Dihydrotanshinone_I (BioDeep_00000229874)

Main id: BioDeep_00000267389

 

PANOMIX_OTCML-2023


代谢物信息卡片


(-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione;4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione;15,16-Dihydrotanshine I;1,6-DiMethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione

化学式: C18H14O3 (278.0943)
中文名称: 二氢丹参酮 I, 二氢丹参酮Ⅰ, 二氢丹参酮I, 二氢丹参酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
InChI: InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1

描述信息

Dihydrotanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent.
Dihydrotanshinone I is a natural product found in Salvia miltiorrhiza, Salvia przewalskii, and other organisms with data available.
See also: Salvia Miltiorrhiza Root (part of).
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

同义名列表

23 个代谢物同义名

(-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione;4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione;15,16-Dihydrotanshine I;1,6-DiMethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione; (1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione; PHENANTHRO(1,2-B)FURAN-10,11-DIONE, 1,2-DIHYDRO-1,6-DIMETHYL-, (1R)-; (1R)-1,6-dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione; (1R)-1,6-Dimethyl-1,2-dihydrophenanthro(1,2-b)furan-10,11-dione; (R)-1,6-dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione; DIHYDROTANSHINONE (CONSTITUENT OF CHINESE SALVIA) [DSC]; DIHYDROTANSHINONE (CONSTITUENT OF CHINESE SALVIA); Dihydrotanshinone I, >=98\\% (HPLC); HARGZZNYNSYSGJ-JTQLQIEISA-N; 15,16-dihydrotanshinone-I; 15,16-dihydrotanshinone I; DIHYDROTANSHINONE I, (-)-; (-)-dihydrotanshinone I; Tanshinone I, dihydro-; Dihydroisotanshinone I; dihydrotanshinone-I; Dihydrotanshinone I; DihydrotanshinoneI; Dihydrotanshinone; DHTS; 4m0e; Phenanthro[3,2-b]furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jing Bai, Qiufeng Qin, Shuying Li, Xulan Cui, Yixuan Zhong, Lei Yang, Lin An, Di Deng, Jinlan Zhao, Rong Zhang, Shasha Bai. Salvia miltiorrhiza inhibited lung cancer through aerobic glycolysis suppression. Journal of ethnopharmacology. 2024 Sep; 331(?):118281. doi: 10.1016/j.jep.2024.118281. [PMID: 38701934]
  • Fangyuan Wang, Jingyin Mai, Haoyi Wang, Ying Xu, Xianglu Zhou, Zhishen Xie, Bao Yu, Ping Liu, Wei Liu, Yang Cheng. Identification of Erzhu Jiedu Recipe and its molecular mechanism underlying inhibited human hepatoma cells by UHPLC-Q-Exactive Orbitrap HRMS and network pharmacology. Journal of ethnopharmacology. 2024 May; 325(?):117893. doi: 10.1016/j.jep.2024.117893. [PMID: 38336184]
  • Elisabetta Molteni, Federica Baldan, Giuseppe Damante, Lorenzo Allegri. Dihydrotanshinone I exhibits antitumor effects via β-catenin downregulation in papillary thyroid cancer cell lines. Scientific reports. 2024 04; 14(1):7853. doi: 10.1038/s41598-024-58495-9. [PMID: 38570592]
  • Ya-Chao Wang, Yi-da Shao, Chang-le Shao, Xiao-Qi Guan, Ping-Ping Lu, Ke Ning, Bao-Nian Liu, Hai-Dong Guo. Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways. In vitro cellular & developmental biology. Animal. 2024 Jan; 60(1):89-97. doi: 10.1007/s11626-023-00839-2. [PMID: 38253954]
  • Xia Niu, Yanan Meng, Jinjin Cui, Rui Li, Xiao Ding, Bingyu Niu, Ge Chang, Ning Xu, Guiling Li, Yucheng Wang, Lulu Wang. Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis. ACS nano. 2023 Dec; 17(23):23608-23625. doi: 10.1021/acsnano.3c06626. [PMID: 37995097]
  • Ya-Chao Wang, Huan Wang, Chang-le Shao, Xiu-Ya Li, Ji Cui, Hai-Dong Guo. Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage. In vitro cellular & developmental biology. Animal. 2023 Jun; ?(?):. doi: 10.1007/s11626-023-00773-3. [PMID: 37294373]
  • Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li. 15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154790. doi: 10.1016/j.phymed.2023.154790. [PMID: 37028247]
