Velbe (BioDeep_00000230688)

Main id: BioDeep_00000277706

 

PANOMIX_OTCML-2023 Chemicals and Drugs Antitumor activity


代谢物信息卡片


WLN: T C6 B5665/BS 2AB S BX IN QN NU & & TTTJ FO1 I1 KVO1 KQ LOV1 M2 E-CT F6 D596A EN ON & & TTJ CVO1 Q

化学式: C46H58N4O9.H2O4S (908.387739)
中文名称: 硫酸长春碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
InChI: InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7

描述信息

Vinblastine sulfate appears as an anticancer drug. White to slightly yellow crystalline powder. (NTP, 1992)
Vincaleukoblastine sulfate is an alkaloid sulfate salt. It is functionally related to a vincaleukoblastine.
Vinblastine Sulfate is the sulfate salt of vinblastine, a natural alkaloid isolated from the plant Catharanthus roseus (Madagascar periwinkle) with antineoplastic properties. Vinblastine disrupts microtubule formation and function during mitosis and interferes with glutamic acid metabolism. (NCI04)
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

同义名列表

31 个代谢物同义名

WLN: T C6 B5665/BS 2AB S BX IN QN NU & & TTTJ FO1 I1 KVO1 KQ LOV1 M2 E-CT F6 D596A EN ON & & TTJ CVO1 Q; WLN: T C6 B5665/BS 2AB S BX IN QN NU & & TTTJ FO1 I1 KVO1 KQ LOV1 M2 E-CT F6D596A EN ON & & TTJ CVO1 Q; Vincaleukoblastine sulfate (1:1) (salt); Vincaleukoblastine, monohydrate; Vincaleukoblastine sulfate salt; Vinblastine sulfate (JP17/USP); KDQAABAKXDWYSZ-JKDPCDLQSA-N; Vinblastine Sulfate Hydrate; Vincaleukoblastine, hydrate; Vincaleukoblastine sulfate; Vincaleucoblastine sulfate; Vinblastine sulphate; Vinblastine, hydrate; Sulfate, Vinblastine; Vinblastinsulfat-Gry; Velban (TN) (Lilly); Vinblastine sulfate; Vincaleukoblastine; Vinblastina Lilly; Vinblastin Hexal; VLB monosulfate; Vinblastine 5; Vinblastine; Belvan, VLB; cellblastin; Lemblastine; Velban (TN); Exal (TN); Velban; Velbe; Vinblastine (sulfate)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Masoomeh Nabaei, Rayhaneh Amooaghaie, Mansour Ghorbanpour, Alimohammad Ahadi. Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don. Plant cell reports. 2024 May; 43(6):139. doi: 10.1007/s00299-024-03229-4. [PMID: 38735908]
  • Pooja Singh, Seema Yadav, Saumya Shah, Karuna Shanker, Velusamy Sundaresan, Ashutosh K Shukla. Characterization of a CrPME indicates its possible role in determining vindoline accumulation in Catharanthus roseus leaves. Physiologia plantarum. 2024 Mar; 176(2):e14276. doi: 10.1111/ppl.14276. [PMID: 38566244]
  • Jun Guo, Di Gao, Jiazhang Lian, Yang Qu. De novo biosynthesis of antiarrhythmic alkaloid ajmaline. Nature communications. 2024 Jan; 15(1):457. doi: 10.1038/s41467-024-44797-z. [PMID: 38212296]
  • Jawad Ahmed, Yasar Sajjad, Aasia Latif, Mohammad Saeed Lodhi, Muhammad Huzafa, Chen Situ, Raza Ahmad, Muhammad Maroof Shah, Amjad Hassan. Genome-wide identification and characterization of wall-associated kinases, molecular docking and polysaccharide elicitation of monoterpenoid indole alkaloids in micro-propagated Catharanthus roseus. Journal of plant research. 2024 Jan; 137(1):125-142. doi: 10.1007/s10265-023-01504-1. [PMID: 37962734]
  • Zhongping Xu, Guanying Wang, Qiongqiong Wang, Xiaoting Li, Guangyu Zhang, Ali Qurban, Can Zhang, Yi Zhou, Huan Si, Lisong Hu, Fuqiu Wang, Ying Wang, Zhitao Tian, Wei Chen, Shuangxia Jin, Fang Ding. A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen. Plant communications. 2023 Nov; 4(6):100661. doi: 10.1016/j.xplc.2023.100661. [PMID: 37464741]
