IlexsaponinA (BioDeep_00000230545)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C36H56O11 (664.3822426)
中文名称: 毛冬青皂苷A, 毛冬青皂苷甲, 冬青皂苷甲
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 50%
分子结构信息
SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C(=O)O)O)C)C)C2C1(C)O)C)C(=O)OC6C(C(C(C(O6)CO)O)O)O
InChI: InChI=1S/C36H56O11/c1-18-9-14-36(30(44)47-28-26(41)25(40)24(39)20(17-37)46-28)16-15-32(3)19(27(36)35(18,6)45)7-8-21-31(2)12-11-23(38)34(5,29(42)43)22(31)10-13-33(21,32)4/h7,18,20-28,37-41,45H,8-17H2,1-6H3,(H,42,43)/t18-,20-,21-,22-,23+,24-,25+,26-,27-,28+,31-,32-,33-,34-,35-,36+/m1/s1
描述信息
Ilexsaponin A1 is a natural product found in Ilex pubescens and Mussaenda pubescens with data available.
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1].
同义名列表
6 个代谢物同义名
(3S,4R,4aR,6aR,6bS,8aS,11R,12R,12aS,14aR,14bR)-3,12-dihydroxy-4,6a,6b,11,12,14b-hexamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,11,12a,14,14a-tetradecahydropicene-4-carboxylic acid; Ilexsaponin A1, >=95\\% (LC/MS-ELSD); Ilexsaponin A1; Ilexsaponin A; IlexsaponinA; IlexsaponinA1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenwen Zhao, Meng Xiao, Jie Yang, Li Zhang, Yinying Ba, Rongrong Xu, Zongyang Liu, Haiyan Zou, Ping Yu, Xia Wu, Xiaoqing Chen. The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Oct; 63(?):153039. doi:
10.1016/j.phymed.2019.153039. [PMID: 31387054] - Jingjing Li, Jinming Zhang, Liang Zou, Simon Ming-Yuen Lee, Cui Yang, Sai-Wang Seto, George Pak-Heng Leung. Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Dec; 36(?):229-237. doi:
10.1016/j.phymed.2017.10.006. [PMID: 29157819] - Guojun Kuang, Huan Yi, Mingjuan Zhu, Jie Zhou, Xueying Shang, Zhongxiang Zhao, Chenchen Zhu, Qiongfeng Liao, Shixia Guan, Lei Zhang. Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC).
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111867. [PMID: 29104273] - Shuang-Wei Zhang, Yu Liu, Fang Wang, Jiao Qiang, Pan Liu, Jun Zhang, Jin-Wen Xu. Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
PloS one.
2017; 12(2):e0170984. doi:
10.1371/journal.pone.0170984. [PMID: 28182689] - Bo Peng, Wei-Hua Huang, Jing Zhao, Hua-Gang Liu. [Chemical constituents from Ilex hainanensis].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 Aug; 35(8):1251-4. doi:
". [PMID: 23320356] - D Wen, X Zheng, K Inoue. [Studies on chemical constituents of Ilex Merr].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
1999 Apr; 24(4):223-5, 255. doi:
". [PMID: 12205946]