Mogroside V (BioDeep_00000230774)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C60H102O29 (1286.6506442)
中文名称: 罗汉果皂苷V, 罗汉果甜苷 V, 罗汉果甜甙 V, 罗汉果甙 V, 罗汉果苷 V, 罗汉果糖苷 V
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC(C(C)(C)O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)C4CCC5(C4(CC(C6(C5CC=C7C6CCC(C7(C)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C)O)C)C
InChI: InChI=1S/C60H102O29/c1-23(9-13-35(57(4,5)79)88-55-50(89-54-49(78)43(72)38(67)29(20-63)84-54)45(74)40(69)31(86-55)22-81-52-47(76)42(71)37(66)28(19-62)83-52)24-15-16-58(6)32-12-10-25-26(60(32,8)33(64)17-59(24,58)7)11-14-34(56(25,2)3)87-53-48(77)44(73)39(68)30(85-53)21-80-51-46(75)41(70)36(65)27(18-61)82-51/h10,23-24,26-55,61-79H,9,11-22H2,1-8H3/t23-,24-,26-,27-,28-,29-,30-,31-,32+,33-,34+,35-,36-,37-,38-,39-,40-,41+,42+,43+,44+,45+,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,58+,59-,60+/m1/s1
描述信息
Mogroside V is a natural product found in Siraitia grosvenorii and Siraitia siamensis with data available.
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research[1][3].
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research[1][3].
同义名列表
12 个代谢物同义名
Mogroside V; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,9.BETA.,10.ALPHA.,11.ALPHA.,24R)-3-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-11,25-DIHYDROXY-9-METHYL-19-NORLANOST-5-EN-24-YL O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->6))-; (3.BETA.,9.BETA.,10.ALPHA.,11.ALPHA.,24R)-3-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-11,25-DIHYDROXY-9-METHYL-19-NORLANOST-5-EN-24-YL O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->6))-.BETA.-D-GLUCOPYRANOSIDE; (1S,4R,9beta,11alpha,24R)-1-{[6-O-(beta-D-Glucopyranosyl)-beta-D-glucopyranosyl]oxy}-11,25-dihydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-en-24-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->6)]-beta-D-glucopyranoside; beta-D-Glucopyranoside, (3beta,9beta,10alpha,11alpha,24R)-3-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl O-beta-D-glucopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-6))-; MOGROL-3-O-(.BETA.-D-GLUCOPYRANOSYL (1-6)-.BETA.-D-GLUCOPYRANOSIDE)-24-O-((.BETA.-D-GLUCOPYRANOSYL (1-2))-(.BETA.-D-GLUCOPYRANOSYL(1-6))-.BETA.-D-GLUCOPYRANOSIDE); mogrol-3-O-(beta-D-glucopyranosyl (1-6)-beta-D-glucopyranoside)-24-O-((beta-D-glucopyranosyl (1-2))-(beta-D-glucopyranosyl(1-6))-beta-D-glucopyranoside); GHBNZZJYBXQAHG-KUVSNLSMSA-N; MOGROSIDE V [USP-RS]; UNII-ZFF6Z51TUR; Mogroside-V; ZFF6Z51TUR
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 53486251
- PubChem: 24721270
- Metlin: METLIN84983
- MeSH: mogroside V
- ChemIDplus: 0088901364
- CAS: 88901-36-4
- medchemexpress: HY-N0502
- PMhub: MS000093118
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Junyu Nie, Peng Xiao, Qianqian Xiong, Xingwei Liang, Xiuling Zhao. Smart seq2 revealed distinct molecular responses during in vitro porcine oocyte maturation before or after the addition of mogroside V.
Reproduction in domestic animals = Zuchthygiene.
2024 May; 59(5):e14595. doi:
10.1111/rda.14595. [PMID: 38773768] - Ke Peng, Kexin Cui, Pan Li, Xinxin Liu, Ya Du, Huiyan Xu, Xiaogan Yang, Shengsheng Lu, Xingwei Liang. Mogroside V alleviates the heat stress-induced disruption of the porcine oocyte in vitro maturation.
Theriogenology.
