Corynoxine (BioDeep_00000230103)

 

Secondary id: BioDeep_00000230104

PANOMIX_OTCML-2023


代谢物信息卡片


methyl (E)-2-[(3S,6S,7S,8aS)-6-ethyl-2-oxospiro[1H-indole-3,1-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7-yl]-3-methoxyprop-2-enoate

化学式: C22H28N2O4 (384.20489680000003)
中文名称: 柯诺辛B, 柯诺辛, 柯诺辛, 柯诺辛碱B
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
InChI: InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1

描述信息

Corynoxine is a member of indolizines. It has a role as a metabolite.
Corynoxine is a natural product found in Mitragyna speciosa, Uncaria attenuata, and Uncaria macrophylla with data available.
A natural product found in Uncaria macrophylla.
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].
Corynoxine B is a natural compound of indole alkaloids and a beclin-1-dependent autophagy inducer.
Corynoxine B is a natural compound of indole alkaloids and a beclin-1-dependent autophagy inducer.

同义名列表

6 个代谢物同义名

methyl (E)-2-[(3S,6S,7S,8aS)-6-ethyl-2-oxospiro[1H-indole-3,1-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7-yl]-3-methoxyprop-2-enoate; Methyl (E)-2-((3S,6S,7S,8aS)-6-ethyl-2-oxo-2,3,6,7,8,8a-hexahydro-5H-spiro[indoline-3,1-indolizin]-7-yl)-3-methoxyacrylate; (E)-methyl 2-((1S,6S,7S,8aS)-6-ethyl-2-oxo-3,5,6,7,8,8a-hexahydro-2H-spiro[indoline-3,1-indolizin]-7-yl)-3-methoxyacrylate; Corynoxine A; Corynoxine B; Corynoxine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Shyam H Kamble, Erin C Berthold, Tamara I King, Siva Rama Raju Kanumuri, Raluca Popa, Julius R Herting, Francisco León, Abhisheak Sharma, Lance R McMahon, Bonnie A Avery, Christopher R McCurdy. Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats. Journal of natural products. 2021 04; 84(4):1104-1112. doi: 10.1021/acs.jnatprod.0c01163. [PMID: 33620222]
  • Nelson Jeng-Yeou Chear, Francisco León, Abhisheak Sharma, Siva Rama Raju Kanumuri, Grant Zwolinski, Khalil A Abboud, Darshan Singh, Luis F Restrepo, Avi Patel, Takato Hiranita, Surash Ramanathan, Aidan J Hampson, Lance R McMahon, Christopher R McCurdy. Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. Journal of natural products. 2021 04; 84(4):1034-1043. doi: 10.1021/acs.jnatprod.0c01055. [PMID: 33635670]
  • Peng Zeng, Xiao-Ming Wang, Chao-Yuan Ye, Hong-Fei Su, Qing Tian. The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer's Disease Mechanism Determined by a Network Pharmacology Approach. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073612. [PMID: 33807157]
  • Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, Han-Li Ruan. Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. Journal of natural products. 2018 08; 81(8):1841-1849. doi: 10.1021/acs.jnatprod.8b00324. [PMID: 30059216]
  • Jun Xu, Li-Dong Shao, Dashan Li, Xu Deng, Yu-Chen Liu, Qin-Shi Zhao, Chengfeng Xia. Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B. Journal of the American Chemical Society. 2014 Dec; 136(52):17962-5. doi: 10.1021/ja5121343. [PMID: 25496352]
  • Kou Wang, Xiao-Yu Zhou, Yuan-Yuan Wang, Ming-Ming Li, Yin-Shan Li, Li-Yan Peng, Xiao Cheng, Yan Li, Yi-Ping Wang, Qin-Shi Zhao. Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla. Journal of natural products. 2011 Jan; 74(1):12-5. doi: 10.1021/np1004938. [PMID: 21070010]