ligustrazine (BioDeep_00000230849)
代谢物信息卡片
Chuanxiongzine hydrochloride;Tetramethylpyrazine hydrochloride
化学式: C8H12N2.HCl (172.0767208)
中文名称: 盐酸川穹嗪
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 6.25%
分子结构信息
SMILES: CC1=C(N=C(C(=N1)C)C)C.Cl
InChI: 1H
描述信息
同义名列表
25 个代谢物同义名
Chuanxiongzine hydrochloride;Tetramethylpyrazine hydrochloride; Ligustrazine Hydrochloride pound>>Chuanxiongzine hydrochloride; Pyrazine, 2,3,5,6-tetramethyl-, hydrochloride (1:1); Tetramethylpyrazine--hydrogen chloride (1/1); 2,3,5,6-tetramethylpyrazine;hydrochloride; PYRAZINE, TETRAMETHYL-, MONOHYDROCHLORIDE; 2,3,5,6-tetramethylpyrazine hydrochloride; Pyrazine, tetramethyl-, hydrochloride; Ligustrazine hydrochloride [WHO-DD]; tetramethylpyrazine hydrochloride; Ligustrazine Hydrochloride ,(S); Ligustrazine (hydrochloride); chuanxiongzine hydrochloride; Ligustrazine hydrochloride; Tetramethylpyrazine HCl; tetramethyl pyrazine; Tetramethylpyrazine; Tetrapyrazine HCl; Ligustrazine HCl; UNII-7YYD00RL0S; chuanxiongzine; ligustrazine; Liqustrazine; 7YYD00RL0S; TMPZ
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 156709
- MeSH: tetramethylpyrazine
- ChemIDplus: 0076494514
- chemspider: 137964
- CAS: 126400-81-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 33090 - 川芎: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiuzhi Chen, Bin Zou, Zhen Yang. CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury.
Journal of bioenergetics and biomembranes.
2024 Jun; 56(3):273-284. doi:
10.1007/s10863-024-10001-6. [PMID: 38427129] - Congyan Liu, Wenting Su, Xi Jiang, Yanli Lv, Fei Kong, Qin Chen, Qun Zhang, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xinrong Xu, Yan Chen, Ding Qu. A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms.
Advanced healthcare materials.
2024 Jun; 13(14):e2303659. doi:
10.1002/adhm.202303659. [PMID: 38386849] - Bowen Deng, Shengyuan Jiang, Gang Liu, Xiaoye Li, Yi Zhao, Xiao Fan, Jingpei Ren, Chengyun Ning, Lin Xu, Linhong Ji, Xiaohong Mu. Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Journal of materials chemistry. B.
2024 May; 12(18):4409-4426. doi:
10.1039/d3tb02160b. [PMID: 38630533] - Xiangyu Chen, Tong Yang, Yue Zhou, Zhigang Mei, Wenli Zhang. Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.
CNS neuroscience & therapeutics.
2024 04; 30(4):e14725. doi:
10.1111/cns.14725. [PMID: 38615367] - Zhongqiang Zhu, Jun Li, Zhiyong Song, Tonglu Li, Zongping Li, Xuezhong Gong. Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species.
Clinical science (London, England : 1979).
2024 03; 138(5):235-249. doi:
10.1042/cs20231184. [PMID: 38357976] - Guodong Qi, Shujun Li, Qiong Jiang, Zhijuan Yu, Zhenggang Peng, Qiurui Li, Wei Qi, Mingjun Guo. Network pharmacology analysis and experimental validation to explore the effect and mechanism of tetramethylpyrazine for spinal cord injury.
Journal of chemical neuroanatomy.
2024 03; 136(?):102386. doi:
10.1016/j.jchemneu.2023.102386. [PMID: 38176475] - Zixuan Zhang, Lei Luo, Xueling Li, Yifei Zhong. The effects of Salvia miltiorrhiza and ligustrazine injection combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysis.
Medicine.
2024 Feb; 103(8):e35853. doi:
10.1097/md.0000000000035853. [PMID: 38394516] - Bowen Deng, Shengyuan Jiang, Gang Liu, Xiaoye Li, Huizhong Bai, Luyao Huo, Jie Xu, Lin Xu, Xiaohong Mu. [Experimental study of tetramethylpyrazine-loaded electroconductive hydrogel on angiogenesis and neuroprotection after spinal cord injury].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2024 Feb; 38(2):189-197. doi:
10.7507/1002-1892.202311009. [PMID: 38385232] - Fan Feng, Ding-Qiao Xu, Shi-Jun Yue, Yan-Yan Chen, Yu-Ping Tang. Neuroprotection by tetramethylpyrazine and its synthesized analogues for central nervous system diseases: a review.
