Cantharidin (BioDeep_00000230843)

 

Secondary id: BioDeep_00000002658

natural product Toxin


代谢物信息卡片


4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)-

化学式: C10H12O4 (196.0736)
中文名称: 斑in素, 斑蝥素
谱图信息: 最多检出来源 Mus musculus(otcml) 10.92%

分子结构信息

SMILES: CC12C(=O)OC(=O)C1(C)C1CCC2O1
InChI: InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3

描述信息

Cantharidin appears as brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac. (EPA, 1998)
Cantharidin is a monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A. It has a role as an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and a herbicide. It is a monoterpenoid and a cyclic dicarboxylic anhydride.
Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle. For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating. Post-copulation, the female beetle places the cantharidin over her eggs as protection against any potential predators. Available synthetically since the 1950s, topical applications of cantharidin have been used predominantly as a treatment for cutaneous warts since that time. In 1962 however, marketers of cantharidin failed to produce sufficient efficacy data, resulting in the FDA revision of approval of cantharidin. Today, topical cantharidin products do not necessarily demonstrate any particular better effectiveness at treating topical skin conditions like warts than other commonly available vesicant and/or keratolytics although various studies have also investigated the possibility of using cantharidin as an inflammatory model or in cancer treatment. Regardless, the onging lack of FDA approval is likely related to certain toxic effects that were observed following oral ingestion, which includes ulceration of the gastrointestinal and genitourinary tracts, along with electrolyte and renal function disturbance in humans and animals.
Cantharidin is a natural product found in Epicauta fabricii, Epicauta sericans, and other organisms with data available.
A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
C78284 - Agent Affecting Integumentary System
D009676 - Noxae > D007509 - Irritants
D004791 - Enzyme Inhibitors
Same as: D11745
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.511

同义名列表

62 个代谢物同义名

4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)-; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3a-alpha,4-beta,7-beta,7a-alpha); Cantharidin:4,7-Epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a- dimethyl-, (3a,4,7,7a)-,; HEXAHYDRO-3A.ALPHA.,7A.ALPHA.-DIMETHYL-4.BETA.,7.BETA.-EPOXYISOBENZOFURAN-1,3-DIONE; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-,(3aR,4S,7R,7aS)-rel-; (1R,5S,6R,9S)-rel-1,5-Dimethyl-3,10-dioxatricyclo[3.2.1.01,5]decane-2,4-dione; (1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione; (1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione; 4,3-dione, hexahydro-3a,7a-dimethyl-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)-; Hexahydro-3aalpha,7aalpha-dimethyl-4beta,7beta-epoxyisobenzofuran-1,3-dione; (1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione; (1R,2S,3R,6S)-1,2-Dimethyl-3,6-epoxycyclohexane-1,2-dicarboxylic anhydride; (1R,2S,6R,7S)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.0,2,6]decane-3,5-dione; (3a?,4?,7?,7a?)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione; (1S,2R,6S,7R)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione; (3aR,4S,7R,7aS)-3a,7a-dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione; (3ar,4s,7r,7as)-3a,7a-dimethylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione; (1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride, 2,3-dimethyl-; 2,3-Dimethyl-7-oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-; Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione; Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione; exo-1,2-cis-Dimethyl-3,6-epoxyhexahydrophthalic anhydride; 1,2-Dimethyl-3,6-epoxyperhydrophthalic anhydride; 5-19-05-00051 (Beilstein Handbook Reference); Hexahydro-3a,7-epoxyisobenzofuran-1,3-dione; 7-Oxabicyclo[2.2.1]heptane-2, 2,3-dimethyl-; exo-1,6-epoxyhexahydrophthalic anhydride; 4,3-dione, hexahydro-3a,7a-dimethyl-; 1,6-epoxyperhydrophthalic anhydride; 2,3-dicarboxylic anhydride; Kantharidin [German]; CANTHARIDIN [WHO-DD]; CANTHARIDINUM [HPUS]; CANTHARIDINE [HSDB]; Cantharides camphor; CANTHARIDIN [MART.]; CANTHARIDIN [VANDF]; CANTHARIDIN [IARC]; Cantharidin [USAN]; Cantharidin (USAN); CANTHARIDIN [INN]; Prestwick3_000885; CANTHARIDIN [MI]; CAN [Alkaloid]; BPBio1_000738; Cantharidinum; NCI60_005413; Cantharidine; Cantharides; CAS-56-25-7; Cantaridina; Kantharidin; Cantharidin; Kantaridin; Cantharone; AI3-04021; 1ST40063; Cantharidin; Cantharidin



