Vinorelbine (BioDeep_00000230619)

Chemicals and Drugs

代谢物信息卡片

化学式: C45H54N4O8 (778.3941444000001)
中文名称: 长春瑞滨
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.78%

分子结构信息

SMILES: CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
InChI: InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1

描述信息

Vinorelbine is a vinca alkaloid with a norvinblastine skeleton. It has a role as an antineoplastic agent and a photosensitizing agent. It is a vinca alkaloid, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a methyl ester, an acetate ester and a ring assembly.
Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990s for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting. A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug.
Vinorelbine is a Vinca Alkaloid.
Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.
See also: Vinorelbine Tartrate (active moiety of).
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CA - Vinca alkaloids and analogues
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
A vinca alkaloid with a norvinblastine skeleton.
C1907 - Drug, Natural Product

同义名列表

45 个代谢物同义名

methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(12S,14R)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3(11),4(9),5,7,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate; methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(12S,14R)-16-ethyl-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate; ASPIDOSPERMIDINE-3-CARBOXYLIC ACID, 4-(ACETYLOXY)-6,7-DIDEHYDRO-15-((2R,6R,8S)-4-ETHYL-1,3,6,7,8,9-HEXAHYDRO-8-(METHOXYCARBONYL)-2,6-METHANO-2H-AZECINO(4,3-B)INDOL-8-YL)-3-HYDROXY-16-METHOXY-1-METHYL-, METHYL ESTER, (2.BETA.,3.BETA.,4.BETA.,5.ALPHA.,12R,19.ALPHA.)-; Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12beta,19alpha)-; Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-; methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-((6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; methyl (2b,3b,4b,5a,12b,19a)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; C-Norvincaleukoblastine, 3,4-didehydro-4-deoxy-; 3,4-Didehydro-4-deoxy-C-norvincaleukoblastine; VINORELBINE TARTRATE IMPURITY J [EP IMPURITY]; 4-DEOXY-3,4-DIDEHYDROVINCALEUKOBLASTINE; Dihydroxydeoxynorvinkaleukoblastine; GBABOYUKABKIAF-IELIFDKJSA-N; VINORELBINE [ORANGE BOOK]; 5 Nor anhydrovinblastine; Nor-5-anhydrovinblastine; 5-nor-anhydrovinblastine; 5-Noranhydrovinblastine; Vinorelbine [INN:BAN]; Vinorelbina [Spanish]; VINORELBINE [WHO-DD]; Vinorelbinum (Latin); Vinorelbinum [Latin]; vinorelbine tartrate; VINORELBINE [VANDF]; VINORELBINE [HSDB]; VINORELBINE [INN]; Vinorelbine (INN); VINORELBINE [MI]; Vinorelbine base; UNII-Q6C979R91Y; Navelbine (TN); Navelbine base; Vinorelbinum; Vinorelbine; Vinorelbina; Q6C979R91Y; Vinorelbin; Navelbine; Navelbin; Exelbine; Eunades; L01CA04; NVB

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:480999
KEGGdrug: D08680
PubChem: 13200033
PubChem: 5311497
Metlin: METLIN43370
DrugBank: DB00361
ChEMBL: CHEMBL553025
Wikipedia: Vinorelbine
MeSH: Vinorelbine
ChemIDplus: 0071486221
chemspider: 4470974
CAS: 71486-22-1
MoNA: FiehnHILIC002415
MoNA: FiehnHILIC000853
MetaboLights: MTBLC480999

