AsperosaponinVI (BioDeep_00000230699)

Main id: BioDeep_00000230860

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

化学式: C47H76O18 (928.5031)
中文名称: 川续断皂苷 VI, 木通皂甙 D
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C
InChI: InChI=1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1

描述信息

Akebia saponin D is a triterpenoid saponin that is hederagenin attached to a alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage and a 6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 28 via an ester linkage. It is the active ingredient found in the traditional Chinese herb Radix Dipsaci. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an anti-inflammatory agent, a bone density conservation agent, a neuroprotective agent and an antilipemic drug. It is a triterpenoid saponin, a trisaccharide derivative, a pentacyclic triterpenoid and a carboxylic ester. It is functionally related to a hederagenin.
Asperosaponin VI is a natural product found in Lonicera japonica, Stauntonia hexaphylla, and other organisms with data available.
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB[2].
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB[2].

同义名列表

7 个代谢物同义名

[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate; 3-O-glucopyranosyl-1-2-arabinopyranosyl-3-norolean-12,20(29)-dien-28-oic acid-28-O-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl ester; Asperosaponin cento; Asperosaponin VI; akebia saponin D; AsperosaponinVI; Asperosaponin Ⅵ



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jin Huang, Xuewen Liang, Minrui Zhao, Yue Zhang, Ziyang Chen. Metabolomics and network pharmacology reveal the mechanism of antithrombotic effect of Asperosaponin VI. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116355. doi: 10.1016/j.biopha.2024.116355. [PMID: 38493592]
  • Yan-Hong Cui, Lin Ma, Dong-Mei Hai, Yan-Nan Chi, Wen-Jing Dong, Xiao-Bing Lan, Wei Wei, Miao-Miao Tian, Xiao-Dong Peng, Jian-Qiang Yu, Ning Liu. Asperosaponin VI protects against spermatogenic dysfunction in mice by regulating testicular cell proliferation and sex hormone disruption. Journal of ethnopharmacology. 2024 Feb; 320(?):117463. doi: 10.1016/j.jep.2023.117463. [PMID: 37981113]
  • Linlin Wei, Hui Luo, Yan Jin, Yue Shu, Cailing Wen, Tian Qin, Xinru Yang, Liqing Ma, Ying Liu, Yan You, Chun Zhou. Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Dec; 121(?):155080. doi: 10.1016/j.phymed.2023.155080. [PMID: 37757711]
  • Wei Chen, Juan Shi, Wei Zhang. Administration of Akebia Saponin D Improved Blood Lipid Levels and Pregnancy Outcomes in Mice with Gestational Diabetes Mellitus. Balkan medical journal. 2023 10; 40(6):422-429. doi: 10.4274/balkanmedj.galenos.2023.2023-6-82. [PMID: 37815409]
  • Yue Shu, Xinru Yang, Linlin Wei, Cailing Wen, Hui Luo, Tian Qin, Liqing Ma, Ying Liu, Bin Wang, Cuiling Liu, Chun Zhou. Akebia saponin D from Dipsacus asper wall. Ex C.B. Clarke ameliorates skeletal muscle insulin resistance through activation of IGF1R/AMPK signaling pathway. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117049. doi: 10.1016/j.jep.2023.117049. [PMID: 37591362]
  • Jinqiang Zhang, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao, Hui He, Zili You, Tao Zhou. Akebia saponin D acts via the PPAR-gamma pathway to reprogramme a pro-neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress. CNS neuroscience & therapeutics. 2023 Mar; ?(?):. doi: 10.1111/cns.14196. [PMID: 36987659]
  • Y-B Niu, Y-H Zhang, Y Sun, X-Z Song, Z-H Li, M Xie, Q-B Mei, Y-H Li, Q Chen. Asperosaponin VI Protects Against Bone Loss Due to Hindlimb Unloading in Skeletally Growing Mice Through Regulating Microbial Dysbiosis Altering the 5-HT Pathway. Calcified tissue international. 2023 03; 112(3):389-402. doi: 10.1007/s00223-022-01057-w. [PMID: 36595050]
