ZiyuglycosideII (BioDeep_00000230478)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,4aS,6bR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid

化学式: C35H56O8 (604.3974976000001)
中文名称: 地榆皂苷II, 地榆皂苷Ⅱ
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 66.67%

分子结构信息

SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(CO6)O)O)O)C)C)C2C1(C)O)C)C(=O)O
InChI: InChI=1S/C35H56O8/c1-19-10-15-35(29(39)40)17-16-32(5)20(27(35)34(19,7)41)8-9-23-31(4)13-12-24(30(2,3)22(31)11-14-33(23,32)6)43-28-26(38)25(37)21(36)18-42-28/h8,19,21-28,36-38,41H,9-18H2,1-7H3,(H,39,40)/t19-,21+,22+,23-,24+,25+,26-,27-,28+,31+,32-,33-,34-,35+/m1/s1

描述信息

ziyuglycoside II is a natural product found in Sanguisorba officinalis with data available.
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1].

同义名列表

12 个代谢物同义名

(1R,4aS,6bR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid; (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; 3.BETA.,19.ALPHA.-DIHYDROXYURS-12-EN-28-OIC ACID 3-O-.ALPHA.-L-ARABINOPYRANOSIDE; URS-12-EN-28-OIC ACID, 3-(.ALPHA.-L-ARABINOPYRANOSYLOXY)-19-HYDROXY-, (3.BETA.)-; 3.BETA.-O-.ALPHA.-L-ARABINOPYRANOSYL-19.ALPHA.-HYDROXYURS-12-EN-28-OIC ACID; POMOLIC ACID 3-O-.ALPHA.-L-ARABINOPYRANOSIDE; 3-O-.ALPHA.-L-ARABINOPYRANOSYLPOMOLIC ACID; ZIGU-GLUCOSIDE II; Ziyuglycoside II; ZiyuglycosideII; Gouguside 1; 8AXK3E8B87



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry. 2021 Jan; 209(?):112932. doi: 10.1016/j.ejmech.2020.112932. [PMID: 33131725]
  • Haihong Fang, Xinxu Xie, Peng Liu, Ying Rao, Yaru Cui, Shilin Yang, Jun Yu, Yingying Luo, Yulin Feng. Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110862. doi: 10.1016/j.biopha.2020.110862. [PMID: 33069969]
  • Xiaolan Chen, Li Liu, Wei Chen, Feng Qin, Fang Zhou, Haifeng Yang. Ziyuglycoside II Inhibits Rotavirus Induced Diarrhea Possibly via TLR4/NF-κB Pathways. Biological & pharmaceutical bulletin. 2020; 43(6):932-937. doi: 10.1248/bpb.b19-00771. [PMID: 32475915]
  • Zhi-Feng Li, Meng-Ying Zhou, Ting Tan, Chen-Cong Zhong, Qi Wang, Ling-Ling Pan, Ying-Ying Luo, Shi-Lin Yang, Yu-Lin Feng, Hui Ouyang. A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics. Molecules (Basel, Switzerland). 2018 Feb; 23(3):. doi: 10.3390/molecules23030543. [PMID: 29495641]
  • Eungyeong Jang, Kyung-Soo Inn, Young Pyo Jang, Kyung-Tae Lee, Jang-Hoon Lee. Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review. The American journal of Chinese medicine. 2018; 46(2):299-318. doi: 10.1142/s0192415x18500155. [PMID: 29433389]
  • Quan Wen, Yan Lu, Zhi Chao, Dao-Feng Chen. Anticomplement triterpenoids from the roots of Ilex asprella. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):880-886. doi: 10.1016/j.bmcl.2017.01.007. [PMID: 28094185]
  • Jingcheng Xiao, Huimin Chen, Hanxu Fu, Wei Ye, Tai Rao, Yuhao Shao, Dian Kang, Boyu Shen, Lin Xie, Guangji Wang, Yan Liang. Development of a novel sectional multiple filtering scheme for rapid screening and classifying metabolites of ziyuglycoside II in rat liver and excreta specimen based on high-resolution mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):310-319. doi: 10.1016/j.jpba.2016.06.053. [PMID: 27454082]
  • Guangji Wang, Hanxu Fu, Wei Ye, Xiao Zheng, Jingcheng Xiao, Dian Kang, Tai Rao, Yuhao Shao, Lin Xie, Yan Liang. Comprehensive characterization of the in vitro and in vivo metabolites of ziyuglycoside I in rat microsome, intestinal flora, excretion specimen and fresh tissues based on LC-Q-TOF/MS. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 128(?):191-200. doi: 10.1016/j.jpba.2016.05.032. [PMID: 27268222]
  • Dong Ju Son, Seock Yeon Hwang, Myung-Hyun Kim, Un Kyu Park, Byoung Soo Kim. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice. Nutrients. 2015 Jul; 7(7):5469-83. doi: 10.3390/nu7075232. [PMID: 26198246]
  • Wei Ye, Hanxu Fu, Lin Xie, Lijun Zhou, Tai Rao, Qian Wang, Yuhao Shao, Jingcheng Xiao, Dian Kang, Guangji Wang, Yan Liang. Development and validation of a quantification method for ziyuglycoside I and II in rat plasma: Application to their pharmacokinetic studies. Journal of separation science. 2015 Jul; 38(13):2340-7. doi: 10.1002/jssc.201500102. [PMID: 25885584]