Molecular biology reports.
2024 Jan; 51(1):159. doi:
10.1007/s11033-023-09068-y. [PMID: 38252346] - Yan Ma, Qian Cui, Wenjing Zhu, Mei Wang, Li Zhai, Wenmin Hu, Dongdong Liu, Min Liu, Yongchun Li, Meng Li, Wei Han. A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK.
Drug design, development and therapy.
2024; 18(?):1531-1546. doi:
10.2147/dddt.s449139. [PMID: 38737331] - Meng-Qi Shu, Yao-Yao Dai, Li-Juan Song, Dong Ma, Ke-Xin Liu, Zhu-Yue Miao, Ru-Heng Wei, Jin-Zhu Yin, Cun-Gen Ma, Jian-Jun Huang. [Tetramethylpyrazine regulates angiogenesis of endothelial cells in cerebral ischemic stroke injury via SIRT1/VEGFA signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Jan; 49(1):162-174. doi:
10.19540/j.cnki.cjcmm.20231116.303. [PMID: 38403349] - Yanli Zhang, Hui Liu, Zongxin Chen, Jialei Meng, Yunfeng Li, Luyao Qi, Suiliang Zhang, Xiaofeng Chen, Ming Lei. A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine.
Acta crystallographica Section B, Structural science, crystal engineering and materials.
2023 Dec; 79(Pt 6):519-524. doi:
10.1107/s2052520623008648. [PMID: 37966478] - Ying Feng, Han Dong, Liyan Zheng. Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis.
Pharmaceutical biology.
2023 Dec; 61(1):666-673. doi:
10.1080/13880209.2023.2195883. [PMID: 37095705] - Ray-Jade Chen, Ming-Cheng Chen, Bruce Chi-Kang Tsai, Rakesh Roy, Yi-Ru Chang, Tso-Fu Wang, Wei-Wen Kuo, Chia-Hua Kuo, Chun-Hsu Yao, Chi-Cheng Li, Chih-Yang Huang. Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats.
Chemical biology & drug design.
2023 12; 102(6):1399-1408. doi:
10.1111/cbdd.14327. [PMID: 37612133] - Xia Qian, Yuqing Deng, Na Zhong, Yuxuan Li, Junhua Wang, Jinhua Yan, Wei Liu, Jinglei Ye, Jingchao Liu, Guobei Xiao. Study on the reversal of epileptic drug resistance by tetramethylpyrazine in combination with carbamazepine through modulation of P-Glycoprotein expression in rat brain microvessel endothelial cell.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Nov; 69(11):254-259. doi:
10.14715/cmb/2023.69.11.38. [PMID: 38015511] - Yi Jia, Haiyan Xiao, Xiaolin Wang, Ying Liu, Jiaxin Wang, Haochen Xie, Hai Shang, Guibo Sun, Yu Tian. Design, synthesis, and evaluation of n-butylphthalide and ligustrazine hybrids as potent neuroprotective agents for the treatment of ischemic stroke in vitro and in vivo.
Bioorganic chemistry.
2023 Nov; 142(?):106961. doi:
10.1016/j.bioorg.2023.106961. [PMID: 37956636] - Di Chu, Junjun Chen, Xingmei Liu, Anqi Liao, Xiaohuan Song, Yutong Li, Leilei Yang, Zheng Chen, Zhuo Yu, Jianfeng Guo. A tetramethylpyrazine-loaded hyaluronic acid-based hydrogel modulates macrophage polarization for promoting wound recovery in diabetic mice.
International journal of biological macromolecules.
2023 Aug; 245(?):125495. doi:
10.1016/j.ijbiomac.2023.125495. [PMID: 37353128] - Dan Yang, Gang Wang, Li-Jun Yang, Ren-Ze Duan, Xian-Bing Chen. [Effect of ligustrazine on hypoxic-ischemic encephalopathy in neonatal rats by regulating autophagy through the PINK1/Parkin pathway].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2023 Jul; 25(7):751-758. doi:
10.7499/j.issn.1008-8830.2302026. [PMID: 37529959] - Xue-Shan Dai, Qing-Hua Wei, Xin Guo, Yi Ding, Xiao-Qian Yang, Yu-Xin Zhang, Xiao-Yu Xu, Cong Li, Yi Chen. Ferulic acid, ligustrazine, and tetrahydropalmatine display the anti-proliferative effect in endometriosis through regulating Notch pathway.
Life sciences.