  • Junting Niu, Yiqing Wang, Yao Meng, Wanli Qi, Jianping Wen. Asperosaponin VI induces osteogenic differentiation of human umbilical cord mesenchymal stem cells via the estrogen signaling pathway. Medicine. 2022 Dec; 101(50):e32344. doi: 10.1097/md.0000000000032344. [PMID: 36550906]
  • Jin-Fang Luo, Hua Zhou, Chon-Kit Lio. Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196236. [PMID: 36234773]
  • Xue Jiang, Saini Yi, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao, Jinqiang Zhang. Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway. Journal of neuroinflammation. 2022 May; 19(1):115. doi: 10.1186/s12974-022-02478-y. [PMID: 35610721]
  • Song Yang, Ting Hu, He Liu, Ya-Li Lv, Wen Zhang, Han Li, Lingling Xuan, Li-Li Gong, Li-Hong Liu. Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111441. doi: 10.1016/j.biopha.2021.111441. [PMID: 33652261]
  • Katarzyna Stępnik. Biomimetic Chromatographic Studies Combined with the Computational Approach to Investigate the Ability of Triterpenoid Saponins of Plant Origin to Cross the Blood-Brain Barrier. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073573. [PMID: 33808219]
  • Yong-Tao Niu, Lin Xie, Rong-Rong Deng, Xiao-Yu Zhang. In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells. BMC complementary medicine and therapies. 2021 Jan; 21(1):32. doi: 10.1186/s12906-020-03169-y. [PMID: 33446173]
  • Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry. 2021 Jan; 209(?):112932. doi: 10.1016/j.ejmech.2020.112932. [PMID: 33131725]
  • Jinqiang Zhang, Saini Yi, Yahui Li, Chenghong Xiao, Chan Liu, Weike Jiang, Changgui Yang, Tao Zhou. The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression. Psychopharmacology. 2020 Aug; 237(8):2531-2545. doi: 10.1007/s00213-020-05553-5. [PMID: 32488348]
  • Congcong Lu, Guoxia Fan, Dianyun Wang. Akebia Saponin D ameliorated kidney injury and exerted anti-inflammatory and anti-apoptotic effects in diabetic nephropathy by activation of NRF2/HO-1 and inhibition of NF-KB pathway. International immunopharmacology. 2020 Jul; 84(?):106467. doi: 10.1016/j.intimp.2020.106467. [PMID: 32344355]
  • Xi-Yang Tang, Zi-Qin Dai, Qing-Chang Wu, Jia-Xing Zeng, Meng-Xue Gao, Hui-Hui Xiao, Zhi-Hong Yao, Yi Dai, Xin-Sheng Yao. Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112836. doi: 10.1016/j.jpba.2019.112836. [PMID: 31473481]
  • Song Yang, Wen Zhang, Ling-Ling Xuan, Fei-Fei Han, Ya-Li Lv, Zi-Rui Wan, He Liu, Lu-Lu Ren, Li-Li Gong, Li-Hong Liu. Akebia Saponin D inhibits the formation of atherosclerosis in ApoE-/- mice by attenuating oxidative stress-induced apoptosis in endothelial cells. Atherosclerosis. 2019 06; 285(?):23-30. doi: 10.1016/j.atherosclerosis.2019.04.202. [PMID: 30999121]
  • Le Ba Vinh, Hyun-Jae Jang, Nguyen Viet Phong, Kyoungwon Cho, Sung Sun Park, Jong Seong Kang, Young Ho Kim, Seo Young Yang. Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. Bioorganic & medicinal chemistry letters. 2019 04; 29(8):965-969. doi: 10.1016/j.bmcl.2019.02.022. [PMID: 30808589]
  • Peipei Zhou, Xiaolin Yang, Zhonglin Yang, Wenzhe Huang, Junping Kou, Fei Li. Akebia Saponin D Regulates the Metabolome and Intestinal Microbiota in High Fat Diet-Induced Hyperlipidemic Rats. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071268. [PMID: 30939835]
  • Li-Li Gong, Song Yang, He Liu, Wen Zhang, Lu-Lu Ren, Fei-Fei Han, Ya-Li Lv, Zi-Rui Wan, Li-Hong Liu. Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D. European journal of pharmacology. 2019 Feb; 845(?):85-90. doi: 10.1016/j.ejphar.2018.11.038. [PMID: 30508505]
