Cyclosporin C (BioDeep_00000230764)

   


代谢物信息卡片


(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotri-triacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

化学式: C62H111N11O13 (1217.8362396)
中文名称: 环孢菌素 C, 环孢菌素C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O
InChI: InChI=1S/C62H111N11O13/c1-25-26-27-39(14)52(76)51-56(80)66-49(42(17)74)60(84)67(18)32-47(75)68(19)43(28-33(2)3)55(79)65-48(37(10)11)61(85)69(20)44(29-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)45(30-35(6)7)58(82)71(22)46(31-36(8)9)59(83)72(23)50(38(12)13)62(86)73(51)24/h25-26,33-46,48-52,74,76H,27-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,79)(H,66,80)/b26-25+/t39-,40+,41-,42-,43+,44+,45+,46+,48+,49+,50+,51+,52-/m1/s1

描述信息

Cyclosporin C is a natural product found in Fusarium neocosmosporiellum, Trichoderma polysporum, and Gliomastix luzulae with data available.

同义名列表

16 个代谢物同义名

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotri-triacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-30-((R)-1-hydroxyethyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone; CYCLO(L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-L-VALYL-(3R,4R,6E)-6,7-DIDEHYDRO-3-HYDROXY-N,4-DIMETHYL-L-2-AMINOOCTANOYL-L-THREONYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL); Cyclo[[(E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-L-threonine-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]; Cyclosporin C, Antibiotic for Culture Media Use Only; CYCLOSPORIN A, 7-L-THREONINE-; JTOKYIBTLUQVQV-QRVTZXGZSA-N; 7-L-Threoninecyclosporin A; 7-threonine-cyclosporin A; CYCLOSPORIN C [MI]; Thr2-cyclosporine; UNII-6S744L5508; Cyclosporin C; 6S744L5508; [Thr2]CsA



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jianhui Wu, Xiaochen Zhang, Muhammad Hamid Bashir, Shaukat Ali. Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.). Toxins. 2022 07; 14(8):. doi: 10.3390/toxins14080514. [PMID: 36006176]
  • Nathalie Khoueiry Zgheib, Raafat Alameddine, Radwan Massoud, Rihab Nasr, Ammar Zahreddine, Jean El Cheikh, Rami Mahfouz, Ali Bazarbachi. The role of candidate genetic polymorphisms in the interaction between voriconazole and cyclosporine in patients undergoing allogeneic hematopoietic cell transplantation: An explorative study. Current research in translational medicine. 2020 04; 68(2):51-58. doi: 10.1016/j.retram.2020.02.001. [PMID: 32094096]
  • P I Campbell, I A al-Nasser. Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A. Toxicology. 1996 Nov; 114(1):11-7. doi: 10.1016/s0300-483x(96)03411-7. [PMID: 8931756]
  • V V Revin, S A Kasatkin, G N Cherkasova, V T Nikolaev, N S Iamashkina, M N Chabushkina, O A Popova, V F Belianina. [Effect of the quality of fat substrate on the dynamics of fatty acid utilization during biosynthesis of cephalosporin C]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1991 Jan; 36(1):5-8. doi: ". [PMID: 2053827]
  • M Nogami, M Suko, H Okudaira, T Miyamoto, J Shiga, M Ito, S Kasuya. Experimental pulmonary eosinophilia in mice by Ascaris suum extract. The American review of respiratory disease. 1990 May; 141(5 Pt 1):1289-95. doi: 10.1164/ajrccm/141.5_pt_1.1289. [PMID: 2339848]
  • P Y Wong, M Cheung, T K Yip, A V Mee. Use of 125I-labeled-histamine-cyclosporin C for monitoring serum cyclosporine concentrations in transplantation patients. Clinical chemistry. 1986 Mar; 32(3):492-5. doi: 10.1093/clinchem/32.3.492. [PMID: 3948391]