2023 Jul; 328(?):121921. doi:
10.1016/j.lfs.2023.121921. [PMID: 37429417] - Shu-Jun Li, Guo-Dong Qi, Wei Qi, Zhu-Xin Yang, Zhi-Juan Yu, Qiong Jiang. [Neuroprotective effect of tetramethylpyrazine on mice after spinal cord injury].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(14):3848-3854. doi:
10.19540/j.cnki.cjcmm.20230215.401. [PMID: 37475076] - Ping Li, Han Ju, Ying Zhang, Jazmin Galvan Achi, Dongwei Kang, Jinmi Zou, Ruikun Du, Qinghua Cui, Xinyong Liu, Lijun Rong, Peng Zhan. Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses.
Journal of medical virology.
2023 07; 95(7):e28968. doi:
10.1002/jmv.28968. [PMID: 37489704] - Shuai Zhang, Yilei Zheng, Hong Du, Wei Zhang, Haohuan Li, Yangping Ou, Funeng Xu, Juchun Lin, Hualin Fu, Xueqing Ni, Li-Jen Chang, Gang Shu. The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy.
Molecules (Basel, Switzerland).
2023 Jun; 28(12):. doi:
10.3390/molecules28124849. [PMID: 37375405] - Xinqiu Li, Zixiang Lin, Penglong Wang, Chaoyu Zhou, Jiawei Xu, Jiahao Lin, Degui Lin, Di Zhang. Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 162(?):114731. doi:
10.1016/j.biopha.2023.114731. [PMID: 37086510] - Gan Li, Kim Sia Sng, Bing Shu, Yong-Jun Wang, Min Yao, Xue-Jun Cui. Effects of tetramethylpyrazine treatment in a rat model of spinal cord injury: A systematic review and meta-analysis.
European journal of pharmacology.
2023 Apr; 945(?):175524. doi:
10.1016/j.ejphar.2023.175524. [PMID: 36803629] - Chun-Kun Yang, Qing-Quan Pan, Kui Ji, Chuan-Chao Luo, Zhuang Tian, Hong-Yuan Zhou, Jun Li. [Protective mechanism of tetramethylpyrazine on cardiovascular system].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Mar; 48(6):1446-1454. doi:
10.19540/j.cnki.cjcmm.20221012.402. [PMID: 37005832] - Chujun Deng, Zeyu Meng, Huize Chen, Shengxi Meng. Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology.
Journal of chemical neuroanatomy.
2023 01; 127(?):102207. doi:
10.1016/j.jchemneu.2022.102207. [PMID: 36470527] - Yu Chen, Fu Peng, Chao Yang, Huan Hou, Ziwei Xing, Junren Chen, Li Liu, Cheng Peng, Dan Li. SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization.
Frontiers in immunology.
2023; 14(?):1206513. doi:
10.3389/fimmu.2023.1206513. [PMID: 37600790] - Simin Min, Weiting Tao, Yuchen Miao, Yan Li, Tianyu Wu, Xiaoyu He, Yijing Zhang, Bangye Liu, Zixin Meng, Ke Han, Saisai Liu, Li Li, Jie Chen, Shidi Zhao, Junjie Zhang, Xiaonan Zhang. Dual Delivery of Tetramethylpyrazine and miR-194-5p Using Soft Mesoporous Organosilica Nanoparticles for Acute Lung Injury Therapy.
International journal of nanomedicine.
2023; 18(?):6469-6486. doi:
10.2147/ijn.s420802. [PMID: 38026537] - Jia Sun, Jing-Ya Zhang, Rong Li, Lin Zheng, Chun-Hua Liu, Ding-Yan Lu, Ting Liu. [Effects and correlation of ligustrazine hydrochloride-Salviae Miltiorrhizae Radix et Rhizoma compatibility on pharmacokinetics and CYP450 enzyme].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(23):6348-6354. doi:
10.19540/j.cnki.cjcmm.20220411.202. [PMID: 36604879] - Ting Zhu, Bin-Yu Fang, Xiang-Bao Meng, Shu-Xia Zhang, Hong Wang, Ge Gao, Fei Liu, Yu Wu, Jin Hu, Gui-Bo Sun, Xiao-Bo Sun. Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Pharmaceutical biology.
2022 Dec; 60(1):195-205. doi:
10.1080/13880209.2021.2014895. [PMID: 35060427] - Yu Wen, Zuxian Zhang, Zhongmou Cai, Baoning Liu, Zhehao Wu, Yude Liu. Ligustrazine-Loaded Borneol Liposome Alleviates Cerebral Ischemia-Reperfusion Injury in Rats.
ACS biomaterials science & engineering.
2022 11; 8(11):4930-4941. doi:
10.1021/acsbiomaterials.2c00847. [PMID: 36227861] - Litao Li, DingWen Zhang, Wentao Yao, Zongkai Wu, Jinming Cheng, Yingxiao Ji, Lipeng Dong, Congying Zhao, Hebo Wang. Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.
