63J46T4EQ3 (BioDeep_00000229931)
Main id: BioDeep_00000026575
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C18H19NO4 (313.1314014)
中文名称: 去甲基异波尔定, 去甲依波而定, 去甲异波尔定, 新木姜子碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C2=C3C(CC4=CC(=C(C=C42)OC)O)NCCC3=C1)O
InChI: InChI=1S/C18H19NO4/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1
描述信息
Norisoboldine is a natural product found in Cassytha pubescens, Cocculus laurifolius, and other organisms with data available.
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].
同义名列表
14 个代谢物同义名
4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (6aS)-; 4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (S)-; (6aS)-5,6,6a,7-Tetrahydro-2,10-dimethoxy-4H-dibenzo[de,g]quinoline-1,9-diol; (6aS)-2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol; 6aalpha-Noraporphine-1,9-diol, 2,10-dimethoxy-; (S)-(+)-Laurelliptine; (+)-N-Norisoboldine; Norisoboldine, (+)-; (+)-Norisoboldine; (+)-Laurelliptine; Laurelliptine; Norisoboldine; 63J46T4EQ3;
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 14539911
- MeSH: norisoboldine
- chemspider: 23282643
- CAS: 23599-69-1
- medchemexpress: HY-N0586
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 545644 - 乌药: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dandan Xing, QiuChang Li, Guanwen Lin, Hui Lin, Wenyue Kang, Min Zhang, Rong Ding, Na Li. The protective effects of propofol against renal ischemia-reperfusion injury are potentiated by norisoboldine treatment via inhibition of oxidative stress pathways.
Journal of biochemical and molecular toxicology.
2022 Jan; 36(1):e22937. doi:
10.1002/jbt.22937. [PMID: 34719823] - Yulai Fang, Cong Duan, Jing Zhang, Yue Dai, Yufeng Xia. NMR-based untargeted metabolomics approach to investigate the systemic lipid metabolism regulation of norisoboldine in collagen-induced arthritis rats.
European journal of pharmacology.
2021 Dec; 912(?):174608. doi:
10.1016/j.ejphar.2021.174608. [PMID: 34743982] - Lan Chang, Qin Zhang, Yunqing Tang, Yulai Fang, Renjie Dou, Yuyao Chu, Yufeng Xia, Zhifeng Wei, Li Chen, Yue Dai. Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells.
Bioorganic & medicinal chemistry letters.
2021 04; 37(?):127844. doi:
10.1016/j.bmcl.2021.127844. [PMID: 33556569] - Jing Zhang, Xiaoxia Wen, Yue Dai, Yufeng Xia. Mechanistic studies on the absorption enhancement of a self-nanoemulsifying drug delivery system loaded with norisoboldine-phospholipid complex.
International journal of nanomedicine.
2019; 14(?):7095-7106. doi:
10.2147/ijn.s211905. [PMID: 31564867] - Qi Lv, Kai Wang, Si-Miao Qiao, Yue Dai, Zhi-Feng Wei. Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome.
Chinese journal of natural medicines.
2018 Mar; 16(3):161-174. doi:
10.1016/s1875-5364(18)30044-x. [PMID: 29576052] - Cong Duan, Jiao-Mei Guo, Yue Dai, Yu-Feng Xia. The absorption enhancement of norisoboldine in the duodenum of adjuvant-induced arthritis rats involves the impairment of P-glycoprotein.
Biopharmaceutics & drug disposition.
2017 Jan; 38(1):75-83. doi:
10.1002/bdd.2053. [PMID: 27925244] - Miao He, Haiyan Wang, Wei Dou, Guixin Chou, Xiaohui Wei, Zhengtao Wang. Preparation and drug release properties of norisoboldine-loaded chitosan microspheres.
International journal of biological macromolecules.
2016 Oct; 91(?):1101-9. doi:
10.1016/j.ijbiomac.2016.06.076. [PMID: 27344949] - Bei Tong, Xusheng Yuan, Yannong Dou, Xin Wu, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Dai. Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis.
