Licochalcone_A (BioDeep_00000229993)
Secondary id: BioDeep_00000018194, BioDeep_00000603123
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
2-PROPEN-1-ONE, 3-(5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-, (2E)-
化学式: C21H22O4 (338.1518012)
中文名称: 甘草查而酮 A, 甘草查耳酮甲, 甘草查尔酮A, 甘草查而酮
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 12.68%
分子结构信息
SMILES: C1(OC)=CC(O)=C(C(C)(C)C=C)C=C1/C=C/C(=O)C1C=CC(O)=CC=1
InChI: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
描述信息
Licochalcone A is a member of chalcones.
Licochalcone a is a natural product found in Euphorbia helioscopia, Pogostemon cablin, and other organisms with data available.
Licochalcone A is a derivative of the phenol chalconoid, found in and extracted from the roots of Glycyrrhiza species G. glabra and inflata, with potential anti-inflammatory, antibacterial, and anticancer activities. Upon administration, licochalcone A inhibits the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway and inhibits the activity of c-Jun N-terminal kinase 1 (JNK-1), a member of the mitogen-activated protein kinase (MAPK) family that plays a role in the MAPK-mediated signaling pathway. Inhibition of the PI3K/Akt/mTOR- and MAPK-signaling pathways induces cell cycle arrest and apoptosis, decreases migration and invasion of cancer cells, and inhibits tumor cell proliferation. Licochalcone A also prevents the production of reactive oxygen species (ROS), and reduces oxidative stress through the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway.
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
同义名列表
26 个代谢物同义名
2-PROPEN-1-ONE, 3-(5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-, (2E)-; 2-Propen-1-one, 3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (E)-; 2-Propen-1-one,3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-; (2E)-3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one; 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)- (E)-; (2E)-3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one; E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one; (E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-[5-(1,1-dimethylallyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one; 3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-[5-(1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone; 3-[5-((E)-1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone; Chalcone base + 2O, 1MeO, 1Prenyl or Licochalcone A (Not validated); 3-dimethylallyl-4,4-dihydroxy-6-methoxychalcone; Licochalcone A, >=96.0\\% (HPLC); KAZSKMJFUPEHHW-DHZHZOJOSA-N; LICOCHALCONE A [WHO-DD]; LICOCHALCONE A [MI]; LICOAGROCHACONE A; Licochalcone a; Licochalcone-A; LicochalconeA; Licochalcone; HSCI1_000078
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:174541
- ChEBI: CHEBI:125689
- PubChem: 5318998
- ChEMBL: CHEMBL139702
- Wikipedia: Licochalcone_A
- LipidMAPS: LMPK12120424
- MeSH: licochalcone A
- ChemIDplus: 0058749227
- chemspider: 4477422
- CAS: 58749-22-7
- CAS: 87080-27-1
- medchemexpress: HY-N0372
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 33090 - 甘草: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Chen, Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Fei Cai, Xiaoming Gong, Ruyi Zhang. Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of alzheimer's with diabetes.
Hereditas.
2024 Jan; 161(1):2. doi:
10.1186/s41065-023-00301-z. [PMID: 38167125] - Yu-Ting Chuang, Yu-Li Lin, Jing-Yi Lin. Licochalcone A regulates viral IRES activity to inhibit enterovirus replication.
Antiviral research.
2024 Jan; 221(?):105755. doi:
10.1016/j.antiviral.2023.105755. [PMID: 37984566] - Ganxiao Chen, Shunxiang Luo, Hongdou Guo, Jiayi Lin, Shanghua Xu. Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Dec; ?(?):. doi:
10.1007/s00210-023-02863-1. [PMID: 38078919] - Xiaoling Ma, Ningxin Jiang, Jingxian Fu, Yuping Li, Lijun Zhou, Ling Yuan, Ying Wang, Yongqing Li. A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata.
Journal of plant physiology.
2023 Nov; 292(?):154145. doi:
10.1016/j.jplph.2023.154145. [PMID: 38091890] - Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study.
European journal of pharmacology.
2023 Nov; 958(?):176080. doi:
10.1016/j.ejphar.2023.176080. [PMID: 37758012] - Jian-Hong Lin, Kun-Ta Yang, Pei-Ching Ting, Wen-Sen Lee, Ding-Jyun Lin, Jui-Chih Chang. Licochalcone a improves cardiac functions after ischemia-reperfusion via reduction of ferroptosis in rats.
European journal of pharmacology.
2023 Oct; 957(?):176031. doi:
10.1016/j.ejphar.2023.176031. [PMID: 37660967] - Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camins. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment.
International journal of molecular sciences.
