Prengenine (BioDeep_00000229886)

 

Secondary id: BioDeep_00000410503

PANOMIX_OTCML-2023


代谢物信息卡片


7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyl-2-oxiranyl]methoxy]-

化学式: C16H14O5 (286.0841194)
中文名称: 独活内酯, 独活素, 独活素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(O1)COC2=C3C(=CC4=C2OC=C4)C=CC(=O)O3)C
InChI: InChI=1S/C16H14O5/c1-16(2)11(21-16)8-19-15-13-10(5-6-18-13)7-9-3-4-12(17)20-14(9)15/h3-7,11H,8H2,1-2H3/t11-/m1/s1

描述信息

Heraclenin is a natural product found in Philotheca spicata, Prangos lophoptera, and other organisms with data available.
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT)[1].
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT)[1].

同义名列表

13 个代谢物同义名

Prengenine; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyl-2-oxiranyl]methoxy]-; 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3,3-dimethyloxiranyl)methoxy)-, (R)-; 7H-FURO(3,2-G)(1)BENZOPYRAN-7-ONE,9-((3,3-DIMETHYLOXIRANYL)METHOXY)-, (R)-; 7H-FURO(3,2-g)(1)BENZOPYRAN-7-ONE, 9-(2,3-EPOXY-3-METHYLBUTOXY)-, (R)-(+)-; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyloxianyl]methoxy]-; 9-{[(2R)-3,3-dimethyloxiran-2-yl]methoxy}-7H-furo[3,2-g]chromen-7-one; (R)-9-((3,3-Dimethyloxiran-2-yl)methoxy)-7H-furo[3,2-g]chromen-7-one; 9-[[(2R)-3,3-dimethyloxiran-2-yl]methoxy]furo[3,2-g]chromen-7-one; UNII-G71S84CX12; (+)-Heraclenin; G71S84CX12; Heraclenin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Haripriya Shanmugam, V Nilan Dharun, Badal Kumar Biswal, S Viji Chandran, M Vairamani, N Selvamurugan. Osteogenic stimulatory effect of heraclenin purified from bael in mouse mesenchymal stem cells in vitro. Chemico-biological interactions. 2019 Sep; 310(?):108750. doi: 10.1016/j.cbi.2019.108750. [PMID: 31319076]
  • Gang Zhao, Cheng Peng, Wei Du, Sicen Wang. Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: application to a bioavailability and protein binding ability study in rat plasma. Biomedical chromatography : BMC. 2014 Jul; 28(7):947-56. doi: 10.1002/bmc.3100. [PMID: 24357077]
  • Jaroslaw Widelski, Milena Popova, Konstantia Graikou, Kazimierz Glowniak, Ioanna Chinou. Coumarins from Angelica lucida L.--antibacterial activities. Molecules (Basel, Switzerland). 2009 Jul; 14(8):2729-34. doi: 10.3390/molecules14082729. [PMID: 19701119]
  • Giovanni Appendino, Federica Bianchi, Ammar Bader, Claudio Campagnuolo, Ernesto Fattorusso, Orazio Taglialatela-Scafati, Magdalena Blanco-Molina, Antonio Macho, Bernd L Fiebich, Paul Bremner, Michael Heinrich, Mauro Ballero, Eduardo Muñoz. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. Journal of natural products. 2004 Apr; 67(4):532-6. doi: 10.1021/np0340652. [PMID: 15104479]
  • A F Miftakhova, G S Burasheva, Z A Abilov, V U Ahmad, M Zahid. Coumarins from the aerial part of Halocnemum strobilaceum. Fitoterapia. 2001 Mar; 72(3):319-21. doi: 10.1016/s0367-326x(00)00301-4. [PMID: 11295318]
  • W N Setzer, M C Setzer, J M Schmidt, D M Moriarity, B Vogler, S Reeb, A M Holmes, W A Haber. Cytotoxic components from the bark of Stauranthus perforatus from Monteverde, Costa Rica. Planta medica. 2000 Jun; 66(5):493-4. doi: 10.1055/s-2000-8595. [PMID: 10909280]
  • P Zhou, Y Takaishi, H Duan, B Chen, G Honda, M Itoh, Y Takeda, O K Kodzhimatov, K H Lee. Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release. Phytochemistry. 2000 Mar; 53(6):689-97. doi: 10.1016/s0031-9422(99)00554-3. [PMID: 10746882]