2024 Mar; 217(?):37-50. doi:
10.1016/j.theriogenology.2024.01.008. [PMID: 38244353] - Mengjie Han, Haiping Liu, Guoxiang Liu, Xiaojuan Li, Luwei Zhou, Yisa Liu, Tong Dou, Sijie Yang, Wei Tang, Yan Wang, Linjun Li, Hongfang Ding, Zhangchi Liu, Juan Wang, Xu Chen. Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis.
Food & function.
2024 Jan; ?(?):. doi:
10.1039/d3fo01901b. [PMID: 38258992] - Hua Liu, Yang Du, Lian Lin Liu, Qing Shan Liu, He Hui Mao, Yong Cheng. Anti-depression-like effect of Mogroside V is related to the inhibition of inflammatory and oxidative stress pathways.
European journal of pharmacology.
2023 Sep; 955(?):175828. doi:
10.1016/j.ejphar.2023.175828. [PMID: 37364672] - Chen Pan, Jingyue Chen, Ying Chen, Yajuan Lu, Xingwei Liang, Bo Xiong, Yangqing Lu. Mogroside V ameliorates the oxidative stress-induced meiotic defects in porcine oocytes in vitro.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):148-157. doi:
10.1016/j.reprotox.2022.05.008. [PMID: 35597324] - Yisa Liu, Juan Wang, Tong Dou, Luwei Zhou, Xiao Guan, Guoxiang Liu, Xiaojuan Li, Mengjie Han, Xu Chen. The liver metabolic features of Mogroside V compared to Siraitia grosvenorii fruit extract in allergic pneumonia mice.
Molecular immunology.
2022 05; 145(?):80-87. doi:
10.1016/j.molimm.2022.03.008. [PMID: 35305534] - Yongming Li, Yudong Chen, Mulan Wei, Chaohe Wei. Preclinical In Silico Evidence Indicates the Pharmacological Targets and Mechanisms of Mogroside V in Patients With Ovarian Cancer and Coronavirus Disease 2019.
Frontiers in endocrinology.
2022; 13(?):845404. doi:
10.3389/fendo.2022.845404. [PMID: 35464051] - Yisa Liu, Juan Wang, Xiao Guan, Dan Yu, Mengjie Huangfu, Tong Dou, Luwei Zhou, Lin Wang, Guoxiang Liu, Xiaojuan Li, Zhaokun Zhai, Mengjie Han, Haiping Liu, Xu Chen. Mogroside V reduce OVA-induced pulmonary inflammation based on lung and serum metabolomics.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153682. doi:
10.1016/j.phymed.2021.153682. [PMID: 34483017] - Shivani, Babit Kumar Thakur, C P Mallikarjun, Mitali Mahajan, Priya Kapoor, Jigyasa Malhotra, Rimpy Dhiman, Dinesh Kumar, Probir Kumar Pal, Sanjay Kumar. Introduction, adaptation and characterization of monk fruit (Siraitia grosvenorii): a non-caloric new natural sweetener.
Scientific reports.
2021 03; 11(1):6205. doi:
10.1038/s41598-021-85689-2. [PMID: 33737610] - Qiuting Mo, Hao Fu, Dan Zhao, Jiachan Zhang, Changtao Wang, Dongdong Wang, Meng Li. Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts.
Drug design, development and therapy.
2021; 15(?):4901-4909. doi:
10.2147/dddt.s337524. [PMID: 34880600] - Naoko Masumoto, Kyoko Ishizuki, Yuzo Nishizaki, Takashi Ohtsuki, Miho Kuroe, Taichi Yamazaki, Masahiko Numata, Hiroshi Matsufuji, Naoki Sugimoto, Kyoko Sato. Determination of Mogroside V in Luohanguo Extract for Daily Quality Control Operation Using Relative Molar Sensitivity to Single-Reference Caffeine.
Chemical & pharmaceutical bulletin.