2023 Sep; 24(18):. doi:
10.3390/ijms241814177. [PMID: 37762479] - Yajun Wang, Yanwu Li, Chunhui Song, Junyu Ke, Yanqiu Zheng, Gang Chen, Ning Li. Licochalcone A promotes renewal of intestinal mucosa through modulating uc.173.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):117044. doi:
10.1016/j.jep.2023.117044. [PMID: 37586439] - Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli.
Biochemical and biophysical research communications.
2023 08; 668(?):90-95. doi:
10.1016/j.bbrc.2023.05.083. [PMID: 37245294] - Zhongyuan Li, Baohong Li, Zinuo Chen, Jinke Xu, Asma El Sabbagh, Yangang Zhao, Ruikun Du, Lijun Rong, Jingzhen Tian, Qinghua Cui. Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage.
Journal of medical virology.
2023 08; 95(8):e29059. doi:
10.1002/jmv.29059. [PMID: 37635463] - Xu Lian, Kaidi Fan, Xuemei Qin, Yuetao Liu. Amalgamated Pharmacoinformatics Study to Investigate the Mechanism of Xiao Jianzhong Tang against Chronic Atrophic Gastritis.
Current computer-aided drug design.
2023 Jul; ?(?):. doi:
10.2174/1573409919666230720141115. [PMID: 37475552] - Qianru Zhao, Xu Zhang, Siru Long, Shaobing Wang, Hui Yu, Yongsheng Zhou, Yi Li, Lu Xue, Yan Hu, Shijin Yin. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel.
Molecular pharmacology.
2023 Jul; ?(?):. doi:
10.1124/molpharm.122.000658. [PMID: 37419692] - Ci-Qin Li, Jin-Hui Shi, Jie Mu, An-Qi Wang, Li-Wei Zou, Guang-Bo Ge. Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects.
Journal of natural products.
2023 Jun; ?(?):. doi:
10.1021/acs.jnatprod.3c00355. [PMID: 37337963] - Jiangyi Zeng, Yun Huang, Lijun Zhou, Xiaoju Liang, Chao Yang, Hongxia Wang, Ling Yuan, Ying Wang, Yongqing Li. Histone Deacetylase GiSRT2 Negatively Regulates Flavonoid Biosynthesis in Glycyrrhiza inflata.
Cells.
2023 May; 12(11):. doi:
10.3390/cells12111501. [PMID: 37296622] - Lei Ye, Ming Su, Xinyi Qiao, Shaowei Wang, Ke Zheng, Yang Zhu, Huitao Li, Yiyan Wang, Ren-Shan Ge. Chalcone derivatives from licorice inhibit human and rat gonadal 3β-hydroxysteroid dehydrogenases as therapeutic uses.
Journal of ethnopharmacology.
2023 May; ?(?):116690. doi:
10.1016/j.jep.2023.116690. [PMID: 37245711] - Harsharan Singh Bhatia, Matthias Apweiler, Lu Sun, Julian Baron, Ashwini Tirkey, Bernd L Fiebich. Licochalcone A Inhibits Prostaglandin E2 by Targeting the MAPK Pathway in LPS Activated Primary Microglia.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041927. [PMID: 36838914] - Min Cai, You-Cai Xu, Bo Deng, Jun-Bang Chen, Ting-Fang Chen, Ke-Feng Zeng, Si Chen, Sui-Hui Deng, Zhang-Bin Tan, Wen-Jun Ding, Shuang-Wei Zhang, Bin Liu, Jing-Zhi Zhang. Radix Glycyrrhizae extract and licochalcone a exert an anti-inflammatory action by direct suppression of toll like receptor 4.
Journal of ethnopharmacology.
2023 Feb; 302(Pt A):115869. doi:
10.1016/j.jep.2022.115869. [PMID: 36309116] - Aaron Boakye, Edward Ntim Gasu, Jehoshaphat Oppong Mensah, Lawrence Sheringham Borquaye. Computational studies on potential small molecule inhibitors of Leishmania pteridine reductase 1.
Journal of biomolecular structure & dynamics.
2023 Jan; ?(?):1-14. doi:
10.1080/07391102.2023.2166119. [PMID: 36632757] - Shuai Lu, Xibo Sun, Zhongbao Zhou, Huazhen Tang, Ruixue Xiao, Qingchen Lv, Bing Wang, Jinxiu Qu, Jinxuan Yu, Fang Sun, Zhuoya Deng, Yuying Tian, Cong Li, Zhenpeng Yang, Penghui Yang, Benqiang Rao. Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation.
Frontiers in immunology.
2023; 14(?):1235575. doi:
10.3389/fimmu.2023.1235575. [PMID: 37799727] - Jin-Xin Zhang, Yan Xiao, Yi-Quan Li, Yi-Long Zhu, Ya-Ru Li, Ren-Shuang Zhao, Ning-Yi Jin, Jin-Bo Fang, Xiao Li, Ji-Cheng Han. Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway.
