Alisol (BioDeep_00000230813)
Main id: BioDeep_00000230406
PANOMIX_OTCML-2023
代谢物信息卡片
[(3R,4S,6R)-2,4-dihydroxy-6-[(5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] acetate
化学式: C32H52O6 (532.3763692)
中文名称: 泽泻醇 A 24-醋酸酯, 泽泻醇A-24-醋酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(C(C(C)(C)O)OC(=O)C)O)C1=C2CC(C3C4(CCC(=O)C(C4CCC3(C2(CC1)C)C)(C)C)C)O
InChI: InChI=1S/C32H52O6/c1-18(16-23(35)27(29(5,6)37)38-19(2)33)20-10-14-31(8)21(20)17-22(34)26-30(7)13-12-25(36)28(3,4)24(30)11-15-32(26,31)9/h18,22-24,26-27,34-35,37H,10-17H2,1-9H3/t18-,22+,23+,24+,26+,27-,30+,31+,32+/m1/s1
描述信息
alisol A 24-acetate is a natural product found in Alisma with data available.
Alisol A 24-acetate (Alisol A 24-monoacetate) is a natural product.
Alisol A 24-acetate (Alisol A 24-monoacetate) is a natural product.
同义名列表
8 个代谢物同义名
[(3R,4S,6R)-2,4-dihydroxy-6-[(5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] acetate; Alisol A 24-monoacetate; Alisol A (24-acetate); Alisol A monoacetate; alisol A 24-acetate; Alisol A,24-acetate; 24-acetylalisol A; Alisol
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 76336194
- MeSH: alisol A 24-acetate
- chemspider: 31140486
- CAS: 18674-16-3
- medchemexpress: HY-N0853A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 泽泻: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Taotao Lu, Huihong Li, Yangjie Zhou, Wei Wei, Linlin Ding, Zengtu Zhan, Weilin Liu, Jing Tao, Xiehua Xue. Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K/AKT pathway.
Journal of neuroinflammation.
2022 Feb; 19(1):37. doi:
10.1186/s12974-022-02392-3. [PMID: 35130910] - Yangjie Zhou, Wei Wei, Julian Shen, Lu Lu, Taotao Lu, Hong Wang, Xiehua Xue. Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.
Pharmaceutical biology.
2021 Dec; 59(1):513-524. doi:
10.1080/13880209.2021.1912117. [PMID: 33905668] - Lu Lu, Taotao Lu, Julian Shen, Xinru Lv, Wei Wei, Hong Wang, Xiehua Xue. Alisol A 24-acetate protects against brain microvascular endothelial cells injury through inhibiting miR-92a-3p/tight junctions axis.
Aging.
2021 06; 13(11):15353-15365. doi:
10.18632/aging.203094. [PMID: 34086605] - Jia-Xiang Chen, Hai-Yan Li, Tian-Tian Li, Wen-Cheng Fu, Xin Du, Chun-Hui Liu, Wen Zhang. Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
BMC complementary medicine and therapies.
2020 Jan; 20(1):22. doi:
10.1186/s12906-019-2802-3. [PMID: 32020870] - Xiaomei Xu, Lisha Li, Yamin Zhang, Xuehua Lu, Wei Lin, Shuangshuang Wu, Xia Qin, Rongqing Xu, Wenjin Lin. Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats.
PloS one.
2020; 15(10):e0240616. doi:
10.1371/journal.pone.0240616. [PMID: 33035272] - Xuan Zhou, Qi Ren, Bing Wang, Ge Fang, Yunzhi Ling, Xiantao Li. Alisol A 24-Acetate Isolated from the Alismatis Rhizoma Improves Hepatic Lipid Deposition in Hyperlipidemic Mice by ABCA1/ABCG1 Pathway.
Journal of nanoscience and nanotechnology.
2019 09; 19(9):5496-5502. doi:
10.1166/jnn.2019.16592. [PMID: 30961702] - Chenqu Wu, Menghui Jing, Lijuan Yang, Lei Jin, Yicun Ding, Juan Lu, Qin Cao, Yuanye Jiang. Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway.
Chemico-biological interactions.
