Bakuchiol (BioDeep_00000229845)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4-(3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl)phenol

化学式: C18H24O (256.1827054)
中文名称: 补骨脂酚, 刺棒棕(BACTRIS GASIPAES)果汁, 补骨脂酚;破故纸酚
谱图信息: 最多检出来源 Viridiplantae(plant) 1.53%

Reviewed

Last reviewed on 2024-10-24.

Cite this Page

Bakuchiol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/bakuchiol (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000229845). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C=CC(C)(C=Cc1ccc(O)cc1)CCC=C(C)C
InChI: InChI=1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1

描述信息

Bakuchiol is under investigation in clinical trial NCT03112863 (Comparison of the Cosmetic Effects of Bakuchiol and Retinol).
Bakuchiol is a natural product found in Otholobium pubescens, Otholobium glandulosum, and other organisms with data available.
See also: Cullen corylifolium fruit (part of).
Bakuchiol is a phytoestrogen derived from psoralen seeds and has anti-tumor and other effects.
Bakuchiol is a phytoestrogen derived from psoralen seeds and has anti-tumor and other effects.

同义名列表

25 个代谢物同义名

Bakuchiol; PHENOL, 4-((1E,3S)-3-ETHENYL-3,7-DIMETHYL-1,6-OCTADIEN-1-YL)-; Phenol, 4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)-, (S-(E))-; Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]-; PHENOL, 4-((1E,3S)-3-ETHENYL-3,7-DIMETHYL-1,6-OCTADIENYL)-; 4-[(1e,3s)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol; 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol; 3,5-Dihydroxytoluene (Orcinol monohydrate / anhydride? ); 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol; P-(3,7-dimethyl-3-vinylocta-trans-1,6-dimethyl) phenol; 4-[(1E,3S)-3,7-dimethyl-3-vinyl-octa-1,6-dienyl]phenol; (S,E)-4-(3,7-Dimethyl-3-vinylocta-1,6-dien-1-yl)phenol; (S)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol; 4-(3,7-Dimethyl-3-vinylocta-1,6-dien-1-yl)phenol; 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol; Bakuchiol, analytical standard; (S)-(+)-Bakuchiol; Bakuchiol, >=95\\%; BAKUCHIOL [INCI]; UNII-OT12HJU3AR; (S)-Bakuchiol; (+)-Bakuchiol; OT12HJU3AR; Sytenol a; C18H24O



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guanjie Peng, Yangsi Li, Yiyan Zeng, Bowen Sun, Lanyue Zhang, Qingqing Liu. Effect of glabridin combined with bakuchiol on UVB-induced skin damage and its underlying mechanism: An experimental study. Journal of cosmetic dermatology. 2024 Jun; 23(6):2256-2269. doi: 10.1111/jocd.16259. [PMID: 38497297]
  • Xiao-Qing Zhang, Yan-Nan Xiang, Tian Qin, Jing-Pei Zou, Qian-Wen Guo, Shu-Tong Han, Zhao-Yuan Zhang, Wei-Wei Liu, Gang Ding, Jing-Quan Dong, Da-Hua Shi. Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease. Fitoterapia. 2024 Apr; 174(?):105867. doi: 10.1016/j.fitote.2024.105867. [PMID: 38382891]
  • Na Zhu, Li-Yuan Cheng, Xiao-Ying Zhang, Yue Zhang, Kun Zhou. [Pharmacokinetics of 11 active components of Psoraleae Fructus in normal and diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(5):1369-1377. doi: 10.19540/j.cnki.cjcmm.20231207.201. [PMID: 38621985]
  • Xi-Yi Peng, Lin Zhang, Shu-Wei Yu, Yu-Qi Zhai, Zhao-Juan Guo. [Correlation between drug-induced liver injury in rats caused by Xianling Gubao oral preparation and extraction process]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(24):6645-6652. doi: 10.19540/j.cnki.cjcmm.20231011.302. [PMID: 38212024]