Integrative cancer therapies.
2023 Jan; 22(?):15347354231210867. doi:
10.1177/15347354231210867. [PMID: 37965730] - Chanidapa Wongtada, Putthamas Pewlong, Pravit Asawanonda, Nopadon Noppakun, Pornkanok Pongpamorn, Atchara Paemanee, Supaart Sirikantaramas, Chanat Kumtornrut. Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants.
Journal of cosmetic dermatology.
2022 Dec; 21(12):7081-7089. doi:
10.1111/jocd.15381. [PMID: 36102580] - Wenfeng Wu, Zhuxian Wang, Yufan Wu, Huiyi Wu, Tingting Chen, Yaqi Xue, Yuan Wang, Cuiping Jiang, Chunyan Shen, Li Liu, Hongxia Zhu, Qiang Liu. Mechanisms of Penetration Enhancement and Transport Utilizing Skin Keratine Liposomes for the Topical Delivery of Licochalcone A.
Molecules (Basel, Switzerland).
2022 Apr; 27(8):. doi:
10.3390/molecules27082504. [PMID: 35458701] - Ruth N Muchiri, James Kibitel, Margaret A Redick, Richard B van Breemen. Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein.
Journal of the American Society for Mass Spectrometry.
2022 Jan; 33(1):181-188. doi:
10.1021/jasms.1c00318. [PMID: 34939787] - Jing Liu, Zhongan Zhu, Yuhang Yang, Michael Adu-Frimpong, Lin Chen, Hao Ji, Elmurat Toreniyazov, Qilong Wang, Jiangnan Yu, Ximing Xu. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A-loaded liposomes.
Journal of food biochemistry.
2022 01; 46(1):e14007. doi:
10.1111/jfbc.14007. [PMID: 34811762] - Jin Shu, Xu Cui, Xin Liu, Wenxing Yu, Weisong Zhang, Xiaojing Huo, Chao Lu. Licochalcone A inhibits IgE-mediated allergic reaction through PLC/ERK/STAT3 pathway.
International journal of immunopathology and pharmacology.
2022 Jan; 36(?):3946320221135462. doi:
10.1177/03946320221135462. [PMID: 36263976] - Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.
Pharmaceutical biology.
2021 Dec; 59(1):1594-1606. doi:
10.1080/13880209.2021.1999275. [PMID: 34808067] - Zhuxian Wang, Yaqi Xue, Tingting Chen, Qunqun Du, Zhaoming Zhu, Yuan Wang, Yufang Wu, Quanfu Zeng, Chunyan Shen, Cuiping Jiang, Zhijun Yang, Hongxia Zhu, Li Liu, Qiang Liu. Glycyrrhiza acid micelles loaded with licochalcone A for topical delivery: Co-penetration and anti-melanogenic effect.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Dec; 167(?):106029. doi:
10.1016/j.ejps.2021.106029. [PMID: 34601069] - Zhonghua Luo, Tao Li, Qingqing Gao, Yu Chen, Guangyue Su, Yuqing Zhao. Impact of licochalcone A on the progression of diabetic nephropathy in type 2 diabetes mellitus of C57BL/6 mice.
Food & function.
2021 Nov; 12(21):10676-10689. doi:
10.1039/d1fo01630j. [PMID: 34605512] - Yiming Cao, En Lei, Xiaolong Wang, Xiangyun Qi, Lei Li, Jin Ren, Jing Yang, Shengqi Wang. Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo.
Antiviral research.
2021 11; 195(?):105091. doi:
10.1016/j.antiviral.2021.105091. [PMID: 34044060] - Zhuoyin Xue, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Jue Wang, Huiling Jing, Nan Wang. Licochalcone A inhibits MAS-related GPR family member X2-induced pseudo-allergic reaction by suppressing nuclear migration of nuclear factor-κB.
Phytotherapy research : PTR.
2021 Nov; 35(11):6270-6280. doi:
10.1002/ptr.7272. [PMID: 34486187] - Hua Bai, Min Zhou, He Zhou, Qiaoyan Han, Han Xu, Peipei Xu, Bing Chen. Licochalcone A suppresses Sp1 expression with potential anti-myeloma activity.
Cancer communications (London, England).
2021 11; 41(11):1239-1242. doi:
10.1002/cac2.12223. [PMID: 34665930] - Lívia Mara Silva, Danielle Gomes Marconato, Marcos Paulo Nascimento da Silva, Nádia Rezende Barbosa Raposo, Gabriela de Faria Silva Facchini, Gilson Costa Macedo, Fernanda de Sá Teixeira, Maria Cecília Barbosa da Silveira Salvadori, Priscila de Faria Pinto, Josué de Moraes, Frederico Pittella, Ademar Alves Da Silva Filho. Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity in vitro and in vivo.
