Panaxatriol (BioDeep_00000230317)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyltetrahydropyran-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

化学式: C30H52O4 (476.3865392)
中文名称: 人参三醇
谱图信息: 最多检出来源 Viridiplantae(plant) 20%

分子结构信息

SMILES: C1C[C@]2(C)[C@@]3([H])C[C@@H](O)[C@]4([H])[C@@]([H])([C@]5(CCCC(C)(C)O5)C)CC[C@@]4(C)[C@]3(C)C[C@@H](O)[C@@]2([H])C(C)(C)[C@H]1O
InChI: InChI=1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1

描述信息

Panaxatriol is a triterpenoid saponin.
Panaxatriol is a natural product found in Panax ginseng with data available.
Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.
Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.

同义名列表

18 个代谢物同义名

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyltetrahydropyran-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol; (3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-PENTAMETHYL-17-((2R)-2,6,6-TRIMETHYLOXAN-2-YL)-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA(A)PHENANTHRENE-3,6,12-TRIOL; (3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol; Dammarane-3,6,12-triol, 20,25-epoxy-, (3.beta.,6.beta.,12.beta.,20R)-; (3beta,6alpha,12beta,20R)-20,25-Epoxydammarane-3,6,12-triol; (20R)-20,25-EPOXYDAMMARANE-3.BETA.,6.BETA.,12.BETA.-TRIOL; 20R,25-Epoxydammarane-3beta,6alpha,12beta-triol; panaxatriol, (3beta,6alpha,12beta)-isomer; UNII-9F5B25FDDG; Panaxatriol; 9F5B25FDDG; Panaxtriol; (3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyl-2-tetrahydropyranyl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol; AIDS-031251; AIDS031251; NSC 308880; 32791-84-7; 2,6,6,10,11-pentamethyl-14-(2,6,6-trimethyloxan-2-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,8,16-triol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huan Yao, Qingman He, Cong Huang, Shujun Wei, Yuanyuan Gong, Xueping Li, Weiwei Liu, Zhiyi Xu, Huihui Wu, Chuan Zheng, Yongxiang Gao. Panaxatriol saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation. Free radical biology & medicine. 2022 09; 190(?):264-275. doi: 10.1016/j.freeradbiomed.2022.08.016. [PMID: 35977659]
  • Huan Yao, Qian Xie, Qingman He, Lei Zeng, Jing Long, Yuanyuan Gong, Xueping Li, Xueping Li, Weiwei Liu, Zhiyi Xu, Huihui Wu, Chuan Zheng, Yongxiang Gao. Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity. Oxidative medicine and cellular longevity. 2022; 2022(?):9626703. doi: 10.1155/2022/9626703. [PMID: 35669855]
  • Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127364. doi: 10.1016/j.bmcl.2020.127364. [PMID: 32738969]
  • Shuyun Zhu, Zhenjia Zheng, Hongwei Peng, Jing Sun, Xian-En Zhao, Huwei Liu. Quadruplex stable isotope derivatization strategy for the determination of panaxadiol and panaxatriol in foodstuffs and medicinal materials using ultra high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. A. 2020 Apr; 1616(?):460794. doi: 10.1016/j.chroma.2019.460794. [PMID: 31870574]
  • Qiong Wu, Ruiying Wang, Yang Shi, Wenchao Li, Meng Li, Peng Chen, Bowen Pan, Qing Wang, Caifeng Li, Jianbing Wang, Guibo Sun, Xiaobo Sun, Hongzheng Fu. Synthesis and biological evaluation of panaxatriol derivatives against myocardial ischemia/reperfusion injury in the rat. European journal of medicinal chemistry. 2020 Jan; 185(?):111729. doi: 10.1016/j.ejmech.2019.111729. [PMID: 31655431]
  • Yuzhong Li, Hong Hu, Zhenguo Li, Ruihua Li, Fang Xu, Chengyan Zhao, Yue An, Yonge Liu, Zhongli Wang, Binbin Zhang, Cong Geng. Pharmacokinetic Characterizations of Ginsenoside Ocotillol, RT5 and F11, the Promising Agents for Alzheimer's Disease from American Ginseng, in Rats and Beagle Dogs. Pharmacology. 2019; 104(1-2):7-20. doi: 10.1159/000499595. [PMID: 30947229]
