Anemoside (BioDeep_00000230947)

Main id: BioDeep_00000230765

 

PANOMIX_OTCML-2023


代谢物信息卡片


[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-[(3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylate

化学式: C59H96O26 (1220.619)
中文名称: 白头翁皂苷B4, 白屈菜皂甙C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OCC3C(C(C(C(O3)OC(=O)C45CCC(C4C6CCC7C8(CCC(C(C8CCC7(C6(CC5)C)C)(C)CO)OC9C(C(C(CO9)O)O)OC1C(C(C(C(O1)C)O)O)O)C)C(=C)C)O)O)O)CO)O)O)O
InChI: InChI=1S/C59H96O26/c1-23(2)26-11-16-59(54(75)85-52-45(73)41(69)38(66)30(81-52)21-77-49-46(74)42(70)47(29(19-60)80-49)83-50-43(71)39(67)35(63)24(3)78-50)18-17-57(7)27(34(26)59)9-10-32-55(5)14-13-33(56(6,22-61)31(55)12-15-58(32,57)8)82-53-48(37(65)28(62)20-76-53)84-51-44(72)40(68)36(64)25(4)79-51/h24-53,60-74H,1,9-22H2,2-8H3/t24-,25-,26?,27+,28-,29+,30+,31+,32+,33-,34+,35-,36-,37-,38+,39+,40+,41-,42+,43+,44+,45+,46+,47+,48+,49+,50-,51-,52-,53?,55-,56-,57+,58+,59?/m0/s1

描述信息

Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

同义名列表

5 个代谢物同义名

[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-[(3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylate; Pulchinenoside B4; anemoside B4; Anemoside; Pulchinenoside C