Nanomedicine (London, England).
2021 08; 16(19):1641-1655. doi:
10.2217/nnm-2021-0146. [PMID: 34256609] - Juan Zhang, Li Cao, Yu Sun, De-Gang Qing, Xiao-Qin Xu, Jun-Chi Wang, Jian-Yong Si, Ning Li. The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Microbiota in Murine Colitis.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144149. [PMID: 34299424] - Fei Zeng, Wenxing Wu, Yiying Zhang, Xin Pan, Jinao Duan. Rapid screening of lipase inhibitors in licorice extract by using porcine pancreatic lipase immobilized on Fe3O4 magnetic nanoparticles.
Food & function.
2021 Jun; 12(12):5650-5657. doi:
10.1039/d0fo03352a. [PMID: 34018495] - Xueshuang Liu, Yue Xing, Mingyue Li, Zhihong Zhang, Jingying Wang, MyongHak Ri, Chenghua Jin, Guanghua Xu, Lianxun Piao, Honglan Jin, Hongxiang Zuo, Juan Ma, Xuejun Jin. Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways.
Journal of ethnopharmacology.
2021 Jun; 273(?):113989. doi:
10.1016/j.jep.2021.113989. [PMID: 33677006] - Zhonghua Luo, Chaofan Fu, Tao Li, Qingqing Gao, Dongyu Miao, Jing Xu, Yuqing Zhao. Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study.
Journal of agricultural and food chemistry.
2021 Mar; 69(8):2444-2456. doi:
10.1021/acs.jafc.0c07630. [PMID: 33605141] - Zijian Yan, Weihui Qi, Jingdi Zhan, Zeng Lin, Jian Lin, Xinghe Xue, Xiaoyun Pan, Yulong Zhou. Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation.
Journal of cellular and molecular medicine.
2020 11; 24(22):13046-13057. doi:
10.1111/jcmm.15905. [PMID: 32965793] - Xiaoqing Fan, Jie Bai, Minwan Hu, Yanxia Xu, Shengyu Zhao, Yanhong Sun, Baolian Wang, Jinping Hu, Yan Li. Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects.
Toxicology.
2020 05; 437(?):152445. doi:
10.1016/j.tox.2020.152445. [PMID: 32259555] - Chao Zhao, Dun Wang, Zexuan Gao, Hongfeng Kan, Feng Qiu, Lixia Chen, Hua Li. Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A.
Chemico-biological interactions.
2020 Jan; 316(?):108913. doi:
10.1016/j.cbi.2019.108913. [PMID: 31838052] - Yang-Liu Xia, Tong-Yi Dou, Xia Lv, Guang-Bo Ge. In vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Jun; 49(6):671-677. doi:
10.1080/00498254.2018.1495345. [PMID: 30044687] - Chian-Jiun Liou, Yau-Ker Lee, Nai-Chun Ting, Ya-Ling Chen, Szu-Chuan Shen, Shu-Ju Wu, Wen-Chung Huang. Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet.
Cells.
2019 05; 8(5):. doi:
10.3390/cells8050447. [PMID: 31083505] - Ying-Ju Lin, Wen-Miin Liang, Chao-Jung Chen, Hsinyi Tsang, Jian-Shiun Chiou, Xiang Liu, Chi-Fung Cheng, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Jianxin Chen, Fuu-Jen Tsai, Te-Mao Li. Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 May; 58(?):152893. doi:
10.1016/j.phymed.2019.152893. [PMID: 30901663] - Zhonghua Luo, Zhenghong Guo, Ting Xiao, Hairong Liu, Guangyue Su, Yuqing Zhao. Enrichment of total flavones and licochalcone A from licorice residues and its hypoglycemic activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 May; 1114-1115(?):134-145. doi:
10.1016/j.jchromb.2019.01.026. [PMID: 30878379] - Waranya Boonchai, Supenya Varothai, Waranaree Winayanuwattikun, Sutasinee Phaitoonvatanakij, Pichanee Chaweekulrat, Pranee Kasemsarn. Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02\% triamcinolone acetonide cream in facial dermatitis.
Journal of cosmetic dermatology.
2018 Dec; 17(6):1130-1135. doi:
10.1111/jocd.12499. [PMID: 29411520] - Jun Wang, Ying-Shuo Zhang, Kiran Thakur, Sayed Sajid Hussain, Jian-Guo Zhang, Gui-Ran Xiao, Zhao-Jun Wei. Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Oct; 120(?):407-417. doi:
10.1016/j.fct.2018.07.044. [PMID: 30055311] - Hye Eun Lee, Gabsik Yang, Sin-Hee Han, Jeong-Hoon Lee, Tae-Jin An, Jae-Ki Jang, Joo Young Lee. Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning.
