Mogrol (BioDeep_00000230318)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-diol

化学式: C30H52O4 (476.3865392)
中文名称: 罗汉果醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(C(C)(C)O)O)C1CCC2(C1(CC(C3(C2CC=C4C3CCC(C4(C)C)O)C)O)C)C
InChI: InChI=1S/C30H52O4/c1-18(9-13-24(32)27(4,5)34)19-15-16-28(6)22-12-10-20-21(11-14-23(31)26(20,2)3)30(22,8)25(33)17-29(19,28)7/h10,18-19,21-25,31-34H,9,11-17H2,1-8H3/t18-,19-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1

描述信息

Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.
Mogrol is a natural product found in Siraitia grosvenorii with data available.
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

同义名列表

11 个代谢物同义名

(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-diol; (3S,8S,9R,10R,11R,13R,14S,17R)-17-((2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl)-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta(a)henanthrene-3,11-diol; (1S,4R,9beta,11alpha,24R)-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-1,11,24,25-tetrol; (10alpha,24R)-9beta-Methyl-19-norlanosta-5-ene-3beta,11alpha,24,25-tetrol; (24R)-cucurbit-5-ene-3beta,11alpha,24,25-tetraol; (23R)-cucurbit-5-ene-3beta,11alpha,23,25-tetraol; JLYBBRAAICDTIS-AYEHCKLZSA-N; Mogrol; 11-oxomogroside \u2164_qt; mogroside \u2162_qt; mogroside V_qt



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yinghui Zhao, Yongxin Su, Zhenlin Li, Chen Luo, Yijun Chen, Xuri Wu. Efficient snailase-based production of mogrol from Luo Han Guo extract in an aqueous-organic system. Enzyme and microbial technology. 2023 Apr; 165(?):110212. doi: 10.1016/j.enzmictec.2023.110212. [PMID: 36804180]
  • Jing-Ru Song, Na Li, Yu-Lu Wei, Feng-Lai Lu, Dian-Peng Li. Design and synthesis of mogrol derivatives modified on a ring with anti-inflammatory and anti-proliferative activities. Bioorganic & medicinal chemistry letters. 2022 10; 74(?):128924. doi: 10.1016/j.bmcl.2022.128924. [PMID: 35944853]
  • Junwei Wang, Junhua Liu, Zhifu Xie, Jia Li, Jingya Li, Lihong Hu. Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators. Bioorganic & medicinal chemistry letters. 2020 01; 30(2):126790. doi: 10.1016/j.bmcl.2019.126790. [PMID: 31744674]
  • Longhai Dai, Can Liu, Yueming Zhu, Jiangsheng Zhang, Yan Men, Yan Zeng, Yuanxia Sun. Functional Characterization of Cucurbitadienol Synthase and Triterpene Glycosyltransferase Involved in Biosynthesis of Mogrosides from Siraitia grosvenorii. Plant & cell physiology. 2015 Jun; 56(6):1172-82. doi: 10.1093/pcp/pcv043. [PMID: 25759326]
  • Xu-bing Chen, Jing-jing Zhuang, Jun-hua Liu, Min Lei, Lei Ma, Jing Chen, Xu Shen, Li-hong Hu. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle. Bioorganic & medicinal chemistry. 2011 Oct; 19(19):5776-81. doi: 10.1016/j.bmc.2011.08.030. [PMID: 21893415]