L-CBN (BioDeep_00000229997)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H21NO4 (339.14705060000006)
中文名称: 克班宁, 克班宁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC(C2=C3C4=CC=C(OC)C(OC)=C4C[C@@]12[H])=CC5=C3OCO5
InChI: InChI=1S/C20H21NO4/c1-21-7-6-11-8-16-20(25-10-24-16)18-12-4-5-15(22-2)19(23-3)13(12)9-14(21)17(11)18/h4-5,8,14H,6-7,9-10H2,1-3H3
描述信息
Crebanine is a natural product found in Stephania abyssinica, Stephania cephalantha, and Stephania hainanensis with data available.
Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].
Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].
Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].
同义名列表
12 个代谢物同义名
(12R)-15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6.0^{8,20.0^{14,19]icosa-1(20),2(6),7,14(19),15,17-hexaene; (12R)-15,16-Dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene; 15,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene; 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (R)-; 9,10-Dimethoxy-7-methyl-6,7,7a,8-tetrahydro-2H,5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline; Aporphine, 8,9-dimethoxy-1,2-(methylenedioxy)-; 8,9-Dimethoxy-1,2-(methylenedioxy)aporphine; 1,2-methylenedioxy-8,9-dimethoxyaporphine; L-crebanine; Crebanine; Crebanin; L-CBN
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 33090 地不容: -
- 301693 Annona squamosa: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanqiu Yang, Tingyu Hao, Xiaohu Yao, Yue Che, Yueyang Liu, Mingxia Fang, Yingjie Wang, Di Zhou, Huifang Chai, Ning Li, Yue Hou. Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Aug; 120(?):155044. doi:
10.1016/j.phymed.2023.155044. [PMID: 37634486] - Phuong Mai Le, Vandana Srivastava, Thanh Tam Nguyen, Bruno Pradines, Marylin Madamet, Joel Mosnier, Thi Thuy Trinh, Hoyun Lee. Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit.
Phytotherapy research : PTR.
2017 Sep; 31(9):1357-1368. doi:
10.1002/ptr.5861. [PMID: 28703314] - Hui Wang, Xin Cheng, Shujun Kong, Zixian Yang, Hongmei Wang, Qiuyan Huang, Jingyu Li, Cheng Chen, Yunshu Ma. Synthesis and Structure-Activity Relationships of a Series of Aporphine Derivatives with Antiarrhythmic Activities and Acute Toxicity.
Molecules (Basel, Switzerland).
2016 Nov; 21(12):. doi:
10.3390/molecules21121555. [PMID: 27916812] - He Xiao-Shan, Lin Qing, Ma Yun-Shu, Yu Ze-Pu. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes.
Chinese journal of natural medicines.
2014 Jan; 12(1):20-3. doi:
10.1016/s1875-5364(14)60004-2. [PMID: 24484592] - Hongjing Dong, Yongqing Zhang, Lei Fang, Wenjuan Duan, Xiao Wang, Luqi Huang. Combinative application of pH-zone-refining and conventional high-speed counter-current chromatography for preparative separation of alkaloids from Stephania kwangsiensis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Apr; 879(13-14):945-9. doi:
10.1016/j.jchromb.2011.02.051. [PMID: 21450539] - Yun-Shu Ma, Qing-Jie Shang, Yi-Cen Bai, Xiao-Fei Meng, Shao-Jian Kang. [Study on pharmacokinetics of crebanine injection in rabbits].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Apr; 32(7):630-2. doi:
NULL. [PMID: 17583209] - Yi-Nan Zhang, Xiang-Gen Zhong, Zong-Ping Zheng, Xu-Dong Hu, Jian-Ping Zuo, Li-Hong Hu. Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
Bioorganic & medicinal chemistry.
2007 Jan; 15(2):988-96. doi:
10.1016/j.bmc.2006.10.034. [PMID: 17081761] - J Huang, J Guo, G Duan. [Determination of 7 bio-active alkaloids in Stephania plants by RP-HPLC].
Yao xue xue bao = Acta pharmaceutica Sinica.
1998 Jul; 33(7):528-33. doi:
. [PMID: 12016887]