Biochemical and biophysical research communications.
2018 09; 503(3):2117-2123. doi:
10.1016/j.bbrc.2018.07.168. [PMID: 30093114] - Hong Xin, Wei Xu. [Effect of licochalcone A on autophagy in renal cell carcinoma via PI3K/Akt/mTOR signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Sep; 43(17):3545-3552. doi:
10.19540/j.cnki.cjcmm.20180427.001. [PMID: 30347925] - Svetlana S Efimova, Anastasiia A Zakharova, Roman Ya Medvedev, Olga S Ostroumova. Ion Channels Induced by Antimicrobial Agents in Model Lipid Membranes are Modulated by Plant Polyphenols Through Surrounding Lipid Media.
The Journal of membrane biology.
2018 08; 251(4):551-562. doi:
10.1007/s00232-018-0031-1. [PMID: 29549386] - Hongfei Si, Chunyan Xu, Jili Zhang, Xukun Zhang, Bing Li, Xuzheng Zhou, Jiyu Zhang. Licochalcone A: An effective and low-toxicity compound against Toxoplasma gondii in vitro and in vivo.
International journal for parasitology. Drugs and drug resistance.
2018 08; 8(2):238-245. doi:
10.1016/j.ijpddr.2018.02.006. [PMID: 29684680] - Dongyu Liu, Xiaowei Huo, Li Gao, Juan Zhang, Hui Ni, Li Cao. NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):922-929. doi:
10.1016/j.biopha.2018.03.130. [PMID: 29710547] - Jian Wu, Xingxing Zhang, Yaohui Wang, Qingmin Sun, Min Chen, Shenlin Liu, Xi Zou. Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
Oncology reports.
2018 Mar; 39(3):1181-1190. doi:
10.3892/or.2017.6155. [PMID: 29286170] - Xiaohui Su, Ting Li, Zhongqiu Liu, Qingchun Huang, Kangsheng Liao, Rutong Ren, Linlin Lu, Xiaoxiao Qi, Maojie Wang, Jianyu Chen, Hua Zhou, Elaine Lai-Han Leung, Hudan Pan, Juan Liu, Hui Wang, Lufen Huang, Liang Liu. Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.
Free radical biology & medicine.
2018 02; 115(?):471-483. doi:
10.1016/j.freeradbiomed.2017.12.004. [PMID: 29233793] - Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds.
Bioorganic & medicinal chemistry.
2018 01; 26(1):278-284. doi:
10.1016/j.bmc.2017.11.046. [PMID: 29224994] - Bruna Aline Michelotto Cantelli, Tamires Aparecida Bitencourt, Tatiana Takahasi Komoto, Rene Oliveira Beleboni, Mozart Marins, Ana Lúcia Fachin. Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):1389-1394. doi:
10.1016/j.biopha.2017.11.051. [PMID: 29174577] - Ritieres Lovo Souza, Ubirajara Oliveira Gonçalves, Fernanda Rafacho Badoco, Lucas de Souza Galvão, Raquel Alves Dos Santos, Paulo Henrique Dias de Carvalho, Lara Soares Aleixo de Carvalho, Ademar Alves da Silva Filho, Rodrigo Cássio Sola Veneziani, Vanderlei Rodrigues, Sérgio Ricardo Ambrósio, Lizandra Guidi Magalhães. Licochalcone A induces morphological and biochemical alterations in Schistosoma mansoni adult worms.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):64-71. doi:
10.1016/j.biopha.2017.09.128. [PMID: 28965009] - Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice.
Bioorganic & medicinal chemistry.
2017 10; 25(20):5522-5530. doi:
10.1016/j.bmc.2017.08.018. [PMID: 28835349] - Charlotte Simmler, David C Lankin, Dejan Nikolić, Richard B van Breemen, Guido F Pauli. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A.
Fitoterapia.
2017 Sep; 121(?):6-15. doi:
10.1016/j.fitote.2017.06.017. [PMID: 28647482] - Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
Bioorganic & medicinal chemistry.
2017 07; 25(14):3706-3713. doi:
10.1016/j.bmc.2017.05.009. [PMID: 28522265] - Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
Journal of natural products.
2017 02; 80(2):334-346. doi:
10.1021/acs.jnatprod.6b00783. [PMID: 28140583] - Xiangrong Chen, Zuojia Liu, Rizeng Meng, Ce Shi, Na Guo. Antioxidative and anticancer properties of Licochalcone A from licorice.
Journal of ethnopharmacology.