  • Shivani Attri, Ajay Kumar, Kirandeep Kaur, Prabhjot Kaur, Sanha Punj, Neena Bedi, Hardeep Singh Tuli, Saroj Arora. Assessment of anti-psoriatic activity of bakuchiol-loaded solid lipid nanoparticles-based gel: design, characterization, and mechanistic insight via NF-kB signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023 09; 396(9):2105-2125. doi: 10.1007/s00210-023-02445-1. [PMID: 36929274]
  • Ana Simona Barna, Claudia Maxim, Adriana Trifan, Alexandra Cristina Blaga, Ramona Cimpoesu, Delia Turcov, Daniela Suteu. Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087004. [PMID: 37108165]
  • Bhawna Chopra, Ashwani Kumar Dhingra, Ajmer Singh Grewal, Akash Jain, Jasmine Chaudhary, Parul Grover. Bakuchiol: A Potential Anticancer Compound from Psoralea corylifolia Linn. Anti-cancer agents in medicinal chemistry. 2023; 23(9):989-998. doi: 10.2174/1871520623666230130102910. [PMID: 36717993]
  • Bhawna Chopra, Ashwani Kumar Dhingra. Therapeutic and Health Promoting Potential of Bakuchiol from Psoralea corylifolia: A Comprehensive Review. Endocrine, metabolic & immune disorders drug targets. 2023; 23(9):1125-1136. doi: 10.2174/1871530323666230207123613. [PMID: 36748816]
  • Nuder Nower Nizam, Sohel Mahmud, S M Albar Ark, Mohammad Kamruzzaman, Md Kamrul Hasan. Bakuchiol, a natural constituent and its pharmacological benefits. F1000Research. 2023; 12(?):29. doi: 10.12688/f1000research.129072.2. [PMID: 38021404]
  • Carolina Puyana, Neha Chandan, Maria Tsoukas. Applications of bakuchiol in dermatology: Systematic review of the literature. Journal of cosmetic dermatology. 2022 Dec; 21(12):6636-6643. doi: 10.1111/jocd.15420. [PMID: 36176207]
  • Tingting Liu, Guang Xu, Yurong Li, Wei Shi, Lutong Ren, Zhie Fang, Longxin Liang, Yan Wang, Yuan Gao, Xiaoyan Zhan, Qiang Li, Wenqing Mou, Li Lin, Ziying Wei, Zhiyong Li, Wenzhang Dai, Jia Zhao, Hui Li, Jiabo Wang, Yanling Zhao, Xiaohe Xiao, Zhaofang Bai. Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity. Journal of ethnopharmacology. 2022 Nov; 298(?):115593. doi: 10.1016/j.jep.2022.115593. [PMID: 35973629]
  • Jonathan Greenzaid, Adam Friedman, Pooja Sodha. The Use of Bakuchiol in Dermatology: A Review of In Vitro and In Vivo Evidence. Journal of drugs in dermatology : JDD. 2022 Jun; 21(6):624-629. doi: 10.36849/jdd.6740. [PMID: 35674758]
  • Anika Bluemke, Annika P Ring, Jeannine Immeyer, Anke Hoff, Tanya Eisenberg, Wolfram Gerwat, Franziska Meyer, Sabrina Breitkreutz, Lina M Klinger, Johanna M Brandner, Grit Sandig, Marietta Seifert, Doerte Segger, Frank Rippke, Dorothea Schweiger. Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach. International journal of cosmetic science. 2022 Jun; 44(3):377-393. doi: 10.1111/ics.12784. [PMID: 35514037]
  • Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka Szopa. Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik. Natural product research. 2021 Dec; 35(24):5828-5842. doi: 10.1080/14786419.2020.1837813. [PMID: 33185126]
  • Dingqi Zhang, Sami Hamdoun, Ruihong Chen, Lijun Yang, Chi Kio Ip, Yuanqing Qu, Runfeng Li, Haiming Jiang, Zifeng Yang, Sookja Kim Chung, Liang Liu, Vincent Kam Wai Wong. Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. Pharmacological research. 2021 10; 172(?):105820. doi: 10.1016/j.phrs.2021.105820. [PMID: 34403732]