  • Qiong Wu, Peng Chen, Guangzhong Tu, Meng Li, Bowen Pan, Yan Guo, Jinbi Zhai, Hongzheng Fu. Synthesis and evaluation of panaxatriol derivatives as Na+, K+-ATPase inhibitors. Bioorganic & medicinal chemistry letters. 2018 09; 28(17):2885-2889. doi: 10.1016/j.bmcl.2018.07.027. [PMID: 30049579]
  • Jingcheng Wang, Yuanlong Hou, Zhiying Jia, Xie Xie, Jiajian Liu, Yani Kang, Xin Wang, Xiaoyan Wang, Wei Jia. Metabonomics Approach To Comparing the Antistress Effects of Four Panax ginseng Components in Rats. Journal of proteome research. 2018 02; 17(2):813-821. doi: 10.1021/acs.jproteome.7b00559. [PMID: 29302971]
  • Jinqiang Zhu, Yubin Liang, Shaoqian Yue, Guanwei Fan, Han Zhang, Meng Zhang. Combination of Panaxadiol and Panaxatriol Type Saponins and Ophioponins From Shenmai Formula Attenuates Lipopolysaccharide-induced Inflammatory Injury in Cardiac Microvascular Endothelial Cells by Blocking NF-kappa B Pathway. Journal of cardiovascular pharmacology. 2017 Mar; 69(3):140-146. doi: 10.1097/fjc.0000000000000450. [PMID: 28266999]
  • Zhen Hui, Du-Juan Sha, Su-Lei Wang, Chao-Sheng Li, Jian Qian, Jing-Qing Wang, Yang Zhao, Jing-Hua Zhang, Hong-Yu Cheng, Hui Yang, Lin-Jie Yu, Yun Xu. Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats. BMC complementary and alternative medicine. 2017 Jan; 17(1):70. doi: 10.1186/s12906-017-1579-5. [PMID: 28114983]
  • Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Lijuan Ma, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Meiwan Chen, Peng Li, Huanxing Su, Simon Ming Yuen Lee, Kechun Liu, Jian-Bo Wan, Chengwei He. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Scientific reports. 2017 01; 7(?):41082. doi: 10.1038/srep41082. [PMID: 28112228]
  • Yusuke Takamura, Mitsuru Nomura, Akira Uchiyama, Satoshi Fujita. Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice. Journal of nutritional science and vitaminology. 2017; 63(5):339-348. doi: 10.3177/jnsv.63.339. [PMID: 29225319]
  • Yusuke Takamura, Yuhei Makanae, Satoru Ato, Naomi Yoshii, Kohei Kido, Mitsuru Nomura, Akira Uchiyama, Naruhiro Shiozawa, Satoshi Fujita. Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle. Nutrition research (New York, N.Y.). 2016 11; 36(11):1193-1201. doi: 10.1016/j.nutres.2016.09.002. [PMID: 27865617]
  • Hongyi Qi, Yongliang Huang, Yi Yang, Guojun Dou, Fang Wan, Wenwu Zhang, Huarong Yang, Li Wang, Chunjie Wu, Li Li. Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation. BMC complementary and alternative medicine. 2016 Jun; 16(?):174. doi: 10.1186/s12906-016-1160-7. [PMID: 27277000]
  • Tanya Biswas, Alok Kalra, A K Mathur, R K Lal, Manju Singh, Archana Mathur. Elicitors' influenced differential ginsenoside production and exudation into medium with concurrent Rg3/Rh2 panaxadiol induction in Panax quinquefolius cell suspensions. Applied microbiology and biotechnology. 2016 Jun; 100(11):4909-22. doi: 10.1007/s00253-015-7264-z. [PMID: 26795963]
  • Shengdong Wang, Xiao Wang, Fucheng Luo, Xiaodan Tang, Kui Li, Xiaomei Hu, Jie Bai. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver international : official journal of the International Association for the Study of the Liver. 2014 Aug; 34(7):1068-73. doi: 10.1111/liv.12329. [PMID: 24119161]
  • Yongliang Huang, Jie Yu, Fang Wan, Wenwu Zhang, Huarong Yang, Li Wang, Hongyi Qi, Chunjie Wu. Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway. Oxidative medicine and cellular longevity. 2014; 2014(?):978034. doi: 10.1155/2014/978034. [PMID: 24955212]
  • Dacheng Peng, Huashan Wang, Chenling Qu, Laihua Xie, Sheila M Wicks, Jingtian Xie. Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. Chinese medicine. 2012 Feb; 7(?):2. doi: 10.1186/1749-8546-7-2. [PMID: 22314249]
  • Subhasree Ashok Nag, Jiang-Jiang Qin, Wei Wang, Ming-Hai Wang, Hui Wang, Ruiwen Zhang. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Frontiers in pharmacology. 2012; 3(?):25. doi: 10.3389/fphar.2012.00025. [PMID: 22403544]