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ruxia Liu, Changfu Yang, Xin Yang, Jia Yu, Wenchao Tang. Network toxicology, molecular docking technology, and experimental verification revealed the mechanism of cantharidin-induced testicular injury in mice. Toxicology and applied pharmacology. 2024 May; 486(?):116921. doi: 10.1016/j.taap.2024.116921. [PMID: 38582374]
  • Shan Li, Xiaotong Duan, Yixin Zhang, Cancan Zhao, Ming Yu, Xiaofei Li, Xiaomei Li, Jianyong Zhang. Lipidomics reveals serum lipid metabolism disorders in CTD-induced liver injury. BMC pharmacology & toxicology. 2024 Jan; 25(1):10. doi: 10.1186/s40360-024-00732-y. [PMID: 38225635]
  • Sanfeng Dong, Ke Hu, Yulong Shi, Guanli Wang, Dandan Yu, Yitian Zhao, Hui Zhang, Yingcong Wang, Haiguo Sun, Zhijian Xu, Qi Jia, Yiming Li, Yingxia Li, Bo Li, Jumei Shi, Weiliang Zhu. Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity in vitro and in vivo. Bioorganic & medicinal chemistry letters. 2024 Jan; 98(?):129590. doi: 10.1016/j.bmcl.2023.129590. [PMID: 38092072]
  • Yuanyuan Xiao, Ruxia Liu, Wenchao Tang, Changfu Yang. Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis. Reproductive toxicology (Elmsford, N.Y.). 2024 Jan; 123(?):108520. doi: 10.1016/j.reprotox.2023.108520. [PMID: 38056682]
  • Yihang Wu, Zixiu Liu, Zhenxiu He, Jumei Yi, Xingfang Qiao, Chunbin Tan, Yajing Xing, Yaobo Zeng, Dajian Yang, Junlin Yin, Baomin Fan, Guangzhi Zeng. Cantharidin analogue alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the activation of NF-κB signaling. European journal of medicinal chemistry. 2023 Nov; 260(?):115731. doi: 10.1016/j.ejmech.2023.115731. [PMID: 37643546]
  • Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai, Yanmin Zhang. Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR. Journal of translational medicine. 2023 09; 21(1):597. doi: 10.1186/s12967-023-04483-y. [PMID: 37670360]
  • Ki Seong Ko, Jae Yong Yoo, Bich Ngoc Vu, Young Eun Lee, Ha Na Choi, Yoo Na Lee, Wahyu Indra Duwi Fanata, Rikno Harmoko, Woo Sik Chung, Jong Chan Hong, Kyun Oh Lee. The role of protein phosphatase 2A (PP2A) in the unfolded protein response (UPR) of plants. Biochemical and biophysical research communications. 2023 08; 670(?):94-101. doi: 10.1016/j.bbrc.2023.05.106. [PMID: 37290287]
  • Jia Yan, Xiu Ling Deng, Shi Qi Ma, Yu Hui Li, Yu Min Gao, Gui Tao Shi, Hai Sheng Wang. Cantharidin suppresses hepatocellular carcinoma development by regulating EZH2/H3K27me3-dependent cell cycle progression and antitumour immune response. BMC complementary medicine and therapies. 2023 May; 23(1):160. doi: 10.1186/s12906-023-03975-0. [PMID: 37202806]
  • Xin Liu, Linghan Zhang, Wenchao Tang, Tingting Zhang, Ping Xiang, Qin Shen, Taotao Ye, Yuanyuan Xiao. Transcriptomic profiling and differential analysis reveal the renal toxicity mechanisms of mice under cantharidin exposure. Toxicology and applied pharmacology. 2023 04; 465(?):116450. doi: 10.1016/j.taap.2023.116450. [PMID: 36907384]
  • Ke-Ming Li, Ji-Jun Li, Li Wan, Yong-Xian Cheng. Five New Cantharidin Derivatives from the Insect Mylabris cichorii L. and Their Potential against Kidney Fibrosis In Vitro. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062822. [PMID: 36985794]
