Pinoresinoldiglucoside (BioDeep_00000230561)

 

Secondary id: BioDeep_00000230933, BioDeep_00000402995, BioDeep_00000869411

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[4-[(3S,3aR,6S,6aR)-6-[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C32H42O16 (682.2472732)
中文名称: 松脂醇二葡萄糖苷, 松酯醇二葡萄糖苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(C=C1[C@@H]2[C@](CO[C@@H]3C4=CC(OC)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)C=C4)([H])[C@]3([H])CO2)=C(C=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO
InChI: InChI=1S/C32H42O16/c1-41-19-7-13(3-5-17(19)45-31-27(39)25(37)23(35)21(9-33)47-31)29-15-11-44-30(16(15)12-43-29)14-4-6-18(20(8-14)42-2)46-32-28(40)26(38)24(36)22(10-34)48-32/h3-8,15-16,21-40H,9-12H2,1-2H3/t15-,16-,21+,22+,23+,24+,25-,26-,27+,28+,29+,30+,31+,32+/m0/s1

描述信息

Pinoresinol diglucoside is a natural product found in Forsythia suspensa, Selaginella sinensis, and other organisms with data available.
Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.
Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.

同义名列表

9 个代谢物同义名

(2S,3R,4S,5S,6R)-2-[4-[(3S,3aR,6S,6aR)-6-[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,2R,3S,3S,4S,4S,5R,5R,6S,6S)-6,6-((((1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxy-4,1-phenylene))bis(oxy))bis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol); beta-D-Glucopyranoside, (tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis(2-methoxy-4,1-phenylene) bis-, (1S-(1alpha,3aalpha,4alpha,6aalpha))-; Pinoresinol diglucoside, >=98\\% (HPLC); Pinoresinol diglucopyranoside; ZJSJQWDXAYNLNS-FUPWJLLWSA-N; Pinoresinol-diglucoside; Pinoresinol diglucoside; Pinoresinoldiglucoside