  • Maneesha Mall, Karuna Shanker, Dinesh A Nagegowda, Abdul Samad, Alok Kalra, Alok Pandey, Velusamy Sundaresan, Ashutosh K Shukla. Temperature-induced lipocalin-mediated membrane integrity: Possible implications for vindoline accumulation in Catharanthus roseus leaves. Physiologia plantarum. 2023 Sep; 175(5):e13994. doi: 10.1111/ppl.13994. [PMID: 37882277]
  • Katalin Nagy, Éva Darkó, Gabriella Szalai, Tibor Janda, Zsuzsa Jókai, Márta Ladányi, Mohamed Ramadan Rady, Mihály Dernovics. UPLC-ESI-QTOF-MS assisted targeted metabolomics to study the enrichment of vinca alkaloids and related metabolites in Catharanthus roseus plants grown under controlled LED environment. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 235(?):115611. doi: 10.1016/j.jpba.2023.115611. [PMID: 37542828]
  • Hossam S El-Beltagi, Salwa M El-Sayed, Ahmed N Abdelhamid, Karim M Hassan, Walaa A Elshalakany, Mona Ibrahim Nossier, Nadiyah M Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A Ibrahim. Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083642. [PMID: 37110876]
  • Yuanjian Yang, Liuyu Ding, Ying Zhou, Zizheng Guo, Rongmin Yu, Jianhua Zhu. Establishment of recombinant Catharanthus roseus stem cells stably overexpressing ORCA4 for terpenoid indole alkaloids biosynthesis. Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):783-792. doi: 10.1016/j.plaphy.2023.02.039. [PMID: 36848864]
  • Valentina Laghezza Masci, Davide Stefanoni, Angelo D'Alessandro, Marta Zambelli, Lorenzo Modesti, Daniele Pollini, Elisa Ovidi, Antonio Tiezzi. Induction of Drug-Resistance and Production of a Culture Medium Able to Induce Drug-Resistance in Vinblastine Untreated Murine Myeloma Cells. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052051. [PMID: 36903299]
  • Dagny Grzech, Benke Hong, Lorenzo Caputi, Prashant D Sonawane, Sarah E O'Connor. Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana. ACS synthetic biology. 2023 01; 12(1):27-34. doi: 10.1021/acssynbio.2c00434. [PMID: 36516122]
  • Fanfan Li, Stephen Bordeleau, Kyung Hee Kim, Jonathan Turcotte, Benjamin Davis, Lan Liu, Stéphane Bayen, Vincenzo De Luca, Mehran Dastmalchi. A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine. Phytochemistry. 2022 Nov; 203(?):113422. doi: 10.1016/j.phytochem.2022.113422. [PMID: 36055422]
  • M Ahmadzadeh, A H Keshtkar, K Moslemkhany, M Ahmadzadeh. Effect of the plant probiotic bacteria on terpenoid indole alkaloid biosynthesis pathway gene expression profiling, vinblastine and vincristine content in the root of Catharanthus roseus. Molecular biology reports. 2022 Nov; 49(11):10357-10365. doi: 10.1007/s11033-022-07841-z. [PMID: 36097118]
  • Armando Moreno-Velasco, Pedro de Jesús Flores-Tafoya, Mabel Fragoso-Serrano, Suzana Guimarães Leitão, Rogelio Pereda-Miranda. Resin Glycosides from Operculina hamiltonii and Their Synergism with Vinblastine in Cancer Cells. Journal of natural products. 2022 10; 85(10):2385-2394. doi: 10.1021/acs.jnatprod.2c00594. [PMID: 36162138]
  • Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr. De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid. Scientific reports. 2022 10; 12(1):17803. doi: 10.1038/s41598-022-20314-4. [PMID: 36280677]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Cryo-derived plants through embryogenesis showed same levels of vinblastine and vincristine (anticancer) in Catharanthus roseus and had normal genome size. Scientific reports. 2022 10; 12(1):16635. doi: 10.1038/s41598-022-20993-z. [PMID: 36198853]
