p-Methoxyamphetamine (BioDeep_00000231051)

Main id: BioDeep_00000174438

 

Volatile Flavor Compounds natural product


代谢物信息卡片


p-Methoxyamphetamine

化学式: C10H15NO (165.115358)
中文名称: N-[（9R，11R，13R，13R）-67,71,75,75,79-四乙基-28,29,44,44,58,59-五（1-羟基丙基亚亚丙基氨基）-11-甲氧基羰基-9,11,11,13-三甲基-14-氧代-3,19,23,34,38,49,53,64-辛氧-7,15,27,30,42,45,57,60-十八氮杂十五碳环[64.13.1.12.12.12,65.13.19,13.19,13.24,28,29,44,44,44,44,58,58,59,59-五五五五五（1-羟基丙基亚亚亚丙基亚氨基）-11-甲氧基-11,11,11,11,11,11,11,33.026,31.035,74.037,72.039,48.041,46.050,70.052,68.054,63.056,61]dooctaconta-1（80），2（81），4（18），5,7,16,20（78），21,24（33），25,31,35（74），36,39（48），40,46,50（70），51,54（63），55,61,65,68,72,76-pentacosaen-43-yl]propanimidic acid, 对甲氧基苯丙胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1c(ccc(c1)C[C@H](N)C)OC
InChI: InChI=1S/C10H15NO/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6,8H,7,11H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens