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chunbo Dong, Qiuyu Shao, Qingsong Ran, Xu Li, Yanfeng Han. Interactions of rhizosphere microbiota-environmental factors-pharmacological active ingredients of Eucommia ulmoides. Planta. 2024 Feb; 259(3):59. doi: 10.1007/s00425-024-04338-w. [PMID: 38311641]
  • Imtiaz Ahmad, Saeed Ahmad, Esra Küpeli Akkol, Huma Rao, Muhammad Nadeem Shahzad, Mehwish Nawaz, Bilal Ahmad Ghalloo, Wayne Thomas Shier, Eduardo Sobarzo-Sánchez. Neuroprotection against Aluminum Chloride-Induced Hippocampus Damage in Albino Wistar Rats by Leucophyllum frutescens (Berl.) I.M. Johnst. Leaf Extracts: A Detailed Insight into Phytochemical Analysis and Antioxidant and Enzyme Inhibition Assays. Frontiers in bioscience (Landmark edition). 2023 08; 28(8):184. doi: 10.31083/j.fbl2808184. [PMID: 37664939]
  • Shuangyuan Lei, Suli Wu, Guanzhuo Wang, Bing Li, Bin Liu, Xia Lei. Pinoresinol diglucoside attenuates neuroinflammation, apoptosis and oxidative stress in a mice model with Alzheimer's disease. Neuroreport. 2021 02; 32(3):259-267. doi: 10.1097/wnr.0000000000001583. [PMID: 33470758]
  • Yazhen Chen, Hetong Lin, Mengshi Lin, Yongzhan Zheng, Jicheng Chen. Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 May; 139(?):111239. doi: 10.1016/j.fct.2020.111239. [PMID: 32145351]
  • Dong Wu, Danmeng Yu, Yujia Zhang, Juane Dong, Dengwu Li, Dongmei Wang. Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081898. [PMID: 30061494]
  • Yanqing Song, Huiyu Yan, Zhihui Sun, Shiyong Teng, Lirui Sun, Sixi Zhang. Development and validation of a LC-MS/MS method for determination of pinoresinol diglucoside in rat plasma: Application to pharmacokinetic study. Pakistan journal of pharmaceutical sciences. 2015 Nov; 28(6):2083-9. doi: NULL. [PMID: 26639501]
  • Yan Zhang, Junling Shi, Zhenhong Gao, Ruiming Yangwu, Huanshi Jiang, Jinxin Che, Yanlin Liu. Production of pinoresinol diglucoside, pinoresinol monoglucoside, and pinoresinol by Phomopsis sp. XP-8 using mung bean and its major components. Applied microbiology and biotechnology. 2015 Jun; 99(11):4629-43. doi: 10.1007/s00253-015-6491-7. [PMID: 25805340]
  • Yan Zhang, Junling Shi, Laping Liu, Zhenhong Gao, Jinxin Che, Dongyan Shao, Yanlin Liu. Bioconversion of Pinoresinol Diglucoside and Pinoresinol from Substrates in the Phenylpropanoid Pathway by Resting Cells of Phomopsis sp.XP-8. PloS one. 2015; 10(9):e0137066. doi: 10.1371/journal.pone.0137066. [PMID: 26331720]
  • Yu-Xing Huang, Er-Wei Liu, Lei Wang, Yan Huo, Qiang Wang, Olajide Olaleye, Tao Wang, Xiu-Mei Gao. LC/MS/MS determination and pharmacokinetic studies of six compounds in rat plasma following oral administration of the single and combined extracts of Eucommia ulmoides and Dipsacus asperoides. Chinese journal of natural medicines. 2014 Jun; 12(6):469-76. doi: 10.1016/s1875-5364(14)60073-x. [PMID: 24969529]
  • Chuan-Zhi Kang, Qing-Qing Wang, Tao Zhou, Wei-Ke Jiang, Cheng-Hong Xiao, Yu Xie. [Study on ecological suitability regionalization of Eucommia ulmoides in Guizhou]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 May; 37(5):760-6. doi: ". [PMID: 25335280]
  • Junling Shi, Chao Liu, Laping Liu, Baowei Yang, Yinzhi Zhang. Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv. Applied microbiology and biotechnology. 2012 Feb; 93(4):1475-83. doi: 10.1007/s00253-011-3613-8. [PMID: 22048615]
  • Wei Li, Suqin Sun, Jieping Qin, Yanhong Yi, Meihua Yang. [Quantitative determination of pinoresinol diglucoside in Eucommiae unloads by NIRS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(24):3318-21. doi: 10.4268/cjcmm20102420. [PMID: 21438399]
  • Zijia Zhang, Jie Chen, Junming Zhao, Liping Liao, Qinglong Sun, Tao Wu, Zhengtao Wang. [Determination of pinoresinol diglucoside in Qing' e Pills by ultra performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2010 Aug; 28(8):805-8. doi: 10.3724/sp.j.1123.2010.00805. [PMID: 21261052]
  • Jing-Zheng Song, Lok Man Cheung, Xin Liu, Chun-Feng Qiao, Yan Zhou, Song-Lin Li, Shi-Lin Chen, Hong-Xi Xu. Development and validation of an ultra high-performance liquid chromatographic method for the determination of a diastereomeric impurity in (+)-pinoresinol diglucoside chemical reference substance. Journal of separation science. 2010 Jul; 33(13):1909-15. doi: 10.1002/jssc.201000053. [PMID: 20533340]
  • Zhi-Yang Lv, Liu-Qing Di, Xiao-Li Zhao, Bao-Chang Cai, Hui-Zhen Jin. [Study on the quality standards of decoction pieces of salt Eucommia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Jan; 33(1):30-3. doi: ". [PMID: 20518299]
  • Liu-Qing Di, Sheng-Jin Liu, Xiao-Li Zhao, Xiao-Lin Bi, Jin-Jun Shan, Yan-Cao Mao, Rong Ma, Yan Song. [Research on the quality changes in pre- and post-processed pieces of Eucommia ulmoides]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 May; 30(5):525-9. doi: ". [PMID: 17727054]
  • Suo-Min Feng, Zhi-Jie Gan, Xi-Feng Zhai, Peng-Fei Fu, Wen-Ji Sun. [Content comparison of pinoresinol diglucoside in original and reborn bark of Eucommia ulmoides]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2006 Aug; 29(8):792-4. doi: ". [PMID: 17076238]
  • Li-Hua Xie, Teruaki Akao, Kenjiro Hamasaki, Takeshi Deyama, Masao Hattori. Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of Enterococcus faecalis strain PDG-1 responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol. Chemical & pharmaceutical bulletin. 2003 May; 51(5):508-15. doi: 10.1248/cpb.51.508. [PMID: 12736449]
  • Britta Schumacher, Silke Scholle, Josef Hölzl, Nasser Khudeir, Sonja Hess, Christa E Müller. Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. Journal of natural products. 2002 Oct; 65(10):1479-85. doi: 10.1021/np010464q. [PMID: 12398547]
  • T Konishi, S Wada, S Kiyosawa. [Constituents of the leaves of Daphne pseudo-mezereum]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1993 Sep; 113(9):670-5. doi: 10.1248/yakushi1947.113.9_670. [PMID: 8229666]
  • Z F Sha, W J Sun. [High performance liquid chromatography of pinoresinol diglucoside in Eucommaia ulmoides oliv bark]. Yao xue xue bao = Acta pharmaceutica Sinica. 1986 Sep; 21(9):708-11. doi: ". [PMID: 3577795]
  • C J Sih, P R Ravikumar, F C Huang, C Buckner, H Whitlock. Letter: Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung(Eucommia ulmoides, Oliver). Journal of the American Chemical Society. 1976 Aug; 98(17):5412-3. doi: 10.1021/ja00433a070. [PMID: 956566]