Brain research bulletin.
2022 11; 190(?):244-255. doi:
10.1016/j.brainresbull.2022.10.011. [PMID: 36244580] - Zongyang Li, Xiangbao Meng, Guoxu Ma, Wenlan Liu, Weiping Li, Qian Cai, Sicen Wang, Guodong Huang, Yuan Zhang. Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice.
Alzheimer's research & therapy.
2022 10; 14(1):150. doi:
10.1186/s13195-022-01092-7. [PMID: 36217155] - Zixin Li, Luchen Shan, Pei Yu. Preventive effect of tetramethylpyrazine on nitroglycerin-tolerance in rats by improving oxidative stress and ribosome homeostasis.
Biochemical and biophysical research communications.
2022 08; 618(?):141-147. doi:
10.1016/j.bbrc.2022.06.013. [PMID: 35724458] - Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopra. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats.
Neurochemical research.
2022 Aug; 47(8):2431-2444. doi:
10.1007/s11064-022-03640-x. [PMID: 35665448] - Zhenli Liu, Yongjun Wu, Lincheng Zhang, Shuoqiu Tong, Jing Jin, Xian Gong, Jie Zhong. rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2.
BMC biotechnology.
2022 07; 22(1):18. doi:
10.1186/s12896-022-00748-4. [PMID: 35787694] - Yafang Zhang, Linfeng He, Cheng Ma, Cheng Wang, Honglin Zhou, Chaocheng Guo, Lihong Gong, Yan Wan, Cheng Peng, Yunxia Li. Research progress on the pharmacy of tetramethylpyrazine and its pharmacological activity in cardiovascular and cerebrovascular diseases.
The Journal of pharmacy and pharmacology.
2022 Jun; 74(6):843-860. doi:
10.1093/jpp/rgac015. [PMID: 35385110] - Jianguo Lin, Qingqing Wang, Simin Zhou, Siyu Xu, Kuiwu Yao. Tetramethylpyrazine: A review on its mechanisms and functions.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):113005. doi:
10.1016/j.biopha.2022.113005. [PMID: 35483189] - Rundong Jiang, Jiaqi Xu, Yuezhong Zhang, Jiachen Liu, Yutong Wang, Mingliang Chen, Xiang Chen, Mingzhu Yin. Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):113010. doi:
10.1016/j.biopha.2022.113010. [PMID: 35468584] - Beibei Fu, Shuqing Meng, Genshan Gao. A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):945-951. doi:
. [PMID: 35791592] - Shenghui Huang, Fengyi Xiao, Sun-Wei Guo, Tingting Zhang. Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.).
2022 04; 29(4):1170-1187. doi:
10.1007/s43032-021-00813-x. [PMID: 35099777] - Haowen Zhang, Hanyu Chen, Xiang Wu, Tong Sun, Manlu Fan, Huaqin Tong, Yejin Zhu, Zhe Yin, Weixin Sun, Chao Zhang, Xiao Zheng, Xiaohu Chen. Tetramethylpyrazine alleviates diabetes-induced high platelet response and endothelial adhesion via inhibiting NLRP3 inflammasome activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Feb; 96(?):153860. doi:
10.1016/j.phymed.2021.153860. [PMID: 34836743] - SiJin Li, Ping Liu, XiaoTeng Feng, YiRu Wang, Min Du, JiaRou Wang. The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis.
PloS one.
2022; 17(5):e0267968. doi:
10.1371/journal.pone.0267968. [PMID: 35500001] - Yajuan Wang, Huizhi Zhu, Jiabing Tong, Zegeng Li. Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.
Computational and mathematical methods in medicine.
2022; 2022(?):1452116. doi:
10.1155/2022/1452116. [PMID: 35047052] - Lili Yang, Zhengjun Li, Yao Chen, Feiyan Chen, Haopeng Sun, Min Zhao, Yanqi Chen, Yali Wang, Wenlin Li, Li Zeng, Yaoyao Bian. Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation.
Oxidative medicine and cellular longevity.
2022; 2022(?):9226022. doi:
10.1155/2022/9226022. [PMID: 35308169] - Yafang Zhang, Cheng Ma, Linfeng He, Li Liao, Chaocheng Guo, Cheng Wang, Lihong Gong, Honglin Zhou, Ke Fu, Cheng Peng, Yunxia Li. Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish.
Oxidative medicine and cellular longevity.
2022; 2022(?):2232365. doi:
10.1155/2022/2232365. [PMID: 35898617] - Fan Xie, Bingcai Zhang, Shengfeng Dai, Binbin Jin, Te Zhang, Feixia Dong. Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis.