The international journal of biochemistry & cell biology.
2016 06; 75(?):63-73. doi:
10.1016/j.biocel.2016.03.014. [PMID: 27032495] - Qi Lv, Si-Miao Qiao, Ying Xia, Can Shi, Yu-Feng Xia, Gui-Xin Chou, Zheng-Tao Wang, Yue Dai, Zhi-Feng Wei. Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons.
International immunopharmacology.
2015 Dec; 29(2):787-797. doi:
10.1016/j.intimp.2015.08.040. [PMID: 26363976] - Zhi-feng Wei, Qi Lv, Ying Xia, Meng-fan Yue, Can Shi, Yu-feng Xia, Gui-xin Chou, Zheng-tao Wang, Yue Dai. Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.
International journal of biological sciences.
2015; 11(9):1113-26. doi:
10.7150/ijbs.12152. [PMID: 26221077] - Bei Tong, Yannong Dou, Ting Wang, Juntao Yu, Xin Wu, Qian Lu, Guixin Chou, Zhengtao Wang, Lingyi Kong, Yue Dai, Yufeng Xia. Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues.
Toxicology and applied pharmacology.
2015 Jan; 282(1):90-9. doi:
10.1016/j.taap.2014.11.008. [PMID: 25481498] - X Gao, Q Lu, G Chou, Z Wang, R Pan, Y Xia, H Hu, Y Dai. Norisoboldine attenuates inflammatory pain via the adenosine A1 receptor.
European journal of pain (London, England).
2014 Aug; 18(7):939-48. doi:
10.1002/j.1532-2149.2013.00439.x. [PMID: 24395183] - Yubin Luo, Zhifeng Wei, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Dai. Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats.
International immunopharmacology.
2014 May; 20(1):110-6. doi:
10.1016/j.intimp.2014.02.023. [PMID: 24613208] - Qian Lu, Bei Tong, Yubin Luo, Li Sha, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Dai. Norisoboldine suppresses VEGF-induced endothelial cell migration via the cAMP-PKA-NF-κB/Notch1 pathway.
PloS one.
2013; 8(12):e81220. doi:
10.1371/journal.pone.0081220. [PMID: 24349042] - Zhifeng Wei, Fengyun Wang, Jie Song, Qian Lu, Peng Zhao, Yufeng Xia, Guixin Chou, Zhengtao Wang, Yue Dai. Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways.
Journal of cellular biochemistry.
2012 Aug; 113(8):2785-95. doi:
10.1002/jcb.24156. [PMID: 22473817] - Jian-Zhong Chen, Ying Xu, Gui-Xin Chou, Chang-Hong Wang, Li Yang, Zheng-Tao Wang. Simultaneous determination of norisoboldine and its major metabolite in rat plasma by ultra-performance liquid chromatography-mass spectrometry and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2011 Mar; 25(3):367-72. doi:
10.1002/bmc.1457. [PMID: 21110388] - Jian-Zhong Chen, Gui-Xin Chou, Chang-Hong Wang, Li Yang, S W Annie Bligh, Zheng-Tao Wang. Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy.
Journal of pharmaceutical and biomedical analysis.
2010 Sep; 52(5):687-93. doi:
10.1016/j.jpba.2010.02.008. [PMID: 20223612] - Li-Hua Gu, Tao Wu, Zi-Jia Zhang, Gui-Xin Chou, Zheng-Tao Wang. [Evaluation of antioxidant activity of Radix Linderae and other two Chinese drugs using TLC-bioautography].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Oct; 41(10):956-62. doi:
. [PMID: 17184113] - Dennis J Milanowski, Rudolph E K Winter, Memory P F Elvin-Lewis, Walter H Lewis. Geographic distribution of three alkaloid chemotypes of Croton lechleri.
Journal of natural products.
2002 Jun; 65(6):814-9. doi:
10.1021/np000270v. [PMID: 12088421]