Calycanthine (BioDeep_00000230009)

Main id: BioDeep_00000003982

 

PANOMIX_OTCML-2023 Toxin


代谢物信息卡片


(1S,2R,10S,11R)-21,24-dimethyl-3,12,21,24-tetraazahexacyclo[9.7.3.3(2,10).0(1,10).0(4,9).0(13,18)]tetracosa-4,6,8,13,15,17-hexaene

化学式: C22H26N4 (346.2157356)
中文名称: 腊梅碱
谱图信息: 最多检出来源 Viridiplantae(plant) 40%

分子结构信息

SMILES: CN1CCC23C4NC5=C(C=CC=C5)C2(CCN4C)C1NC1=C3C=CC=C1
InChI: InChI=1S/C22H26N4/c1-25-13-11-22-16-8-4-5-9-17(16)23-19(25)21(22)12-14-26(2)20(22)24-18-10-6-3-7-15(18)21/h3-10,19-20,23-24H,11-14H2,1-2H3

描述信息

Calycanthine is the principal alkaloid of the plant family Calycanthaceae. It is a calycanthaceous alkaloid, an aminal and an organonitrogen heterocyclic compound. It derives from a hydride of a calycanine.
Calycanthine is a natural product found in Chimonanthus praecox, Idiospermum australiense, and other organisms with data available.
The principal alkaloid of the plant family Calycanthaceae.
Annotation level-1
Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus Psychotria, and is a central nervous system toxin, causing convulsions[1][2].
Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus Psychotria, and is a central nervous system toxin, causing convulsions[1][2].

同义名列表

12 个代谢物同义名

(1S,2R,10S,11R)-21,24-dimethyl-3,12,21,24-tetraazahexacyclo[9.7.3.3(2,10).0(1,10).0(4,9).0(13,18)]tetracosa-4,6,8,13,15,17-hexaene; (1S,2R,10S,11R)-21,24-dimethyl-3,12,21,24-tetrazahexacyclo[9.7.3.32,10.01,10.04,9.013,18]tetracosa-4,6,8,13,15,17-hexaene; 5,10B:11,4B-BIS(IMINOETHANO)DIBENZO(C,H)(2,6)NAPHTHYRIDINE, 5,6,11,12-TETRAHYDRO-13,18-DIMETHYL-, (4BS,5R,10BS,11R)-; (4BS,5R,10BS,11R)-5,6,11,12-TETRAHYDRO-13,18-DIMETHYL-5,10B:11,4B-BIS(IMINOETHANO)-DIBENZO(C,H)(2,6)NAPHTHYRIDINE; (4bS,5R,10bS,11R)-13,18-dimethyl-5,6,11,12-tetrahydro-5,10b:11,4b-di(epiminoethano)dibenzo[c,h]-2,6-naphthyridine; CALYCANTHINE [MI]; Prestwick3_000595; UNII-F62N8QPR7V; D-CALYCANTHINE; BPBio1_000518; Calycanthine; F62N8QPR7V



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shaojun Zheng, Yongdong Gu, Longbo Li, Rui Zhu, Xingwei Cai, Hongjin Bai, Jiwen Zhang. Synthesis and fungicidal activity of tryptophan analogues - the unexpected calycanthaceous alkaloid derivatives. Natural product research. 2017 May; 31(10):1142-1149. doi: 10.1080/14786419.2016.1230117. [PMID: 27653454]
  • R W Numan, S S Ackermann, J S Shelgren. Wintersweet (Chimonanthus praecox) toxicity in four goats. New Zealand veterinary journal. 2016 May; 64(3):179-81. doi: 10.1080/00480169.2015.1111779. [PMID: 26503546]
  • Ming Ding, Kangjiang Liang, Rui Pan, Hongbin Zhang, Chengfeng Xia. Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (-)-Calycanthine. The Journal of organic chemistry. 2015 Oct; 80(20):10309-16. doi: 10.1021/acs.joc.5b01907. [PMID: 26402317]
  • Ji-Wen Zhang, Jin-Ming Gao, Tian Xu, Xing-Chang Zhang, Ya-Tuan Ma, Suwatchai Jarussophon, Yasuo Konishi. Antifungal activity of alkaloids from the seeds of Chimonanthus praecox. Chemistry & biodiversity. 2009 Jun; 6(6):838-45. doi: 10.1002/cbdv.200800089. [PMID: 19551726]
  • Virginia Claudia da Silva, Mário Geraldo de Carvalho, Aline Nogueira Alves. Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). Journal of natural medicines. 2008 Jul; 62(3):356-7. doi: 10.1007/s11418-008-0227-2. [PMID: 18404310]
  • R K Kuke, R D Allan, G A Johnston, K N Mewett, A D Mitrovic, C C Duke, T W Hambley. Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense. Journal of natural products. 1995 Aug; 58(8):1200-8. doi: 10.1021/np50122a007. [PMID: 7595588]