/t13-,14-,15+,16+,17+,18-,20+/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ursula Waack, Tanya L Johnson, Khalil Chedid, Chuanwu Xi, Lyle A Simmons, Harry L T Mobley, Maria Sandkvist. Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.
Frontiers in cellular and infection microbiology.
2017; 7(?):380. doi:
10.3389/fcimb.2017.00380. [PMID: 28894700] - Makoto Katori, Masataka Majima. Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.
2014; 69(?):59-109. doi:
10.1007/978-3-319-06683-7_4. [PMID: 25130040] - Andrew L Darrow, Matthew W Olson, Hong Xin, Sharon L Burke, Charles Smith, Celine Schalk-Hihi, Robyn Williams, Shariff S Bayoumy, Ingrid C Deckman, Matthew J Todd, Bruce P Damiano, Margery A Connelly. A novel fluorogenic substrate for the measurement of endothelial lipase activity.
Journal of lipid research.
2011 Feb; 52(2):374-82. doi:
10.1194/jlr.d007971. [PMID: 21062953] - Zhiyong Lou, Ming Li, Yuna Sun, Ye Liu, Zheng Liu, Wenping Wu, Zihe Rao. Crystal structure of a secreted lipase from Gibberella zeae reveals a novel 'double-lock' mechanism.
Protein & cell.
2010 Aug; 1(8):760-70. doi:
10.1007/s13238-010-0094-y. [PMID: 21203917] - Weerapong Juntachai, Takahiro Oura, Somay Yamagata Murayama, Susumu Kajiwara. The lipolytic enzymes activities of Malassezia species.
Medical mycology.
2009; 47(5):477-84. doi:
10.1080/13693780802314825. [PMID: 18798119] - Susannah Lee, Gary Gustafson, Pari Skamnioti, Roobina Baloch, Sarah Gurr. Host perception and signal transduction studies in wild-type Blumeria graminis f. sp. hordei and a quinoxyfen-resistant mutant implicate quinoxyfen in the inhibition of serine esterase activity.
Pest management science.
2008 May; 64(5):544-55. doi:
10.1002/ps.1538. [PMID: 18229890] - Halina Ostrowska, Joanna Kalinowska, Ewa Chabielska, Adrian Stankiewicz, Kamil Kruszewski, Wlodzimierz Buczko. Ebelactone B, an inhibitor of extracellular cathepsin A-type enzyme, suppresses platelet aggregation ex vivo in renovascular hypertensive rats.
Journal of cardiovascular pharmacology.
2005 Apr; 45(4):348-53. doi:
10.1097/01.fjc.0000157441.95354.d6. [PMID: 15772524] - T Kajiro, T Fukushima, K Imai. Determination of bradykinin in rat urine by coupled-column high pressure liquid chromatography with precolumn derivatization with a water-soluble fluorogenic reagent.
Analytical biochemistry.
2001 Oct; 297(1):52-9. doi:
10.1006/abio.2001.5315. [PMID: 11567527] - S Nakajima, H Ito, I Hayashi, Y Kuribayashi, T Okumura, Y Yajima, M Katori, M Majima. Inhibition of kinin degradation on the luminal side of renal tubules reduces high blood pressure in deoxycorticosterone acetate salt-treated rats.
Clinical and experimental pharmacology & physiology.
2000 Jan; 27(1-2):80-7. doi:
10.1046/j.1440-1681.2000.03209.x. [PMID: 10696533] - H Ito, M Majima, S Nakajima, I Hayashi, M Katori, T Izumi. Effect of prolonged administration of a urinary kinase inhibitor, ebelactone B on the development of deoxycorticosterone acetate-salt hypertension in rats.
British journal of pharmacology.
1999 Feb; 126(3):613-20. doi:
10.1038/sj.bjp.0702340. [PMID: 10188971] - M Katori, M Majima, I Hayashi. Crucial suppressive role of renal kallikrein-kinin system in development of salt-sensitive hypertension.
Biological research.
1998; 31(3):143-9. doi:
NULL. [PMID: 9830501] - M Katori, M Majima. Role of the renal kallikrein-kinin system in the development of hypertension.
Immunopharmacology.
1997 Jun; 36(2-3):237-42. doi:
10.1016/s0162-3109(97)00029-5. [PMID: 9228552] - Y Nonaka, H Ohtaki, E Ohtsuka, T Kocha, T Fukuda, T Takeuchi, T Aoyagi. Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat.
Journal of enzyme inhibition.
1996; 10(1):57-63. doi:
10.3109/14756369509021471. [PMID: 8835930] - M Majima, Y Ikeda, Y Kuribayashi, S Mizogami, M Katori, T Aoyagi. Ebelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats.
European journal of pharmacology.
1995 Sep; 284(1-2):1-11. doi:
10.1016/0014-2999(95)00320-k. [PMID: 8549611] - M Saito, M Majima, M Katori, Y Sanjou, I Suyama, H Shiokawa, K Koshiba, T Aoyagi. Degradation of bradykinin in human urine by carboxypeptidase Y-like exopeptidase and neutral endopeptidase and their inhibition by ebelactone B and phosphoramidon.
International journal of tissue reactions.
1995; 17(5-6):181-90. doi:
. [PMID: 8835628] - M Majima, Y Kuribayashi, Y Ikeda, K Adachi, H Kato, M Katori, T Aoyagi. Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase.
Japanese journal of pharmacology.
1994 May; 65(1):79-82. doi:
10.1254/jjp.65.79. [PMID: 8089934] - W Köller, F Trail, D M Parker. Ebelactones inhibit cutinases produced by fungal plant pathogens.
The Journal of antibiotics.
1990 Jun; 43(6):734-5. doi:
10.7164/antibiotics.43.734. [PMID: 2380118]
