Brevilin A (BioDeep_00000230008)

   

PANOMIX_OTCML-2023


代谢物信息卡片


2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno(6,5-b)furan-4-yl ester, (2Z)-

化学式: C20H26O5 (346.17801460000004)
中文名称: 短叶老鹤草素 A, 短叶老鹳草素 A, 短叶老鹳草素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C(/C)C(=O)O[C@H]1[C@@H]2[C@H](C)C(=O)O[C@@H]2C[C@@H](C)[C@@H]2C=CC(=O)[C@@]12C
InChI: InChI=1S/C20H26O5/c1-6-10(2)18(22)25-17-16-12(4)19(23)24-14(16)9-11(3)13-7-8-15(21)20(13,17)5/h6-8,11-14,16-17H,9H2,1-5H3/b10-6-/t11-,12+,13+,14-,16-,17+,20+/m1/s1

描述信息

Brevilin A is a natural product found in Arnica longifolia with data available.
See also: Centipeda minima flowering top (part of).
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC50=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy[1][2].
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC50=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy[1][2].

同义名列表

11 个代谢物同义名

2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno(6,5-b)furan-4-yl ester, (2Z)-; 2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)-; (3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno(6,5-b)furan-4-yl (2Z)-2-methyl-2-butenoate; [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate; (3S,3AR,4S,4AR,7AR,8R,9AR)-3,4A,8-TRIMETHYL-2,5-DIOXO-3H,3AH,4H,7AH,8H,9H,9AH-AZULENO[6,5-B]FURAN-4-YL (2Z)-2-METHYLBUT-2-ENOATE; AMBROS-2-EN-12-OIC ACID, 6.ALPHA.,8.BETA.-DIHYDROXY-4-OXO-, 12,8-LACTONE, 2-METHYLCROTONATE, (Z)-; Ambros-2-en-12-oic acid, 6alpha,8beta-dihydroxy-4-oxo-, 12,8-lactone, 2-methylcrotonate, (Z)-; 6-O-angeloylplenolin; 6-O-angeloylprenolin; Brevilin A; Brevelin A



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jian Yang, Xue Wang, Tao Hu, He Huang, Gang Chen, Bo Jin, Guilin Zeng, Jian Liu. Entero-toxigenic Bacteroides fragilis contributes to intestinal barrier injury and colorectal cancer progression by mediating the BFT/STAT3/ZEB2 pathway. Cell cycle (Georgetown, Tex.). 2024 Jan; ?(?):1-13. doi: 10.1080/15384101.2024.2309005. [PMID: 38273425]
  • Jinfu Wei, Zihong Lin, Zeyu Dai, Zibin Zhou, Yonghao Bi, Ruiwu Zheng, Xianghua Hu, Zhaoxin Xu, Guixin Yuan, Weidong Wang. Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption. In vitro cellular & developmental biology. Animal. 2023 Jun; 59(6):420-430. doi: 10.1007/s11626-023-00783-1. [PMID: 37460875]
  • Meiqi Liu, Xiaoran Zhao, Zicheng Ma, Ziying Qiu, Lili Sun, Meng Wang, Xiaoliang Ren, Yanru Deng. Discovery of potential Q-marker of traditional Chinese medicine based on chemical profiling, chemometrics, network pharmacology, and molecular docking: Centipeda minima as an example. Phytochemical analysis : PCA. 2022 Dec; 33(8):1225-1234. doi: 10.1002/pca.3173. [PMID: 36117130]
  • Qin Qin, Guang Xu, Xiaoyan Zhan, Zhilei Wang, Yan Wang, Hongbin Liu, Xiaorong Hou, Wei Shi, Jianli Ma, Zhaofang Bai, Xiaohe Xiao. Brevilin A inhibits NLRP3 inflammasome activation in vivo and in vitro by acting on the upstream of NLRP3-induced ASC oligomerization. Molecular immunology. 2021 07; 135(?):116-126. doi: 10.1016/j.molimm.2021.03.025. [PMID: 33892379]
  • Peng-Hui Xue, Nan Zhang, Da Liu, Qing-Ran Zhang, Jing-Shi Duan, Ya-Qin Yu, Jin-Yan Li, Shi-Jie Cao, Feng Zhao, Ning Kang, Feng Qiu. Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima. Journal of natural products. 2021 02; 84(2):247-258. doi: 10.1021/acs.jnatprod.0c00884. [PMID: 33533247]
  • Ji Hoon Kim, Eun Ju Jung, Yun Jung Lee, En Mei Gao, Ahmed Shah Syed, Chul Young Kim. Bioassay-Guided Separation of Centipeda minima Using Comprehensive Linear Gradient Centrifugal Partition Chromatography. Molecules (Basel, Switzerland). 2020 Jul; 25(13):. doi: 10.3390/molecules25133077. [PMID: 32640706]
  • Tao Su, Ya-Ping Wang, Xin-Ning Wang, Chun-Yu Li, Pei-Li Zhu, Yu-Mei Huang, Zhi-Ye Yang, Si-Bao Chen, Zhi-Ling Yu. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of brevilin A. Life sciences. 2020 Jan; 241(?):117169. doi: 10.1016/j.lfs.2019.117169. [PMID: 31843524]
  • Xiaoli Zhang, Yiping Xia, Li Yang, Jun He, Yaolan Li, Chuan Xia. Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo. Viruses. 2019 09; 11(9):. doi: 10.3390/v11090835. [PMID: 31500389]
  • Pengtao You, Hezhen Wu, Meng Deng, Jingling Peng, Fangping Li, Yanfang Yang. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Feb; 98(?):619-625. doi: 10.1016/j.biopha.2017.12.057. [PMID: 29289836]