Bafilomycin B1 (BioDeep_00000231070)
代谢物信息卡片
化学式: C44H65NO13 (815.4456)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 100%
分子结构信息
SMILES: COC1=CC(C)=CC(C)C(O)C(C)CC(C)=CC=CC(OC)C(C(C)C(O)C(C)C2(O)CC(OC(=O)C=CC(=O)NC3=C(O)CCC3=O)C(C)C(C(C)C)O2)OC1=O
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jun Hirao, Akihiro Tojo, Saaya Hatakeyama, Hiroshi Satonaka, Toshihiko Ishimitsu. V-ATPase blockade reduces renal gluconeogenesis and improves insulin secretion in type 2 diabetic rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2020 10; 43(10):1079-1088. doi:
10.1038/s41440-020-0450-0. [PMID: 32382157] - Akihiro Tojo, Saaya Hatakeyama, Masaomi Nangaku, Toshihiko Ishimitsu. H+-ATPase blockade reduced renal gluconeogenesis and plasma glucose in a diabetic rat model.
Medical molecular morphology.
2018 Jun; 51(2):89-95. doi:
10.1007/s00795-017-0175-6. [PMID: 29318388] - Zerihun T Dame, Pornthip Ruanpanun. Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB.
World journal of microbiology & biotechnology.
2017 Jul; 33(7):139. doi:
10.1007/s11274-017-2306-6. [PMID: 28585168] - Hua-Qi Pan, Su-Ya Yu, Chun-Feng Song, Nan Wang, Hui-Ming Hua, Jiang-Chun Hu, Shu-Jin Wang. Identification and characterization of the antifungal substances of a novel Streptomyces cavourensis NA4.
Journal of microbiology and biotechnology.
2015 Mar; 25(3):353-7. doi:
10.4014/jmb.1407.07025. [PMID: 25269816] - K D Hettiarachchi, P Z Zimmet, M A Myers. Transplacental exposure to bafilomycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice.
Journal of autoimmunity.
2004 Jun; 22(4):287-96. doi:
10.1016/j.jaut.2004.02.004. [PMID: 15120752] - S Dröse, C Boddien, M Gassel, G Ingenhorst, A Zeeck, K Altendorf. Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes.
Biochemistry.
2001 Mar; 40(9):2816-25. doi:
10.1021/bi001759q. [PMID: 11258892] - J Dørup, H Scholz, A B Maunsbach, B Kaissling. Effects of inhibition of the vacuolar-type proton pump on nephron ultrastructure and acidification in the isolated perfused rat kidney.
Experimental nephrology.
1995 May; 3(3):180-92. doi:
NULL. [PMID: 7620856] - S Naganuma, N Kuzuya, K Sakai, K Hasumi, A Endo. Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.
Biochimica et biophysica acta.
1992 Jun; 1126(1):41-8. doi:
10.1016/0005-2760(92)90214-g. [PMID: 1606174] - K Jehmlich, J Sablotni, B J Simon, G Burckhardt. Biochemical aspects of H(+)-ATPase in renal proximal tubules: inhibition by N,N'-dicyclohexylcarbodiimide, N-ethylmaleimide, and bafilomycin.
Kidney international. Supplement.
1991 Jul; 33(?):S64-70. doi:
NULL. [PMID: 1832471] - U Löhden-Bendinger, T Bakker-Grunwald. Evidence for a vacuolar-type proton ATPase in Entamoeba histolytica.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
1990 Mar; 45(3-4):229-32. doi:
10.1515/znc-1990-3-414. [PMID: 2141984] - E J Bowman, A Siebers, K Altendorf. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.
Proceedings of the National Academy of Sciences of the United States of America.
1988 Nov; 85(21):7972-6. doi:
10.1073/pnas.85.21.7972. [PMID: 2973058]