  • Shagufta Iqbal, Caitlin Flux, Deborah A Briggs, Evelyne Deplazes, Jiansi Long, Ruth Skrzypek, Alice Rothnie, Ian D Kerr, Richard Callaghan. Vinca alkaloid binding to P-glycoprotein occurs in a processive manner. Biochimica et biophysica acta. Biomembranes. 2022 10; 1864(10):184005. doi: 10.1016/j.bbamem.2022.184005. [PMID: 35863425]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Gamma ray-induced tissue responses and improved secondary metabolites accumulation in Catharanthus roseus. Applied microbiology and biotechnology. 2022 Sep; 106(18):6109-6123. doi: 10.1007/s00253-022-12122-7. [PMID: 35962802]
  • Jie Zhang, Lea G Hansen, Olga Gudich, Konrad Viehrig, Lærke M M Lassen, Lars Schrübbers, Khem B Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D'Ambrosio, Beata Lehka, Ahmad K Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A K Jørgensen, Leanne Jade G Chan, Mette Kristensen, Hanne B Christensen, Suresh Sudarsan, Emily A Stander, Edward Baidoo, Christopher J Petzold, Tune Wulff, Sarah E O'Connor, Vincent Courdavault, Michael K Jensen, Jay D Keasling. A microbial supply chain for production of the anti-cancer drug vinblastine. Nature. 2022 09; 609(7926):341-347. doi: 10.1038/s41586-022-05157-3. [PMID: 36045295]
  • Wojciech Trybus, Ewa Trybus, Teodora Król. Emodin Sensitizes Cervical Cancer Cells to Vinblastine by Inducing Apoptosis and Mitotic Death. International journal of molecular sciences. 2022 Jul; 23(15):. doi: 10.3390/ijms23158510. [PMID: 35955645]
  • Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hájíček, Vincenzo De Luca, Yang Qu. A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis. Nature communications. 2022 06; 13(1):3335. doi: 10.1038/s41467-022-31100-1. [PMID: 35680936]
  • L T van der Heijden, A Gebretensae, B Thijssen, L van Andel, A L Nijstad, Y Wang, H Rosing, A D R Huitema, J H Beijnen. A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114772. doi: 10.1016/j.jpba.2022.114772. [PMID: 35462284]
  • K Zhao, H Q Wang, L Li, T Song, S P Li, M H Qiu. [Efficacy and safety of Camrelizumab and AVD in the first-line treatment of classic Hodgkin's lymphoma]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2022 05; 43(5):431-434. doi: 10.3760/cma.j.issn.0253-2727.2022.05.015. [PMID: 35680603]
  • Maneesha Mall, Karuna Shanker, Abdul Samad, Alok Kalra, Velusamy Sundaresan, Ashutosh K Shukla. Stress responsiveness of vindoline accumulation in Catharanthus roseus leaves is mediated through co-expression of allene oxide cyclase with pathway genes. Protoplasma. 2022 May; 259(3):755-773. doi: 10.1007/s00709-021-01701-6. [PMID: 34459997]
  • Vyoma Mistry, Siddhi Darji, Pragya Tiwari, Abhishek Sharma. Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast. Applied microbiology and biotechnology. 2022 Apr; 106(7):2337-2347. doi: 10.1007/s00253-022-11883-5. [PMID: 35333954]
  • Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang. Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation. Marine drugs. 2022 Mar; 20(3):. doi: 10.3390/md20030188. [PMID: 35323487]
  • Tuan-Anh Minh Nguyen, Matthew McConnachie, Trinh-Don Nguyen, Thu-Thuy T Dang. Discovery and Characterization of Oxidative Enzymes Involved in Monoterpenoid Indole Alkaloid Biosynthesis. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):141-164. doi: 10.1007/978-1-0716-2349-7_11. [PMID: 35732943]
  • Zhichun Li, Liliang Ren. Study on Effects of Cyclophosphamide Combined with Vinorelbine in Advanced Small Cell Lung Cancer and Anteroposterior Changes in MRI. Contrast media & molecular imaging. 2022; 2022(?):3104879. doi: 10.1155/2022/3104879. [PMID: 36043147]
