ArnicolideD (BioDeep_00000229978)

 

Secondary id: BioDeep_00000404302

PANOMIX_OTCML-2023


代谢物信息卡片


2-Propenoic acid, 2-methyl-, 2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8- trimethyl-2,5-dioxoazuleno(6,5-b)furan-4-yl ester, (3S-(3alpha,3abeta,4beta,4aalpha,7abeta,8beta,9abeta))-

化学式: C19H24O5 (332.1623654)
中文名称: 山金车内酯 D, 山金车内酯D
谱图信息: 最多检出来源 Viridiplantae(plant) 26.43%

分子结构信息

SMILES: CC(C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O)=C
InChI: InChI=1S/C19H24O5/c1-9(2)17(21)24-16-15-11(4)18(22)23-13(15)8-10(3)12-6-7-14(20)19(12,16)5/h6-7,10-13,15-16H,1,8H2,2-5H3/t10-,11+,12+,13-,15-,16+,19+/m1/s1

描述信息

Arnicolide D is a sesquiterpene lactone.
Arnicolide D is a natural product found in Centipeda minima, Arnica montana, and Arnica acaulis with data available.
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1].

同义名列表

9 个代谢物同义名

2-Propenoic acid, 2-methyl-, 2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8- trimethyl-2,5-dioxoazuleno(6,5-b)furan-4-yl ester, (3S-(3alpha,3abeta,4beta,4aalpha,7abeta,8beta,9abeta))-; (3aR)-4,4a,7aalpha,8,9,9aalpha-Hexahydro-4alpha-(methacryloyloxy)-3beta,4abeta,8alpha-trimethylazuleno[6,5-b]furan-2,5(3H,3aalphaH)-dione; [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate; [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]uran-9-yl] 2-methylprop-2-enoate; Methacryl-dihydrohelenalin (Arnicolide D); 11alpha,13-dihydrohelenalinmethacrylate; 11,13-Dihydrohelenalin methacrylate; Arnicolide D; ArnicolideD



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Meiqi Liu, Xiaoran Zhao, Zicheng Ma, Ziying Qiu, Lili Sun, Meng Wang, Xiaoliang Ren, Yanru Deng. Discovery of potential Q-marker of traditional Chinese medicine based on chemical profiling, chemometrics, network pharmacology, and molecular docking: Centipeda minima as an example. Phytochemical analysis : PCA. 2022 Dec; 33(8):1225-1234. doi: 10.1002/pca.3173. [PMID: 36117130]
  • Jingjing Yao, Qinghong Shen, Min Huang, Ming Ding, Yajuan Guo, Wenbo Chen, Yuefang Lin, Yaqiu Zheng, Shaofang Yu, Wenxin Yan, Tao Su, Zhongqiu Liu, Linlin Lu. Screening tumor specificity targeted by arnicolide D, the active compound of Centipeda minima and molecular mechanism underlying by integrative pharmacology. Journal of ethnopharmacology. 2022 Jan; 282(?):114583. doi: 10.1016/j.jep.2021.114583. [PMID: 34487850]
  • Zhao Qu, Yushan Lin, Daniel Kam-Wah Mok, Qingya Bian, William Chi-Shing Tai, Sibao Chen. Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways. International journal of medical sciences. 2020; 17(11):1482-1490. doi: 10.7150/ijms.46925. [PMID: 32669950]
  • Peili Zhu, Zhongyu Zheng, Xiuqiong Fu, Junkui Li, Chengle Yin, Jiyao Chou, Yaping Wang, Yuxi Liu, Yingjie Chen, Jingxuan Bai, Jiaying Wu, Sibao Chen, Zhi-Ling Yu. Arnicolide D exerts anti-melanoma effects and inhibits the NF-κB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):153065. doi: 10.1016/j.phymed.2019.153065. [PMID: 31408803]
  • Rui Liu, Brandon Dow Chan, Daniel Kam-Wah Mok, Chi-Sing Lee, William Chi-Shing Tai, Sibao Chen. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101908. [PMID: 31108969]