Journal of ethnopharmacology.
2021 Dec; 281(?):114346. doi:
10.1016/j.jep.2021.114346. [PMID: 34153447] - Hong-Yan Du, Rong Wang, Jian-Liang Li, Huang Luo, Xiao-Yan Xie, Ran Yan, Yue-Ling Jian, Jin-Ying Cai. Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway.
Bioengineered.
2021 12; 12(1):507-515. doi:
10.1080/21655979.2021.1880060. [PMID: 33522374] - Bo Chen, Jing An, Yun-Shan Guo, Juan Tang, Jing-Jing Zhao, Rui Zhang, Hao Yang. Tetramethylpyrazine induces the release of BDNF from BM-MSCs through activation of the PI3K/AKT/CREB pathway.
Cell biology international.
2021 Dec; 45(12):2429-2442. doi:
10.1002/cbin.11687. [PMID: 34374467] - Xin Lin, Yong Zhu, Guohui Le. Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2021 11; 41(11):415-424. doi:
10.1089/jir.2021.0083. [PMID: 34698528] - Zeyu Meng, Huize Chen, Shengxi Meng. The Roles of Tetramethylpyrazine During Neurodegenerative Disease.
Neurotoxicity research.
2021 Oct; 39(5):1665-1677. doi:
10.1007/s12640-021-00398-y. [PMID: 34351568] - Xueqin Guan, Sisi Liu, Minjie Liang, Guangming Li, Jun Dong, Quan Zhou. Diffusion kurtosis imaging to evaluate the effect and mechanism of tetramethylpyrazine on cognitive impairment induced by lipopolysaccharide in rats.
Brain imaging and behavior.
2021 Oct; 15(5):2492-2501. doi:
10.1007/s11682-021-00449-0. [PMID: 33570727] - Hanmei Li, Hongyi Zhuo, Dan Yin, Wei Li, Yamei Zhang, Peng Li, Liang Zou. Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis.
Journal of biomedical nanotechnology.
2021 Jun; 17(6):1199-1207. doi:
10.1166/jbn.2021.3094. [PMID: 34167632] - Qing Zhang, Jing Wang, Liang Zhu, Shi-Jie Jiang, Juan Liu, Lin-Xiao Wang, Xi-Hu Qin. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats.
Current medical science.
2021 Jun; 41(3):548-554. doi:
10.1007/s11596-021-2379-1. [PMID: 34169425] - Lianshuang Zhang, Xueyan Lu, Lihua Gong, Linlu Cui, Hongqin Zhang, Wei Zhao, Pengyu Jiang, GuiGe Hou, Yun Hou. Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice.
Cellular and molecular neurobiology.
2021 May; 41(4):717-731. doi:
10.1007/s10571-020-00878-3. [PMID: 32424774] - Lili Yang, Ziyu Lian, Bin Zhang, Zhengjun Li, Li Zeng, Wenlin Li, Yaoyao Bian. Effect of ligustrazine nanoparticles on Th1/Th2 balance by TLR4/MyD88/NF-κB pathway in rats with postoperative peritoneal adhesion.
BMC surgery.
2021 Apr; 21(1):211. doi:
10.1186/s12893-021-01201-7. [PMID: 33902534] - Xiaowen Wu, Xingxing Dai, Yuyao Liao, Mengke Sheng, Xinyuan Shi. Investigation on drug entrapment location in liposomes and transfersomes based on molecular dynamics simulation.
Journal of molecular modeling.
2021 Mar; 27(4):111. doi:
10.1007/s00894-021-04722-3. [PMID: 33745026] - Fangqin Cui, Mingji Hu, Li Huang, Yunxia Zhao. [Ligustrazine alleviates the tissue injury of the submandibular glands by enhanceing the antioxidant and anti-inflammatory effects in diabetic rats].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2021 Mar; 37(3):212-218. doi:
NULL. [PMID: 33766228] - Xin Zhao, Yao Chen, Lin Li, Jingbo Zhai, Bin Yu, Hongbo Wang, Dongli Yang, Qilong Wang, Yanxu Chang, Jinghao Li, Peng Zhang, Han Zhang, Yuhong Li. Effect of DLT-SML on Chronic Stable Angina Through Ameliorating Inflammation, Correcting Dyslipidemia, and Regulating Gut Microbiota.
Journal of cardiovascular pharmacology.
2021 02; 77(4):458-469. doi:
10.1097/fjc.0000000000000970. [PMID: 33657052] - Tingting Ye, Yufei Li, Difeifei Xiong, Shuqing Gong, Luquan Zhang, Bailing Li, Jianyang Pan, Yi Wang, Jing Qian, Haibin Qu. Combination of Danshen and ligustrazine has dual anti-inflammatory effect on macrophages and endothelial cells.
