Magnolin (BioDeep_00000230168)

 

Secondary id: BioDeep_00000230167

PANOMIX_OTCML-2023


代谢物信息卡片


(1S-(1.ALPHA.,3A.ALPHA.,4.ALPHA.,6A.ALPHA.))-1H,3H-FURO(3,4-C)FURAN, 1.ALPHA.-(3,4-DIMETHOXYPHENYL)-3A.ALPHA.,4,6,6A.ALPHA.-TETRAHYDRO-4.ALPHA.-(3,4,5-TRIMETHOXYPHENYL)-, (+)-

化学式: C23H28O7 (416.1834938)
中文名称: 表木兰脂素A, 木兰脂素, 木兰苷, 表木兰脂素B, 表木兰脂素A, 木兰脂素, 表木兰脂素 B
谱图信息: 最多检出来源 Viridiplantae(plant) 8.51%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)OC)OC)OC
InChI: InChI=1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3

描述信息

Magnolin is a natural product found in Geranium platyanthum, Licaria armeniaca, and other organisms with data available.
See also: Centipeda minima flowering top (part of).
3-(3,4-Dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan is a natural product found in Hernandia nymphaeifolia, Hernandia sonora, and Magnolia biondii with data available.
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

同义名列表

22 个代谢物同义名

(1S-(1.ALPHA.,3A.ALPHA.,4.ALPHA.,6A.ALPHA.))-1H,3H-FURO(3,4-C)FURAN, 1.ALPHA.-(3,4-DIMETHOXYPHENYL)-3A.ALPHA.,4,6,6A.ALPHA.-TETRAHYDRO-4.ALPHA.-(3,4,5-TRIMETHOXYPHENYL)-, (+)-; (1S-(1alpha,3Aalpha,4alpha,6Aalpha))-1H,3H-FURO(3,4-C)FURAN, 1alpha-(3,4-DIMETHOXYPHENYL)-3Aalpha,4,6,6Aalpha-TETRAHYDRO-4alpha-(3,4,5-TRIMETHOXYPHENYL)-, (+)-; 1H,3H-Furo(3,4-c)furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S-(1alpha,3alpha,4alpha,6aalpha))-; (3S,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan; 1H,3H-FURO(3,4-C)FURAN, 1-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-4-(3,4,5-TRIMETHOXYPHENYL)-, (1S,3AR,4S,6AR)-; 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-; (1s,3ar,4s,6ar)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1h,3h-furo[3,4-c]furan; (1S,3AR,4S,6AR)-1-(3,4-DIMETHOXYPHENYL)-4-(3,4,5-TRIMETHOXYPHENYL)-HEXAHYDROFURO(3,4-C)FURAN; (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-hexahydrofuro[3,4-c]furan; 1-(3,4-Dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan; 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)perhydrofuro[3,4-c]furan; Medioresinol dimethyl ether; UNII-95DA2NWV8P; (+/-)-Magnolin; epimagnolin A; (+)-magnolin; epimagnolin; 95DA2NWV8P; Magnolin; (1S,3abeta,6abeta)-1beta-(3,4-Dimethoxyphenyl)-3a,4,6,6a-tetrahydro-4alpha-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan; 3-(3,4-Dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan; CHOLESTERYLBUTYLETHER



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chia-Liang Lin, Tsung-Ho Ying, Shun-Fa Yang, Chu-Liang Lin, Hui-Ling Chiou, Yi-Hsien Hsieh. Magnolin targeting of the JNK/Sp1/MMP15 signaling axis suppresses cervical cancer microenvironment and metastasis via microbiota modulation. Cancer letters. 2024 Feb; 583(?):216584. doi: 10.1016/j.canlet.2023.216584. [PMID: 38123014]
  • Md Shimul Bhuia, Polrat Wilairatana, Raihan Chowdhury, Asraful Islam Rakib, Hossam Kamli, Ahmad Shaikh, Henrique D M Coutinho, Muhammad Torequl Islam. Anticancer Potentials of the Lignan Magnolin: A Systematic Review. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093671. [PMID: 37175081]
  • María Y Rios, Yordin D Ocampo-Acuña, M Ángeles Ramírez-Cisneros, María E Salazar-Rios. Furofuranone Lignans from Leucophyllum ambiguum. Journal of natural products. 2020 05; 83(5):1424-1431. doi: 10.1021/acs.jnatprod.9b00759. [PMID: 32239935]
  • Haiyang Yu, Shuangshuang Yin, Shiyue Zhou, Yingying Shao, Jiachen Sun, Xu Pang, Lifeng Han, Yi Zhang, Xiumei Gao, Chengyun Jin, Yuling Qiu, Tao Wang. Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers. Cell death & disease. 2018 06; 9(6):702. doi: 10.1038/s41419-018-0660-4. [PMID: 29899555]
  • Cai-Yun Peng, Yan-Qun Liu, Yi-Hui Deng, Yue-Hu Wang, Xiao-Jiang Zhou. Lignans from the bark of Zanthoxylum simulans. Journal of Asian natural products research. 2015; 17(3):232-8. doi: 10.1080/10286020.2014.978303. [PMID: 25379867]
  • Feng Wang, Guangyuan Zhang, Yang Zhou, Dingkun Gui, Junhui Li, Tao Xing, Niansong Wang. Magnolin protects against contrast-induced nephropathy in rats via antioxidation and antiapoptosis. Oxidative medicine and cellular longevity. 2014; 2014(?):203458. doi: 10.1155/2014/203458. [PMID: 25400863]
  • Ji Hyun Jeong, Dong Kyun Kim, Hye Young Ji, Sei Ryang Oh, Hyung-Kyu Lee, Hye Suk Lee. Liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry for the simultaneous determination of dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, epimagnolin A, fargesin and magnolin in rat plasma. Biomedical chromatography : BMC. 2011 Aug; 25(8):879-89. doi: 10.1002/bmc.1538. [PMID: 21058411]
  • Nam Jin Kim, Won Young Song, Sun Dong Yoo, Sei-Ryang Oh, Hyeong-Kyu Lee, Hye Suk Lee. Pharmacokinetics of magnolin in rats. Archives of pharmacal research. 2010 Jun; 33(6):933-8. doi: 10.1007/s12272-010-0617-3. [PMID: 20607499]
  • Nam Jin Kim, Sei-Ryang Oh, Hyung Kyu Lee, Hye Suk Lee. Simultaneous determination of magnolin and epimagnolin A in rat plasma by liquid chromatography with tandem mass spectrometry: Application to pharmacokinetic study of a purified extract of the dried flower buds of Magnolia fargesii, NDC-052 in rats. Journal of pharmaceutical and biomedical analysis. 2009 Aug; 50(1):53-7. doi: 10.1016/j.jpba.2009.03.036. [PMID: 19409747]
  • Jin Ah Baek, Yang Deok Lee, Chan Bog Lee, Hyeon Kyu Go, Jin Pyo Kim, Jeong Ju Seo, Yang Keun Rhee, A Mi Kim, Dong Jib Na. Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells. Nitric oxide : biology and chemistry. 2009 Mar; 20(2):122-8. doi: 10.1016/j.niox.2008.10.003. [PMID: 18976718]
  • Jae Yeon Kim, Hyo Jin Lim, Da Yeon Lee, Ji Sun Kim, Do Hee Kim, Hwa Jin Lee, Hee Doo Kim, Raok Jeon, Jae-Ha Ryu. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorganic & medicinal chemistry letters. 2009 Feb; 19(3):937-40. doi: 10.1016/j.bmcl.2008.11.103. [PMID: 19110419]