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

33090 - 长春花: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Chen Guo, Xichun Zhu, Haoyang Yuan, Haoyu Liu, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang. Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine. AAPS PharmSciTech. 2022 Jun; 23(5):163. doi: 10.1208/s12249-022-02308-7. [PMID: 35680728]
L T van der Heijden, A Gebretensae, B Thijssen, L van Andel, A L Nijstad, Y Wang, H Rosing, A D R Huitema, J H Beijnen. A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114772. doi: 10.1016/j.jpba.2022.114772. [PMID: 35462284]
Zhichun Li, Liliang Ren. Study on Effects of Cyclophosphamide Combined with Vinorelbine in Advanced Small Cell Lung Cancer and Anteroposterior Changes in MRI. Contrast media & molecular imaging. 2022; 2022(?):3104879. doi: 10.1155/2022/3104879. [PMID: 36043147]
Tianjiao Zeng, Mingshi Xu, Wanli Zhang, Xiaofan Gu, Fangqing Zhao, Xuan Liu, Xiongwen Zhang. Autophagy inhibition and microRNA‑199a‑5p upregulation in paclitaxel‑resistant A549/T lung cancer cells. Oncology reports. 2021 07; 46(1):. doi: 10.3892/or.2021.8100. [PMID: 34080652]
Paola Orlandi, Marta Banchi, Greta Alì, Teresa Di Desidero, Elisabetta Fini, Gabriella Fontanini, Guido Bocci. Active metronomic vinorelbine schedules decrease plasma interleukin-2 levels in mice with Lewis lung carcinoma. Journal of chemotherapy (Florence, Italy). 2021 May; 33(3):198-202. doi: 10.1080/1120009x.2020.1819069. [PMID: 32930084]
Xiu-Ying Li, Luan-Xia Shi, Xue-Min Yao, Ming Jing, Qin-Qing Li, Ying-Li Wang, Qing-Shan Li. Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer. Drug development and industrial pharmacy. 2021 Jan; 47(1):100-112. doi: 10.1080/03639045.2020.1862169. [PMID: 33295825]
Benay Özbay, Ecem Gürses, Hatice S Kemal, Evrim Şimşek, Hakan Kültürsay. Takotsubo syndrome early after treatment due to non cardiotoxic chemotherapy agents. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2021 01; 49(1):72-75. doi: 10.5543/tkda.2020.25590. [PMID: 33390577]
Shuhang Wang, Jingxin Gou, Yue Wang, Xinyi Tan, Linxuan Zhao, Xiangqun Jin, Xing Tang. Synergistic Antitumor Efficacy Mediated by Liposomal Co-Delivery of Polymeric Micelles of Vinorelbine and Cisplatin in Non-Small Cell Lung Cancer. International journal of nanomedicine. 2021; 16(?):2357-2372. doi: 10.2147/ijn.s290263. [PMID: 33790554]
Binghe Xu, Tao Sun, Shusen Wang, Yingcheng Lin. Metronomic therapy in advanced breast cancer and NSCLC: vinorelbine as a paradigm of recent progress. Expert review of anticancer therapy. 2021 01; 21(1):71-79. doi: 10.1080/14737140.2021.1835478. [PMID: 33054438]
Hongyu Liu, Qingshan Fu, Yao Lu, Wenqiang Zhang, Peng Yu, Zhen Liu, Xiaosheng Sun. Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition. European journal of medicinal chemistry. 2020 Aug; 200(?):112332. doi: 10.1016/j.ejmech.2020.112332. [PMID: 32473523]
Qian Li, Ren-Long Liang, Qian-Ru Yu, De-Qing Tian, Li-Na Zhao, Wen-Wen Wang, Hua Xiao, Xiao-Jia Yong, Xiao-Dong Peng. Efficacy and safety of cinobufacini injection combined with vinorelbine and cisplatin regimen chemotherapy for stage III/IV non-small cell lung cancer: A protocol for systematic review and meta-analysis of randomized controlled trials. Medicine. 2020 Jul; 99(31):e21539. doi: 10.1097/md.0000000000021539. [PMID: 32756206]
David Rossi. Metronomic oral vinorelbine and lung cancer therapy during the COVID 19 pandemic: A single-center experience. Lung cancer (Amsterdam, Netherlands). 2020 07; 145(?):83-84. doi: 10.1016/j.lungcan.2020.05.001. [PMID: 32416433]
Hailing Xu, Dongqing Lv, Yinnan Meng, Miao Wang, Wei Wang, Chao Zhou, Suna Zhou, Xiaofeng Chen, Haihua Yang. Endostar improved efficacy of concurrent chemoradiotherapy with vinorelbine plus carboplatin in locally advanced lung squamous cell carcinoma patients with high serum Lp(a) concentration. Annals of palliative medicine. 2020 Mar; 9(2):298-307. doi: 10.21037/apm.2020.01.16. [PMID: 32075401]