Journal of ethnopharmacology.
2021 Feb; 266(?):113425. doi:
10.1016/j.jep.2020.113425. [PMID: 33010405] - Lei Ji, Weihua Li, Wenbin Qian, Shuang Feng, Hui Shi, Yuhai Wang. The Role of Nanoparticles-Mediated Ligustrazine in the Treatment of Knee Osteoarthritis and Its Effect on Matrix Metalloproteinases and Upstream NF-κB Signaling Pathway in Knee Osteoarthritis.
Journal of nanoscience and nanotechnology.
2021 02; 21(2):1372-1377. doi:
10.1166/jnn.2021.18647. [PMID: 33183486] - Yaoyao Bian, Lili Yang, Wei Sheng, Zhengjun Li, Yuying Xu, Wenlin Li, Li Zeng. Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase.
Annals of palliative medicine.
2021 Feb; 10(2):1578-1588. doi:
10.21037/apm-20-288. [PMID: 33302638] - Hairong Zhang, Shichao Ding, Lei Xia. Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211.
Bioscience reports.
2021 01; 41(1):. doi:
10.1042/bsr20200199. [PMID: 33245099] - Zhiyuan Deng, Manjia Wang, Yaohua Fan, Min Liu. Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with mecobalamin for treating diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.
Medicine.
2021 Jan; 100(3):e24103. doi:
10.1097/md.0000000000024103. [PMID: 33546016] - Yan Lin, Yujie Wan, Xingjie Du, Jian Li, Jun Wei, Ting Li, Chunhong Li, Zhongbing Liu, Meiling Zhou, Zhirong Zhong. TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury.
Journal of nanobiotechnology.
2021 Jan; 19(1):28. doi:
10.1186/s12951-020-00766-4. [PMID: 33478501] - Jianyang Pan, Luquan Zhang, Difeifei Xiong, Bailing Li, Haibin Qu. A HPLC-DAD-MS/MS Method for Simultaneous Determination of Six Active Ingredients of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in Rat Plasma and its Application to Pharmacokinetic Studies.
Current drug metabolism.
2021; 22(1):60-69. doi:
10.2174/1389200221999200819143230. [PMID: 32819255] - Hong-Yan Du, Rong Wang, Jian-Liang Li, Huang Luo, Xiao-Yan Xie, Ran Yan, Yue-Ling Jian, Jin-Ying Cai. Ligustrazine protects against chronic hypertensive glaucoma in rats by inhibiting autophagy via the PI3K-Akt/mTOR pathway.
Molecular vision.
2021; 27(?):725-733. doi:
". [PMID: 35035207] - Guohu Weng, Bo Zhou, Tao Liu, Zhengxin Huang, Shixiong Huang. Tetramethylpyrazine Improves Cognitive Function of Alzheimer's Disease Mice by Regulating SSTR4 Ubiquitination.
Drug design, development and therapy.
2021; 15(?):2385-2399. doi:
10.2147/dddt.s290030. [PMID: 34103899] - Xialin Tang, Huajun Wang, Huihuan Chen, Shuangxi Sun, Hongxia Chen, Ruihuan Pan. Protective Effects of Astragalus Membranaceus and Ligustrazine on Rat Brain Microvascular Endothelial Cell Injury after Oxygen-Glucose Deprivation/ Reoxygenation by Suppressing the PKCδ/MARCKS Pathway.
Combinatorial chemistry & high throughput screening.
2021; 24(7):947-956. doi:
10.2174/1386207323999200818170415. [PMID: 32819229] - Huiping Huang, Lingjin Kong, Shaohua Luan, Chuanzong Qi, Fanrong Wu. Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway.
The American journal of Chinese medicine.
2021; 49(2):437-459. doi:
10.1142/s0192415x21500208. [PMID: 33622214] - Chengling Zhang, Ying Zhang, Haiying Pan, Yi Tan, Qinghua Wei, Xueshan Dai, Jiahui Wei, Yi Chen. Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis.
International journal of biological sciences.
2021; 17(10):2449-2460. doi:
10.7150/ijbs.60167. [PMID: 34326686] - Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Chaomei Fu, Jinming Zhang, Zhongwei Gu. Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy.
Theranostics.
2021; 11(9):4171-4186. doi:
10.7150/thno.42260. [PMID: 33754055] - Guofang Guan, Xiao He, Jingjing Chen, Li Bin, Xuxia Tang. Identifying the mechanisms underlying the protective effect of tetramethylpyrazine against cisplatin‑induced in vitro ototoxicity in HEI‑OC1 auditory cells using gene expression profiling.