2017 Feb; 198(?):331-337. doi:
10.1016/j.jep.2017.01.028. [PMID: 28111219] - Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu. Role of licochalcone A in VEGF-induced proliferation of human airway smooth muscle cells: implications for asthma.
Growth factors (Chur, Switzerland).
2017 02; 35(1):39-47. doi:
10.1080/08977194.2017.1338694. [PMID: 28635361] - Xu Fu, Zhihua Wang, Lixin Li, Shishang Dong, Zhucui Li, Zhenzuo Jiang, Yuefei Wang, Wenqing Shui. Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches.
Scientific reports.
2016 07; 6(?):29680. doi:
10.1038/srep29680. [PMID: 27403722] - Jun Hu, Jun Liu. Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation.
Inflammation.
2016 Apr; 39(2):569-74. doi:
10.1007/s10753-015-0281-3. [PMID: 26552405] - A M Schoelermann, T M Weber, C Arrowitz, R L Rizer, K Qian, M Babcock. Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2016 Feb; 30 Suppl 1(?):21-7. doi:
10.1111/jdv.13531. [PMID: 26805419] - Atieh Hajirahimkhan, Charlotte Simmler, Huali Dong, Daniel D Lantvit, Guannan Li, Shao-Nong Chen, Dejan Nikolić, Guido F Pauli, Richard B van Breemen, Birgit M Dietz, Judy L Bolton. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.
Chemical research in toxicology.
2015 Nov; 28(11):2130-41. doi:
10.1021/acs.chemrestox.5b00310. [PMID: 26473469] - Wei He, Jing-Jing Wu, Jing Ning, Jie Hou, Hong Xin, Yu-Qi He, Guang-Bo Ge, Wei Xu. Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Oct; 29(7):1569-76. doi:
10.1016/j.tiv.2015.06.014. [PMID: 26100226] - Tareisha L Dunlap, Shuai Wang, Charlotte Simmler, Shao-Nong Chen, Guido F Pauli, Birgit M Dietz, Judy L Bolton. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
Chemical research in toxicology.
2015 Aug; 28(8):1584-94. doi:
10.1021/acs.chemrestox.5b00157. [PMID: 26134484] - Mi-Ra Park, Su-Gwan Kim, In-A Cho, Dahye Oh, Kyeong-Rok Kang, Sook-Young Lee, Sung-Min Moon, Seung Sik Cho, Goo Yoon, Chun Sung Kim, Ji-Su Oh, Jae-Seek You, Do Kyung Kim, Yo-Seob Seo, Hee-Jeong Im, Jae-Sung Kim. Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Mar; 77(?):34-43. doi:
10.1016/j.fct.2014.12.013. [PMID: 25572524] - Atsuko Tada, Kyoko Ishizuki, Naoki Sugimoto, Kayo Yoshimatsu, Nobuo Kawahara, Takako Suematsu, Kazunori Arifuku, Toshio Fukai, Yukiyoshi Tamura, Takashi Ohtsuki, Maiko Tahara, Takeshi Yamazaki, Hiroshi Akiyama. [Determination of the Plant Origin of Licorice Oil Extract, a Natural Food Additive, by Principal Component Analysis Based on Chemical Components].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan.
2015; 56(5):217-27. doi:
10.3358/shokueishi.56.217. [PMID: 26537652] - Fengge Shen, Xudong Tang, Yang Wang, Zhiqiang Yang, Xiaochen Shi, Chao Wang, Qiaoli Zhang, Yanan An, Wei Cheng, Kunqi Jin, Mingyuan Liu, Na Guo, Lu Yu. Phenotype and expression profile analysis of Staphylococcus aureus biofilms and planktonic cells in response to licochalcone A.
Applied microbiology and biotechnology.
2015 Jan; 99(1):359-73. doi:
10.1007/s00253-014-6076-x. [PMID: 25256617] - Jochen Kühnl, Dennis Roggenkamp, Sandra A Gehrke, Franz Stäb, Horst Wenck, Ludger Kolbe, Gitta Neufang. Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo.
Experimental dermatology.
2015 Jan; 24(1):42-7. doi:
10.1111/exd.12588. [PMID: 25381913] - Jin-Seok Choi, Jun-Shik Choi, Dong-Hyun Choi. Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A.
Biopharmaceutics & drug disposition.
2014 Oct; 35(7):382-90. doi:
10.1002/bdd.1905. [PMID: 24903704] - Jung Jae Cho, Jung-Il Chae, Goo Yoon, Ka Hwi Kim, Jin Hyoung Cho, Seung-Sik Cho, Young Sik Cho, Jung-Hyun Shim. Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma.
International journal of oncology.
