Gymnemagenin (BioDeep_00000230366)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3R,4R,4aR,5S,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-3,4,5,10-tetrol

化学式: C30H50O6 (506.3607)
中文名称: 裸子体素, 匙羹藤新苷元
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 95.58%

分子结构信息

SMILES: CC1(C)C[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]4(C)[C@]3(C)C[C@H](O)[C@@]2(CO)[C@@H](O)[C@@H]1O
InChI: InChI=1S/C30H50O6/c1-25(2)13-18-17-7-8-20-26(3)11-10-21(33)27(4,15-31)19(26)9-12-28(20,5)29(17,6)14-22(34)30(18,16-32)24(36)23(25)35/h7,18-24,31-36H,8-16H2,1-6H3/t18-,19+,20+,21-,22-,23-,24-,26-,27-,28+,29+,30-/m0/s1

描述信息

Gymnemagenin is a natural product found in Gymnema sylvestre with data available.
See also: Gymnema sylvestre leaf (part of).
Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties[1][2].
Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties[1][2].

同义名列表

15 个代谢物同义名

(3R,4R,4aR,5S,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-4a,9-bis(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-3,4,5,10-tetrol; Olean-12-ene-3,16,21,22,23,28-hexol, (3.beta.,4.alpha.,16.beta.,21.beta.,22.alpha.)-; OLEAN-12-ENE-3,16,21,22,23,28-HEXOL, (3beta,4alpha,16beta,21beta,22alpha)-; Olean-12-ene-3,16,21,22,23,28-hexol, (3beta,16beta,21beta,22alpha)-; Gymnemagenin, United States Pharmacopeia (USP) Reference Standard; OLEAN-12-ENE-3.BETA.,16.BETA.,21.BETA.,22.ALPHA.,23,28-HEXO; Olean-12-ene-3beta,16beta,21beta,22alpha,23,28-hexol; OLEAN-12-ENE-3beta,16beta,21beta,22alpha,23,28-HEXO; GYMNEMAGENIN (CONSTITUENT OF GYMNEMA) [DSC]; GYMNEMAGENIN (CONSTITUENT OF GYMNEMA); Gymnemagenin, analytical standard; GYMNEMAGENIN (USP-RS); GYMNEMAGENIN [USP-RS]; Gymnemagenin; Olean-12-ene-3,16,21,22,23,28-hexol,(3b,4a,16b,21b,22a)-



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Raghavendra Ramalingam, Chetna Dhand, Chak Ming Leung, Seow Theng Ong, Sathesh Kumar Annamalai, Mohammed Kamruddin, Navin Kumar Verma, Seeram Ramakrishna, Rajamani Lakshminarayanan, Kantha Deivi Arunachalam. Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract. Materials science & engineering. C, Materials for biological applications. 2019 May; 98(?):503-514. doi: 10.1016/j.msec.2018.12.135. [PMID: 30813052]
  • Pamela Sinha, Kantha D Arunachalam, Sathesh Kumar Annamalai. Radio-protective dosimetry of Pangasius sutchi as a biomarker, against gamma radiation dosages perceived by genotoxic assays. Ecotoxicology and environmental safety. 2018 Nov; 164(?):629-640. doi: 10.1016/j.ecoenv.2018.08.071. [PMID: 30165340]
  • Rammohan Bera, Amit Kundu, Tuhinadri Sen, Dipan Adhikari, Sanmoy Karmakar. In Vitro Metabolic Stability and Permeability of Gymnemagenin and Its In Vivo Pharmacokinetic Correlation in Rats - A Pilot Study. Planta medica. 2016 Apr; 82(6):544-50. doi: 10.1055/s-0042-101032. [PMID: 26916641]
  • Bhagyashree Kamble, Ankur Gupta, Ismail Moothedath, Laxman Khatal, Shirish Janrao, Amol Jadhav, B Duraiswamy. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chemico-biological interactions. 2016 Feb; 245(?):30-8. doi: 10.1016/j.cbi.2015.12.008. [PMID: 26721197]
  • Sunita Sheoran, Bibhu Prasad Panda, Prasad S Admane, Amulya Kumar Panda, Saima Wajid. Ultrasound-assisted extraction of gymnemic acids from Gymnema sylvestre leaves and its effect on insulin-producing RINm-5 F β cell lines. Phytochemical analysis : PCA. 2015 Mar; 26(2):97-104. doi: 10.1002/pca.2540. [PMID: 25469471]
  • Ramalingam Parthasarathy, Muthukrishnan Sathiyabama. Gymnemagenin-producing endophytic fungus isolated from a medicinal plant Gymnema sylvestre R.Br. Applied biochemistry and biotechnology. 2014 Mar; 172(6):3141-52. doi: 10.1007/s12010-014-0754-0. [PMID: 24497046]
  • Bhagyashree Kamble, Ankur Gupta, Dada Patil, Laxman Khatal, Shirish Janrao, Ismail Moothedath, Basavan Duraiswamy. Determination of gymnemagenin in rat plasma using high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics after oral administration of Gymnema sylvestre extract. Biomedical chromatography : BMC. 2013 May; 27(5):669-75. doi: 10.1002/bmc.2845. [PMID: 23225496]
  • Bhagyashree Kamble, Ankur Gupta, Dada Patil, Shirish Janrao, Laxman Khatal, B Duraiswamy. Quantitative estimation of gymnemagenin in Gymnema sylvestre extract and its marketed formulations using the HPLC-ESI-MS/MS method. Phytochemical analysis : PCA. 2013 Feb; 24(2):135-40. doi: 10.1002/pca.2392. [PMID: 22987643]
  • P V Kanetkar, R S Singhal, K S Laddha, M Y Kamat. Extraction and quantification of gymnemic acids through gymnemagenin from callus cultures of Gymnema sylvestre. Phytochemical analysis : PCA. 2006 Nov; 17(6):409-13. doi: 10.1002/pca.939. [PMID: 17144249]