  • Yue Li, Qian Wang, Jingyi Jin, Bo Tan, Jie Ren, Guochao Song, Bin Zou, Fengyi Weng, Dongming Yan, Furong Qiu. 15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation. Toxicology letters. 2023 Feb; 377(?):62-70. doi: 10.1016/j.toxlet.2023.02.005. [PMID: 36804361]
  • Jiahao Fang, Yuzhen He, Yuhong Cao, Yiwei Shi, Hui Wang, Zhanying Hong, Yifeng Chai. Effect of P-Glycoprotein on the Blood-Brain Barrier Transport of the Major Active Constituents of Salvia miltiorrhiza Based on the MDCK-MDR1 Cell Model. ACS chemical neuroscience. 2023 02; 14(4):766-772. doi: 10.1021/acschemneuro.2c00757. [PMID: 36704945]
  • Mengge Wang, Yusen Xiang, Ruyu Wang, Lijun Zhang, Hong Zhang, Hongzhuan Chen, Xin Luan, Lili Chen. Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227774. [PMID: 36431875]
  • Fan Yang, Xiao-Lan Jiang, Akash Tariq, Sehrish Sadia, Zeeshan Ahmed, Jordi Sardans, Muhammad Aleem, Riaz Ullah, Rainer W Bussmann. Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19. Journal of integrative medicine. 2022 11; 20(6):488-496. doi: 10.1016/j.joim.2022.08.001. [PMID: 35985974]
  • Shulan Han, Shengnan Bi, Tingting Guo, Dandan Sun, Yifang Zou, Lingzhi Wang, Liu Song, Di Chu, Anqi Liao, Xiaohuan Song, Zhuo Yu, Jianfeng Guo. Nano co-delivery of Plumbagin and Dihydrotanshinone I reverses immunosuppressive TME of liver cancer. Journal of controlled release : official journal of the Controlled Release Society. 2022 08; 348(?):250-263. doi: 10.1016/j.jconrel.2022.05.057. [PMID: 35660631]
  • Małgorzata Majewska, Piotr Szymczyk, Jan Gomulski, Agnieszka Jeleń, Renata Grąbkowska, Ewa Balcerczak, Łukasz Kuźma. The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144354. [PMID: 35889227]
  • Lanyan Fan, Chen Peng, Xiaoping Zhu, Yawen Liang, Tianyi Xu, Peng Xu, Shihua Wu. Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U-2 OS Cells through CD44 and Chemokine Signaling. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123714. [PMID: 35744840]
  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Meijuan Xu, Ying Chen, Xiaoyun Xi, Chao Jiang, Qian Zhang, Ting Wu, Jihong Chu, Guoliang Dai, Yongtao Bai, Qian Yu, Jiandong Zou, Wenzheng Ju. In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human Arachidonic acid ω-hydroxylases. Drug metabolism and pharmacokinetics. 2022 Apr; 43(?):100402. doi: 10.1016/j.dmpk.2021.100402. [PMID: 35051733]
  • Xiu-Ping Wang, Run-Qin Wang, Xia-Yu Pan, Rong-Rong Xing, Li Yang, Xuan Chen, Shuang Hu. Preconcentration of liposoluble constituents in Salvia Miltiorrhiza using acid-assisted liquid phase microextraction based on a switchable deep eutectic solvent. Journal of chromatography. A. 2022 Mar; 1666(?):462858. doi: 10.1016/j.chroma.2022.462858. [PMID: 35124359]
  • Jing Yue, Kai Su, Guangxin Zhang, Jinghui Yang, Chengbi Xu, Xueshibojie Liu. Dihydrotanshinone Attenuates LPS-Induced Acute Lung Injury in Mice by Upregulating LXRα. Inflammation. 2022 Feb; 45(1):212-221. doi: 10.1007/s10753-021-01539-3. [PMID: 34467464]
  • Taoli Sun, Wenjuan Quan, Sha Peng, Dongmei Yang, Jiaqin Liu, Chaoping He, Yu Chen, Bo Hu, Qinhui Tuo. Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis. Drug design, development and therapy. 2022; 16(?):1621-1645. doi: 10.2147/dddt.s357483. [PMID: 35669282]
  • Xiao-Li Jiang, Bo Deng, Sui-Hui Deng, Min Cai, Wen-Jun Ding, Zhang-Bin Tan, Rui-Xue Chen, You-Cai Xu, Hong-Lin Xu, Shuang-Wei Zhang, Shi-Qing Zhang, Bin Liu, Jing-Zhi Zhang. Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153705. doi: 10.1016/j.phymed.2021.153705. [PMID: 34538671]
  • Wei Shi, Han Han, Jia Zou, Ying Zhang, Haitao Li, Hefeng Zhou, Guozhen Cui. Identification of dihydrotanshinone I as an ERp57 inhibitor with anti-breast cancer properties via the UPR pathway. Biochemical pharmacology. 2021 08; 190(?):114637. doi: 10.1016/j.bcp.2021.114637. [PMID: 34062127]