Molecular medicine reports.
2020 Dec; 22(6):5053-5068. doi:
10.3892/mmr.2020.11631. [PMID: 33174043] - Yuan Yuan, Ling Zhao, Xiaoying Wang, Feng Lian, Yan Cai. Ligustrazine-induced microRNA-16-5p inhibition alleviates preeclampsia through IGF-2.
Reproduction (Cambridge, England).
2020 12; 160(6):905-917. doi:
10.1530/rep-20-0309. [PMID: 33112793] - Kai Peng, Dan Guo, Qianqian Lou, Xiaoyun Lu, Jian Cheng, Jing Qiao, Lina Lu, Tao Cai, Yuwan Liu, Huifeng Jiang. Synthesis of Ligustrazine from Acetaldehyde by a Combined Biological-Chemical Approach.
ACS synthetic biology.
2020 11; 9(11):2902-2908. doi:
10.1021/acssynbio.0c00113. [PMID: 33156612] - Yuyao Xiang, Yanyu Liu, Fan Xiao, Xiaoting Sun, Xiaofei Wang, Yongliang Wang. 2,3,5,6-Tetramethylpyrazine improves diet-induced whole-body insulin resistance via suppressing white adipose tissue lipolysis in mice.
Biochemical and biophysical research communications.
2020 11; 532(4):605-612. doi:
10.1016/j.bbrc.2020.08.099. [PMID: 32900485] - Wangnan Sun, Aiqun Li, Zhiqiang Wang, Xuhong Sun, Menghua Dong, Fu Qi, Lin Wang, Yueheng Zhang, Pengchao Du. Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis.
Molecular medicine reports.
2020 10; 22(4):2655-2664. doi:
10.3892/mmr.2020.11378. [PMID: 32945382] - Weijie Jiao, Zhen Lei, Xu Zhao, Kun Wang, Ailing Ma, Lei Du, Ruiying Hou, Jing Han, Meng Chen. Pharmacokinetic study of tanshinol and ligustrazine in rat plasma after intravenous administration of tanshinol and Danshen Chuanxiongqin Injection.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4869. doi:
10.1002/bmc.4869. [PMID: 32346872] - Huifang Ge, Peixuan Lin, Taiduan Luo, Zhiming Yan, Jianbo Xiao, Song Miao, Jicheng Chen. Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients.
Food chemistry.
2020 Jul; 317(?):126377. doi:
10.1016/j.foodchem.2020.126377. [PMID: 32113137] - Guangming Li, Sisi Liu, Huili Wang, Rui Pan, Haijie Tang, Xueqin Yan, Yanping Wang, Yongmei Fu, Fujun Jing, Jun Dong. Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway.
International journal of molecular medicine.
2020 Jun; 45(6):1711-1720. doi:
10.3892/ijmm.2020.4548. [PMID: 32236586] - Yuqin Chen, Wenju Lu, Kai Yang, Xin Duan, Mengxi Li, Xiuqing Chen, Jie Zhang, Meidan Kuang, Shiyun Liu, Xiongting Wu, Guofa Zou, Chunli Liu, Cheng Hong, Wenjun He, Jing Liao, Chi Hou, Zhe Zhang, Qiuyu Zheng, Jiyuan Chen, Nuofu Zhang, Haiyang Tang, Rebecca R Vanderpool, Ankit A Desai, Franz Rischard, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan, Nanshan Zhong, Jian Wang. Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
British journal of pharmacology.
2020 06; 177(12):2743-2764. doi:
10.1111/bph.15000. [PMID: 31976548] - Zhuang Zhuang, Zi-Hao Wang, Yue-Yue Huang, Qun Zheng, Xiao-Dong Pan. Protective effect and possible mechanisms of ligustrazine isolated from Ligusticum wallichii on nephropathy in rats with diabetes: A preclinical systematic review and meta-analysis.
Journal of ethnopharmacology.
2020 Apr; 252(?):112568. doi:
10.1016/j.jep.2020.112568. [PMID: 31978520] - Jialong Xie, Shichun Chen, Shaobo Ding. Efficacy and safety of the injection of the traditional Chinese medicine salviae miltiorrhizae and ligustrazine hydrochloride for the treatment of perioperative period of fracture: A meta-analysis of randomized controlled trials.
Medicine.
2020 Apr; 99(16):e19777. doi:
10.1097/md.0000000000019777. [PMID: 32311985] - Guosheng Jiang, Rui Xin, Wendan Yuan, Lixia Zhang, Xianghui Meng, Wangnan Sun, Huirong Han, Yun Hou, Lin Wang, Pengchao Du. Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.
International journal of molecular medicine.