2018 Aug; 291(?):111-119. doi:
10.1016/j.cbi.2018.06.005. [PMID: 29883724] - Maoliang Liao, Haihua Shang, Yazhuo Li, Tian Li, Miao Wang, Yanan Zheng, Wenbin Hou, Changxiao Liu. An integrated approach to uncover quality marker underlying the effects of Alisma orientale on lipid metabolism, using chemical analysis and network pharmacology.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Jun; 45(?):93-104. doi:
10.1016/j.phymed.2018.04.006. [PMID: 29705003] - Wei Wei, Xiao-Mao Zhou, Yu-Cheng Wang, Zhi-Cheng Lin, Ji-Hua Xue. [Effect of alisol A 24-acetate on proliferation of aorta smooth muscle cells in rats induced by ox-LDL].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 May; 43(10):2147-2152. doi:
10.19540/j.cnki.cjcmm.20180104.025. [PMID: 29933685] - Wen Xu, Xiaoyan Li, Na Lin, Xue Zhang, Xiaoqiang Huang, Tingting Wu, Yanni Tai, Shuyun Chen, Chieh-Hsi Wu, Mingqing Huang, Shuisheng Wu. Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2017 Nov; 146(?):314-323. doi:
10.1016/j.jpba.2017.09.009. [PMID: 28910706] - Qiang Meng, Xing-Ping Duan, Chang-Yuan Wang, Zhi-Hao Liu, Peng-Yuan Sun, Xiao-Kui Huo, Hui-Jun Sun, Jin-Yong Peng, Ke-Xin Liu. Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Acta pharmacologica Sinica.
2017 Jan; 38(1):69-79. doi:
10.1038/aps.2016.119. [PMID: 27773935] - Yun-Ho Hwang, Kyung-Yun Kang, Sung-Ju Lee, Sang-Jip Nam, Young-Jin Son, Sung-Tae Yee. The Protective Effects of Alisol A 24-Acetate from Alisma canaliculatum on Ovariectomy Induced Bone Loss in Vivo.
Molecules (Basel, Switzerland).
2016 Jan; 21(1):74. doi:
10.3390/molecules21010074. [PMID: 26760992] - Lu Zeng, WaiJiao Tang, JinJin Yin, LiJuan Feng, Yabing Li, Xiaorui Yao, BenJie Zhou. Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 40(3-4):453-464. doi:
10.1159/000452560. [PMID: 27889747] - Xie-Hua Xue, Xiao-Mao Zhou, Wei Wei, Tong Chen, Qing-Ping Su, Jing Tao, Li-Dian Chen. Alisol A 24-Acetate, a Triterpenoid Derived from Alisma orientale, Inhibits Ox-LDL-Induced Phenotypic Transformation and Migration of Rat Vascular Smooth Muscle Cells through Suppressing ERK1/2 Signaling.
Journal of vascular research.
2016; 53(5-6):291-300. doi:
10.1159/000448715. [PMID: 27924795] - Wen Xu, Ting Li, Jian-Fang Qiu, Shui-Sheng Wu, Ming-Qing Huang, Li-Gen Lin, Qing-Wen Zhang, Xiu-Ping Chen, Jin-Jian Lu. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships.
Anti-cancer agents in medicinal chemistry.
2015; 15(2):228-35. doi:
10.2174/1871520614666140601213514. [PMID: 24893804] - Fei Xu, Qi-nan Wu, Jun Chen, Wei Gu, Fang Fang, Lin-qun Zhang, Bo Zhao. The binding mechanisms of plasma protein to active compounds in Alismaorientale rhizomes (Alismatis Rhizoma).
Bioorganic & medicinal chemistry letters.
2014 Sep; 24(17):4099-105. doi:
10.1016/j.bmcl.2014.07.065. [PMID: 25106886] - Qin Li, Haibin Qu. Study on the hypoglycemic activities and metabolism of alcohol extract of Alismatis Rhizoma.
Fitoterapia.
2012 Sep; 83(6):1046-53. doi:
10.1016/j.fitote.2012.05.009. [PMID: 22613807] - Yue Yu, Qing Li, Kaishun Bi, Pu Xie, Guoguang Yang, Xiaohui Chen. A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of alisol A and alisol A 24-acetate from Alisma orientale (Sam.) Juz. in rat plasma.
Analytical and bioanalytical chemistry.
2011 Jan; 399(3):1363-9. doi:
10.1007/s00216-010-4426-9. [PMID: 21107819] - Chaofeng Zhang, Aichun Zhou, Mian Zhang. [Chemical constituents of Alisma orientalis and their immunosuppressive function].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Apr; 34(8):994-8. doi:
. [PMID: 19639784] - Bolat Makabel, Yuying Zhao, Bin Wang, Yanjing Bai, Qingying Zhang, Li Wu, Yang Lv. Stability and structure studies on alisol a 24-acetate.
Chemical & pharmaceutical bulletin.
2008 Jan; 56(1):41-5. doi:
10.1248/cpb.56.41. [PMID: 18175972] - Hong-Chang Liu, Wen-Yu Yang, Xing-Fu Chen. [Establishment of chromatographic fingerprint and quality assessment on Sichuan native medicinal plant Alisma plantago-aquatica].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Sep; 32(18):1844-7. doi:
". [PMID: 18051885] - Zhi-Yong Jiang, Xue-Mei Zhang, Feng-Xue Zhang, Ni Liu, Fang Zhao, Jun Zhou, Ji-Jun Chen. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.
Planta medica.
2006 Aug; 72(10):951-4. doi:
10.1055/s-2006-947178. [PMID: 16858666]