同义名列表

4 个代谢物同义名

p-Methoxyamphetamine; 4-Methoxyamphetamine; N-[(9R,11R,13R)-67,71,75,79-tetraethyl-28,29,44,58,59-pentakis(1-hydroxypropylideneamino)-11-methoxycarbonyl-9,11,13-trimethyl-14-oxo-3,19,23,34,38,49,53,64-octaoxa-7,15,27,30,42,45,57,60-octazanonadecacyclo[64.13.1.12,65.19,13.04,18.06,16.08,15.020,78.022,76.024,33.026,31.035,74.037,72.039,48.041,46.050,70.052,68.054,63.056,61]dooctaconta-1(80),2(81),4(18),5,7,16,20(78),21,24(33),25,31,35(74),36,39(48),40,46,50(70),51,54(63),55,61,65,68,72,76-pentacosaen-43-yl]propanimidic acid; p-Methoxyamphetamine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yael Lurie, Asher Gopher, Ophir Lavon, Shlomo Almog, Liron Sulimani, Yedidia Bentur. Severe paramethoxymethamphetamine (PMMA) and paramethoxyamphetamine (PMA) outbreak in Israel. Clinical toxicology (Philadelphia, Pa.). 2012 Jan; 50(1):39-43. doi: 10.3109/15563650.2011.635148. [PMID: 22148985]
  • Maria Kała, Wojciech Lechowicz, Agnieszka Skulska, Małgorzata Barwina, Jacek Sein Anand. [Resurgence in paramethoxamphetamine use. Review of poisonings and two recent cases study]. Przeglad lekarski. 2011; 68(8):548-52. doi: NULL. [PMID: 22010464]
  • Suzanne M Cloonan, John J Keating, Stephen G Butler, Andrew J S Knox, Anne M Jørgensen, Günther H Peters, Dilip Rai, Desmond Corrigan, David G Lloyd, D Clive Williams, Mary J Meegan. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. European journal of medicinal chemistry. 2009 Dec; 44(12):4862-88. doi: 10.1016/j.ejmech.2009.07.027. [PMID: 19717215]
  • Miroslava Rohanova, Marie Balikova. Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) in rats after subcutaneous administration. Toxicology. 2009 May; 259(1-2):61-8. doi: 10.1016/j.tox.2009.02.003. [PMID: 19428944]
  • Andrew Crowe, Susanna Diep. pH dependent efflux of methamphetamine derivatives and their reversal through human Caco-2 cell monolayers. European journal of pharmacology. 2008 Sep; 592(1-3):7-12. doi: 10.1016/j.ejphar.2008.06.090. [PMID: 18638470]
  • Amparo Fornés, Enrique Núñez, Pablo Alonso-Torres, Carmen Aragón, Beatriz López-Corcuera. Trafficking properties and activity regulation of the neuronal glycine transporter GLYT2 by protein kinase C. The Biochemical journal. 2008 Jun; 412(3):495-506. doi: 10.1042/bj20071018. [PMID: 18341477]
  • Kei Zaitsu, Munehiro Katagi, Tooru Kamata, Hiroe Kamata, Noriaki Shima, Hitoshi Tsuchihashi, Takeshi Hayashi, Hisanaga Kuroki, Ryoji Matoba. Determination of a newly encountered designer drug 'p-methoxyethylamphetamine' and its metabolites in human urine and blood. Forensic science international. 2008 May; 177(1):77-84. doi: 10.1016/j.forsciint.2007.11.001. [PMID: 18155375]
  • Paul D Callaghan, W Anthony Owens, Martin A Javors, Teresa A Sanchez, David J Jones, Rodney J Irvine, Lynette C Daws. In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. Journal of neurochemistry. 2007 Feb; 100(3):617-27. doi: 10.1111/j.1471-4159.2006.04247.x. [PMID: 17181558]
  • Paul D Callaghan, Kirsten Farrand, Abdallah Salem, Patrick Hughes, Lynette C Daws, Rodney J Irvine. Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European journal of pharmacology. 2006 Sep; 546(1-3):74-81. doi: 10.1016/j.ejphar.2006.07.011. [PMID: 16925993]
  • Nahal Ketabi-Kiyanvash, Johanna Weiss, Walter Emil Haefeli, Gerd Mikus. P-glycoprotein modulation by the designer drugs methylenedioxymethamphetamine, methylenedioxyethylamphetamine and paramethoxyamphetamine. Addiction biology. 2003 Dec; 8(4):413-8. doi: 10.1080/13556210310001646475. [PMID: 14690877]
  • S Refstad. Paramethoxyamphetamine (PMA) poisoning; a 'party drug' with lethal effects. Acta anaesthesiologica Scandinavica. 2003 Nov; 47(10):1298-9. doi: 10.1046/j.1399-6576.2003.00245.x. [PMID: 14616331]
  • R Dams, E A De Letter, K A Mortier, J A Cordonnier, W E Lambert, M H A Piette, S Van Calenbergh, A P De Leenheer. Fatality due to combined use of the designer drugs MDMA and PMA: a distribution study. Journal of analytical toxicology. 2003 Jul; 27(5):318-22. doi: 10.1093/jat/27.5.318. [PMID: 12908947]
  • Sys Stybe Johansen, A Carsten Hansen, Irene Breum Müller, Jytte Banner Lundemose, Maria-B Franzmann. Three fatal cases of PMA and PMMA poisoning in Denmark. Journal of analytical toxicology. 2003 May; 27(4):253-6. doi: 10.1093/jat/27.4.253. [PMID: 12820749]
  • David G E Caldicott, Nicholas A Edwards, Amanda Kruys, K Paul Kirkbride, D Noel Sims, Roger W Byard, Michael Prior, Rod J Irvine. Dancing with 'death': p-methoxyamphetamine overdose and its acute management. Journal of toxicology. Clinical toxicology. 2003; 41(2):143-54. doi: 10.1081/clt-120019130. [PMID: 12733852]
  • Kjell A Mortier, Riet Dams, Willy E Lambert, Els A De Letter, Serge Van Calenbergh, André P De Leenheer. Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry. Rapid communications in mass spectrometry : RCM. 2002; 16(9):865-70. doi: 10.1002/rcm.657. [PMID: 11948818]
  • Zygmunt Chodorowski, Marek Wiergowski, Jacek Sein Anand. [Fatal intoxication with paramethoxyamphetamine]. Przeglad lekarski. 2002; 59(4-5):379-80. doi: NULL. [PMID: 12184013]
  • L H Ling, C Marchant, N A Buckley, M Prior, R J Irvine. Poisoning with the recreational drug paramethoxyamphetamine ('death'). The Medical journal of Australia. 2001 May; 174(9):453-5. doi: 10.5694/j.1326-5377.2001.tb143372.x. [PMID: 11386590]
  • L N Domelsmith, T A Eaton, K N Houk, G M Anderson, R A Glennon, A T Shulgin, N Castagnoli, P A Kollman. Photoelectron spectra of psychotropic drugs. 6. Relationships between the physical properties and pharmacological actions of amphetamine analogues. Journal of medicinal chemistry. 1981 Dec; 24(12):1414-21. doi: 10.1021/jm00144a009. [PMID: 7310818]
  • J W Hubbard, K Bailey, K K Midha, J K Cooper. 3-O-methyl-alpha-methyldopamine, a urinary metabolite of p-methoxyamphetamine in dog and monkey. Drug metabolism and disposition: the biological fate of chemicals. 1981 May; 9(3):250-4. doi: NULL. [PMID: 6113935]
  • K K Midha, J K Cooper, K Bailey, J W Hubbard. The metabolism of 3-methoxyamphetamine in dog, monkey and man. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Feb; 11(2):137-46. doi: 10.3109/00498258109045284. [PMID: 6894510]