Forsythoside_B (BioDeep_00000230600)

Main id: BioDeep_00000231274

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2R,3R,4R,5R,6R)-2-((((2R,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate

化学式: C34H44O19 (756.2476674)
中文名称: 连翘酯苷 B, 连翘脂苷 B, 连翘酯甙 B, 连翘酯苷B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(CO4)(CO)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
InChI: InChI=1S/C34H44O19/c1-15-24(41)25(42)26(43)32(50-15)53-29-27(44)31(47-9-8-17-3-6-19(37)21(39)11-17)51-22(12-48-33-30(45)34(46,13-35)14-49-33)28(29)52-23(40)7-4-16-2-5-18(36)20(38)10-16/h2-7,10-11,15,22,24-33,35-39,41-46H,8-9,12-14H2,1H3/b7-4+/t15-,22+,24-,25+,26+,27+,28+,29+,30-,31+,32-,33+,34+/m0/s1

描述信息

Forsythoside B is a natural product found in Barleria lupulina, Callicarpa japonica, and other organisms with data available.
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.

同义名列表

7 个代谢物同义名

(2R,3R,4R,5R,6R)-2-((((2R,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate; [(2R,3R,4R,5R,6R)-2-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; Forsythoside B; Forsythoside-B; ForsythosideB; MEGxp0_000314; ACon1_000521



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yitong Yang, Nisha Wang, Zhenyi Wang, Miaomiao Zhao, Luping Chen, Zhaoling Shi. Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway. Chemico-biological interactions. 2024 Apr; 392(?):110953. doi: 10.1016/j.cbi.2024.110953. [PMID: 38471628]
  • Heng Zhang, Xiaoying Sun, Hang Qi, Qingxia Ma, Qiqi Zhou, Wei Wang, KeWei Wang. Pharmacological Inhibition of the Temperature-Sensitive and Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel by Natural Forsythoside B Attenuates Pruritus and Cytotoxicity of Keratinocytes. The Journal of pharmacology and experimental therapeutics. 2019 01; 368(1):21-31. doi: 10.1124/jpet.118.254045. [PMID: 30377214]
  • Jian-Xing Liu, Xiong Li, Feng-Gen Yan, Qing-Jun Pan, Chen Yang, Mao-Yong Wu, Geng Li, Hua-Feng Liu. Protective effect of forsythoside B against lipopolysaccharide-induced acute lung injury by attenuating the TLR4/NF-κB pathway. International immunopharmacology. 2019 Jan; 66(?):336-346. doi: 10.1016/j.intimp.2018.11.033. [PMID: 30521962]
  • Claudio Frezza, Alessandro Venditti, Giorgia Matrone, Ilaria Serafini, Sebastiano Foddai, Armandodoriano Bianco, Mauro Serafini. Iridoid glycosides and polyphenolic compounds from Teucrium chamaedrys L. Natural product research. 2018 Jul; 32(13):1583-1589. doi: 10.1080/14786419.2017.1392948. [PMID: 29058476]
  • Wei Zhou, Xiaobin Tan, Jinjun Shan, Ting Liu, Baochang Cai, Liuqing Di. Effect of chito-oligosaccharide on the intestinal absorptions of phenylethanoid glycosides in Fructus Forsythiae extract. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Oct; 21(12):1549-58. doi: 10.1016/j.phymed.2014.06.016. [PMID: 25442264]
  • Xiao Hu, Li Li, Yi-Fang Yang, Chun-Yue Huang, Guang-Lei Huang. [Caffeoyl phenylethanoid glycosides from Callicarpa kwangtungensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1630-4. doi: ". [PMID: 25095374]
  • Xiuman Sun, Qiongfeng Liao, Guanghui Liu, Hao Cai, Lei Zhang, Chenchen Zhu, Zhiyong Xie. Simultaneous determination of three phenylethanoid glycosides from Callicarpae Caulis et Folium in rat plasma by LC-MS/MS and its application to PK study. Bioanalysis. 2013 Aug; 5(15):1883-95. doi: 10.4155/bio.13.124. [PMID: 23905862]
  • Petya Dimitrova, Emanuela Kostadinova, Viktoriya Milanova, Kalina Alipieva, Milen Georgiev, Nina Ivanovska. Antiinflammatory properties of extracts and compounds isolated from Verbascum xanthophoeniceum Griseb. Phytotherapy research : PTR. 2012 Nov; 26(11):1681-7. doi: 10.1002/ptr.4641. [PMID: 22389249]
  • Anna Sgarbossa, Martina Dal Bosco, Giovanna Pressi, Salvatore Cuzzocrea, Roberto Dal Toso, Marta Menegazzi. Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors. Chemico-biological interactions. 2012 Aug; 199(2):87-95. doi: 10.1016/j.cbi.2012.06.006. [PMID: 22735309]
  • Wang-Lin Jiang, Yong-Xu, Shu-Ping Zhang, Hai-Bo Zhu, Jian-Hou. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytotherapy research : PTR. 2012 Jul; 26(7):981-7. doi: 10.1002/ptr.3668. [PMID: 22147417]
  • Nabila Zaabat, Anne-Emmanuelle Hay, Serge Michalet, Nicole Darbour, Christine Bayet, Inès Skandrani, Leila Chekir-Ghedira, Salah Akkal, Marie-Geneviève Dijoux-Franca. Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Dec; 49(12):3328-35. doi: 10.1016/j.fct.2011.08.026. [PMID: 21924316]