2014 Aug; 45(2):667-74. doi:
10.3892/ijo.2014.2461. [PMID: 24858379] - Jong-Min Park, Sang-Ho Park, Kyung-Sook Hong, Young-Min Han, Sang-Ho Jang, Eun-Hee Kim, Ki-Baik Hahm. Special licorice extracts containing lowered glycyrrhizin and enhanced licochalcone A prevented Helicobacter pylori-initiated, salt diet-promoted gastric tumorigenesis.
Helicobacter.
2014 Jun; 19(3):221-36. doi:
10.1111/hel.12121. [PMID: 24646026] - Chiung-Mei Chen, Yu-Ting Weng, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, I-Cheng Chen, Li-Ching Lee, Hsuan-Yuan Lin, Yih-Ru Wu, Yi-Chun Chen, Kuo-Hsuan Chang, Hsiang-Yu Tang, Mei-Ling Cheng, Guey-Jen Lee-Chen, Jung-Yaw Lin. Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
Free radical biology & medicine.
2014 Jun; 71(?):339-350. doi:
10.1016/j.freeradbiomed.2014.03.023. [PMID: 24675225] - Myrna Adianti, Chie Aoki, Mari Komoto, Lin Deng, Ikuo Shoji, Tutik Sri Wahyuni, Maria Inge Lusida, Soetjipto, Hiroyuki Fuchino, Nobuo Kawahara, Hak Hotta. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.
Microbiology and immunology.
2014 Mar; 58(3):180-7. doi:
10.1111/1348-0421.12127. [PMID: 24397541] - Ke Yao, Hanyong Chen, Mee-Hyun Lee, Haitao Li, Weiya Ma, Cong Peng, Nu Ry Song, Ki Won Lee, Ann M Bode, Ziming Dong, Zigang Dong. Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.
Cancer prevention research (Philadelphia, Pa.).
2014 Jan; 7(1):139-49. doi:
10.1158/1940-6207.capr-13-0117. [PMID: 24253317] - Jiangtao Jiang, Xuan Yuan, Hong Zhao, Xinyan Yan, Xiling Sun, Qiusheng Zheng. Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production.
Bio-medical materials and engineering.
2014; 24(1):1019-25. doi:
10.3233/bme-130899. [PMID: 24211992] - Sun Kyoung Lee, Kwang-Kyun Park, Jung Han Yoon Park, Soon Sung Lim, Won-Yoon Chung. The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction.
Phytotherapy research : PTR.
2013 Dec; 27(12):1776-83. doi:
10.1002/ptr.4930. [PMID: 23401151] - Hai Yan Quan, Soo Jung Kim, Do Yeon Kim, Hee Kyung Jo, Go Woon Kim, Sung Hyun Chung. Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase.
Fitoterapia.
2013 Apr; 86(?):208-16. doi:
10.1016/j.fitote.2013.03.005. [PMID: 23500383] - Imran Ahmad, Jay Prakash Thakur, Debabrata Chanda, Dharmendra Saikia, Feroz Khan, Shivani Dixit, Amit Kumar, Rituraj Konwar, Arvind Singh Negi, Atul Gupta. Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents.
Bioorganic & medicinal chemistry letters.
2013 Mar; 23(5):1322-5. doi:
10.1016/j.bmcl.2012.12.096. [PMID: 23369537] - Dorothea Schweiger, Caroline Baufeld, Philip Drescher, Bernhardt Oltrogge, Simone Höpfner, Aylin Mess, Juliane Lüttke, Frank Rippke, Alexander Filbry, Heiner Max. Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp.
Skin pharmacology and physiology.
2013; 26(2):108-18. doi:
10.1159/000348473. [PMID: 23549137] - M Feldman, D Grenier. Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages.
Journal of applied microbiology.
2012 Aug; 113(2):438-47. doi:
10.1111/j.1365-2672.2012.05329.x. [PMID: 22563853] - Hai-Yan Quan, Nam In Baek, Sung Hyun Chung. Licochalcone A prevents adipocyte differentiation and lipogenesis via suppression of peroxisome proliferator-activated receptor γ and sterol regulatory element-binding protein pathways.
Journal of agricultural and food chemistry.
2012 May; 60(20):5112-20. doi:
10.1021/jf2050763. [PMID: 22563885] - Xiao Chu, Xinxin Ci, Miaomiao Wei, Xiaofeng Yang, Qingjun Cao, Mingfeng Guan, Hongyu Li, Yanhong Deng, Haihua Feng, Xuming Deng. Licochalcone a inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo.
Journal of agricultural and food chemistry.
2012 Apr; 60(15):3947-54. doi:
10.1021/jf2051587. [PMID: 22400806] - Hai-Chao Zhang, Jing-Mei Liu, Hai-Min Chen, Chun-Chun Gao, Hong-Yu Lu, Hua Zhou, Yi Li, Shan-Lin Gao. Up-regulation of licochalcone A biosynthesis and secretion by Tween 80 in hairy root cultures of Glycyrrhiza uralensis Fisch.
