GomisinJ (BioDeep_00000230111)

 

Secondary id: BioDeep_00000230962

PANOMIX_OTCML-2023


代谢物信息卡片


(9S,10R)-3,4,15,16-tetramethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-5,14-diol

化学式: C22H28O6 (388.1885788)
中文名称: 戈米辛J
谱图信息: 最多检出来源 unclassified Codonopsis(otcml) 39.77%

分子结构信息

SMILES: CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)O)OC)OC)OC)OC)O
InChI: InChI=1S/C22H28O6/c1-11-7-13-9-15(23)19(25-3)21(27-5)17(13)18-14(8-12(11)2)10-16(24)20(26-4)22(18)28-6/h9-12,23-24H,7-8H2,1-6H3/t11-,12+

描述信息

Gomisin J is a natural product found in Kadsura coccinea, Kadsura heteroclita, and other organisms with data available.
See also: Schisandra chinensis fruit (part of).
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].

同义名列表

11 个代谢物同义名

(9S,10R)-3,4,15,16-tetramethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-5,14-diol; DIBENZO(A,C)CYCLOOCTENE-3,10-DIOL, 5,6,7,8-TETRAHYDRO-1,2,11,12-TETRAMETHOXY-6,7-DIMETHYL-, (6R,7S,12AS)-; Dibenzo(a,c)cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-, stereoisomer; (6R,7S,12AS)-1,2,11,12-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene-3,10-diol; 6(S),7(R)-Dibenzo(a,c)cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-; UNII-X13A57600T; (-)-Gomisin J; X13A57600T; Gomisin J; Gomisin-J; GomisinJ



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu. Gomisin J attenuates cerebral ischemia/reperfusion injury by inducing anti-apoptotic, anti-inflammatory, and antioxidant effects in rats. Bioengineered. 2022 03; 13(3):6908-6918. doi: 10.1080/21655979.2022.2026709. [PMID: 35235758]
  • Joong Suk Jeon, He Mi Kang, Sun Young Park, Young-Whan Choi. Comparative study of the photo‑protective and anti‑melanogenic properties of gomisin D, J and O. Molecular medicine reports. 2022 Jan; 25(1):. doi: 10.3892/mmr.2021.12524. [PMID: 34751410]
  • Shan-Shan Guo, Xue Pang, Yang Wang, Zhu-Feng Geng, Ju-Qin Cao, Jun-Yu Liang, Zhi-Wei Deng, Shu-Shan Du. Chemical constituents isolated from stems of Schisandra chinensis and their antifeedant activity against Tribolium castaneum. Natural product research. 2020 Sep; 34(18):2595-2601. doi: 10.1080/14786419.2018.1547291. [PMID: 30623674]
  • Lian-lin Su, Xue Cheng, De Ji, Li-jun Wang, Xi-yan Ding, Tu-lin Lu, Chun-qin Mao, Ji Zhang. [Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 10; 51(10):1600-8. doi: . [PMID: 29932608]
  • Myungsuk Kim, Sue Ji Lim, Hee-Ju Lee, Sun Young Kim, Chu Won Nho. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. Journal of agricultural and food chemistry. 2015 Nov; 63(44):9729-39. doi: 10.1021/acs.jafc.5b04089. [PMID: 26455261]
  • Jin-Hui Song, Li Cui, Li-Bin An, Wen-Tao Li, Zhong-Ze Fang, Yan-Yan Zhang, Pei-Pei Dong, Xue Wu, Li-Xuan Wang, Frank J Gonzalez, Xiao-Yu Sun, De-Wei Zhao. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytotherapy research : PTR. 2015 Oct; 29(10):1658-64. doi: 10.1002/ptr.5395. [PMID: 26084208]
  • Byeong Hyeok Ye, Seung Jin Lee, Young Whan Choi, So Youn Park, Chi Dae Kim. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertension research : official journal of the Japanese Society of Hypertension. 2015 Mar; 38(3):169-77. doi: 10.1038/hr.2014.162. [PMID: 25427681]
  • Eun Yeon Ryu, Sun Young Park, Sun Gun Kim, Da Jung Park, Jum Soon Kang, Young Hun Kim, Rajaseker Seetharaman, Young-Whan Choi, Sang-Joon Lee. Anti-inflammatory effect of heme oxygenase-1 toward Porphyromonas gingivalis lipopolysaccharide in macrophages exposed to gomisins A, G, and J. Journal of medicinal food. 2011 Dec; 14(12):1519-26. doi: 10.1089/jmf.2011.1656. [PMID: 22145771]
  • Su-Yeon Oh, Young Hoon Kim, Deok Sung Bae, Byung Hun Um, Cheol-Ho Pan, Chul Young Kim, Hee Ju Lee, Jae Kwon Lee. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Bioscience, biotechnology, and biochemistry. 2010; 74(2):285-91. doi: 10.1271/bbb.90597. [PMID: 20139628]
  • Wei-Lie Xiao, Sheng-Xiong Huang, Rui-Rui Wang, Jia-Liang Zhong, Xue-Mei Gao, Fei He, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun. Nortriterpenoids and lignans from Schisandra sphenanthera. Phytochemistry. 2008 Nov; 69(16):2862-6. doi: 10.1016/j.phytochem.2008.09.010. [PMID: 18951592]
  • H L Peng, D F Chen, H X Lan, X M Zhang, Z Gu, M H Jiang. Anti-lipid peroxidation of gomisin J on liver mitochondria and cultured myocardial cells. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1996 Nov; 17(6):538-41. doi: ". [PMID: 9863151]
  • M Suekawa, T Shiga, H Sone, Y Ikeya, H Taguchi, M Aburada, E Hosoya. [Effects of gomisin J and analogous lignan compounds in schisandra fruits on isolated smooth muscles]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1987 Sep; 107(9):720-6. doi: 10.1248/yakushi1947.107.9_720. [PMID: 2830398]