Caulophyllin (BioDeep_00000229798)

Main id: BioDeep_00000008304

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


1,5-METHANO-8H-PYRIDO(1,2-A)(1,5)DIAZOCIN-8-ONE, 1,2,3,4,5,6-HEXAHYDRO-3-METHYL-, (1R,5S)-

化学式: C12H16N2O (204.12625659999998)
中文名称: N-甲基金雀花碱, N-甲基野靛碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CC2CC(C1)c1cccc(=O)n1C2
InChI: InChI=1S/C12H16N2O/c1-13-6-9-5-10(8-13)11-3-2-4-12(15)14(11)7-9/h2-4,9-10H,5-8H2,1H3/t9-,10+/m0/s1

描述信息

N-Methylcytisine is a natural product found in Thermopsis lanceolata, Sophora chrysophylla, and other organisms with data available.
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].

同义名列表

24 个代谢物同义名

1,5-METHANO-8H-PYRIDO(1,2-A)(1,5)DIAZOCIN-8-ONE, 1,2,3,4,5,6-HEXAHYDRO-3-METHYL-, (1R,5S)-; 1,5-Methano-8H-pyrido(1,2a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-; (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one; (1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one; N-methylcytisine, monohydroiodide, (1R-cis)-isomer; N-methylcytisine, monohydrochloride, (1S)-isomer; 5-24-02-00538 (Beilstein Handbook Reference); N-Methylcytisine, >=98\\% (HPLC); N-Methylcytisine, AldrichCPR; CYTISINE, 12-METHYL-; (-)-N-methylcytisine; CYTISINE, N-METHYL-; METHYLCYTISINE [MI]; N-methyl-cytisine; 12-Methylcytisine; 3-Methylcytisine; N-methylcytisine; UNII-TT0MW69NCI; Methylcytisine; Caulophylline; Caulophyllin; TT0MW69NCI; Caulophylline; (1R,9R)-11-methyl-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna Petruczynik, Karol Wróblewski, Justyna Misiurek, Tomasz Plech, Karolina Szalast, Krzysztof Wojtanowski, Tomasz Mroczek, Grażyna Szymczak, Monika Waksmundzka-Hajnos, Piotr Tutka. Determination of Cytisine and N-Methylcytisine from Selected Plant Extracts by High-Performance Liquid Chromatography and Comparison of Their Cytotoxic Activity. Toxins. 2020 08; 12(9):. doi: 10.3390/toxins12090557. [PMID: 32872484]
  • Li Yao, Hong Yi, Hui-Min Gao, Hui-Wen Ma, Ji-Yuan Zhang, Lian-Chao Tian, Xiao-Qian Liu, Zhi-Min Wang. [Comparison of alkaloids in roots of cultivated and wild Sophora flavsecens]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Nov; 41(21):3968-3974. doi: 10.4268/cjcmm20162114. [PMID: 28929683]
  • Yan Zhang, Wen-Zhong Hu, Xiao-Zhong Chen, Yu-Bo Peng, Li-Yan Song, Yu-Sheng Shi. [Bioactive quinolizidine alkaloids from Sophora tonkinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jun; 41(12):2261-2266. doi: 10.4268/cjcmm20161215. [PMID: 28901070]
  • Owen M McDougal, Peter B Heenan, Peter Jaksons, Catherine E Sansom, Bruce M Smallfield, Nigel B Perry, John W van Klink. Alkaloid variation in New Zealand kōwhai, Sophora species. Phytochemistry. 2015 Oct; 118(?):9-16. doi: 10.1016/j.phytochem.2015.07.019. [PMID: 26253652]
  • Shuanghu Wang, Haiya Wu, Xueli Huang, Peiwu Geng, Congcong Wen, Jianshe Ma, Yunfang Zhou, Xianqin Wang. Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 May; 990(?):118-24. doi: 10.1016/j.jchromb.2015.03.025. [PMID: 25864013]
  • Jeanne I Rader, Rahul S Pawar. Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity. Analytical and bioanalytical chemistry. 2013 May; 405(13):4409-17. doi: 10.1007/s00216-013-6783-7. [PMID: 23420136]
  • M Terada, M Sano, A I Ishii, H Kino, S Fukushima, T Noro. [Studies on chemotherapy of parasitic helminths (IV). Effects of alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated host tissues (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Feb; 79(2):105-11. doi: 10.1254/fpj.79.105. [PMID: 7200047]