  • Mohammadamin Shahsavarani, Maisha Farzana, Vincenzo De Luca, Yang Qu. Generating an EMS Mutant Population and Rapid Mutant Screening by Thin-Layer Chromatography Enables the Studies of Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus Roseus. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):181-190. doi: 10.1007/978-1-0716-2349-7_13. [PMID: 35732945]
  • Dikki Pedenla Bomzan, H B Shilpashree, Dinesh A Nagegowda. Agrobacterium-Mediated in Planta Transformation in Periwinkle. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):301-315. doi: 10.1007/978-1-0716-2349-7_22. [PMID: 35732954]
  • Szabolcs Mayer, Nóra Nagy, Péter Keglevich, Áron Szigetvári, Miklós Dékány, Csaba Szántay Junior, László Hazai. Synthesis of Novel Vindoline-Chrysin Hybrids. Chemistry & biodiversity. 2022 Jan; 19(1):e202100725. doi: 10.1002/cbdv.202100725. [PMID: 34874114]
  • Matthew J Murray, Rafael Moleron, Jennifer Adamski, Martin English, G A Amos Burke, Justin Cross, Thankamma Ajithkumar, Sara Stoneham, James C Nicholson. Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. Pediatric blood & cancer. 2022 01; 69(1):e29359. doi: 10.1002/pbc.29359. [PMID: 34520101]
  • Stéphane Culine, Valentin Harter, Gwenaelle Gravis, Aude Fléchon, Christine Chevreau, Hakim Mahammedi, Brigitte Laguerre, Aline Guillot, Florence Joly, Sophie Abadie-Lacourtoisie, Lionnel Geoffrois, Frédéric Di Fiore, Guilhem Roubaud, Philippe Barthélémy, Eric Voog, Sheik Emambux, Camille Serrate, Carolina Saldana, Thierry Nguyen-Tan-Hon, Yohann Loriot, Jean-Christophe Eymard, Olivier Huillard, Frédéric Rolland, Nadine Houédé, Jean-Philippe Spano, Mounira El Demery, Sabine Vieillot, Tifenn L'Haridon, Werner Hilgers, Yves Allory, Christian Pfister. Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial. Clinical genitourinary cancer. 2021 12; 19(6):554-562. doi: 10.1016/j.clgc.2021.08.005. [PMID: 34602349]
  • Hiroyuki Fujii, Taisuke Tsuji, Mio Sugitani, Yosuke Matsumoto, Tatsuya Yuba, Shunya Tanaka, Yoshifumi Suga, Aosa Matsuyama, Shiho Goda, Ayaka Omura, Shinsuke Shiotsu, Chieko Takumi, Seiko Ono, Noriya Hiraoka. Prolonged persistence of SARS-CoV-2 infection during A+AVD therapy for classical Hodgkin's lymphoma: A case report. Current problems in cancer. 2021 12; 45(6):100739. doi: 10.1016/j.currproblcancer.2021.100739. [PMID: 33810911]
  • E R El-Sayed. Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis. Journal of applied microbiology. 2021 Dec; 131(6):2886-2898. doi: 10.1111/jam.15169. [PMID: 34062037]
  • Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos-Cruz, Ines Carqueijeiro, Johan-Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St-Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli-Guivarc'h, Jillian Marc, Sébastien Besseau, Vincent Courdavault. Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories. Microbial biotechnology. 2021 11; 14(6):2693-2699. doi: 10.1111/1751-7915.13898. [PMID: 34302444]
  • Shamsher Ali, Eric Hénon, Ritchy Leroy, Georges Massiot. Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216395. [PMID: 34770804]
  • Oktay Perk, Tanıl Kendirli, Handan Dinçaslan, Ebru Azapağası, Gokcen Meral. Overlap Stevens Johnson Syndrome/Toxic Epidermal Necrolysis developed due to the use of toxic-dose vinblastine in case of Langerhans Cell Histiocytosis(Letterer-Siwe). Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2021 Oct; 60(5):103173. doi: 10.1016/j.transci.2021.103173. [PMID: 34215518]