2021; 69(1):18-25. doi:
10.1248/cpb.c20-00245. [PMID: 33390516] - Zemin Sun, Bo Lü, Yongjun Feng. [Synthetic biology for the synthesis of mogroside V - a review].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2020 Oct; 36(10):2017-2028. doi:
10.13345/j.cjb.200072. [PMID: 33169567] - Virly, Chun-Hui Chiu, Tsan-Yu Tsai, Yi-Cheun Yeh, Reuben Wang. Encapsulation of β-Glucosidase within PVA Fibers by CCD-RSM-Guided Coelectrospinning: A Novel Approach for Specific Mogroside Sweetener Production.
Journal of agricultural and food chemistry.
2020 Oct; 68(42):11790-11801. doi:
10.1021/acs.jafc.0c02513. [PMID: 32991810] - Chen Bin, Yu Fangming, Jiang Zhi. Mogroside V-producing Endophytic Fungi Isolated from Siraitia grosvenorii.
Planta medica.
2020 Sep; 86(13-14):983-987. doi:
10.1055/a-1102-1168. [PMID: 32005041] - Yuqin Luo, Chunyan Gong, Mingmin Wei, Yi Chen, Ting Song, Chunyong Wu, Liying Mo, Junying Zhang. Evaluation of Mogroside V as a Promising Carrier in Drug Delivery: Improving the Bioavailability and Liver Distribution of Silybin.
AAPS PharmSciTech.
2020 Apr; 21(4):123. doi:
10.1208/s12249-020-01645-9. [PMID: 32337654] - Peijun Ju, Wenhua Ding, Jianhua Chen, Ying Cheng, Beibei Yang, Lanting Huang, Qiong Zhou, Cuizhen Zhu, Xiaobo Li, Mengyue Wang, Jinghong Chen. The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages.
Psychopharmacology.
2020 Apr; 237(4):1011-1026. doi:
10.1007/s00213-019-05431-9. [PMID: 31900523] - Jia-Le Song, Bo Qian, Cailing Pan, Fangfang Lv, Haipeng Wang, Yang Gao, Yanyuan Zhou. Protective activity of mogroside V against ovalbumin-induced experimental allergic asthma in Kunming mice.
Journal of food biochemistry.
2019 09; 43(9):e12973. doi:
10.1111/jfbc.12973. [PMID: 31489660] - Yong Li, Luyan Zou, Tao Li, Dengni Lai, Yanyang Wu, Si Qin. Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells.
Acta biochimica et biophysica Sinica.
2019 Apr; 51(4):365-374. doi:
10.1093/abbs/gmz014. [PMID: 30877761] - Jing Qiao, Zuliang Luo, Zhe Gu, Yanling Zhang, Xindan Zhang, Xiaojun Ma. Identification of a Novel Specific Cucurbitadienol Synthase Allele in Siraitia grosvenorii Correlates with High Catalytic Efficiency.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030627. [PMID: 30754652] - Huiyu Yan, Lina Tao, Xiaoyu Qu, Liting Zhou, Sixi Zhang. Quantitative determination of mogroside V in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Pakistan journal of pharmaceutical sciences.
2018 May; 31(3):867-873. doi:
NULL. [PMID: 29716867] - Guisheng Zhou, Yulong Zhang, Yang Li, Mengyue Wang, Xiaobo Li. The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Mar; 1079(?):25-33. doi:
10.1016/j.jchromb.2018.02.002. [PMID: 29428672] - Xiaodong Yu, Binna Bi, Ning Dong, Huanli Zhao, Lixin Ji, Minghua Lu. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2017 Mar; 31(3):. doi:
10.1002/bmc.3813. [PMID: 27518831] - Maxim Itkin, Rachel Davidovich-Rikanati, Shahar Cohen, Vitaly Portnoy, Adi Doron-Faigenboim, Elad Oren, Shiri Freilich, Galil Tzuri, Nadine Baranes, Shmuel Shen, Marina Petreikov, Rotem Sertchook, Shifra Ben-Dor, Hugo Gottlieb, Alvaro Hernandez, David R Nelson, Harry S Paris, Yaakov Tadmor, Yosef Burger, Efraim Lewinsohn, Nurit Katzir, Arthur Schaffer. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.
Proceedings of the National Academy of Sciences of the United States of America.