  • Yuewei Xu, Xiaoming Gao, Li Wang, Manqin Yang, Ruonan Xie. Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling. Respiratory physiology & neurobiology. 2021 10; 292(?):103707. doi: 10.1016/j.resp.2021.103707. [PMID: 34087492]
  • Da-Eun Lee, Eun Hyang Jang, Chaeeun Bang, Gye Lim Kim, So Young Yoon, Do Hyun Lee, Jaeun Koo, Jin Hee Na, Sangmin Lee, Jong-Ho Kim. Bakuchiol, main component of root bark of Ulmus davidiana var. japonica, inhibits TGF-β-induced in vitro EMT and in vivo metastasis. Archives of biochemistry and biophysics. 2021 09; 709(?):108969. doi: 10.1016/j.abb.2021.108969. [PMID: 34153297]
  • Jiazheng Wang, Min Luo, Jiafan Shen, Zhiwen Liu, Ying Chen, Jie Luo, Zhiying Zeng, Dinling Deng, Ji Xiao. Bakuchiol from Psoralea corylifolia L. Ameliorates acute kidney injury and improves survival in experimental polymicrobial sepsis. International immunopharmacology. 2020 Dec; 89(Pt A):107000. doi: 10.1016/j.intimp.2020.107000. [PMID: 33039956]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • David J Goldberg, Deanne Mraz-Robinson, Corinne Granger. Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis. Journal of cosmetic dermatology. 2020 Apr; 19(4):884-890. doi: 10.1111/jocd.13329. [PMID: 32061043]
  • Lin Miao, Chanyuan Jiao, Rui Shao, Yaxin Qi, Guanwei Fan, Xiaojiang Li, Yuefei Wang, Yan Zhu, Ju Zhang, Xiumei Gao. Bakuchiol suppresses oestrogen/testosterone-induced Benign Prostatic Hyperplasia development through up-regulation of epithelial estrogen receptor β and down-regulation of stromal aromatase. Toxicology and applied pharmacology. 2019 10; 381(?):114637. doi: 10.1016/j.taap.2019.114637. [PMID: 31238046]
  • David J Goldberg, Deanne Mraz Robinson, Corinne Granger. Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days. Journal of cosmetic dermatology. 2019 Jun; 18(3):806-814. doi: 10.1111/jocd.12896. [PMID: 30924254]
  • Zhenlong Xin, Xue Wu, Ting Ji, Baoping Xu, Yuehu Han, Meng Sun, Shuai Jiang, Tian Li, Wei Hu, Chao Deng, Yang Yang. Bakuchiol: A newly discovered warrior against organ damage. Pharmacological research. 2019 03; 141(?):208-213. doi: 10.1016/j.phrs.2019.01.001. [PMID: 30610961]
  • Jie Du, Chun-Hua Wang, Jing Yang, Xin He, Xiao-Liang Han, Cong-Cong Li, Xin Chai, Yue-Fei Wang, Yan Zhu, Zheng Li. Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury. Natural product research. 2019 Mar; 33(5):673-680. doi: 10.1080/14786419.2017.1405407. [PMID: 29156966]
  • Ahmed Alalaiwe, Chi-Feng Hung, Yann-Lii Leu, Kohei Tahara, Hi-Han Chen, Kai-Yin Hu, Jia-You Fang. The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Nov; 124(?):114-126. doi: 10.1016/j.ejps.2018.08.031. [PMID: 30153523]
  • Zheng Wang, Lu Gao, Lili Xiao, Lingyao Kong, Huiting Shi, Xinyu Tian, Luosha Zhao. Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway. Bioscience reports. 2018 10; 38(5):. doi: 10.1042/bsr20181043. [PMID: 30242058]
  • Lin Miao, Xiaoting Yun, Rui Tao, Yuefei Wang, Guanwei Fan, Yan Zhu, Ting Cai, Zhipeng Zhu, Chunlin Yan, Xiumei Gao. Bakuchiol exhibits anti-metastasis activity through NF-κB cross-talk signaling with AR and ERβ in androgen-independent prostate cancer cells PC-3. Journal of pharmacological sciences. 2018 Sep; 138(1):1-8. doi: 10.1016/j.jphs.2017.04.004. [PMID: 30236540]
