Kudinoside H (BioDeep_00000230606)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C41H66O13 (766.4503186000001)
中文名称: 苦丁冬青甙 H, 地榆皂苷 I, 苦丁冬青甙H
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(CO6)O)O)O)C)C)C2C1(C)O)C)C(=O)OC7C(C(C(C(O7)CO)O)O)O
InChI: InChI=1S/C41H66O13/c1-20-10-15-41(35(49)54-34-31(48)29(46)28(45)23(18-42)52-34)17-16-38(5)21(32(41)40(20,7)50)8-9-25-37(4)13-12-26(36(2,3)24(37)11-14-39(25,38)6)53-33-30(47)27(44)22(43)19-51-33/h8,20,22-34,42-48,50H,9-19H2,1-7H3/t20-,22+,23-,24+,25-,26+,27+,28-,29+,30-,31-,32-,33+,34+,37+,38-,39-,40-,41+/m1/s1
描述信息
Ziyuglycoside I is a natural product found in Sanguisorba officinalis, Ilex paraguariensis, and other organisms with data available.
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1]. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC)[2].
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1]. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC)[2].
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1]. Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC)[2].
同义名列表
9 个代谢物同义名
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate; 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester; Ziyu-glycoside I; Zigu-glucoside I; Ziyuglycoside-I; Ziyuglycoside I; ZiyuglycosideI; Kudinoside H; Gouguside 7
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yongai Xiong, Tingting Chen, Lei Chen, Rongshan Cai. Gold Nanoparticles Coated with SH-PEG-NH2 and Loaded with Ziyuglycoside I for Promoting Autophagy in Hematopoietic Stem Cells.
International journal of nanomedicine.
2023; 18(?):1347-1362. doi:
10.2147/ijn.s399568. [PMID: 36974074] - Hanfei Sun, Manman Wang, Tiantian Su, Paipai Guo, Yu Tai, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Shangxue Yan, Wei Wei, Lingling Zhang, Qingtong Wang. Ziyuglycoside I attenuates collagen-induced arthritis through inhibiting plasma cell expansion.
Journal of ethnopharmacology.
2022 Aug; 294(?):115348. doi:
10.1016/j.jep.2022.115348. [PMID: 35533910] - Kyung-Ran Park, Joon Yeop Lee, MyoungLae Cho, Hyung-Mun Yun. Ziyuglycoside I Upregulates RUNX2 through ERK1/2 in Promoting Osteoblast Differentiation and Bone Mineralization.
The American journal of Chinese medicine.
2021; 49(4):883-900. doi:
10.1142/s0192415x21500427. [PMID: 33829967] - Tingting Song, Hong Wang, Yue Liu, Rongshan Cai, Dezhi Yang, Yongai Xiong. TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression.
International journal of nanomedicine.
2021; 16(?):6281-6295. doi:
10.2147/ijn.s326629. [PMID: 34548791] - Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
European journal of medicinal chemistry.
2021 Jan; 209(?):112932. doi:
10.1016/j.ejmech.2020.112932. [PMID: 33131725] - Lin-Jie Zhu, Lin Chen, Chong-Fei Bai, An-Guo Wu, Si-Cheng Liang, Fei-Hong Huang, Shou-Song Cao, Le Yang, Wen-Jun Zou, Jian-Ming Wu. A rapid and sensitive UHPLC-MS/MS method for the determination of ziyuglycoside I and its application in a preliminary pharmacokinetic study in healthy and leukopenic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Mar; 123(?):109756. doi:
10.1016/j.biopha.2019.109756. [PMID: 31864212] - H Yoshida, K Yamazaki, A Komiya, M Aoki, S Kasamatsu, T Murata, T Sayo, M Z Cilek, Y Okada, Y Takahashi. Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling.
International journal of cosmetic science.
2019 Feb; 41(1):12-20. doi:
10.1111/ics.12505. [PMID: 30485450] - Zhi-Feng Li, Meng-Ying Zhou, Ting Tan, Chen-Cong Zhong, Qi Wang, Ling-Ling Pan, Ying-Ying Luo, Shi-Lin Yang, Yu-Lin Feng, Hui Ouyang. A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics.
Molecules (Basel, Switzerland).
2018 Feb; 23(3):. doi:
10.3390/molecules23030543. [PMID: 29495641] - Eungyeong Jang, Kyung-Soo Inn, Young Pyo Jang, Kyung-Tae Lee, Jang-Hoon Lee. Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review.
The American journal of Chinese medicine.
2018; 46(2):299-318. doi:
10.1142/s0192415x18500155. [PMID: 29433389] - Quan Wen, Yan Lu, Zhi Chao, Dao-Feng Chen. Anticomplement triterpenoids from the roots of Ilex asprella.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):880-886. doi:
10.1016/j.bmcl.2017.01.007. [PMID: 28094185] - Yong-Ai Xiong, Ming Yang. [Effects of sanguisorba tannins and saponins compatibility on pharmacokinetic parameters of catechin, epicatechin and ziyuglycoside Ⅰ in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Oct; 41(19):3661-3667. doi:
10.4268/cjcmm20161927. [PMID: 28925165] - Guangji Wang, Hanxu Fu, Wei Ye, Xiao Zheng, Jingcheng Xiao, Dian Kang, Tai Rao, Yuhao Shao, Lin Xie, Yan Liang. Comprehensive characterization of the in vitro and in vivo metabolites of ziyuglycoside I in rat microsome, intestinal flora, excretion specimen and fresh tissues based on LC-Q-TOF/MS.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):191-200. doi:
10.1016/j.jpba.2016.05.032. [PMID: 27268222] - Wei Ye, Hanxu Fu, Lin Xie, Lijun Zhou, Tai Rao, Qian Wang, Yuhao Shao, Jingcheng Xiao, Dian Kang, Guangji Wang, Yan Liang. Development and validation of a quantification method for ziyuglycoside I and II in rat plasma: Application to their pharmacokinetic studies.
Journal of separation science.
2015 Jul; 38(13):2340-7. doi:
10.1002/jssc.201500102. [PMID: 25885584] - Young Heui Kim, Chan Bok Chung, Jin Guk Kim, Kang Il Ko, Sun Hee Park, Jong-Heon Kim, Sang Yong Eom, Young Sil Kim, Yong-Il Hwang, Ki Ho Kim. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient.
Bioscience, biotechnology, and biochemistry.
2008 Feb; 72(2):303-11. doi:
10.1271/bbb.70268. [PMID: 18256460] - Jun-bo Xie, Zhi-ming Bi, Ping Li. HPLC-ELSD determination of triterpenoids and triterpenoid saponins in Ilex pupurea leaves.
Yao xue xue bao = Acta pharmaceutica Sinica.
2003 Jul; 38(7):534-6. doi:
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