Polyphyllin (BioDeep_00000230967)

Main id: BioDeep_00000230668

 

PANOMIX_OTCML-2023


代谢物信息卡片


(25R)-Spirost-5-en-3-yl alpha-L-arabinofuranosyl-(1->4)-[6-deoxy-alpha-L-mannopyranosyl-(1->2)]-(4xi)-D-xylo-hexopyranoside

化学式: C44H70O16 (854.466362)
中文名称: 重楼皂甙A, 重楼皂苷I
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(O8)CO)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1
InChI: InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-38(59-39-35(51)33(49)31(47)21(3)54-39)36(52)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3/t19-,20+,21+,23?,24-,25+,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36+,37?,38-,39+,40+,41?,42+,43+,44-/m1/s1

描述信息

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

同义名列表

3 个代谢物同义名

(25R)-Spirost-5-en-3-yl alpha-L-arabinofuranosyl-(1->4)-[6-deoxy-alpha-L-mannopyranosyl-(1->2)]-(4xi)-D-xylo-hexopyranoside; Polyphyllin I; Polyphyllin



数据库引用编号

4 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yaoyao Cai, Fengfeng Xie, Haiou Wang, Qi Zhai, Feng Lin, Shishi Pan. Polyphyllin I alleviates inflammatory injury in mice with gestational diabetes through AMPK pathway. General physiology and biophysics. 2022 Mar; 41(2):159-164. doi: 10.4149/gpb_2022006. [PMID: 35416179]
  • Fangli Mao, Aiping Wu. Polyphyllin I alleviates lipopolysaccharide-induced inflammation reduces pyroptosis in BEAS-2B and HPAEC cells by inhibiting NF-κB signaling. Allergologia et immunopathologia. 2022; 50(4):23-30. doi: 10.15586/aei.v50i4.591. [PMID: 35789400]
  • Shan Peng, Ligai Bai, Laisen Wang, Fanrong Sun, Haiyan Liu, Hongyuan Yan. Fabrication of a cycloalkyl-monolith for on-line solid-phase extraction and determination of four polyphyllins in plasma. Analytical biochemistry. 2020 02; 591(?):113555. doi: 10.1016/j.ab.2019.113555. [PMID: 31874172]
  • Feng-Ling Yu, Wei-Liang Gong, Fang-Jiang Xu, Jun-Wen Wu, Shailendra Shakya, He Zhu. Influence of Nutritional Status on the Absorption of Polyphyllin I, an Anticancer Candidate from Paris polyphylla in Rats. European journal of drug metabolism and pharmacokinetics. 2018 Oct; 43(5):587-597. doi: 10.1007/s13318-018-0473-y. [PMID: 29589340]
  • Yun Liang, Xian Li, Xin He, Xi Qiu, Xue-Li Jin, Xiao-Ying Zhao, Rong-Zhen Xu. Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway. European journal of haematology. 2016 Oct; 97(4):371-8. doi: 10.1111/ejh.12741. [PMID: 26821882]
  • He Zhu, Si-Can Zhu, Shailendra Shakya, Qian Mao, Chuan-Hua Ding, Min-Hui Long, Song-Lin Li. Study on the pharmacokinetics profiles of polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2015 Mar; 107(?):119-24. doi: 10.1016/j.jpba.2014.12.002. [PMID: 25590941]
  • Benwei Wang, Songgang Ji, Hai Zhang, Liang Zhao, Lei Lv, Yueyue Li, Guichen Zhou, Guoqing Zhang. Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats. Steroids. 2013 Dec; 78(12-13):1164-70. doi: 10.1016/j.steroids.2013.08.009. [PMID: 24012730]
  • Xingbin Yin, Changhai Qu, Zhaoxia Li, Yujing Zhai, Sali Cao, Longfei Lin, Lijun Feng, Lei Yan, Jian Ni. Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS. Biomedical chromatography : BMC. 2013 Mar; 27(3):343-8. doi: 10.1002/bmc.2797. [PMID: 22903625]