  • Lijuan Chai, Kun Zhou, Shaoxia Wang, Han Zhang, Na Fan, Jie Li, Xiaofeng Tan, Limin Hu, Xiang Fan. Psoralen and Bakuchiol Ameliorate M-CSF Plus RANKL-Induced Osteoclast Differentiation and Bone Resorption Via Inhibition of AKT and AP-1 Pathways in Vitro. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(5):2123-2133. doi: 10.1159/000492554. [PMID: 30110702]
  • Fohad Mabood Husain, Iqbal Ahmad, Faez Iqbal Khan, Nasser A Al-Shabib, Mohammad Hassan Baig, Afzal Hussain, Md Tabish Rehman, Mohamed F Alajmi, Kevin A Lobb. Seed Extract of Psoralea corylifolia and Its Constituent Bakuchiol Impairs AHL-Based Quorum Sensing and Biofilm Formation in Food- and Human-Related Pathogens. Frontiers in cellular and infection microbiology. 2018; 8(?):351. doi: 10.3389/fcimb.2018.00351. [PMID: 30410871]
  • Xiao-Jing Hu, You-Bo Zhang, Zi-Jing Zhao, Lei Zhang, Qi Wang, Xiu-Wei Yang. Metabolic detoxification of bakuchiol is mediated by oxidation of CYP 450s in liver microsomes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jan; 111(?):385-392. doi: 10.1016/j.fct.2017.11.048. [PMID: 29180062]
  • Long Lv, Bo Liu. Anti‑tumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways. Molecular medicine reports. 2017 Dec; 16(6):8977-8982. doi: 10.3892/mmr.2017.7696. [PMID: 28990045]
  • Zhi-Jian Li, Abudumijiti Abulizi, Guo-Lin Zhao, Tao Wang, Fan Zhou, Zhen-Zhou Jiang, Silafu Aibai, Lu-Yong Zhang. Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats. Phytotherapy research : PTR. 2017 Aug; 31(8):1265-1272. doi: 10.1002/ptr.5851. [PMID: 28639266]
  • Feng Li, Shuai Wang, Danyi Lu, Yifei Wang, Dong Dong, Baojian Wu. Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound. Xenobiotica; the fate of foreign compounds in biological systems. 2017 May; 47(5):369-375. doi: 10.1080/00498254.2016.1195523. [PMID: 27314830]
  • Jia-Rong Gao, Shuang-Zhi Xu, Yan-Quan Han, Liang-Bing Wei, Hui Jiang, Jun-Mei Song, Xue Xue. [Determination and pharmacokinetics of main components for Psoralea corylifolia-Myristica fragrants drug pair by using UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 May; 42(9):1782-1786. doi: 10.19540/j.cnki.cjcmm.2017.0071. [PMID: 29082707]
  • Yu Jin Kim, Hye-Sun Lim, Jun Lee, Soo-Jin Jeong. Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia. Molecules (Basel, Switzerland). 2016 Aug; 21(8):. doi: 10.3390/molecules21081076. [PMID: 27548120]
  • Jong-Eun Kim, Jae Hwan Kim, Younghyun Lee, Hee Yang, Yong-Seok Heo, Ann M Bode, Ki Won Lee, Zigang Dong. Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase. Oncotarget. 2016 Mar; 7(12):14616-27. doi: 10.18632/oncotarget.7524. [PMID: 26910280]
  • Pei-le Wang, Feng-xiang Zhang, Zuo-cheng Qiu, Zhi-hong Yao, Man-sau Wong, Xin-sheng Yao, Yi Dai. Isolation and identification of metabolites of bakuchiol in rats. Fitoterapia. 2016 Mar; 109(?):31-8. doi: 10.1016/j.fitote.2015.11.006. [PMID: 26586623]
  • Meina Chi, Ying Peng, Jiang Zheng. Characterization of glutathione conjugates derived from reactive metabolites of bakuchiol. Chemico-biological interactions. 2016 Jan; 244(?):178-86. doi: 10.1016/j.cbi.2015.12.009. [PMID: 26712081]
  • Ze-Bin Weng, Qian-Qian Gao, Fang Wang, Gen-Hua Zhao, Fang-Zhou Yin, Bao-Chang Cai, Zhi-Peng Chen, Wei-Dong Li. Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiency-induced osteoporosis and the possible mechanisms of action. Molecular and cellular endocrinology. 2015 Dec; 417(?):103-13. doi: 10.1016/j.mce.2015.09.025. [PMID: 26419930]