Zheng Xiao, Yuan Jiang, Cheng-Qiong Wang, Shan-Shan Hu, Xiao-Rong Huang, Xiao-Fan Chen, Jun Huang, Li-Jing Shan, Yu-Hong Tang, Yu-He Wang, Qi-Hai Gong, Ji-Hong Feng, Xue Xiao, Xiao-Fei Li. Clinical efficacy and safety of aidi injection combination with vinorelbine and cisplatin for advanced non-small-cell lung carcinoma: A systematic review and meta-analysis of 54 randomized controlled trials. Pharmacological research. 2020 03; 153(?):104637. doi: 10.1016/j.phrs.2020.104637. [PMID: 31935454]
Xi-En Wang, You-Hui Wang, Qiang Zhou, Min Peng, Jing Zhang, Mi Chen, Li-Juan Ma, Guo-Ming Xie. Immunomodulatory Effect of Lentinan on Aberrant T Subsets and Cytokines Profile in Non-small Cell Lung Cancer Patients. Pathology oncology research : POR. 2020 Jan; 26(1):499-505. doi: 10.1007/s12253-018-0545-y. [PMID: 30460541]
Liang Kong, Shi-Meng Zhang, Jia-Hao Chu, Xin-Ze Liu, Lu Zhang, Si-Yu He, Si-Min Yang, Rui-Jun Ju, Xue-Tao Li. Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC. International journal of nanomedicine. 2020; 15(?):6451-6468. doi: 10.2147/ijn.s258906. [PMID: 32922011]
Thomas Decker, Norbert Marschner, Axel Muendlein, Anja Welt, Volker Hagen, Jaqueline Rauh, Helge Schröder, Peter Jaehnig, Karin Potthoff, Christian Lerchenmüller. VicTORia: a randomised phase II study to compare vinorelbine in combination with the mTOR inhibitor everolimus versus vinorelbine monotherapy for second-line chemotherapy in advanced HER2-negative breast cancer. Breast cancer research and treatment. 2019 Aug; 176(3):637-647. doi: 10.1007/s10549-019-05280-2. [PMID: 31115844]
Yue-Guo Wu, Kui-Wu Wang, Zheng-Rong Zhao, Ping Zhang, Hua Liu, Gui-Jiao Zhou, Yan Cheng, Wen-Jie Wu, Yi-Heng Cai, Bei-Li Wu, Feng-Yang Chen. A novel polysaccharide from Dendrobium devonianum serves as a TLR4 agonist for activating macrophages. International journal of biological macromolecules. 2019 Jul; 133(?):564-574. doi: 10.1016/j.ijbiomac.2019.04.125. [PMID: 31004640]
Shengxin Cai, April L Risinger, Cora L Petersen, Tanja Grkovic, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines. Journal of natural products. 2019 04; 82(4):928-936. doi: 10.1021/acs.jnatprod.8b01015. [PMID: 30830773]
Xue-Tao Li, Wei Tang, Hong-Jun Xie, Shuang Liu, Xiao-Li Song, Yao Xiao, Xin Wang, Lan Cheng, Gui-Rong Chen. The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma. Journal of liposome research. 2019 Mar; 29(1):21-34. doi: 10.1080/08982104.2017.1408649. [PMID: 29166813]
Ikumi Washio, Takeo Nakanishi, Naoki Ishiguro, Bojan Bister, Ikumi Tamai. Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines. Biopharmaceutics & drug disposition. 2019 Jan; 40(1):32-43. doi: 10.1002/bdd.2167. [PMID: 30556139]
Krishnendu Pal, Vijay Sagar Madamsetty, Shamit Kumar Dutta, Debabrata Mukhopadhyay. Co-delivery of everolimus and vinorelbine via a tumor-targeted liposomal formulation inhibits tumor growth and metastasis in RCC. International journal of nanomedicine. 2019; 14(?):5109-5123. doi: 10.2147/ijn.s204221. [PMID: 31371950]
Rong-Sheng Qin, Zhen-Hua Zhang, Neng-Ping Zhu, Fei Chen, Qian Guo, Hao-Wen Hu, Shao-Zhi Fu, Shan-Shan Liu, Yue Chen, Juan Fan, Yun-Wei Han. Enhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma. BMC cancer. 2018 Oct; 18(1):967. doi: 10.1186/s12885-018-4738-2. [PMID: 30305062]
Chenghui Huang, Hui Wu, Haihua Zhu, Lan Liu, Ruifang Tian, Cong Xu, Xiaofei Li, Lihui Wang, Ke Cao, Peiguo Cao. [NAPD regimen for patients with recurrent refractory diffuse large B-cell lymphoma]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2018 Jul; 43(7):754-759. doi: 10.11817/j.issn.1672-7347.2018.07.009. [PMID: 30124211]
Meric A Altinoz, Aysel Ozpinar, Ebru Emekli Alturfan, Ilhan Elmaci. Vinorelbine's anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas. Journal of chemotherapy (Florence, Italy). 2018 Jul; 30(4):203-212. doi: 10.1080/1120009x.2018.1487149. [PMID: 30025492]
Rahul Dhande, Amit Tyagi, Rakesh Kumar Sharma, Hetal Thakkar. 99mTc-vinorelbine tartrate loaded spherulites: Lung disposition study in Sprague-Dawley rats by gamma scintigraphy. Pulmonary pharmacology & therapeutics. 2018 04; 49(?):36-45. doi: 10.1016/j.pupt.2018.01.002. [PMID: 29337265]