2020 Mar; 45(3):731-742. doi:
10.3892/ijmm.2020.4464. [PMID: 31985025] - Beilin Zhang, Ying Zhang, Fang Deng, Shaokuan Fang. Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
Microvascular research.
2020 03; 128(?):103938. doi:
10.1016/j.mvr.2019.103938. [PMID: 31682800] - Sirui Xiao, Yulu Yan, Jihui Zhao, Yongtai Zhang, Nianping Feng. Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention.
International journal of pharmaceutics.
2020 Feb; 575(?):118962. doi:
10.1016/j.ijpharm.2019.118962. [PMID: 31857187] - Han Zhang, Weiwei Tang, Shuang Wang, Junhua Zhang, Xiang Fan. Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways.
Inflammation.
2020 Feb; 43(1):286-297. doi:
10.1007/s10753-019-01119-6. [PMID: 31720990] - Min Wang, Jian-Xun Liu, Ming-Jiang Yao, Jun-Guo Ren. [Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Feb; 45(3):513-517. doi:
10.19540/j.cnki.cjcmm.20191022.403. [PMID: 32237507] - Yahui Mi, Siyu Guo, Huan Cheng, Mingping Liu, Pinqing Wei, Meijing Wang, Yukang Mao, Guohan Ke. Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 177(?):112885. doi:
10.1016/j.jpba.2019.112885. [PMID: 31563759] - Jie Huang, Yan Liu, Ke Mao, Qing Gu, Xingwei Wu. Tetramethylpyrazine protects mice retinas against sodium iodate-induced oxidative injury.
Molecular vision.
2020; 26(?):494-504. doi:
". [PMID: 32636604] - Jing Ying, Jin Wu, Yiwei Zhang, Yangyang Han, Xinger Qian, Qiuhong Yang, Yongjie Chen, Yijun Chen, Hao Zhu. Ligustrazine suppresses renal NMDAR1 and caspase-3 expressions in a mouse model of sepsis-associated acute kidney injury.
Molecular and cellular biochemistry.
2020 Jan; 464(1-2):73-81. doi:
10.1007/s11010-019-03650-4. [PMID: 31732832] - Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu, Jian Wang. Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study.
Trials.
2019 Dec; 20(1):725. doi:
10.1186/s13063-019-3770-0. [PMID: 31842950] - Uddipak Rai, Ramoji Kosuru, Swati Prakash, Vinod Tiwari, Sanjay Singh. Tetramethylpyrazine alleviates diabetic nephropathy through the activation of Akt signalling pathway in rats.
European journal of pharmacology.
2019 Dec; 865(?):172763. doi:
10.1016/j.ejphar.2019.172763. [PMID: 31682792] - Jiawen Wang, Ge Hong, Guoliang Li, Wenzhi Wang, Tianjun Liu. Novel Homo-Bivalent and Polyvalent Compounds Based on Ligustrazine and Heterocyclic Ring as Anticancer Agents.
Molecules (Basel, Switzerland).
2019 Dec; 24(24):. doi:
10.3390/molecules24244505. [PMID: 31835359] - Longying Chen, Yongjun Chen, Hao Yun, Zhang Jianli. Tetramethylpyrazine (TMP) protects rats against acute pancreatitis through NF-κB pathway.
Bioengineered.
2019 12; 10(1):172-181. doi:
10.1080/21655979.2019.1613103. [PMID: 31034353] - Dan Mao, Fang Li, Qun Ma, Manman Dai, Huimin Zhang, Luyu Bai, Ning He. Intraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting?.
Drug delivery.
2019 Dec; 26(1):841-848. doi:
10.1080/10717544.2019.1650849. [PMID: 31401891] - Dong Chen, Dong Cao, Ping Sui. Tetramethylpyrazine relieves LPS-induced pancreatic β-cell Min6 injury via regulation of miR-101/MKP-1.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):2545-2552. doi:
10.1080/21691401.2019.1628039. [PMID: 31213095] - Wen-Xi Zhang, Hui Wang, He-Rong Cui, Wen-Bo Guo, Fei Zhou, De-Sheng Cai, Bing Xu, Xiao-Hui Jia, Xue-Mei Huang, Yu-Qin Yang, Hong-Shan Chen, Jin-Chai Qi, Peng-Long Wang, Hai-Min Lei. Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.
European journal of medicinal chemistry.
2019 Dec; 183(?):111695. doi:
10.1016/j.ejmech.2019.111695. [PMID: 31541868] - Yalou Jiao, Sheng Zhang, Jian Zhang, Jie Du. Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus.
Archives of pharmacal research.
2019 Dec; 42(12):1092-1100. doi:
10.1007/s12272-019-01197-y. [PMID: 31797253]