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qing-Hua Liang, Qiu-Rong Li, Zhong Chen, Li-Juan Lv, Yu Lin, Hong-Lv Jiang, Ke-Xin Wang, Ming-Yue Xiao, Nai-Xin Kang, Peng-Fei Tu, Shi-Liang Ji, Ke-Jun Deng, Hong-Wei Gao, Li Zhang, Kun Li, Fei Ge, Guo-Qiang Xu, Shi-Lin Yang, Yan-Li Liu, Qiong-Ming Xu. Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024 Mar; 73(3):345-362. doi: 10.1007/s00011-023-01840-x. [PMID: 38157008]
  • Liuhong Shen, Hao Luo, Lei Fan, Zhetong Su, Shumin Yu, Suizhong Cao, Xiaofeng Wu. Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155302. doi: 10.1016/j.phymed.2023.155302. [PMID: 38176273]
  • Chenlu Guo, Yuanfen Yue, Bojun Wang, Shaohui Chen, Dai Li, Fangshou Zhen, Ling Liu, Haili Zhu, Min Xie. Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation. Journal of cellular and molecular medicine. 2024 Feb; 28(4):e18136. doi: 10.1111/jcmm.18136. [PMID: 38334255]
  • Wen Feng, Yi Zhang, Yawei Zhang, Yang Dong, Jiaqi Wu, Qian Chen, Mengyang Liu, Dan Wang, Yuzheng Wu, Tao Wang. Anemoside B4 ameliorates dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome and modulating gut microbiota. European journal of pharmacology. 2023 Oct; ?(?):176164. doi: 10.1016/j.ejphar.2023.176164. [PMID: 37918500]
  • Yaqing Ye, Mingzhen Xue, Xiaoting Tian, Hongwei Gao, Pei Hu, Linwei Wang, Jing Leng, Yaru Xue, Chenggang Huang. Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository. Journal of ethnopharmacology. 2023 Oct; 315(?):116694. doi: 10.1016/j.jep.2023.116694. [PMID: 37253396]
  • Qin Gong, Jilei Yin, Mulan Wang, Chengliang Zha, Dong Yu, Shilin Yang, Yulin Feng, Jun Li, Lijun Du. Anemoside B4 Exerts Hypoglycemic Effect by Regulating the Expression of GLUT4 in HFD/STZ Rats. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28030968. [PMID: 36770636]
  • Huimiao Ma, Ziye Zhou, Lanying Chen, Lingling Wang, Qi Muge. Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154431. doi: 10.1016/j.phymed.2022.154431. [PMID: 36115169]
  • Min Zou, Fang-Jun Chen, Li-Rong Deng, Qian Han, Chang-Yin Huang, Shi-Shi Shen, Brian Tomlinson, Yan-Hong Li. Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota. European journal of pharmacology. 2022 Sep; 931(?):175185. doi: 10.1016/j.ejphar.2022.175185. [PMID: 35987252]
  • Qin Gong, Mulan Wang, Ya Jiang, Chengliang Zha, Dong Yu, Fan Lei, Yingying Luo, Yulin Feng, Shilin Yang, Jun Li, Lijun Du. The abrupt pathological deterioration of cisplatin-induced acute kidney injury: Emerging of a critical time point. Pharmacology research & perspectives. 2021 12; 9(6):e00895. doi: 10.1002/prp2.895. [PMID: 34817124]
  • Liang Pei, Linxi He. Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy. Chemico-biological interactions. 2021 Aug; 345(?):109534. doi: 10.1016/j.cbi.2021.109534. [PMID: 34051206]
  • Ling-Ling Wang, Lan-Ying Chen, Hui-Miao Ma, Xin-Xu Xie, Ying-Ying Luo, Bin-Yao Shou, Li Yin. [Study on effect of anemoside B4 in improving COPD rats by regulating IL-12/STAT4 and IL-4/STAT6 signaling pathways]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jul; 46(14):3660-3671. doi: 10.19540/j.cnki.cjcmm.20210304.401. [PMID: 34402290]
  • Shuang Wang, Shan Tang, Xuan Chen, Xin Li, Shuang Jiang, Hui-Ping Li, Pin-Hui Jia, Ming-Jie Song, Peng Di, Wei Li. Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice. Chemico-biological interactions. 2020 Nov; 331(?):109233. doi: 10.1016/j.cbi.2020.109233. [PMID: 32991863]
  • Yan-Hong Li, Min Zou, Qian Han, Li-Rong Deng, Richard M Weinshilboum. Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis. Pharmacological research. 2020 10; 160(?):105079. doi: 10.1016/j.phrs.2020.105079. [PMID: 32679180]
  • Huimiao Ma, Mengjing Zhou, Wenbin Duan, Lanying Chen, Lingling Wang, Peng Liu. Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4/NF-κB/MAPK signaling pathway. International immunopharmacology. 2020 Oct; 87(?):106794. doi: 10.1016/j.intimp.2020.106794. [PMID: 32688280]
  • Jun Li, Sha-Sha Zuo, Xiao-Xuan Qiu, Lu-Ling He, Mu-Lan Wang, Yu-Lin Feng, Ying-Ying Luo, Li-Jun DU, Qin Gong. [Study on therapeutic effect and its related mechanism of anemoside B4 on ischemia reperfusion injury induced by renal artery and vein ligation in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Feb; 45(3):617-622. doi: 10.19540/j.cnki.cjcmm.20191209.401. [PMID: 32237521]
  • Jun Li, Sha-Sha Zuo, Xiao-Xuan Qiu, Xi Xu, Ying-Ying Luo, Hong-Wei Gao, Yu-Lin Feng, Li-Jun DU, Qin Gong. [Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jan; 45(1):157-162. doi: 10.19540/j.cnki.cjcmm.20190918.402. [PMID: 32237425]
  • Renyikun Yuan, Jia He, Liting Huang, Li-Jun Du, Hongwei Gao, Qiongming Xu, Shilin Yang. Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization. Journal of immunology research. 2020; 2020(?):7502301. doi: 10.1155/2020/7502301. [PMID: 33344657]
  • Sicong Li, Xuting Li, Rui Yang, Bin Wang, Jinliang Li, Liang Cao, Songyang Xiao, Wei Huang. Effects of anemoside B4 on pharmacokinetics of florfenicol and mRNA expression of CXR, MDR1, CYP3A37 and UGT1E in broilers. The Journal of veterinary medical science. 2019 Dec; 81(12):1804-1809. doi: 10.1292/jvms.19-0293. [PMID: 31611492]
  • Naixin Kang, Wenhua Shen, Yong Zhang, Zhetong Su, Shilin Yang, Yanli Liu, Qiongming Xu. Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatilla chinensis in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):152934. doi: 10.1016/j.phymed.2019.152934. [PMID: 31454651]
  • Luan He, Yong Zhang, Naixin Kang, Yaner Wang, Ziyu Zhang, Zhengxia Zha, Shilin Yang, Qiongming Xu, Yanli Liu. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 56(?):136-146. doi: 10.1016/j.phymed.2018.10.035. [PMID: 30668334]
  • Xiaozhen Guo, Yang Xie, Shan Lian, Zhixiong Li, Yu Gao, Zhou Xu, Pei Hu, Mingcang Chen, Zhaolin Sun, Xiaoting Tian, Chenggang Huang. A sensitive HPLC-MS/MS method for the simultaneous determination of anemoside B4, anemoside A3 and 23-hydroxybetulinic acid: Application to the pharmacokinetics and liver distribution of Pulsatilla chinensis saponins. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4124. [PMID: 29078255]
  • Mingyu He, Hui Ouyang, Mingzhen He, Ting Tan, Junmao Li, Xiaoyong Zhang, Jia Jia, Yulin Feng, Shilin Yang. Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion in the study of anemoside B4, a novel antiviral agent candidate, in rats. Biomedical chromatography : BMC. 2017 Jul; 31(7):. doi: 10.1002/bmc.3914. [PMID: 27957737]
  • Jin-Yi Wan, Yu-Zhen Zhang, Jin-Bin Yuan, Feng-Qing Yang, Yan Chen, Lian-Di Zhou, Qi-Hui Zhang. Biotransformation and metabolic profile of anemoside B4 with rat small and large intestine microflora by ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. Biomedical chromatography : BMC. 2017 May; 31(5):. doi: 10.1002/bmc.3873. [PMID: 27761923]