regelide (BioDeep_00000230266)

 

Secondary id: BioDeep_00000243464

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,5S,5aR,7aS,7bR,9aR,11S,13aR,13bR,15bS)-11-hydroxy-2,5a,7a,7b,10,10,13a-heptamethyl-1,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-octadecahydro-2,5-methanochryseno[2,1-c]oxepin-3(2H)-one

化学式: C30H46O3 (454.3447)
中文名称: 雷公藤内酯 A, 雷公藤内酯甲
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C2CCC3(C(C2(CCC1O)C)CC=C4C3(CCC5(C4CC6(CC5OC6=O)C)C)C)C)C
InChI: InChI=1S/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1

描述信息

Wilforlide A is a natural product found in Plenckia populnea, Tripterygium regelii, and other organisms with data available.
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects[1].
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects[1].

同义名列表

15 个代谢物同义名

(2S,5S,5aR,7aS,7bR,9aR,11S,13aR,13bR,15bS)-11-hydroxy-2,5a,7a,7b,10,10,13a-heptamethyl-1,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-octadecahydro-2,5-methanochryseno[2,1-c]oxepin-3(2H)-one; (1S,2R,5S,6R,9R,11S,14R,15R,19S,21S)-11-hydroxy-2,5,6,10,10,14,21-heptamethyl-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-en-22-one; OLEAN-12-EN-29-OIC ACID, 3,22-DIHYDROXY-, .GAMMA.-LACTONE, (3.BETA.,20.ALPHA.,22.ALPHA.)-; Olean-12-en-29-oic acid, 3,22-dihydroxy-, gamma-lactone, (3beta,20alpha,22alpha)-; 3-Hydroxy-22,29-epoxyolean-12-en-29-one; Regelide;Abruslactone A; 3-epiabruslactone A; (-)-ABRUSLACTONE A; UNII-JW7QMP68BC; Abruslactone A; Wilforlide A; Wilforlide-A; JW7QMP68BC; regelide; Wilforlide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yuan Liu, Jiawei Zhou, Panting Liu, Tianyuan Hu, Xuan Liu, Jie Gao, Lin Ma, Yun Lu, Dan Li, Zhouqian Jiang, Xianan Zhang, Luqi Huang, Wei Gao, Xiaoyi Wu, Yifeng Zhang, Changli Liu. Gene identification and semisynthesis of the anti-inflammatory oleanane-type triterpenoid wilforlide A. The New phytologist. 2024 Feb; 241(4):1720-1731. doi: 10.1111/nph.19427. [PMID: 38013483]
  • Yunxiang Cao, Jian Liu, Chuanbing Huang, Yanhong Tao, Yuan Wang, Xi Chen, Dan Huang. Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization. Journal of pharmacological sciences. 2022 Jan; 148(1):116-124. doi: 10.1016/j.jphs.2021.10.005. [PMID: 34924115]
  • Shanshan Zhao, Chaoyue Wang, Xiang Wang, Yang Jin, Wenyu Sun, Xingchu Gong, Shengqiang Tong. Liquid-liquid chromatography in sample pretreatment for quantitative analysis of trace component in traditional Chinese medicines by conventional liquid chromatography. Journal of chromatography. A. 2020 May; 1619(?):460917. doi: 10.1016/j.chroma.2020.460917. [PMID: 32037073]
  • Zhijun Wang, Steven Yeung, Shang Chen, Yasmin Moatazedi, Moses S S Chow. Bioavailability of wilforlide A in mice and its concentration determination using an HPLC-APCI-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jul; 1090(?):65-72. doi: 10.1016/j.jchromb.2018.05.018. [PMID: 29787994]
  • Jin-xiao Zhai, Wei Liu. [Determination of Triptolide and Wilforlide A in Biological Samples by LC-MS/MS]. Fa yi xue za zhi. 2015 Dec; 31(6):445-9, 453. doi: NULL. [PMID: 27141802]
  • Dong Zhou, Lu Zhang, Wei Sun. [Study of wilforlide on foot cells and renal tubular epithelial cells protection]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Apr; 31(4):569-71. doi: ". [PMID: 21608234]
  • Mei Xue, Zhen-zhou Jiang, Ji-ping Liu, Lu-yong Zhang, Tao Wang, Hao Wang, Li Liu, Zhi-xing Zhou. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A. Fitoterapia. 2010 Dec; 81(8):1109-12. doi: 10.1016/j.fitote.2010.07.007. [PMID: 20621167]
  • Jincheng Yao, Luyong Zhang, Xuyuan Zhao, Ling Hu, Zhenzhou Jiang. Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. Biological & pharmaceutical bulletin. 2006 Jul; 29(7):1483-6. doi: 10.1248/bpb.29.1483. [PMID: 16819194]
  • Hiroyuki Nakagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Cristina Garzon, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Uddin Ahmed. Chemical constituents from the Colombian medicinal plant Maytenus laevis. Journal of natural products. 2004 Nov; 67(11):1919-24. doi: 10.1021/np040006s. [PMID: 15568791]
  • Q P Gao. [Chemical constituents of heiman (Tripterygium regelii)]. Zhong yao tong bao (Beijing, China : 1981). 1987 Jan; 12(1):41-2. doi: ". [PMID: 2954704]