  • Faming Wu, Jie Peng, Junfeng Ran, Yubo Tian, Xiang Li, Yan Ren, Rongyin Gai, Yunying Zhang. Quality Evaluation of Traditional Chinese Medicine Mylabris Based on Heavy Metal Risk Assessment and Analysis of Pharmacological Component Contents. Chemistry & biodiversity. 2023 Feb; 20(2):e202200563. doi: 10.1002/cbdv.202200563. [PMID: 36573697]
  • Manshu Zou, Yilin Xu, Peng Lin, Lili Zhou, Xinhua Xia. Use of different ligand modification liposomes to evaluate the anti-liver tumor activity of cantharidin. Journal of liposome research. 2023 Jan; ?(?):1-17. doi: 10.1080/08982104.2022.2163254. [PMID: 36594207]
  • Tianmu He, Lijuan Xiong, Yixin Zhang, Rong Yan, Ming Yu, Meichen Liu, Liu Liu, Cancan Duan, Xiaofei Li, Jianyong Zhang. Mice kidney biometabolic process analysis after cantharidin exposure using widely-targeted metabolomics combined with network pharmacology. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113541. doi: 10.1016/j.fct.2022.113541. [PMID: 36464109]
  • Qian Liu, Henglai Sun, Xinyu Li, Huagang Sheng, Liqiao Zhu. Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227740. [PMID: 36431851]
  • Yujing Shi, Yi Lv, Qi You, Weidong Qian. Cantharidin induces senescence via inhibition of AMP-activated protein kinase and activation of NLRP3 inflammasome in H9c2 cardiomyocytes. Pakistan journal of pharmaceutical sciences. 2022 Nov; 35(6(Special)):1827-1834. doi: ". [PMID: 36861250]
  • Hong Sun, Pei Wang, Chunqi Wei, Yifan Li, Yalin Zhang. The Detoxification Enzymatic Responses of Plutella xylostella (Lepidoptera: Plutellidae) to Cantharidin. Journal of economic entomology. 2022 10; 115(5):1551-1556. doi: 10.1093/jee/toac139. [PMID: 36073195]
  • Yilin Xu, Min Wang, Shuangcheng Ning, Zhonglan Yang, Lili Zhou, Xinhua Xia. Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206786. [PMID: 36296377]
  • Tianmu He, Qiyi Wang, Jingwen Ao, Kuan Chen, Xiaofei Li, Jianyong Zhang, Cancan Duan. Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 May; 163(?):112986. doi: 10.1016/j.fct.2022.112986. [PMID: 35398186]
  • José Carlos Campos-Sánchez, Francisco A Guardiola, María Ángeles Esteban. In vitro effects of cantharidin on gilthead seabream (Sparus aurata) head-kidney leucocytes. Fish & shellfish immunology. 2022 Apr; 123(?):20-35. doi: 10.1016/j.fsi.2022.02.045. [PMID: 35218974]
  • Shuang Sun, Eryu Shang, Aixia Ju, Yalun Li, Qian Wu, Qiuhong Li, Yang Yang, Yuyan Guo, Dayu Yang, Shaowa Lv. Tumor-targeted hyaluronic acid-mPEG modified nanostructured lipid carriers for cantharidin delivery: An in vivo and in vitro study. Fitoterapia. 2021 Nov; 155(?):105033. doi: 10.1016/j.fitote.2021.105033. [PMID: 34517057]
  • Cancan Duan, Weina Cheng, Qihong Chen, Xiaofei Li, Jianyong Zhang. Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats. Biomedical chromatography : BMC. 2021 Oct; 35(10):e5172. doi: 10.1002/bmc.5172. [PMID: 33982312]
  • Xiaoduo Huang, Wenchao Tang, Chang Lin, Zongge Sa, Mengdan Xu, Jieying Liu, Lina Wang, Wen Li, Yunzhi Chen, Changfu Yang. Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics. Basic & clinical pharmacology & toxicology. 2021 Jul; 129(1):61-71. doi: 10.1111/bcpt.13585. [PMID: 33834601]
  • Chen-Wen Lu, Andrey V Belashov, Anna A Zhikhoreva, Irina V Semenova, Chau-Jern Cheng, Li-Yu Su, Chung-Hsin Wu. Application of digital holographic tomography in antitumor effect of cantharides complex on 4T1 breast cancer cells. Applied optics. 2021 Apr; 60(12):3365-3373. doi: 10.1364/ao.416943. [PMID: 33983241]