  • Chew Theng Lim, Kang Wei Tan, Mary Wu, Rachel Ulferts, Lee A Armstrong, Eiko Ozono, Lucy S Drury, Jennifer C Milligan, Theresa U Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim Labib, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical journal. 2021 07; 478(13):2517-2531. doi: 10.1042/bcj20210244. [PMID: 34198325]
  • Akanksha Kashyap, Sheikh Mohammad Umar, Arundhathi Dev J R, Chandra Prakash Prasad. Dihydrotanshinone-I modulates Epithelial Mesenchymal Transition (EMT) Thereby Impairing Migration and Clonogenicity of Triple Negative Breast Cancer Cells. Asian Pacific journal of cancer prevention : APJCP. 2021 Jul; 22(7):2177-2184. doi: 10.31557/apjcp.2021.22.7.2177. [PMID: 34319041]
  • Ying-Shih Su, Min Zhan Kuo, Yi Ting Kuo, Shu-Wei Huang, Chia-Jung Lee, Zheng-Yuan Su, Yu-Hui Ni, Dian-Kun Li, Tien-Yuan Wu. Diterpenoid anthraquinones as chemopreventive agents altered microRNA and transcriptome expressions in cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Apr; 136(?):111260. doi: 10.1016/j.biopha.2021.111260. [PMID: 33465676]
  • Dong-Jun Fu, Jun Li, Bin Yu. Annual review of LSD1/KDM1A inhibitors in 2020. European journal of medicinal chemistry. 2021 Mar; 214(?):113254. doi: 10.1016/j.ejmech.2021.113254. [PMID: 33581557]
  • Bin Zhang, Xueying Li, Xiuhong Li, Zhigang Lu, Xiaona Cai, Qing Ou Yang, Pengda Ma, Juane Dong. Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca2+-Dependent Manner in Salvia miltiorrhiza Hairy Roots. International journal of molecular sciences. 2020 Dec; 21(24):. doi: 10.3390/ijms21249576. [PMID: 33339149]
  • Lin Wang, Rui Wang, Guang-Yi Wei, Shu-Me Wang, Guan-Hua Du. Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug; 128(?):110262. doi: 10.1016/j.biopha.2020.110262. [PMID: 32447214]
  • Xiaoping Wang, Qiyan Wang, Weili Li, Qian Zhang, Yanyan Jiang, Dongqing Guo, Xiaoqian Sun, Wenji Lu, Chun Li, Yong Wang. TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity. Journal of experimental & clinical cancer research : CR. 2020 May; 39(1):93. doi: 10.1186/s13046-020-01595-x. [PMID: 32448281]
  • Yuanyuan Li, Zhuoni Hou, Feng Su, Jipeng Chen, Xiaodan Zhang, Ling Xu, Dongfeng Yang, Zongsuo Liang. Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092043. [PMID: 32353926]
  • Zhonglei Bao, Huixue Zhang, Hong Jiao, Xiaojie Chu, Jin Fu, Lihua Wang. Dihydrotanshinone I Increase Amyloid-β Clearance and Decrease Tau Phosphorylation via Enhancing Autophagy. Pharmacology. 2020; 105(5-6):311-319. doi: 10.1159/000503792. [PMID: 32200384]
  • Xiuping Chen, Jie Yu, Bingling Zhong, Jiahong Lu, Jin-Jian Lu, Shaojing Li, Yang Lu. Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge. Pharmacological research. 2019 07; 145(?):104254. doi: 10.1016/j.phrs.2019.104254. [PMID: 31054311]
  • Renyikun Yuan, Liting Huang, Li-Jun Du, Jian-Fang Feng, Jun Li, Ying-Ying Luo, Qiong-Ming Xu, Shi-Lin Yang, Hongwei Gao, Yu-Lin Feng. Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization. Pharmacological research. 2019 04; 142(?):102-114. doi: 10.1016/j.phrs.2019.02.017. [PMID: 30794925]
  • Mei-Juan Xu, Li-Feng Jiang, Ting Wu, Ji-Hong Chu, Yi-Dan Wei, Ji-Ye Aa, Guang-Ji Wang, Hai-Ping Hao, Wen-Zheng Ju, Ping Li. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chemico-biological interactions. 2018 Jun; 289(?):15-22. doi: 10.1016/j.cbi.2018.04.011. [PMID: 29689254]
  • Varun Kumar, Daniel Radin, Donna Leonardi. Probing the Oncolytic and Chemosensitizing Effects of Dihydrotanshinone in an In Vitro Glioblastoma Model. Anticancer research. 2017 11; 37(11):6025-6030. doi: 10.21873/anticanres.12049. [PMID: 29061781]