2016 11; 113(47):E7619-E7628. doi:
10.1073/pnas.1604828113. [PMID: 27821754] - Feng Xu, Dian-Peng Li, Zhen-Cong Huang, Feng-Lai Lu, Lei Wang, Yong-Lin Huang, Ru-Feng Wang, Guang-Xue Liu, Ming-Ying Shang, Shao-Qing Cai. Exploring in vitro, in vivo metabolism of mogroside V and distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MS(n).
Journal of pharmaceutical and biomedical analysis.
2015 Nov; 115(?):418-30. doi:
10.1016/j.jpba.2015.07.024. [PMID: 26280925] - Dongfang Shi, Meizhu Zheng, Yumeng Wang, Chunming Liu, Shan Chen. Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice.
Pharmaceutical biology.
2014 Jun; 52(6):729-34. doi:
10.3109/13880209.2013.867451. [PMID: 24621273] - Fuli Deng, Xiangfeng Liang, Liangrong Yang, Qingfen Liu, Huizhou Liu. Analysis of Mogroside V in Siraitia grosvenorii with micelle-mediated cloud-point extraction.
Phytochemical analysis : PCA.
2013 Jul; 24(4):381-5. doi:
10.1002/pca.2420. [PMID: 23349010] - Rahul S Pawar, Alexander J Krynitsky, Jeanne I Rader. Sweeteners from plants--with emphasis on Stevia rebaudiana (Bertoni) and Siraitia grosvenorii (Swingle).
Analytical and bioanalytical chemistry.
2013 May; 405(13):4397-407. doi:
10.1007/s00216-012-6693-0. [PMID: 23341001] - Xu-bing Chen, Jing-jing Zhuang, Jun-hua Liu, Min Lei, Lei Ma, Jing Chen, Xu Shen, Li-hong Hu. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.
Bioorganic & medicinal chemistry.
2011 Oct; 19(19):5776-81. doi:
10.1016/j.bmc.2011.08.030. [PMID: 21893415] - Min Zhang, Huihua Yang, Hongyang Zhang, Yuerong Wang, Ping Hu. Development of a process for separation of mogroside V from Siraitia grosvenorii by macroporous resins.
Molecules (Basel, Switzerland).
2011 Aug; 16(9):7288-301. doi:
10.3390/molecules16097288. [PMID: 22143539] - Yuji Murata, Takahisa Ogawa, Yasushi A Suzuki, Shinichi Yoshikawa, Hiroshi Inui, Masaki Sugiura, Yoshihisa Nakano. Digestion and absorption of Siraitia grosvenori triterpenoids in the rat.
Bioscience, biotechnology, and biochemistry.
2010; 74(3):673-6. doi:
10.1271/bbb.90832. [PMID: 20208371] - Long-Hua Bai, Xiao-Jun Ma, Chang-Ming Mo, Lei Shi, Shi-Xin Feng, Xiang-Jun Jiang. [Study on quantitative assessment of Siraitia grosvenorii germplasms by general index].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Dec; 32(23):2482-4. doi:
". [PMID: 18330237] - W J Chen, J Wang, X Y Qi, B J Xie. The antioxidant activities of natural sweeteners, mogrosides, from fruits of Siraitia grosvenori.
International journal of food sciences and nutrition.
2007 Nov; 58(7):548-56. doi:
10.1080/09637480701336360. [PMID: 17852496] - Qi Xiangyang, Chen Weijun, Liu Liegang, Yao Ping, Xie Bijun. Effect of a Siraitia grosvenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice.
Molecular nutrition & food research.
2006 Aug; 50(8):732-8. doi:
10.1002/mnfr.200500252. [PMID: 16835866] - Eiichiro Takeo, Hiroshi Yoshida, Norio Tada, Tetsuji Shingu, Hideo Matsuura, Yuji Murata, Shinichi Yoshikawa, Toshitsugu Ishikawa, Haruo Nakamura, Fumitaka Ohsuzu, Hiroshi Kohda. Sweet elements of Siraitia grosvenori inhibit oxidative modification of low-density lipoprotein.
Journal of atherosclerosis and thrombosis.
2002; 9(2):114-20. doi:
10.5551/jat.9.114. [PMID: 12236315]