  • Chao Du, Wujiao Li, Zhaohui Fu, Chunyan Yi, Xu Liu, Bisong Yue. De novo transcriptome assemblies of Epicauta tibialis provide insights into the sexual dimorphism in the production of cantharidin. Archives of insect biochemistry and physiology. 2021 Apr; 106(4):e21784. doi: 10.1002/arch.21784. [PMID: 33719055]
  • Yulin Ren, A Douglas Kinghorn. Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives. Bioorganic & medicinal chemistry. 2021 02; 32(?):116012. doi: 10.1016/j.bmc.2021.116012. [PMID: 33454654]
  • Yifan Li, Hong Sun, Hassan Yasoob, Zhen Tian, Yue Li, Ruichi Li, Shengli Zheng, Jiyuan Liu, Yalin Zhang. Biogenetic cantharidin is a promising leading compound to manage insecticide resistance of Mythimna separata (Lepidoptera: Noctuidae). Pesticide biochemistry and physiology. 2021 Feb; 172(?):104769. doi: 10.1016/j.pestbp.2020.104769. [PMID: 33518040]
  • Shaopu Hu, Junli Chang, Hongfeng Ruan, Wenlan Zhi, Xiaobo Wang, Fulai Zhao, Xiaoping Ma, Xingyuan Sun, Qianqian Liang, Hao Xu, Yongjun Wang, Yanping Yang. Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate β-catenin nuclear translocation and LEF1 translation. International journal of biological sciences. 2021; 17(10):2504-2522. doi: 10.7150/ijbs.51638. [PMID: 34326690]
  • Sahra Niazi, Bradford Brabec, Luke Anschutz, Cynthia Willson, Matthew Davidson, Patrick Burnett. A Phase 2 Open-Label Study to Evaluate VP-102 for the Treatment of Molluscum Contagiosum. Journal of drugs in dermatology : JDD. 2021 01; 20(1):70-75. doi: 10.36849/jdd.5626. [PMID: 33400412]
  • Hailu Yao, Junli Zhao, Zhen Wang, Jinwei Lv, Gangjun Du, Yiguang Jin, Yu Zhang, Shiyong Song, Guang Han. Enhanced anticancer efficacy of cantharidin by mPEG-PLGA micellar encapsulation: An effective strategy for application of a poisonous traditional Chinese medicine. Colloids and surfaces. B, Biointerfaces. 2020 Dec; 196(?):111285. doi: 10.1016/j.colsurfb.2020.111285. [PMID: 32771818]
  • Tianmu He, Jingxian Liu, Xiaoning Wang, Cancan Duan, Xiaofei Li, Jianyong Zhang. Analysis of cantharidin-induced nephrotoxicity in HK-2 cells using untargeted metabolomics and an integrative network pharmacology analysis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Dec; 146(?):111845. doi: 10.1016/j.fct.2020.111845. [PMID: 33152469]
  • Fang Liu, Cancan Duan, Jianyong Zhang, Xiaofei Li. Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro. Journal of applied toxicology : JAT. 2020 12; 40(12):1622-1635. doi: 10.1002/jat.4022. [PMID: 32638414]
  • Youyou Zhang, Liang Liu, Liang Ren. RNA-sequencing-based transcriptome analysis of cantharidin-induced myocardial injury. Journal of applied toxicology : JAT. 2020 11; 40(11):1491-1497. doi: 10.1002/jat.4000. [PMID: 32618016]
  • Jianbo Zhou, Yali Ren, Lu Tan, Xiaominting Song, Miao Wang, Yuzhi Li, Zhixing Cao, Chuanjie Guo. Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110755. doi: 10.1016/j.biopha.2020.110755. [PMID: 33152920]
  • Ying Jiang, Xiaolin Liu, Xinyi Tan, Ye Hou, Wanxiao Sun, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang. In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting. AAPS PharmSciTech. 2020 Oct; 21(7):277. doi: 10.1208/s12249-020-01829-3. [PMID: 33033942]