  • Hanzhou Feng, Wei Chen, Chunyan Zhu. Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins. International archives of medicine. 2011 Jun; 4(1):18. doi: 10.1186/1755-7682-4-18. [PMID: 21658246]
  • Kuen-Daw Tsai, Shu-Mei Yang, Jen-Chih Lee, Ho-Yiu Wong, Chuen-Ming Shih, Ting-Hui Lin, Min-Jen Tseng, Wei Chen. Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):404761. doi: 10.1155/2011/404761. [PMID: 21423633]
  • Andrew Scholey, Anastasia Ossoukhova, Lauren Owen, Alvin Ibarra, Andrew Pipingas, Kan He, Marc Roller, Con Stough. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology. 2010 Oct; 212(3):345-56. doi: 10.1007/s00213-010-1964-y. [PMID: 20676609]
  • Stella Chai, Kenneth Kw To, Ge Lin. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. Chinese medicine. 2010 Jul; 5(?):26. doi: 10.1186/1749-8546-5-26. [PMID: 20653978]
  • Tae-Hoon Kim, Sun-Mee Lee. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Jun; 48(6):1516-20. doi: 10.1016/j.fct.2010.03.018. [PMID: 20353807]
  • Wei Chen, Yunjie Dang, Chunyan Zhu. Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study. Chinese medicine. 2010 Mar; 5(?):12. doi: 10.1186/1749-8546-5-12. [PMID: 20331853]
  • Fu-Cheng Luo, Sheng-Dong Wang, Kui Li, Hajime Nakamura, Junji Yodoi, Jie Bai. Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Journal of ethnopharmacology. 2010 Feb; 127(2):419-23. doi: 10.1016/j.jep.2009.10.023. [PMID: 19857566]
  • Davy C W Lee, Cindy L H Yang, Stanley C C Chik, James C B Li, Jian-hui Rong, Godfrey C F Chan, Allan S Y Lau. Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells. Journal of translational medicine. 2009 May; 7(?):34. doi: 10.1186/1479-5876-7-34. [PMID: 19442267]
  • Li Lai, Yitong Liu, Haiping Hao, Guangji Wang, Xijing Chen, Hongcan Ren. Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. European journal of mass spectrometry (Chichester, England). 2009; 15(1):57-65. doi: 10.1255/ejms.974. [PMID: 19174594]
  • Xi-Sheng Xie, Man Yang, Heng-Cuang Liu, Chuan Zuo, Zi Li, Yao Deng, Jun-Ming Fan. Influence of ginsenoside Rg1, a panaxatriol saponin from Panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction. Journal of Zhejiang University. Science. B. 2008 Nov; 9(11):885-94. doi: 10.1631/jzus.b0820024. [PMID: 18988308]
  • Xiaoyan Chen, Muke Zhou, Qifu Li, Jie Yang, Yun Zhang, Dongping Zhang, Shaugyan Kong, Dong Zhou, Li He. Sanchi for acute ischaemic stroke. The Cochrane database of systematic reviews. 2008 Oct; ?(4):CD006305. doi: 10.1002/14651858.cd006305.pub2. [PMID: 18843711]
  • Fen Y Liu, Jun N Wang, Shu D Yu, Bo Wang, Ji D Zhang. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi medical journal. 2007 Dec; 28(12):1791-5. doi: ". [PMID: 18060204]
  • Hae June Lee, Se Ra Kim, Jong Choon Kim, Chang Mo Kang, Yun Sil Lee, Sung Kee Jo, Tae Hwan Kim, Jong Sik Jang, Seung Yeol Nah, Sung Ho Kim. In Vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides. Phytotherapy research : PTR. 2006 May; 20(5):392-5. doi: 10.1002/ptr.1867. [PMID: 16619368]
  • Yang-ping Niu, Xu-dai Qian, Wen-xi Wang. [Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2004 Feb; 24(2):127-9, 132. doi: ". [PMID: 15015445]
  • Y W Zhang, D Q Dou, L Zhang, Y J Chen, X S Yao. Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. Planta medica. 2001 Jul; 67(5):417-22. doi: 10.1055/s-2001-15816. [PMID: 11488454]
  • Y Jia, B Zhao, Q Liu, Y Liu. [Determination of panaxadiol and panaxatriol in shihu yeguang pills]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1995 Dec; 20(12):732-5, 763. doi: ". [PMID: 8703336]
  • S L Gong, X M Li, Z Lü, S Z Liu. [Protective effect of panaxatriols on function of reproductive endocrine axis in radiation-injured rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1993 Jul; 14(4):358-60. doi: NULL. [PMID: 8249635]