Notoginsenoside R2 (BioDeep_00000230616)

 

Secondary id: BioDeep_00000018795

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

化学式: C41H70O13 (770.4816)
中文名称: 三七皂甙 R2, 三七皂苷R2
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 94.23%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(CO6)O)O)O)C)O)C)O)C
InChI: InChI=1S/C41H70O13/c1-20(2)10-9-13-41(8,50)21-11-15-39(6)28(21)22(43)16-26-38(5)14-12-27(45)37(3,4)34(38)24(17-40(26,39)7)52-36-33(31(48)30(47)25(18-42)53-36)54-35-32(49)29(46)23(44)19-51-35/h10,21-36,42-50H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26+,27-,28-,29-,30+,31-,32+,33+,34-,35-,36+,38+,39+,40+,41-/m0/s1

描述信息

Notoginsenoside R2 is a triterpenoid saponin.
Notoginsenoside R2 is a natural product found in Panax notoginseng and Panax japonicus with data available.
Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.
Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

同义名列表

6 个代谢物同义名

(2S,3R,4S,5R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol; 20(S)-Notoginsenoside R2; Notoginsenoside R2; Ginsenoside Ng-R2; 2-[(2-{[5,16-dihydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-8-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy]oxane-3,4,5-triol; Notoginsenoside R2/F3



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yueqiang Hu, Lin Wu, Lingfei Jiang, Ni Liang, Xiaomin Zhu, Qianchao He, Hongling Qin, Wei Chen. Notoginsenoside R2 reduces Aβ25-35-induced neuronal apoptosis and inflammation via miR-27a/SOX8/β-catenin axis. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S347-S358. doi: 10.1177/09603271211041996. [PMID: 34533063]
  • Xuewei Ye, Siran Yu, Ying Liang, Haocai Huang, Xiao-Yuan Lian, Zhizhen Zhang. Bioactive triterpenoid saponins and phenolic compounds against glioma cells. Bioorganic & medicinal chemistry letters. 2014 Nov; 24(22):5157-63. doi: 10.1016/j.bmcl.2014.09.087. [PMID: 25442304]
  • Wen Xu, Xiao-Hui Qiu, Jing Zhang, Da-Yuan Zhu, Yi-Ming Yang, Chuan-Jian Lu. [Analysis of saponins in Panax notoginseng by UPLC-LTQ-Orbitrap MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Jun; 47(6):773-8. doi: ". [PMID: 22919726]
  • Guangtong Chen, Min Yang, Zhiqiang Lu, Jinqiang Zhang, Huilian Huang, Yan Liang, Shuhong Guan, Yan Song, Lijun Wu, De-an Guo. Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. Journal of natural products. 2007 Jul; 70(7):1203-6. doi: 10.1021/np070053v. [PMID: 17629326]
  • Bai-hai Su, Zi Li, Jun-ming Fan, Mi Wang, Rong Tang. [Effects of panax notoginseng saponins on the process of renal interstitial fibrosis after unilateral ureteral obstruction in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2005 May; 36(3):368-71. doi: NULL. [PMID: 15931871]
  • De-qiang Dou, Jie Ren, Ying Chen, Yu-ping Pei, Ying-jie Chen. [Study on the chemical constituents of the roots of commercial ginseng]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Jun; 28(6):522-4. doi: . [PMID: 15015330]
  • Xu-Dai Qian, Rui-Lan Gao, Ke Ma, Jin-Mei Jin. [Proliferation and differentiation of human CD34+ hematopoietic stem/progenitor cells induced by Panax notoginosides]. Zhongguo shi yan xue ye xue za zhi. 2003 Apr; 11(2):120-3. doi: ". [PMID: 12744730]