Polyphyllin (BioDeep_00000230969)

 

Secondary id: BioDeep_00000396440

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5R,6R,7S,8R,9S,12S,13R,16S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol

化学式: C51H82O20 (1014.5399172)
中文名称: 重楼皂苷B, 重楼皂甙B, 重楼皂苷E, 重楼皂甙E
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 93.75%

分子结构信息

SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)OC9C(C(C(C(O9)C)O)O)O)OC2C(C(C(C(O2)C)O)O)O)O)C)C)C)OC1
InChI: InChI=1S/C51H82O20/c1-20-10-15-51(62-19-20)21(2)32-30(71-51)17-29-27-9-8-25-16-26(11-13-49(25,6)28(27)12-14-50(29,32)7)66-47-41(61)43(69-45-39(59)36(56)33(53)22(3)63-45)42(31(18-52)67-47)68-48-44(38(58)35(55)24(5)65-48)70-46-40(60)37(57)34(54)23(4)64-46/h8,20-24,26-48,52-61H,9-19H2,1-7H3

描述信息

Formosanin C is a natural product found in Ypsilandra thibetica, Trachycarpus fortunei, and other organisms with data available.
Formosanin C is a diosgenin saponin isolated from Paris polyphylla and an immunomodulator with antitumor activity. Formosanin C induces apoptosis[1][2].
Formosanin C is a diosgenin saponin isolated from Paris polyphylla and an immunomodulator with antitumor activity. Formosanin C induces apoptosis[1][2].

同义名列表

10 个代谢物同义名

(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5R,6R,7S,8R,9S,12S,13R,16S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol; diosgenin 3-O-alpha-rhamnopyranosyl-(1-4)-alpha-rhamnopyranosyl-(1-4)-(alpha-rhamnopyranosyl-(1-2))-beta-glucopyranoside; Pennogenin rahamnosyl chacotrioside; Paris saponin II; formosanin C; Polyphyllin; 2-[4,5-Dihydroxy-2-[5-hydroxy-2-(hydroxymethyl)-6-(5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-16-yl)oxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]oxy-6-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol; |A-D-Glucopyranoside, (3|A,25R)-spirost-5-en-3-yl O-6-deoxy-|A-L-mannopyranosyl-(1 inverted exclamation marku3)-O-[O-6-deoxy-|A-L-mannopyranosyl-(1 inverted exclamation marku2)-6-deoxy-|A-L-mannopyranosyl-(1 inverted exclamation marku4)]-; (3beta,25R)-Spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-->3)-O-[O-6-deoxy-alpha-L-mannopyranosyl-(1-->2)-6-deoxy-alpha-L-mannopyranosyl-(1-->4)]-beta-D-glucopyranoside; (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->3)-[6-deoxy-α-L-mannopyranosyl-(1->2)-6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang. Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis. International journal of biological sciences. 2024; 20(7):2454-2475. doi: 10.7150/ijbs.91861. [PMID: 38725854]
  • Nguyen Thi Duyen, Le Ba Vinh, Nguyen Viet Phong, Nguyen Minh Khoi, Do Thi Ha, Pham Quoc Long, Le Viet Dung, Tran Thi Hien, Nguyen Tien Dat, Ki Yong Lee. Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest. Carbohydrate research. 2022 Sep; 519(?):108613. doi: 10.1016/j.carres.2022.108613. [PMID: 35752103]
  • Zhi Dai, Hui Liu, Bei Wang, Dong Yang, Yan-Yan Zhu, Huan Yan, Pei-Feng Zhu, Ya-Ping Liu, Hui-Cheng Chen, Yun-Li Zhao, Li-Xing Zhao, Xu-Dong Zhao, Hai-Yang Liu, Xiao-Dong Luo. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A. European journal of medicinal chemistry. 2021 Jan; 210(?):113068. doi: 10.1016/j.ejmech.2020.113068. [PMID: 33310292]
  • Mei Yang, Juan Zou, Hongmei Zhu, Shanling Liu, He Wang, Peng Bai, Xue Xiao. Paris saponin II inhibits human ovarian cancer cell-induced angiogenesis by modulating NF-κB signaling. Oncology reports. 2015 May; 33(5):2190-8. doi: 10.3892/or.2015.3836. [PMID: 25760800]
  • Lei Fan, Yuhua Li, Yang Sun, Zhenggang Yue, Jin Meng, Xutao Zhang, Rong Zhang, Dian Zhang, Feng Zhang, Qibing Mei. Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells. Molecular medicine reports. 2015 Jan; 11(1):705-11. doi: 10.3892/mmr.2014.2728. [PMID: 25333739]
  • Xue Xiao, Mei Yang, Jianguo Xiao, Juan Zou, Qin Huang, Kaixuan Yang, Bo Zhang, Fan Yang, Shanling Liu, He Wang, Peng Bai. Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration. Cancer chemotherapy and pharmacology. 2014 Apr; 73(4):807-18. doi: 10.1007/s00280-014-2408-x. [PMID: 24638862]
  • Ze-Hong Li, Jia-Yu Wan, Gui-Qin Wang, Fu-Guang Zhao, Ji-Hong Wen. Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius. Parasitology. 2013 Jul; 140(8):952-8. doi: 10.1017/s0031182013000139. [PMID: 23552446]
  • Xue Xiao, Juan Zou, Tri Minh Bui-Nguyen, Peng Bai, Linbo Gao, Jinsong Liu, Shanling Liu, Jianguo Xiao, Xinlian Chen, Xuemei Zhang, He Wang. Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells. Bioscience trends. 2012 Aug; 6(4):201-11. doi: 10.5582/bst.2012.v6.4.201. [PMID: 23006967]
  • Y Mimaki, K Watanabe, Y Ando, C Sakuma, Y Sashida, S Furuya, H Sakagami. Flavonol glycosides and steroidal saponins from the leaves of Cestrum nocturnum and their cytotoxicity. Journal of natural products. 2001 Jan; 64(1):17-22. doi: 10.1021/np0003701. [PMID: 11170659]
  • R T Wu, W J Lin, H C Chiang, L Y Horng, Y M Chung. Modulation of experimental autoimmune uveitis with formosanin-C in guinea pigs. Journal of ocular pharmacology. 1990; 6(4):301-11. doi: 10.1089/jop.1990.6.301. [PMID: 2097314]
  • C D Hufford, S C Liu, A M Clark. Antifungal activity of Trillium grandiflorum constituents. Journal of natural products. 1988 Jan; 51(1):94-8. doi: 10.1021/np50055a013. [PMID: 3373231]