  • Jianyong Zhang, Qihong Chen, Le Wang, Kuan Chen, Wenbi Mu, Cancan Duan, Xiaofei Li. Study on the mechanism of cantharidin-induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods. Journal of applied toxicology : JAT. 2020 09; 40(9):1259-1271. doi: 10.1002/jat.3983. [PMID: 32468647]
  • Min Zhu, Xiujing Liu, Changhui Zhou, Juan Li. Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma: Protocol for a meta-analysis. Medicine. 2020 Aug; 99(34):e21952. doi: 10.1097/md.0000000000021952. [PMID: 32846865]
  • Zhang Youyou, Yu Yalei, Zhang Jie, Guan Chuhuai, Liu Liang, Ren Liang. Molecular biomarkers of cantharidin-induced cardiotoxicity in Sprague-Dawley rats: Troponin T, vascular endothelial growth factor and hypoxia inducible factor-1α. Journal of applied toxicology : JAT. 2020 08; 40(8):1153-1161. doi: 10.1002/jat.3974. [PMID: 32162354]
  • Uddin Md Nazim, Honghua Yin, Sang-Youel Park. Downregulation of c‑FLIP and upregulation of DR‑5 by cantharidin sensitizes TRAIL‑mediated apoptosis in prostate cancer cells via autophagy flux. International journal of molecular medicine. 2020 Jul; 46(1):280-288. doi: 10.3892/ijmm.2020.4566. [PMID: 32319535]
  • Youyou Zhang, Liang Liu, Liang Ren. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of cantharidin in biological specimens and application to postmortem interval estimation in cantharidin poisoning. Scientific reports. 2020 06; 10(1):10438. doi: 10.1038/s41598-020-67278-x. [PMID: 32591575]
  • Yaobo Zeng, Yanlei Guo, Yi Zhang, Xianying Wang, Yao Jiang, Dajian Yang. Rapid profiling of cantharidin analogs in Mylabris phalerata Pallas by ultra-performance liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry. Biomedical chromatography : BMC. 2020 Jun; 34(6):e4801. doi: 10.1002/bmc.4801. [PMID: 31999361]
  • Hongwei Gao, Naixin Kang, Chao Hu, Ziyu Zhang, Qiongming Xu, Yanli Liu, Shilin Yang. Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153197. doi: 10.1016/j.phymed.2020.153197. [PMID: 32146298]
  • Priscila Diaz, António Carneiro, Vera Montes, Sara Alves. [A Potentially Fatal Aphrodisiac: Cantharidin Poisoning]. Acta medica portuguesa. 2020 Apr; 33(4):284-287. doi: 10.20344/amp.11567. [PMID: 32238244]
  • Mengyun Song, Xianfei Wang, Yajun Luo, Zilin Liu, Wang Tan, Pengcheng Ye, Zhiming Fu, Fei Lu, Wanping Xiang, Linghan Tang, Lin Yao, Yuqiang Nie, Jiangwei Xiao. Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chemico-biological interactions. 2020 Feb; 317(?):108939. doi: 10.1016/j.cbi.2020.108939. [PMID: 31945315]
  • Shi-Sheng Zhu, Ren Long, Tao Song, Li Zhang, Ya-Lei Dai, Si-Wen Liu, Peng Zhang. UPLC-Q-TOF/MS Based Metabolomics Approach to Study the Hepatotoxicity of Cantharidin on Mice. Chemical research in toxicology. 2019 11; 32(11):2204-2213. doi: 10.1021/acs.chemrestox.9b00233. [PMID: 31617706]
  • Xue Zhang, Congcong Lin, Waikei Chan, Kanglun Liu, Aiping Lu, Ge Lin, Rong Hu, Hongcan Shi, Hongqi Zhang, Zhijun Yang. Dual-Functional Liposomes with Carbonic Anhydrase IX Antibody and BR2 Peptide Modification Effectively Improve Intracellular Delivery of Cantharidin to Treat Orthotopic Hepatocellular Carcinoma Mice. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183332. [PMID: 31547459]
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