  • Maoxu Ge, Hong Liu, Yixuan Zhang, Naren Li, Shuangshuang Zhao, Wuli Zhao, Yongzhan Zhen, Jianzhong Yu, Hongwei He, Rong-Guang Shao. The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy. British journal of pharmacology. 2017 05; 174(10):1147-1160. doi: 10.1111/bph.13766. [PMID: 28257144]
  • Hua Yang, Yao Ding, Wen Gao, Lian-Wen Qi, Jun Cao, Ping Li. Efficient separation of tanshinones by polyvinylpyrrolidone-stabilized graphene-modified micellar electrokinetic chromatography. Electrophoresis. 2015 Dec; 36(23):2874-80. doi: 10.1002/elps.201500264. [PMID: 26331266]
  • Vito Giuseppe D'Agostino, Preet Lal, Barbara Mantelli, Christopher Tiedje, Chiara Zucal, Natthakan Thongon, Matthias Gaestel, Elisa Latorre, Luciana Marinelli, Pierfausto Seneci, Marialaura Amadio, Alessandro Provenzani. Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. Scientific reports. 2015 Nov; 5(?):16478. doi: 10.1038/srep16478. [PMID: 26553968]
  • Xuelin Zhou, Yan Wang, Wayne Y W Lee, Penelope M Y Or, David C C Wan, Yiu Wa Kwan, John H K Yeung. Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells. Journal of natural products. 2015 Sep; 78(9):2266-75. doi: 10.1021/acs.jnatprod.5b00516. [PMID: 26339922]
  • Xian Li, Ju Hye Yang, Ye Jin, Fansi Jin, Dong-Young Kim, Jae-Hoon Chang, Jung-Ae Kim, Jong-Keun Son, Tae Chul Moon, Kun Ho Son, Hyeun Wook Chang. 15,16-Dihydrotanshinone I suppresses IgE-Ag stimulated mouse bone marrow-derived mast cell activation by inhibiting Syk kinase. Journal of ethnopharmacology. 2015 Jul; 169(?):138-44. doi: 10.1016/j.jep.2015.04.022. [PMID: 25917838]
  • Tao Hu, Kenneth K W To, Lin Wang, Lin Zhang, Lan Lu, Jing Shen, Ruby L Y Chan, Mingxing Li, John H K Yeung, Chi Hin Cho. Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Sep; 21(11):1264-72. doi: 10.1016/j.phymed.2014.06.013. [PMID: 25172788]
  • Fat-Moon Suk, Wen-Ju Jou, Ren-Jye Lin, Shyr-Yi Lin, Fang-Yu Tzeng, Yu-Chih Liang. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer research. 2013 Aug; 33(8):3225-31. doi: ". [PMID: 23898083]
  • Ming Cong, Cui-Min Hu, Yun-Feng Cao, Zhong-Ze Fang, Shu-Hong Tang, Jia-Rui Wang, Jun-Sheng Luo. Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation. Fitoterapia. 2013 Mar; 85(?):109-13. doi: 10.1016/j.fitote.2013.01.002. [PMID: 23333907]
  • M Jason Hatfield, Lyudmila G Tsurkan, Janice L Hyatt, Carol C Edwards, Andrew Lemoff, Cynthia Jeffries, Bing Yan, Philip M Potter. Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ('Danshen'). Journal of natural products. 2013 Jan; 76(1):36-44. doi: 10.1021/np300628a. [PMID: 23286284]
  • Qiong Liu, Yu Zhang, Zhonghui Lin, Hong Shen, Lili Chen, Lihong Hu, Hualiang Jiang, Xu Shen. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. The Journal of steroid biochemistry and molecular biology. 2010 Jun; 120(4-5):155-63. doi: 10.1016/j.jsbmb.2010.03.090. [PMID: 20380878]
  • Su Jin Jeon, Kun Ho Son, Yeong Shik Kim, Yong Hwan Choi, Hyun Pyo Kim. Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge. Archives of pharmacal research. 2008 Jun; 31(6):758-63. doi: 10.1007/s12272-001-1223-4. [PMID: 18563358]
  • Peng Li, Shao-Ping Li, Feng-Qing Yang, Yi-Tao Wang. Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography. Journal of separation science. 2007 Apr; 30(6):900-5. doi: 10.1002/jssc.200600368. [PMID: 17536735]
  • Song-Yi Lee, Doo-Youn Choi, Eun-Rhan Woo. Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge. Archives of pharmacal research. 2005 Aug; 28(8):909-13. doi: 10.1007/bf02973876. [PMID: 16178416]
  • D S Lee, S H Lee, J G Noh, S D Hong. Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge. Bioscience, biotechnology, and biochemistry. 1999 Dec; 63(12):2236-9. doi: 10.1271/bbb.63.2236. [PMID: 10664860]
  • S Y Ryu, M H Oak, K M Kim. Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza. Planta medica. 1999 Oct; 65(7):654-5. doi: 10.1055/s-2006-960839. [PMID: 10575380]