Tuberstemonine (BioDeep_00000230082)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-

化学式: C22H33NO4 (375.2409458000001)
中文名称: 对叶百部碱, 对叶百部碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.2%

分子结构信息

SMILES: CCC1C2CCCCN3C2C(CC3C4CC(C(=O)O4)C)C5C1OC(=O)C5C
InChI: InChI=1S/C22H33NO4/c1-4-13-14-7-5-6-8-23-16(17-9-11(2)21(24)26-17)10-15(19(14)23)18-12(3)22(25)27-20(13)18/h11-20H,4-10H2,1-3H3

描述信息

Tuberostemonine is an alkaloid. It has a role as a metabolite.
Tuberostemonine is a natural product found in Stemona tuberosa, Stemona sessilifolia, and other organisms with data available.
A natural product found in Stemona phyllantha and Stemona tuberosa.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.534
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.531
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR)[1].
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR)[1].

同义名列表

9 个代谢物同义名

Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-; (2S,31R,7AR,8R,8aS,11S,11aS,11bR)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one; (1R,3S,9R,10R,11S,14S,15S,16R)-10-ethyl-14-methyl-3-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-12-oxa-4-azatetracyclo[7.6.1.04,16.011,15]hexadecan-13-one; Stenine, 2-(tetrahydro-4-methyl-5-oxo-2-furanyl)-, (2beta(2S,4S))-; GYOGHROCTSEKDY-JJDZUBOLSA-N; tubero-stemonine; Tuberostemonine; TimTec1_001671; Tuberstemonine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Li, Mingjie Sun, Songtao Su, Xinyi Qi, Siqi Liu, Tingli Pan, Lei Zhou, Yixing Li. Tuberostemonine alleviates high-fat diet-induced obesity and hepatic steatosis by increasing energy consumption. Chemico-biological interactions. 2023 Aug; 381(?):110545. doi: 10.1016/j.cbi.2023.110545. [PMID: 37236577]
  • Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang. Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):116983. doi: 10.1016/j.jep.2023.116983. [PMID: 37532076]
  • G Chen, L Brecker, S Felsinger, X-H Cai, S Kongkiatpaiboon, J Schinnerl. Morphological and chemical variation of Stemona tuberosa from southern China - Evidence for heterogeneity of this medicinal plant species. Plant biology (Stuttgart, Germany). 2017 Sep; 19(5):835-842. doi: 10.1111/plb.12587. [PMID: 28580601]
  • Yongbin Tong, Weitong Xu, Yan Wu, Liting Ou, Mian Zhang, Xianghong Xu, Chaofeng Zhang. Metabolic profiles of neotuberostemonine and tuberostemonine in rats by high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2017 Jul; 141(?):210-221. doi: 10.1016/j.jpba.2017.04.018. [PMID: 28448890]
  • Kyung-Hwa Jung, Yun-Seo Kil, Jaehoon Jung, Soojin Park, Dasom Shin, Kyeseok Lee, Eun Kyoung Seo, Hyunsu Bae. Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Jan; 23(1):79-86. doi: 10.1016/j.phymed.2015.11.015. [PMID: 26902410]
  • Jing-ni Liao, Shan-ding Qin, Xiao-sheng Qu, Kui Lin, Dao-Ping Huang, Feng-xin Li, Lan-lan Fan. [Comparative study of four alkaloids contents and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Nov; 37(11):1956-60. doi: ". [PMID: 26027114]
  • Hui Sun, Wei Dong, Aihua Zhang, Weiming Wang, Xijun Wang. Ultra-performance liquid-chromatography with tandem mass spectrometry performing pharmacokinetic and biodistribution studies of croomine, neotuberostemonine and tuberostemonine alkaloids absorbed in the rat plasma after oral administration of Stemonae Radix. Fitoterapia. 2012 Dec; 83(8):1699-705. doi: 10.1016/j.fitote.2012.09.027. [PMID: 23041522]
  • Yan-Tong Xu, Pang-Chui Shaw, Ren-Wang Jiang, Po-Ming Hon, Yiu-Man Chan, Paul Pui-Hay But. Antitussive and central respiratory depressant effects of Stemona tuberosa. Journal of ethnopharmacology. 2010 Apr; 128(3):679-84. doi: 10.1016/j.jep.2010.02.018. [PMID: 20219659]
  • Xin Zhou, Pak Ho Henry Leung, Na Li, Yang Ye, Li Zhang, Zhong Zuo, Ge Lin. Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta medica. 2009 May; 75(6):575-80. doi: 10.1055/s-0029-1185363. [PMID: 19214944]
  • Song-Lin Li, Ren-Wang Jiang, Po-Ming Hon, Ling Cheng, Hong-Xi Xu, Harald Greger, Paul Pui-Hay But, Pang-Chui Shaw. Quality evaluation of Radix Stemonae through simultaneous quantification of bioactive alkaloids by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. Biomedical chromatography : BMC. 2007 Oct; 21(10):1088-94. doi: 10.1002/bmc.862. [PMID: 17583876]
  • Johann Schinnerl, Brigitte Brem, Paul Pui-Hay But, Srunya Vajrodaya, Otmar Hofer, Harald Greger. Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Phytochemistry. 2007 May; 68(10):1417-27. doi: 10.1016/j.phytochem.2007.03.002. [PMID: 17449078]
  • Yan-Tong Xu, Po-Ming Hon, Ren-Wang Jiang, Ling Cheng, Sheng-Hong Li, Yiu-Pong Chan, Hong-Xi Xu, Pang-Chui Shaw, Paul Pui-Hay But. Antitussive effects of Stemona tuberosa with different chemical profiles. Journal of ethnopharmacology. 2006 Nov; 108(1):46-53. doi: 10.1016/j.jep.2006.04.022. [PMID: 16750339]
  • Harald Greger. Structural relationships, distribution and biological activities of stemona alkaloids. Planta medica. 2006 Feb; 72(2):99-113. doi: 10.1055/s-2005-916258. [PMID: 16491444]
  • Brigitte Brem, Christoph Seger, Thomas Pacher, Otmar Hofer, Srunya Vajrodaya, Harald Greger. Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. Journal of agricultural and food chemistry. 2002 Oct; 50(22):6383-8. doi: 10.1021/jf0205615. [PMID: 12381121]
  • M Terada, M Sano, A I Ishii, H Kino, S Fukushima, T Noro. [Studies on chemotherapy of parasitic helminths (III). Effects of tuberostemonine from Stemona japonica on the motility of parasitic helminths and isolated host tissues (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Feb; 79(2):93-103. doi: 10.1254/fpj.79.93. [PMID: 7200048]