  • Masaki Shoji, Yumie Arakaki, Tomoyuki Esumi, Shuntaro Kohnomi, Chihiro Yamamoto, Yutaka Suzuki, Etsuhisa Takahashi, Shiro Konishi, Hiroshi Kido, Takashi Kuzuhara. Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation. The Journal of biological chemistry. 2015 Nov; 290(46):28001-17. doi: 10.1074/jbc.m115.669465. [PMID: 26446794]
  • Chao Hu, Qiande Liang, Xianglin Tang, Yuguang Wang, Zengchun Ma, Chengrong Xiao, Hongling Tan, Yue Gao, Xianju Huang. In vivo metabolite identification of bakuchiol in rats by UPLC/ESI-PDA-QTOF-MS. Fitoterapia. 2015 Oct; 106(?):129-34. doi: 10.1016/j.fitote.2015.09.005. [PMID: 26347955]
  • Mijeong Jeong, Thao Hong, Kangwoo Lee, Hyunjung Hwangbo, Minjung Kim, Wenwen Ma, Michael Zahn. HPLC Method for Simultaneous Quantification of Bakuchiol and Minor Furocoumarins in Bakuchiol Extract from Psoralea corylifolia. Journal of AOAC International. 2015 Jul; 98(4):902-6. doi: 10.5740/jaoacint.14-228. [PMID: 26268970]
  • Zi-jing Zhao, Zheng Gong, Shao-ze Shi, Jin-lan Yang, Na-na Ma, Qi Wang. [Toxicokinetics of bakuchiol, hepatic and renal toxicity in rats after single oral administration of Psoraleae Fructus and combination with Glycyrrhizae Radix et Rhizoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jun; 40(11):2221-6. doi: NULL. [PMID: 26552185]
  • Alejandro Madrid, Venera Cardile, César González, Ivan Montenegro, Joan Villena, Silvia Caggia, Adriana Graziano, Alessandra Russo. Psoralea glandulosa as a potential source of anticancer agents for melanoma treatment. International journal of molecular sciences. 2015 Apr; 16(4):7944-59. doi: 10.3390/ijms16047944. [PMID: 25860949]
  • Alejandro Madrid Villegas, Katy Díaz Peralta, César González Tapia, Karen Catalán Marín, Luis Espinoza Catalán. Antiphytopathogenic activity of Psoralea glandulosa (Fabaceae) against Botrytis cinerea and Phytophthora cinnamomi. Natural product research. 2015; 29(6):586-8. doi: 10.1080/14786419.2014.955486. [PMID: 25184663]
  • Youwu Huang, Xiaoyu Liu, Yingchun Wu, Yiming Li, Fujiang Guo. Meroterpenes from Psoralea corylifolia against Pyricularia oryzae. Planta medica. 2014 Oct; 80(15):1298-303. doi: 10.1055/s-0034-1382995. [PMID: 25127019]
  • Kit-Man Lau, Jack Ho Wong, Yu-On Wu, Ling Cheng, Chun-Wai Wong, Ming-Ho To, Ching-Po Lau, David Tai-Wai Yew, Ping-Chung Leung, Kwok-Pui Fung, Mamie Hui, Tzi-Bun Ng, Clara Bik-San Lau. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Jun; 21(7):942-5. doi: 10.1016/j.phymed.2014.03.005. [PMID: 24703327]
  • R K Chaudhuri, K Bojanowski. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International journal of cosmetic science. 2014 Jun; 36(3):221-30. doi: 10.1111/ics.12117. [PMID: 24471735]
  • Shuang-Qing Zhang, Yu-Ming Fan. Ultra-high-performance liquid chromatography-tandem mass spectrometry for pharmacokinetics of bakuchiol in rats. Biomedical chromatography : BMC. 2014 Mar; 28(3):433-8. doi: 10.1002/bmc.3051. [PMID: 24115152]
  • De-Gang Dong, Yao Zhang, Shu-Lan Zhang, Jing Lv, En-Mian Guo, Zhong-Ze Fang, Yun-Feng Cao. Inhibition potential of UDP-glucuronosyltransferases (Ugts) 1A isoforms by the analogue of resveratrol, bakuchiol. Die Pharmazie. 2014 Jan; 69(1):60-3. doi: . [PMID: 24601226]
