Bacopaside II (BioDeep_00000230698)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-O-alpha-L-arabinofuranosyl-(1-2)-(beta-D-glucopyranosyl (1-3))-beta-D-glucopyranosyl pseudo-jujubogenin

化学式: C47H76O18 (928.5031)
中文名称: 假马齿苋皂苷II, 假马齿苋苷 II
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CC1COC23CC4(CO2)C(C3C1(C)O)CCC5C4(CCC6C5(CCC(C6(C)C)OC7C(C(C(C(O7)CO)O)OC8C(C(C(C(O8)CO)O)O)O)OC9C(C(C(O9)CO)O)O)C)C)C
InChI: InChI=1S/C47H76O18/c1-21(2)14-22-18-58-47-19-46(20-59-47)23(38(47)45(22,7)57)8-9-28-43(5)12-11-29(42(3,4)27(43)10-13-44(28,46)6)63-41-37(65-39-34(55)31(52)25(16-49)61-39)36(32(53)26(17-50)62-41)64-40-35(56)33(54)30(51)24(15-48)60-40/h14,22-41,48-57H,8-13,15-20H2,1-7H3/t22-,23-,24-,25+,26-,27+,28-,29+,30-,31+,32-,33+,34-,35-,36+,37-,38+,39+,40+,41+,43+,44-,45+,46+,47-/m1/s1

描述信息

[Raw Data] CBA80_Bacopaside-II_pos_50eV.txt
[Raw Data] CBA80_Bacopaside-II_pos_40eV.txt
[Raw Data] CBA80_Bacopaside-II_pos_30eV.txt
[Raw Data] CBA80_Bacopaside-II_pos_20eV.txt
[Raw Data] CBA80_Bacopaside-II_pos_10eV.txt
bacopaside II is a natural product found in Bacopa monnieri with data available.
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis[1][2].

同义名列表

7 个代谢物同义名

Bacopaside II; 3-O-alpha-L-arabinofuranosyl-(1-2)-(beta-D-glucopyranosyl (1-3))-beta-D-glucopyranosyl pseudo-jujubogenin; Bacopaside II (constituent of bacopa) [DSC]; Bacopaside ii, (-)-; BACOPASIDE II(P); UNII-ZO6L404Y9T; ZO6L404Y9T



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sunil Kumar, Neeti Singh, Vaibhavi Lahane, Vineeta Tripathi, Akhilesh Kumar Yadav, Rakesh Kumar Shukla. Methyl jasmonate inducible UGT79A18 is a novel glycosyltransferase involved in the bacoside biosynthetic pathway in Bacopa monnieri. Physiologia plantarum. 2024 Mar; 176(2):e14260. doi: 10.1111/ppl.14260. [PMID: 38511471]
  • Saleha Anwar, Taj Mohammad, Md Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md Imtaiyaz Hassan. Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease. International journal of biological macromolecules. 2023 Jun; ?(?):125364. doi: 10.1016/j.ijbiomac.2023.125364. [PMID: 37315665]
  • Helen M Palethorpe, Yoko Tomita, Eric Smith, Jinxin V Pei, Amanda R Townsend, Timothy J Price, Joanne P Young, Andrea J Yool, Jennifer E Hardingham. The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis. International journal of molecular sciences. 2018 Feb; 19(3):. doi: 10.3390/ijms19030653. [PMID: 29495367]
  • Jinxin V Pei, Mohamad Kourghi, Michael L De Ieso, Ewan M Campbell, Hilary S Dorward, Jennifer E Hardingham, Andrea J Yool. Differential Inhibition of Water and Ion Channel Activities of Mammalian Aquaporin-1 by Two Structurally Related Bacopaside Compounds Derived from the Medicinal Plant Bacopa monnieri. Molecular pharmacology. 2016 10; 90(4):496-507. doi: 10.1124/mol.116.105882. [PMID: 27474162]
  • Mundkinajeddu Deepak, Agarwal Amit. 'Bacoside B'--the need remains for establishing identity. Fitoterapia. 2013 Jun; 87(?):7-10. doi: 10.1016/j.fitote.2013.03.011. [PMID: 23506783]
  • Sukanya Majumdar, Saraswati Garai, Sumita Jha. Use of the cryptogein gene to stimulate the accumulation of Bacopa saponins in transgenic Bacopa monnieri plants. Plant cell reports. 2012 Oct; 31(10):1899-909. doi: 10.1007/s00299-012-1303-3. [PMID: 22733208]
  • Khalid Rauf, Fazal Subhan, Robert D E Sewell. A Bacoside containing Bacopa monnieri extract reduces both morphine hyperactivity plus the elevated striatal dopamine and serotonin turnover. Phytotherapy research : PTR. 2012 May; 26(5):758-63. doi: 10.1002/ptr.3631. [PMID: 22105846]
  • Khalid Rauf, Fazal Subhan, Muzaffar Abbas, Amir Badshah, Ihsan Ullah, Sami Ullah. Effect of Bacopasides on acquisition and expression of morphine tolerance. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Jul; 18(10):836-42. doi: 10.1016/j.phymed.2011.01.023. [PMID: 21377853]
  • Ling Peng, Yun Zhou, De Yun Kong, Wei Dong Zhang. Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytotherapy research : PTR. 2010 Jun; 24(6):864-8. doi: 10.1002/ptr.3034. [PMID: 19960417]
  • Yun Zhou, Yun-Heng Shen, Chuan Zhang, Juan Su, Run-Hui Liu, Wei-Dong Zhang. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. Journal of natural products. 2007 Apr; 70(4):652-5. doi: 10.1021/np060470s. [PMID: 17343408]
  • Watoo Phrompittayarat, Waraporn Putalun, Hiroyuki Tanaka, Sakchai Wittaya-Areekul, Kanchalee Jetiyanon, Kornkanok Ingkaninan. An enzyme-linked immunosorbant assay using polyclonal antibodies against bacopaside I. Analytica chimica acta. 2007 Feb; 584(1):1-6. doi: 10.1016/j.aca.2006.11.017. [PMID: 17386577]
  • Papolu Bhargava Sriramachandra Murthy, Valivarti Raghava Raju, Tummala Ramakrisana, Mangu Srinivasa Chakravarthy, Katta Vijay Kumar, Sukala Kannababu, Gottumukkala Venkata Subbaraju. Estimation of twelve bacopa saponins in Bacopa monnieri extracts and formulations by high-performance liquid chromatography. Chemical & pharmaceutical bulletin. 2006 Jun; 54(6):907-11. doi: 10.1248/cpb.54.907. [PMID: 16755069]