α-Lapachone (BioDeep_00000231171)

 

Secondary id: BioDeep_00000396495

natural product PANOMIX_OTCML-2023


代谢物信息卡片


alpha-Lapachone

化学式: C15H14O3 (242.0943)
中文名称: ALPHA-拉杷醌, Α-拉杷醌
谱图信息: 最多检出来源 Viridiplantae(plant) 53.55%

分子结构信息

SMILES: c1ccc2c(c1)C(=O)C1=C(C2=O)CCC(O1)(C)C
InChI: InChI=1S/C15H14O3/c1-15(2)8-7-11-12(16)9-5-3-4-6-10(9)13(17)14(11)18-15/h3-6H,7-8H2,1-2H3

描述信息

D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
[Raw Data] CB137_alpha-Lapachone_pos_50eV_CB000049.txt
D004791 - Enzyme Inhibitors
[Raw Data] CB137_alpha-Lapachone_pos_40eV_CB000049.txt
[Raw Data] CB137_alpha-Lapachone_pos_30eV_CB000049.txt
[Raw Data] CB137_alpha-Lapachone_pos_20eV_CB000049.txt
[Raw Data] CB137_alpha-Lapachone_pos_10eV_CB000049.txt
α-Lapachone shows trypanocidal activity[1].
α-Lapachone shows trypanocidal activity[1].

同义名列表

3 个代谢物同义名

alpha-Lapachone; α-Lapachone; alpha-Lapachone



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves. In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123537. [PMID: 34200517]
  • Hauke Löcken, Cinzia Clamor, Klaus Müller. Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells. Journal of natural products. 2018 07; 81(7):1636-1644. doi: 10.1021/acs.jnatprod.8b00247. [PMID: 30003778]
  • K M Fardin, M C M Young. Antifungal potential of Avicennia schaueriana Stapf & Leech. (Acanthaceae) against Cladosporium and Colletotrichum species. Letters in applied microbiology. 2015 Jul; 61(1):50-7. doi: 10.1111/lam.12423. [PMID: 25825048]
  • Franklin Souza-Silva, Saulo Cabral Bourguignon, Bernardo Acácio Santini Pereira, Luzia Monteiro de Castro Côrtes, Luiz Filipe Gonçalves de Oliveira, Andrea Henriques-Pons, Lea Cysne Finkelstein, Vitor Francisco Ferreira, Paula Fernandes Carneiro, Rosa Teixeira de Pinho, Ernesto Raul Caffarena, Carlos Roberto Alves. Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite. Antimicrobial agents and chemotherapy. 2015 Apr; 59(4):1910-8. doi: 10.1128/aac.04742-14. [PMID: 25583728]
  • K Müller, A Sellmer, W Wiegrebe. Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. Journal of natural products. 1999 Aug; 62(8):1134-6. doi: 10.1021/np990139r. [PMID: 10479319]