RA-XII (BioDeep_00000231644)
代谢物信息卡片
化学式: C46H58N6O14 (918.4011)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C2CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC(C(=O)N1)N(C2=O)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)CC6=CC=C(C=C6)OC)C)C
InChI: InChI=1S/C46H58N6O14/c1-23-40(57)48-24(2)43(60)50(4)31(18-26-8-13-29(63-7)14-9-26)42(59)49-25(3)44(61)52(6)33-19-27-10-15-30(16-11-27)64-35-21-28(20-32(41(58)47-23)51(5)45(33)62)12-17-34(35)65-46-39(56)38(55)37(54)36(22-53)66-46/h8-17,21,23-25,31-33,36-39,46,53-56H,18-20,22H2,1-7H3,(H,47,58)(H,48,57)(H,49,59)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Qianwen Lin, Mingyu Liu, Grace Gar-Lee Yue, Man Kit Cheung, Zhixing Lai, Frankie Hin-Fai Kwok, Julia Kin-Ming Lee, Zhe Wang, Clara Bik-San Lau, Ninghua Tan. Anti-inflammatory activities of natural cyclopeptide RA-XII in colitis-associated colon cancer mouse model and its effect on gut microbiome.
Phytotherapy research : PTR.
2022 Jun; 36(6):2641-2659. doi:
10.1002/ptr.7482. [PMID: 35537703] - Jing Wang, Jia Wang, Ling Li, Li Feng, Yu-Rong Wang, Zhe Wang, Ning-Hua Tan. RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells.
Journal of ethnopharmacology.
2021 Feb; 266(?):113438. doi:
10.1016/j.jep.2020.113438. [PMID: 33017635] - Yurong Wang, Di Guo, Junqiu He, Lihua Song, Huachao Chen, Zhihao Zhang, Ninghuan Tan. Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Biochemical and biophysical research communications.
2019 05; 512(4):819-824. doi:
10.1016/j.bbrc.2019.03.088. [PMID: 30928092] - Di Guo, Yurong Wang, Jing Wang, Lihua Song, Zhe Wang, Bingyu Mao, Ninghua Tan. RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091829. [PMID: 31083642] - Xusheng An, Futai Shang. RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-κB and MAPKs regulated by HO-1/Nrf2 pathway.
Biochemical and biophysical research communications.
2018 01; 495(3):2317-2323. doi:
10.1016/j.bbrc.2017.12.131. [PMID: 29277609] - Lihua Song, Zhe Wang, Yurong Wang, Di Guo, Jianhong Yang, Lijuan Chen, Ninghua Tan. Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111934. [PMID: 29137114] - Hoi-Wing Leung, Si-Meng Zhao, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan, Clara Bik-San Lau. RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.
Scientific reports.
2015 Nov; 5(?):16985. doi:
10.1038/srep16985. [PMID: 26592552] - Jing Tao, Toshio Morikawa, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa. Bioactive constituents from Chinese natural medicines. XI. inhibitors on NO production and degranulation in RBL-2H3 from Rubia yunnanensis: structures of rubianosides II, III, and IV, rubianol-g, and rubianthraquinone.
Chemical & pharmaceutical bulletin.
2003 Jun; 51(6):654-62. doi:
10.1248/cpb.51.654. [PMID: 12808242]