  • Yuhui Wang, Jinyang Shen, Xiaolin Yang, Ye Jin, Zhonglin Yang, Rufeng Wang, Fuming Zhang, Robert J Linhardt. Mechanism of enhanced oral absorption of akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex. Drug development and industrial pharmacy. 2019 Jan; 45(1):124-129. doi: 10.1080/03639045.2018.1526183. [PMID: 30229685]
  • Yuhui Wang, Jinyang Shen, Xiaolin Yang, Ye Jin, Zhonglin Yang, Rufeng Wang, Fuming Zhang, Robert J Linhardt. Akebia saponin D reverses corticosterone hypersecretion in an Alzheimer's disease rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Nov; 107(?):219-225. doi: 10.1016/j.biopha.2018.07.149. [PMID: 30092401]
  • Li-Li Gong, Song Yang, Wen Zhang, Fei-Fei Han, Ya-Li Lv, Zi-Rui Wan, He Liu, Yang-Jie Jia, Ling-Ling Xuan, Li-Hong Liu. Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy. Journal of pharmacological sciences. 2018 Apr; 136(4):189-195. doi: 10.1016/j.jphs.2017.11.007. [PMID: 29609842]
  • Cheng-Gui Wang, Yi-Ting Lou, Min-Ji Tong, Li-Lian Zhang, Zeng-Jie Zhang, Yong-Zeng Feng, Shi Li, Hua-Zi Xu, Cong Mao. Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling. Acta pharmacologica Sinica. 2018 Mar; 39(3):393-404. doi: 10.1038/aps.2017.161. [PMID: 29219948]
  • Yi Tao, Yingshan Du, Weidong Li, Baochang Cai, Liuqing Di, Liyun Shi, Lihong Hu. Integrating UHPLC-MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jun; 1055-1056(?):135-143. doi: 10.1016/j.jchromb.2017.04.035. [PMID: 28467948]
  • Li-Li Gong, Guang-Run Li, Wen Zhang, He Liu, Ya-Li Lv, Fei-Fei Han, Zi-Rui Wan, Ming-Biao Shi, Li-Hong Liu. Akebia Saponin D Decreases Hepatic Steatosis through Autophagy Modulation. The Journal of pharmacology and experimental therapeutics. 2016 Dec; 359(3):392-400. doi: 10.1124/jpet.116.236562. [PMID: 27672081]
  • Yi Tao, Yuchao Ren, Weidong Li, Baochang Cai, Liuqing Di, Liyun Shi, Lihong Hu. Comparative pharmacokinetic analysis of extracts of crude and wine-processed Dipsacus asper in rats by a sensitive ultra performance liquid chromatography-tandem mass spectrometry approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Nov; 1036-1037(?):33-41. doi: 10.1016/j.jchromb.2016.09.024. [PMID: 27710888]
  • Ke Ke, Qi Li, Xiaofeng Yang, Zhijian Xie, Yu Wang, Jue Shi, Linfeng Chi, Weijian Xu, Lingling Hu, Huali Shi. Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model. Scientific reports. 2016 10; 6(?):35233. doi: 10.1038/srep35233. [PMID: 27756897]
  • Jie Gao, Chun Zhou, Yadi Li, Feixia Gao, Haiwang Wu, Lilin Yang, Weiyu Qiu, Lin Zhu, Xin Du, Weixian Lin, Dandan Huang, Haibin Liu, Chun Liang, Songping Luo. Asperosaponin VI promotes progesterone receptor expression in decidual cells via the notch signaling pathway. Fitoterapia. 2016 Sep; 113(?):58-63. doi: 10.1016/j.fitote.2016.06.013. [PMID: 27370099]
  • Jinyang Shen, Jianping Bi, Hongli Tian, Ye Jin, Yuan Wang, Xiaolin Yang, Zhonglin Yang, Junping Kou, Fei Li. Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D-phospholipid complex. International journal of nanomedicine. 2016 ; 11(?):4919-4929. doi: 10.2147/ijn.s108765. [PMID: 27713630]
  • Jun Luo, Juan Qing, Li-yan Zhang, Li-li Zhang. [HPLC Fingerprint and Analysis of Component Difference of Crude and Wine Processed Products for Dipsacus asper Root]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Mar; 38(3):493-6. doi: ". [PMID: 26495648]
  • Liang Yan, Xiaolin Yang, Zhaoqing Meng, Yongliang Yuan, Wei Xiao, Zhenzhong Wang, Wenze Huang, Zhonglin Yang, Chunfeng Zhang. Simultaneous quantification of Akebia saponin D and its five metabolites in human intestinal bacteria using ultra-performance liquid chromatography triple quadrupole mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 971(?):81-8. doi: 10.1016/j.jchromb.2014.09.013. [PMID: 25264916]