Xuenong Ouyang, Meiqi Shi, Fangwei Jie, Yuxian Bai, Peng Shen, Zhuang Yu, Xiuwen Wang, Cheng Huang, Min Tao, Zhehai Wang, Conghua Xie, Qi Wu, Yongqian Shu, Baohui Han, Fengchun Zhang, Yiping Zhang, Chunhong Hu, Xitao Ma, Yongjie Liang, Anlan Wang, Bing Lu, Yi Shi, Jinfei Chen, Zhixiang Zhuang, Jiejun Wang, Jianjin Huang, Changhui Wang, Chunxue Bai, Xin Zhou, Qiang Li, Feng Chen, Hao Yu, Jifeng Feng. Phase III study of dulanermin (recombinant human tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand) combined with vinorelbine and cisplatin in patients with advanced non-small-cell lung cancer. Investigational new drugs. 2018 04; 36(2):315-322. doi: 10.1007/s10637-017-0536-y. [PMID: 29134432]
Lakshmi Maurya, Sanjay Singh, Vijayakumar M Rajamanickam, Gopeshwar Narayan. Vitamin E TPGS Emulsified Vinorelbine Bitartrate Loaded Solid Lipid Nanoparticles (SLN): Formulation Development, Optimization and In vitro Characterization. Current drug delivery. 2018; 15(8):1135-1145. doi: 10.2174/1567201815666180409105410. [PMID: 29629662]
Yao Xiao, Lan Cheng, Hong-Jun Xie, Rui-Jun Ju, Xin Wang, Min Fu, Jing-Jing Liu, Xue-Tao Li. Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup3):S524-S537. doi: 10.1080/21691401.2018.1501377. [PMID: 30299160]
Xiaoliang Zhao, Xiaohua Wen, Wei Wei, Yanjun Su, Jian You, Liqun Gong, Zhenfa Zhang, Meng Wang, Jianyu Xiao, Xiyin Wei, Changli Wang. Predictors for the efficacy of Endostar combined with neoadjuvant chemotherapy for stage IIIA (N2) NSCLC. Cancer biomarkers : section A of Disease markers. 2017 Dec; 21(1):169-177. doi: 10.3233/cbm-170565. [PMID: 29036790]
Agnieszka Krawczyk, Dariusz Nowak, Piotr Jan Nowak, Gianluca Padula, Sylwia Kwiatkowska. Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy. Redox report : communications in free radical research. 2017 Nov; 22(6):308-314. doi: 10.1080/13510002.2016.1229885. [PMID: 27611345]
Xiaobin Gong, Le Yang, Feng Zhang, Youtian Liang, Shouhong Gao, Ke Liu, Wansheng Chen. Validated UHPLC-MS/MS assay for quantitative determination of etoposide, gemcitabine, vinorelbine and their metabolites in patients with lung cancer. Biomedical chromatography : BMC. 2017 Nov; 31(11):. doi: 10.1002/bmc.3989. [PMID: 28409868]
Kewen He, Xinzhao Wang, Xiyun Guan, Qian Yu, Qinghua Ma, Zhaoyun Liu, Zhiyong Yu. Vinorelbine Plus Gemcitabine or Cisplatin as First-line Treatment of HER2-negative Advanced Breast Cancer. Anticancer research. 2017 10; 37(10):5647-5653. doi: 10.21873/anticanres.12000. [PMID: 28982882]
Jun-Jie Ma, Hui-Ping Liu. Efficacy of Aidi Injection () on overexpression of P-glycoprotein induced by vinorelbine and cisplatin regimen in patients with non-small cell lung cancer. Chinese journal of integrative medicine. 2017 Jul; 23(7):504-509. doi: 10.1007/s11655-016-2511-4. [PMID: 27484766]
Jia-Shuan Wu, Li-Min Mu, Ying-Zi Bu, Lei Liu, Yan Yan, Ying-Jie Hu, Jing Bai, Jing-Ying Zhang, Weiyue Lu, Wan-Liang Lu. C-type natriuretic peptide-modified lipid vesicles: fabrication and use for the treatment of brain glioma. Oncotarget. 2017 Jun; 8(25):40906-40921. doi: 10.18632/oncotarget.16641. [PMID: 28402948]
Hongyang Li, Li Sun, Hang Li, Xiaodan Lv, Herve Semukunzi, Ruiming Li, Jun Yu, Shengtao Yuan, Sensen Lin. DT-13, a saponin monomer 13 of the Dwarf lilyturf tuber, synergized with vinorelbine to induce mitotic arrest via activation of ERK signaling pathway in NCI-H1299 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):1277-1285. doi: 10.1016/j.biopha.2017.02.104. [PMID: 28320095]
Bjørg Sjøblom, Jūratė Šaltytė Benth, Bjørn H Grønberg, Vickie E Baracos, Michael B Sawyer, Øystein Fløtten, Marianne J Hjermstad, Nina Aass, Marit Jordhøy. Drug Dose Per Kilogram Lean Body Mass Predicts Hematologic Toxicity From Carboplatin-Doublet Chemotherapy in Advanced Non-Small-Cell Lung Cancer. Clinical lung cancer. 2017 03; 18(2):e129-e136. doi: 10.1016/j.cllc.2016.09.008. [PMID: 27825639]
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