  • Haoping Mao, Hong Wang, Shangwei Ma, Yantong Xu, Han Zhang, Yuefei Wang, Zichang Niu, Guanwei Fan, Yan Zhu, Xiu Mei Gao. Bidirectional regulation of bakuchiol, an estrogenic-like compound, on catecholamine secretion. Toxicology and applied pharmacology. 2014 Jan; 274(1):180-9. doi: 10.1016/j.taap.2013.11.001. [PMID: 24231057]
  • Kyung-A Kim, Sang Hee Shim, Hong Ryul Ahn, Sang Hoon Jung. Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage. Toxicology and applied pharmacology. 2013 Jun; 269(2):109-20. doi: 10.1016/j.taap.2013.03.017. [PMID: 23545180]
  • Xiaomei Zhuang, Yuhuan Zhong, Mei Yuan, Hua Li. Pre-column derivatization combined with UHPLC-MS/MS for rapid and sensitive quantification of bakuchiol in rat plasma. Journal of pharmaceutical and biomedical analysis. 2013 Mar; 75(?):18-24. doi: 10.1016/j.jpba.2012.11.001. [PMID: 23312380]
  • Ai-fang Li, Guo-lin Shen, Shi-yong Jiao, Hua Li, Qi Wang. [Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in human liver microsomes]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2012 Jun; 44(3):431-6. doi: NULL. [PMID: 22692316]
  • Seung Woong Lee, Bo Ra Yun, Mi Hwa Kim, Chan Sun Park, Woo Song Lee, Hyun-Mee Oh, Mun-Chual Rho. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta medica. 2012 Jun; 78(9):903-6. doi: 10.1055/s-0031-1298482. [PMID: 22573369]
  • Sun-Hye Lim, Tae-Youl Ha, Jiyun Ahn, Suna Kim. Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Mar; 18(5):425-30. doi: 10.1016/j.phymed.2011.02.002. [PMID: 21382704]
  • Sang Yoon Choi, Sanghyun Lee, Won-Hee Choi, Yeonmi Lee, Youn Ock Jo, Tae-Youl Ha. Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica. Journal of medicinal food. 2010 Aug; 13(4):1019-23. doi: 10.1089/jmf.2009.1207. [PMID: 20553183]
  • Dong-Mei Yan, Yan-Xu Chang, Yue-Fei Wang, Er-Wei Liu, Jin Li, Li-Yuan Kang, Xiu-Mei Gao. In vivo pharmacokinetics of bakuchiol after oral administration of bakuchiol extraction in rat plasma. Journal of ethnopharmacology. 2010 Apr; 128(3):697-702. doi: 10.1016/j.jep.2009.12.039. [PMID: 20051255]
  • Huanjie Yang, Jinbao Liu, Q Ping Dou. Targeting tumor proteasome with traditional Chinese medicine. Current drug discovery technologies. 2010 Mar; 7(1):46-53. doi: 10.2174/157016310791162785. [PMID: 20156140]
  • Kit-Man Lau, Lai-Hong Fu, Ling Cheng, Chun-Wai Wong, Yin-Lai Wong, Ching-Po Lau, Simon Quan-Bin Han, Paul Kay-Sheung Chan, Kwok-Pui Fung, Clara Bik-San Lau, Mamie Hui, Ping-Chung Leung. Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification. The American journal of Chinese medicine. 2010; 38(5):1005-14. doi: 10.1142/s0192415x10008421. [PMID: 20821830]
  • Osamu Ohno, Taeko Watabe, Kazuhiko Nakamura, Masaru Kawagoshi, Nobuo Uotsu, Tomohiro Chiba, Masayoshi Yamada, Kohji Yamaguchi, Kaoru Yamada, Kenji Miyamoto, Daisuke Uemura. Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells. Bioscience, biotechnology, and biochemistry. 2010; 74(7):1504-6. doi: 10.1271/bbb.100221. [PMID: 20622433]
  • Sun-Hye Lim, Tae-Youl Ha, Sung-Ran Kim, Jiyun Ahn, Hyun Jin Park, Suna Kim. Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats. The British journal of nutrition. 2009 Apr; 101(7):1031-9. doi: 10.1017/s0007114508066750. [PMID: 18801207]
  • Gang Zhao, Shao-Yun Zang, Xiang-Wei Zheng, Xiao-Hua Zhang, Li-He Guo. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochemical pharmacology. 2008 May; 75(9):1835-47. doi: 10.1016/j.bcp.2008.01.014. [PMID: 18329002]