  • Er-Wei Liu, Jia-Long Wang, Li-Feng Han, Yan-Xu Chang, Tao Wang, Yan Huo, Lei Wang, Xiu-Mei Gao. Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin. Journal of natural medicines. 2014 Jul; 68(3):488-97. doi: 10.1007/s11418-014-0821-4. [PMID: 24615060]
  • Li Song, Shaoyun Wang, Xiaoju Duan, Xinhua Liu, Zhaofang Li, Lei Nie, Guangyi Chu. Chromatographic fingerprint combined with content of asperosaponin VI and antioxidant activity for quality evaluation of wine-fried Dipsaci Radix. Natural product communications. 2014 Jun; 9(6):773-8. doi: ". [PMID: 25115076]
  • Wei-Feng Ma, Tao Zhou, Wei-Ke Jiang, Yong He, Shou-Dong Zhu, Lan-Ping Guo. [Spatial structure and geographic distribution of major active component in medical herb Dipsacus asperoides population]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(20):3419-23. doi: ". [PMID: 24490546]
  • Rui-Juan Liu, He Zhu, Li Ding, Shailendra Shakya, Zhong-Lin Yang, Lu Cheng. [Study on pharmacokinetics of asperosaponin VI and its active metabolite in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Jul; 38(14):2378-83. doi: NULL. [PMID: 24199576]
  • Ying-Jie Wei, Xiao-Lu Xue, Wei Liu, Chang-Mei Wang, Yang Zhan, Xiao-Bin Jia. [Metabolism study of asperosaponin VI by using zebrafish]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Feb; 48(2):281-5. doi: ". [PMID: 23672027]
  • Peng Zhou, Liang Ma, Jun Zhou. [Study on the mechanism of akebia saponin D for leukemia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012 Jan; 32(1):84-8. doi: ". [PMID: 22500401]
  • Shailendra Shakya, He Zhu, Li Ding, Xiao Lang Du, Xie Min Qi, Xiao Lin Yang, Zhong Lin Yang. Determination of asperosaponin VI in dog plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pilot pharmacokinetic study. Biomedical chromatography : BMC. 2012 Jan; 26(1):109-14. doi: 10.1002/bmc.1634. [PMID: 21465503]
  • He Zhu, Li Ding, Shailendra Shakya, Xiemin Qi, Linlin Hu, Xiaolin Yang, Zhonglin Yang. Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3407-14. doi: 10.1016/j.jchromb.2011.09.014. [PMID: 21963276]
  • Li Hua Peng, Chun Hay Ko, Sum Wing Siu, Chi Man Koon, Gar Lee Yue, Wai Hing Cheng, Tai Wai Lau, Quan Bin Han, Ka Ming Ng, Kwok Pui Fung, Clara Bik San Lau, Ping Chung Leung. In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment. Journal of ethnopharmacology. 2010 Sep; 131(2):282-9. doi: 10.1016/j.jep.2010.06.039. [PMID: 20600749]
  • Kai Li, Li Ding, Zhong-Lin Yang, E-Hu Liu, Lian-Wen Qi, Ping Li, Yu-Zhu Hu. Determination of asperosaponin VI in rat plasma by HPLC-ESI-MS and its application to preliminary pharmacokinetic studies. Biomedical chromatography : BMC. 2010 May; 24(5):550-5. doi: 10.1002/bmc.1325. [PMID: 19795392]
  • Chunmei Li, Zhifeng Liu, Jingwei Tian, Guisheng Li, Wanglin Jiang, Guanbo Zhang, Fangfang Chen, Peiyan Lin, Zuguang Ye. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. European journal of pharmacology. 2010 Feb; 627(1-3):235-41. doi: 10.1016/j.ejphar.2009.11.004. [PMID: 19909736]
  • Yong-Qiang Zhou, Zhong-Lin Yang, Lei Xu, Ping Li, Yu-Zhu Hu. Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity. Cell biology international. 2009 Oct; 33(10):1102-10. doi: 10.1016/j.cellbi.2009.06.028. [PMID: 19615455]
  • Seung-Il Jeong, Beng Zhou, Jin-Beom Bae, Nam-Seok Kim, Sun-Geun Kim, Jin Kwon, Dae-Keun Kim, Tae-Yong Shin, Hoon Jeon, Jong-Phil Lim, Hongjun Kim, Ho Kyoung Kim, Chan-Ho Oh. Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper Wall in U937 cells. Archives of pharmacal research. 2008 Nov; 31(11):1399-404. doi: 10.1007/s12272-001-2123-0. [PMID: 19023535]