Dihomolinoleic acid (BioDeep_00000023256)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


10,12-Octadecadienoic acid, (10E,12Z)-

化学式: C18H32O2 (280.2402172)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 1.29%

分子结构信息

SMILES: CCCCCC=CC=CCCCCCCCCC(=O)O
InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-9H,2-5,10-17H2,1H3,(H,19,20)/b7-6-,9-8-

描述信息

Dihomolinoleic acid, also known as 10Z,12Z-octadecadienoic acid, is classified as a linoleic acid or a linoleic acid derivative. Linoleic acid is a polyunsaturated omega-6 18-carbon fatty acid with two CC double bonds at the 9- and 12-positions. Dihomolinoleic acid is considered to be practically insoluble (in water) and a very weak acidic compound. Dihomolinoleic acid can be found in black walnut, which makes dihomolinoleic acid a potential biomarker for the consumption of this food product. Dihomolinoleic acid can be found in blood, saliva, and feces.

同义名列表

20 个代谢物同义名

10,12-Octadecadienoic acid, (10E,12Z)-; (10Z,12Z)-octadeca-10,12-dienoic acid; (10Z,12Z)-10,12-Octadecadienoic acid; cis-10,cis-12-Octadecadienoic acid; 10-cis-12-cis-Octadecadienoic acid; (Z,Z)-10,12-Octadecadienoic acid; cis-10,cis-12-Octadecadienoate; 10Z,12Z-octadecadienoic acid; Dihomolinoleic acid (20:2n6); cis-10,cis-12-Linoleic acid; 10-cis,12-cis-Linoleic acid; 10,12-Octadecadienoic acid; 10Z,12Z-Octadecadienoate; Dihomolinoleate (20:2n6); Dihomolinoleic acid; FA(20:2(10Z,12Z)); Dihomo-linoleate; Dihomolinoleate; FA(20:2n6); 20:2n6



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elena Giordano, Sebastiano Banni, Loredana Quadro. A single dose of c9,t11 or t10,c12 conjugated linoleic acid isomers perturbs vitamin A metabolism in mice. Nutrition research (New York, N.Y.). 2011 Nov; 31(11):855-62. doi: 10.1016/j.nutres.2011.09.013. [PMID: 22118757]
  • Carolina Ramírez-Santana, Cristina Castellote, Margarida Castell, Carolina Moltó-Puigmartí, Montserrat Rivero, Francisco J Pérez-Cano, Angels Franch. Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life. The Journal of nutritional biochemistry. 2011 May; 22(5):495-501. doi: 10.1016/j.jnutbio.2010.04.005. [PMID: 20688497]
  • Eva Rosberg-Cody, Catherine Stanton, Liam O'Mahony, Rebecca Wall, Fergus Shanahan, Eamonn M Quigley, Gerald F Fitzgerald, R Paul Ross. Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. Microbiology (Reading, England). 2011 Feb; 157(Pt 2):609-615. doi: 10.1099/mic.0.043406-0. [PMID: 21178166]
  • Arion Kennedy, Kristina Martinez, Soonkyu Chung, Kathy LaPoint, Robin Hopkins, Soren F Schmidt, Kenneth Andersen, Susanne Mandrup, Michael McIntosh. Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes. Journal of lipid research. 2010 Jul; 51(7):1906-17. doi: 10.1194/jlr.m005447. [PMID: 20154361]
  • Hyun-Seuk Moon, Hong-Gu Lee, Chung-Soo Chung, Yun-Jaie Choi, Chong-Su Cho. Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. Nutrition & metabolism. 2008 Jun; 5(?):16. doi: 10.1186/1743-7075-5-16. [PMID: 18513443]
  • Jessica R Miller, Pilaiwan Siripurkpong, Jennifer Hawes, Amin Majdalawieh, Hyo-Sung Ro, Roger S McLeod. The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms. Journal of lipid research. 2008 Mar; 49(3):550-62. doi: 10.1194/jlr.m700275-jlr200. [PMID: 18056926]
  • Magdalena Franczyk-Zarów, Renata B Kostogrys, Beata Szymczyk, Jacek Jawień, Mariusz Gajda, Tadeusz Cichocki, Leszek Wojnar, Stefan Chlopicki, Paweł M Pisulewski. Functional effects of eggs, naturally enriched with conjugated linoleic acid, on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low-density lipoprotein receptor double-knockout mice (apoE/LDLR-/-). The British journal of nutrition. 2008 Jan; 99(1):49-58. doi: 10.1017/s0007114507793893. [PMID: 17678565]
  • Anne Mullen, Fiona Moloney, Anne P Nugent, Lorna Doyle, Kevin D Cashman, Helen M Roche. Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males. The Journal of nutritional biochemistry. 2007 Oct; 18(10):658-66. doi: 10.1016/j.jnutbio.2006.12.008. [PMID: 17368881]
  • Tsuyoshi Tsuzuki, Ikuo Ikeda. Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid. Bioscience, biotechnology, and biochemistry. 2007 Aug; 71(8):2034-40. doi: 10.1271/bbb.70238. [PMID: 17690459]
  • Graham C Burdge, Berit Lupoli, Jennifer J Russell, Sabine Tricon, Samantha Kew, Tapati Banerjee, Kevin J Shingfield, David E Beever, Robert F Grimble, Christine M Williams, Parveen Yaqoob, Philip C Calder. Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men. Journal of lipid research. 2004 Apr; 45(4):736-41. doi: 10.1194/jlr.m300447-jlr200. [PMID: 14754909]
  • May M Al-Madaney, John K G Kramer, Zeyuan Deng, Jack Y Vanderhoek. Effects of lipid-esterified conjugated linoleic acid isomers on platelet function: evidence for stimulation of platelet phospholipase activity. Biochimica et biophysica acta. 2003 Dec; 1635(2-3):75-82. doi: 10.1016/j.bbalip.2003.10.008. [PMID: 14729070]
  • Youngjin Choi, Yeonhwa Park, Jayne M Storkson, Michael W Pariza, James M Ntambi. Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. Biochemical and biophysical research communications. 2002 Jun; 294(4):785-90. doi: 10.1016/s0006-291x(02)00554-5. [PMID: 12061775]