  • Chun-Feng Qiao, Quan-Bin Han, Jing-Zheng Song, Shi-Fu Mo, Ling-Dong Kong, Hsiang-Fu Kung, Hong-Xi Xu. Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography. Journal of separation science. 2007 Apr; 30(6):813-8. doi: 10.1002/jssc.200600339. [PMID: 17536725]
  • Eun-Jeon Park, Yu-Zhe Zhao, Youn-Chul Kim, Dong Hwan Sohn. Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo. Planta medica. 2005 Jun; 71(6):508-13. doi: 10.1055/s-2005-864150. [PMID: 15971120]
  • Ketaki Bapat, G J Chintalwar, Usha Pandey, V S Thakur, H D Sarma, Grace Samuel, M R A Pillai, S Chattopadhyay, Meera Venkatesh. Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2005 Mar; 62(3):389-93. doi: 10.1016/j.apradiso.2004.07.007. [PMID: 15607914]
  • S Adhikari, R Joshi, B S Patro, T K Ghanty, G J Chintalwar, A Sharma, S Chattopadhyay, T Mukherjee. Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain. Chemical research in toxicology. 2003 Sep; 16(9):1062-9. doi: 10.1021/tx034082r. [PMID: 12971793]
  • Hiroyuki Haraguchi, Junji Inoue, Yukiyoshi Tamura, Kenji Mizutani. Antioxidative components of Psoralea corylifolia (Leguminosae). Phytotherapy research : PTR. 2002 Sep; 16(6):539-44. doi: 10.1002/ptr.972. [PMID: 12237811]
  • Sandra M Newton, Clara Lau, Sudagar S Gurcha, Gurdyal S Besra, Colin W Wright. The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. Journal of ethnopharmacology. 2002 Jan; 79(1):57-67. doi: 10.1016/s0378-8741(01)00350-6. [PMID: 11744296]
  • H O Pae, H Cho, G S Oh, N Y Kim, E K Song, Y C Kim, Y G Yun, C L Kang, J D Kim, J M Kim, H T Chung. Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages. International immunopharmacology. 2001 Sep; 1(9-10):1849-55. doi: 10.1016/s1567-5769(01)00110-2. [PMID: 11562076]
  • H Haraguchi, J Inoue, Y Tamura, K Mizutani. Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia. Planta medica. 2000 Aug; 66(6):569-71. doi: 10.1055/s-2000-8605. [PMID: 10985089]
  • J M Krenisky, J Luo, M J Reed, J R Carney. Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes. Biological & pharmaceutical bulletin. 1999 Oct; 22(10):1137-40. doi: 10.1248/bpb.22.1137. [PMID: 10549873]
  • B Yang, S Yao, S Cui. [Comparison of ancient and modern processing methods for fructus Psoraleae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1996 Sep; 21(9):537-9, 575. doi: ". [PMID: 9772642]
  • S Yao, B Yang, Z Xu. [Determination of bakuchiol in the fruit of Psoralea corylifolia L]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1995 Nov; 20(11):681-3, 704. doi: ". [PMID: 8737473]
  • A Banerji, G J Chintalwar. Fate of leucine in the biosynthesis of bakuchiol, a meroterpene from Psoralea corylifolia. Indian journal of biochemistry & biophysics. 1989 Dec; 26(6):394-6. doi: . [PMID: 2632364]
  • M E Wall, M C Wani, G Manikumar, P Abraham, H Taylor, T J Hughes, J Warner, R McGivney. Plant antimutagenic agents, 2. Flavonoids. Journal of natural products. 1988 Nov; 51(6):1084-91. doi: 10.1021/np50060a006. [PMID: 3069957]
  • Y S Zhang. [A study on toxicity of bakuchiol to mice's kidney (author's transl)]. Zhong yao tong bao (Beijing, China : 1981). 1981 May; 6(3):30-2. doi: NULL. [PMID: 6211267]
  • V A Prikhod'ko, A S Bondarenko, E L Mishenkova. [Antimicrobial activity and toxicity of the antibiotic, bakuchiol]. Mikrobiologicheskii zhurnal. 1980 Sep; 42(5):646-50. doi: ". [PMID: 6776390]