Molecular biotechnology.
2011 Jan; 47(1):50-6. doi:
10.1007/s12033-010-9311-4. [PMID: 20607624] - Rakesh Kumar, Dinesh Mohanakrishnan, Abhishek Sharma, Naveen Kumar Kaushik, Kalpana Kalia, Arun Kumar Sinha, Dinkar Sahal. Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.
European journal of medicinal chemistry.
2010 Nov; 45(11):5292-301. doi:
10.1016/j.ejmech.2010.08.049. [PMID: 20863599] - Shota Tanifuji, Eriko Aizu-Yokota, Megumi Funakoshi-Tago, Yoshiko Sonoda, Hideo Inoue, Tadashi Kasahara. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.
International immunopharmacology.
2010 Jul; 10(7):769-76. doi:
10.1016/j.intimp.2010.04.007. [PMID: 20399908] - Goo Yoon, Woojung Lee, Su-Nam Kim, Seung Hoon Cheon. Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.
Bioorganic & medicinal chemistry letters.
2009 Sep; 19(17):5155-7. doi:
10.1016/j.bmcl.2009.07.054. [PMID: 19632832] - Sandra Monti, Ilse Manet, Francesco Manoli, Stefano Ottani, Giancarlo Marconi. Licochalcone A bound to bovine serum albumin: a spectroscopic, photophysical and structural study.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2009 Jun; 8(6):805-13. doi:
10.1039/b823227j. [PMID: 19492108] - Megumi Funakoshi-Tago, Kenji Tago, Chiho Nishizawa, Kyoko Takahashi, Tadahiko Mashino, Susumu Iwata, Hideo Inoue, Yoshiko Sonoda, Tadashi Kasahara. Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation.
Biochemical pharmacology.
2008 Dec; 76(12):1681-93. doi:
10.1016/j.bcp.2008.09.012. [PMID: 18848530] - Sandra Monti, Ilse Manet, Francesco Manoli, Giancarlo Marconi. Structure and properties of licochalcone A-human serum albumin complexes in solution: a spectroscopic, photophysical and computational approach to understand drug-protein interaction.
Physical chemistry chemical physics : PCCP.
2008 Nov; 10(44):6597-606. doi:
10.1039/b809241a. [PMID: 18989470] - Chang Ki Lee, Seung Hwa Son, Kwang Kyun Park, Jung Han Yoon Park, Soon Sung Lim, Sook-Hyang Kim, Won Yoon Chung. Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice.
Basic & clinical pharmacology & toxicology.
2008 Jul; 103(1):48-54. doi:
10.1111/j.1742-7843.2008.00238.x. [PMID: 18484961] - Hidemasa Nagai, Ju-Xiu He, Tadato Tani, Teruaki Akao. Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots.
The Journal of pharmacy and pharmacology.
2007 Oct; 59(10):1421-6. doi:
10.1211/jpp.59.10.0013. [PMID: 17910818] - T M Weber, R I Ceilley, A Buerger, L Kolbe, N S Trookman, R L Rizer, A Schoelermann. Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A.
Journal of cosmetic dermatology.
2006 Sep; 5(3):227-32. doi:
10.1111/j.1473-2165.2006.00261.x. [PMID: 17177744] - Ludger Kolbe, Jeannine Immeyer, Jan Batzer, Ursula Wensorra, Karen tom Dieck, Claudia Mundt, Rainer Wolber, Franz Stäb, Uwe Schönrock, Roger I Ceilley, Horst Wenck. Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects.
Archives of dermatological research.
2006 Jun; 298(1):23-30. doi:
10.1007/s00403-006-0654-4. [PMID: 16552540] - Shi-hai Yang, Xiao-feng Liu, Xin Shen, Jun-hua Zheng. [Ri plasmid transformation of Glycyrrhiza uralensis and effects of some factors on growth of hairy roots].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2006 Jun; 31(11):875-8. doi:
". [PMID: 17048620] - Ikue Furuhashi, Susumu Iwata, Shoji Shibata, Toshitsugu Sato, Hideo Inoue. Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.
The Journal of pharmacy and pharmacology.
2005 Dec; 57(12):1661-6. doi:
10.1211/jpp.57.12.0017. [PMID: 16354411] - Yue Fu, Tze-chen Hsieh, Junqiao Guo, Jan Kunicki, Marietta Y W T Lee, Zbigniew Darzynkiewicz, Joseph M Wu. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.
Biochemical and biophysical research communications.
2004 Sep; 322(1):263-70. doi:
10.1016/j.bbrc.2004.07.094. [PMID: 15313200]