Anemoside A3 (BioDeep_00000230594)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

化学式: C41H66O12 (750.4554036000001)
中文名称: 白头翁皂苷 A, 白屈菜皂甙A, 白头翁皂苷A, 白头翁皂苷A3
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(OC6OCC(O)C(O)C6OC6OC(C)C(O)C(O)C6O)C(C)(CO)C5CCC43C)C12
InChI: InChI=1S/C41H66O12/c1-20(2)22-10-15-41(36(48)49)17-16-39(6)23(28(22)41)8-9-26-37(4)13-12-27(38(5,19-42)25(37)11-14-40(26,39)7)52-35-33(30(45)24(43)18-50-35)53-34-32(47)31(46)29(44)21(3)51-34/h21-35,42-47H,1,8-19H2,2-7H3,(H,48,49)/t21-,22-,23+,24-,25+,26+,27-,28+,29-,30-,31+,32+,33+,34-,35-,37-,38-,39+,40+,41-/m0/s1

描述信息

AA3 is a natural Pulsatilla saponin A that can improve synaptic plasticity in the hippocampus of adult mice and spatial memory in adult mice. It is also a non-competitive regulator of NMDA receptors.
AA3 is a natural Pulsatilla saponin A that can improve synaptic plasticity in the hippocampus of adult mice and spatial memory in adult mice. It is also a non-competitive regulator of NMDA receptors.
AA3 is a natural Pulsatilla saponin A that can improve synaptic plasticity in the hippocampus of adult mice and spatial memory in adult mice. It is also a non-competitive regulator of NMDA receptors.

同义名列表

9 个代谢物同义名

(1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; (1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid; (3beta,4alpha)-3-[[2-O-(6-Deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy]-23-hydroxylup-20(29)-en-28-oic acid; Anemoside A3 Pulchinenoside A3; ISNDTNDJSXYNKT-DVIRKNLQSA-N; Pulchinenoside A3; Pulchinenoside A; Anemoside A3; Pulchinenoside



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Yin, Zeping Fan, Peng Liu, Lanying Chen, Ziyi Guan, Yahui Liu, Yingying Luo. Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis. Toxicology and applied pharmacology. 2021 12; 432(?):115755. doi: 10.1016/j.taap.2021.115755. [PMID: 34673087]
  • Xiaozhen Guo, Yang Xie, Shan Lian, Zhixiong Li, Yu Gao, Zhou Xu, Pei Hu, Mingcang Chen, Zhaolin Sun, Xiaoting Tian, Chenggang Huang. A sensitive HPLC-MS/MS method for the simultaneous determination of anemoside B4, anemoside A3 and 23-hydroxybetulinic acid: Application to the pharmacokinetics and liver distribution of Pulsatilla chinensis saponins. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4124. [PMID: 29078255]
  • Fanny C F Ip, Yu Pong Ng, Terry C T Or, Peiran Sun, Guangmiao Fu, Jessica Y H Li, Wen-Cai Ye, Tom H Cheung, Nancy Y Ip. Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response. PloS one. 2017; 12(7):e0182069. doi: 10.1371/journal.pone.0182069. [PMID: 28759648]
  • Fanny C F Ip, Wing-Yu Fu, Elaine Y L Cheng, Estella P S Tong, Ka-Chun Lok, Yan Liang, Wen-Cai Ye, Nancy Y Ip. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Jul; 40(8):1877-87. doi: 10.1038/npp.2015.37. [PMID: 25649278]
  • Dong-Mei Zhang, Shun-Ming Lin, Chi-Wai Lau, Anita Yiu, Jiao Wang, Yong Li, Chun-Lin Fan, Yu Huang, Wen-Cai Ye. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta medica. 2010 Nov; 76(16):1814-9. doi: 10.1055/s-0030-1250003. [PMID: 20506075]
  • Xiang-Dong Gao, Wen-Cai Ye, Albert C H Yu, Yun Zhang, Ren-Xiang Tan, Ming Li, W L Wendy Hsiao. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta medica. 2003 Feb; 69(2):171-4. doi: 10.1055/s-2003-37705. [PMID: 12624827]
  • Y Mimaki, A Yokosuka, M Kuroda, M Hamanaka, C Sakuma, Y Sashida. New bisdesmosidic triterpene saponins from the roots of Pulsatilla chinensis. Journal of natural products. 2001 Sep; 64(9):1226-9. doi: 10.1021/np010252t. [PMID: 11575962]