Caudatin (BioDeep_00000230342)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C28H42O7 (490.2930382)
中文名称: 告达亭苷元, 告达庭, 告达亭
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 20%
分子结构信息
SMILES: CC(=O)C1(O)CCC2(O)C3(O)CC=C4CC(O)CCC4(C)C3CC(OC(=O)C=C(C)C(C)C)C12C
InChI: InChI=1S/C28H42O7/c1-16(2)17(3)13-23(31)35-22-15-21-24(5)9-8-20(30)14-19(24)7-10-27(21,33)28(34)12-11-26(32,18(4)29)25(22,28)6/h7,13,16,20-22,30,32-34H,8-12,14-15H2,1-6H3/b17-13+/t20-,21+,22+,24-,25+,26+,27-,28+/m0/s1
描述信息
Caudatin is a natural product found in Araujia sericifera with data available.
同义名列表
4 个代谢物同义名
[(3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-1,2,3,4,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-12-yl] (E)-3,4-dimethylpent-2-enoate; 12beta-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-3beta,8beta,14beta,17alpha-tetrahydroxy-pregn-5-en-20-one; ST 28:4;O7; Caudatin
数据库引用编号
11 个数据库交叉引用编号
- PubChem: 21633059
- PubChem: 73816098
- PubChem: 72948694
- LipidMAPS: LMST02030262
- MeSH: caudatin
- KNApSAcK: C00031659
- chemspider: 10264325
- CAS: 38395-02-7
- medchemexpress: HY-N1983
- PMhub: MS000077731
- RefMet: ST 28:4;O7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 33090 - 青阳参: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fan Xia, Suling Sun, Shuyang Li, Wei Jiang, Li Xia, Hongzhi Wang, Xueran Chen. Chinese herb related molecules Catechins, Caudatin and Cucurbitacin-I inhibit the proliferation of glioblastoma by activating KDELR2-mediated endoplasmic reticulum stress.
Biochemical and biophysical research communications.
2023 Oct; 687(?):149196. doi:
10.1016/j.bbrc.2023.149196. [PMID: 37939504] - Xiao-San Li, Tang-Ji Chen, Zhi-Peng Xu, Juan Long, Miao-Ying He, He-Hui Zhan, Hai-Cai Zhuang, Qi-Lin Wang, Li Liu, Xue-Mei Yang, Jin-Shan Tang. Synthesis and biological evaluation of 3β-O-neoglycosides of caudatin and its analogues as potential anticancer agents.
Bioorganic & medicinal chemistry.
2022 01; 54(?):116581. doi:
10.1016/j.bmc.2021.116581. [PMID: 34968813] - Shuai Qiu, Jae Seok Cho, Jin Tae Kim, Ji Hyun Moon, Yimeng Zhou, Seung Beom Lee, Ho Jin Park, Hong Jin Lee. Caudatin suppresses adipogenesis in 3T3-L1 adipocytes and reduces body weight gain in high-fat diet-fed mice through activation of hedgehog signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Nov; 92(?):153715. doi:
10.1016/j.phymed.2021.153715. [PMID: 34474353] - Christian Bailly. Anticancer properties of caudatin and related C-21 steroidal glycosides from Cynanchum plants.
Steroids.
2021 08; 172(?):108855. doi:
10.1016/j.steroids.2021.108855. [PMID: 33945800] - Jie Song, Wenbo Ding, Bojia Liu, Dan Liu, Zhi Xia, Li Zhang, Li Cui, Yi Luo, Xiaobin Jia, Liang Feng. Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Molecular medicine reports.
2020 08; 22(2):697-706. doi:
10.3892/mmr.2020.11135. [PMID: 32626931] - Yunru Peng, Yongfang Ding. Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats.
Molecules (Basel, Switzerland).
2015 Mar; 20(3):4225-37. doi:
10.3390/molecules20034225. [PMID: 25751784] - Qiqi Zhu, Yuanyuan Hu, Yuanyuan Shan, Yiyan Wang, Xiaolong Wu, Baiping Mao, Ren-Shan Ge. Determination of Caudatin in Rat Plasma by UPLC-MS/MS: Application to a Preclinical Pharmacokinetic Study.
Pharmacology.
2015; 96(1-2):49-54. doi:
10.1159/000381784. [PMID: 26088709] - Li-Jun Wang, Hao Chen, Yun-Bao Ma, Xiao-Yan Huang, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen. Design, synthesis and biological evaluation of caudatin analogs as potent hepatitis B virus inhibitors.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2015; 11(2):165-79. doi:
10.2174/1573406410666140902111326. [PMID: 25181984] - Li-Jun Wang, Chang-An Geng, Yun-Bao Ma, Jie Luo, Xiao-Yan Huang, Hao Chen, Ning-Jia Zhou, Xue-Mei Zhang, Ji-Jun Chen. Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents.
European journal of medicinal chemistry.
2012 Aug; 54(?):352-65. doi:
10.1016/j.ejmech.2012.05.012. [PMID: 22687441] - Li-Jun Wang, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Hao Chen, Rui-Hua Guo, Xue-Mei Zhang, Ji-Jun Chen. Synthesis, structure-activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents.
Bioorganic & medicinal chemistry.
2012 May; 20(9):2877-88. doi:
10.1016/j.bmc.2012.03.023. [PMID: 22472044] - Hong Rong Fei, Hong Lei Chen, Ting Xiao, Geng Chen, Feng Ze Wang. Caudatin induces cell cycle arrest and caspase-dependent apoptosis in HepG2 cell.
Molecular biology reports.
2012 Jan; 39(1):131-8. doi:
10.1007/s11033-011-0721-6. [PMID: 21553057] - Yun-ru Peng, You-bin Li, Xiao-dong Liu, Jian-feng Zhang, Jin-ao Duan. Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2008 Nov; 15(11):1016-20. doi:
10.1016/j.phymed.2008.02.021. [PMID: 18539445]