Ginsenoside Rk3 (BioDeep_00000230501)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C36H60O8 (620.4288)
中文名称: 人参皂甙 Rk3, 人参皂苷Rk3, 人参皂苷 RK3
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 69.28%

分子结构信息

SMILES: CC(=CCCC(=C)C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)C
InChI: InChI=1S/C36H60O8/c1-19(2)10-9-11-20(3)21-12-15-35(7)27(21)22(38)16-25-34(6)14-13-26(39)33(4,5)31(34)23(17-36(25,35)8)43-32-30(42)29(41)28(40)24(18-37)44-32/h10,21-32,37-42H,3,9,11-18H2,1-2,4-8H3/t21-,22-,23+,24-,25-,26+,27+,28-,29+,30-,31+,32-,34-,35-,36-/m1/s1

描述信息

Ginsenoside Rk3 is a natural product found in Panax ginseng and Panax notoginseng with data available.
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.

同义名列表

4 个代谢物同义名

(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; 3beta,12beta-dihydroxydammar-20(21),24-diene-3-O-beta-D-glucopyranosyl(1-2)-beta-D-glucopyranoside; Ginsenoside Rk3; Ginsenoside Rk3 standard



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Weimin Wang, Hongwei Chen, Wenyuan Zhang, Daidi Fan, Jianjun Deng, Haixia Yang. Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Modulating Lipid Metabolism in C57BL/6 Mice. Journal of agricultural and food chemistry. 2024 Feb; ?(?):. doi: 10.1021/acs.jafc.3c08253. [PMID: 38300824]
  • Mengdi Guo, Chenhui Zhu, Rongzhan Fu, Xiaoxuan Ma, Zhiguang Duan, Daidi Fan. Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice. Journal of agricultural and food chemistry. 2023 Jun; 71(24):9370-9380. doi: 10.1021/acs.jafc.3c00789. [PMID: 37288986]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • Yao Liu, Jianjun Deng, Daidi Fan. Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway. Food & function. 2019 May; 10(5):2538-2551. doi: 10.1039/c9fo00095j. [PMID: 30993294]
  • Xiu-Wei Yang, Li-Yuan Ma, Qi-Le Zhou, Wei Xu, You-Bo Zhang. SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng. Bioorganic & medicinal chemistry letters. 2018 02; 28(3):240-243. doi: 10.1016/j.bmcl.2017.12.067. [PMID: 29317167]
  • Ang Ying, Qing-Tao Yu, Li Guo, Wen-Song Zhang, Jin-Feng Liu, Yun Li, Hong Song, Ping Li, Lian-Wen Qi, Ya-Zhong Ge, E-Hu Liu, Qun Liu. Structural-Activity Relationship of Ginsenosides from Steamed Ginseng in the Treatment of Erectile Dysfunction. The American journal of Chinese medicine. 2018; 46(1):137-155. doi: 10.1142/s0192415x18500088. [PMID: 29298510]
  • Bin Chen, Yingjie Wei, Dandan Wang, Xiaobin Jia. Metabolism of ginsenosides Rk₃ and Rh₄ from steamed notoginseng in zebrafish by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Archives of pharmacal research. 2015 Aug; 38(8):1468-76. doi: 10.1007/s12272-014-0538-7. [PMID: 25547981]
  • Dhavalkumar Narendrabhai Patel, Hai-Shu Lin, Hwee-Ling Koh. Quantification of ginsenosides Rh4 and Rk3 in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pre-clinical pharmacokinetic study. Journal of mass spectrometry : JMS. 2012 Nov; 47(11):1510-7. doi: 10.1002/jms.3095. [PMID: 23147830]
  • Jin Gyun Lee, Seung Hoon Baek, Yong Yook Lee, Seo Young Park, Jeong Hill Park. Anti-complementary ginsenosides isolated from processed ginseng. Biological & pharmaceutical bulletin. 2011; 34(6):898-900. doi: 10.1248/bpb.34.898. [PMID: 21628891]
  • Il Ho Park, Na Young Kim, Sang Beom Han, Jong Moon Kim, Sung Won Kwon, Hyun Jung Kim, Man Ki Park, Jeong Hill Park. Three new dammarane glycosides from heat processed ginseng. Archives of pharmacal research. 2002 Aug; 25(4):428-32. doi: 10.1007/bf02976595. [PMID: 12214849]