6-Methoxydihydrosanguinarine (BioDeep_00000230048)

 

Secondary id: BioDeep_00000396681

PANOMIX_OTCML-2023


代谢物信息卡片


23-methoxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21)-octaene

化学式: C21H17NO5 (363.1106672)
中文名称: 6-甲氧基二氢血根碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 61.9%

分子结构信息

SMILES: c12c(cc3c(c1)c1c(cc3)c3c([C@H](N1C)OC)c1c(cc3)OCO1)OCO2
InChI: InChI=1S/C21H17NO5/c1-22-19-13(4-3-11-7-16-17(8-14(11)19)26-9-25-16)12-5-6-15-20(27-10-24-15)18(12)21(22)23-2/h3-8,21H,9-10H2,1-2H3

描述信息

同义名列表

7 个代谢物同义名

23-methoxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21)-octaene; (-)-14-Methoxy-13-methyl-13,14-dihydro-[1,3]dioxolo[4,5:4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine, 13,14-dihydro-14-methoxy-13-methyl-; 6-Methoxydihydrosanguinarine72401-54-8; 6-methoxydihydro-sanguinarine; 6-Methoxydihydrosanguinarine; (-)-Sanguinarine pseudomethanolate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Zhang, Xinyue Zhang, Delu Che, Lizhong Zeng, Yu Zhang, Kai Nan, Xinxin Zhang, Hui Zhang, Zengjun Guo. 6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway. Phytotherapy research : PTR. 2023 Jan; 37(1):124-139. doi: 10.1002/ptr.7601. [PMID: 36116140]
  • Liang Jiang, Xiaolu Wang, Yuting Wang, Fang Xu, Zhang Zhang, Ke Ding, Xiaoyun Lu. The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents. RSC medicinal chemistry. 2020 Feb; 11(2):293-296. doi: 10.1039/c9md00494g. [PMID: 33479636]
  • Phurpa Wangchuk, Wangchuk Phurpa, Paul A Keller, Stephen G Pyne, Wilford Lie, Anthony C Willis, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan. A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain. Journal of ethnopharmacology. 2013 Dec; 150(3):953-9. doi: 10.1016/j.jep.2013.09.052. [PMID: 24120516]
  • Jang-Gi Choi, Ok-Hwa Kang, Hee-Sung Chae, Brice Obiang-Obounou, Young-Seob Lee, You-Chang Oh, Min-San Kim, Dong-Won Shin, Jeong-Ah Kim, Young-Ho Kim, Dong-Yeul Kwon. Antibacterial activity of Hylomecon hylomeconoides against methicillin-resistant Staphylococcus aureus. Applied biochemistry and biotechnology. 2010 Apr; 160(8):2467-74. doi: 10.1007/s12010-009-8698-5. [PMID: 19578993]
  • Enqi Wu, Sang-Hun Jung, Jianbo Chen, Young Ho Kim, Kyung Lae Park, Wonjae Lee, Jong Seong Kang. Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC. Journal of pharmaceutical and biomedical analysis. 2010 Jan; 51(1):103-6. doi: 10.1016/j.jpba.2009.08.014. [PMID: 19735990]
  • Hu-Quan Yin, Young-Ho Kim, Chang-Kiu Moon, Byung-Hoon Lee. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells. Biochemical pharmacology. 2005 Jul; 70(2):242-8. doi: 10.1016/j.bcp.2005.04.020. [PMID: 15904897]
  • Yong-Jin Lee, Hu-Quan Yin, Young-Ho Kim, Guang-Yong Li, Byung-Hoon Lee. Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. Archives of pharmacal research. 2004 Dec; 27(12):1253-7. doi: 10.1007/bf02975890. [PMID: 15646800]
  • J J Chen, Y L Chang, C M Teng, W Y Lin, Y C Chen, I S Chen. A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi. Planta medica. 2001 Jul; 67(5):423-7. doi: 10.1055/s-2001-15820. [PMID: 11488455]