  • Tengfei Liu, Ying Huang, Lihong Jiang, Chang Dong, Yuanwei Gou, Jiazhang Lian. Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae. Communications biology. 2021 09; 4(1):1089. doi: 10.1038/s42003-021-02617-w. [PMID: 34531512]
  • Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Marc Clastre, Vincent Courdavault. Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123596. [PMID: 34208368]
  • Minghui Kang, Rao Fu, Pingyu Zhang, Shangling Lou, Xuchen Yang, Yang Chen, Tao Ma, Yang Zhang, Zhenxiang Xi, Jianquan Liu. A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis. Nature communications. 2021 06; 12(1):3531. doi: 10.1038/s41467-021-23872-9. [PMID: 34112794]
  • David D'Andrea, Surena Matin, Peter C Black, Firas G Petros, Homayoun Zargar, Colin P Dinney, Michael S Cookson, Wassim Kassouf, Marc A Dall'Era, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeffrey M Holzbeierlein, Trinity J Bivalacqua, Srikala S Sridhar, Scott North, Daniel A Barocas, Yair Lotan, Andrew J Stephenson, Bas W van Rhijn, Philippe E Spiess, Siamak Daneshmand, Shahrokh F Shariat. Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma. BJU international. 2021 05; 127(5):528-537. doi: 10.1111/bju.15253. [PMID: 32981193]
  • Buket Kara, Kubilay K Kart, Yavuz Koksal. A Prolonged Activated Partial Thromboplastin Time in a Child With Hodgkin Lymphoma. Journal of pediatric hematology/oncology. 2021 04; 43(3):e401-e403. doi: 10.1097/mph.0000000000001732. [PMID: 32000198]
  • Ying Liu, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Lin Wang, Lei-Lei Yuan, Zhi-Gui Zeng. Post-transplant lymphoproliferative disorder after paediatric liver transplantation. International journal of clinical practice. 2021 Apr; 75(4):e13843. doi: 10.1111/ijcp.13843. [PMID: 33222369]
  • Kenji Zennami, Makoto Sumitomo, Kiyoshi Takahara, Takuhisa Nukaya, Masashi Takenaka, Kosuke Fukaya, Manabu Ichino, Naohiko Fukami, Hitomi Sasaki, Mamoru Kusaka, Ryoichi Shiroki. Two cycles of neoadjuvant chemotherapy improves survival in patients with high-risk upper tract urothelial carcinoma. BJU international. 2021 03; 127(3):332-339. doi: 10.1111/bju.15230. [PMID: 32896105]
  • Guilherme Machado Xavier, André Luiz Sena Guimarães, Carlos Alberto de Carvalho Fraga, Talita Antunes Guimarães, Marcela Gonçalves de Souza, Kimberly Marie Jones, Lucyana Conceição Farias. Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma. Protein and peptide letters. 2021; 28(7):735-749. doi: 10.2174/0929866527999201209221012. [PMID: 33302827]
  • Matthew R Trendowski, Heather E Wheeler, Omar El-Charif, Darren R Feldman, Robert J Hamilton, David J Vaughn, Chunkit Fung, Christian Kollmannsberger, Lawrence H Einhorn, Lois B Travis, M Eileen Dolan. Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 12; 26(24):6550-6558. doi: 10.1158/1078-0432.ccr-20-2682. [PMID: 32998964]
  • Mediline Goboza, Mervin Meyer, Yapo G Aboua, Oluwafemi O Oguntibeju. In Vitro Antidiabetic and Antioxidant Effects of Different Extracts of Catharanthus roseus and Its Indole Alkaloid, Vindoline. Molecules (Basel, Switzerland). 2020 Nov; 25(23):. doi: 10.3390/molecules25235546. [PMID: 33256043]
  • Oleg O Glebov. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. The FEBS journal. 2020 09; 287(17):3664-3671. doi: 10.1111/febs.15369. [PMID: 32428379]
  • Zhili Jin, Yini Wang, Na Wei, Zhao Wang. Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis-a dangerous disease. Annals of hematology. 2020 Jul; 99(7):1575-1581. doi: 10.1007/s00277-020-04093-4. [PMID: 32500223]
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