Norcantharidin (BioDeep_00000229779)
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
4,10-Dioxatricyclo[5.2.1.0(2,6)]decane-3,5-dione; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride
化学式: C8H8O4 (168.0423)
中文名称: 去甲斑蝥素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2C3C(C1O2)C(=O)OC3=O
InChI: InChI=1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
描述信息
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.176
(Rac)-Norcantharidin ((Rac)-NCTD) is the isoform of Norcantharidin, which is a synthetic and demethylated anticancer agent derived from Cantharidin (HY-N0209). Norcantharidin has lighter side effects and stronger bioactivity than Cantharidin. And Norcantharidin inhibits cell proliferation, migration and metastasis, and causes apoptosis and autophagy[1][2].
同义名列表
50 个代谢物同义名
4,10-Dioxatricyclo[5.2.1.0(2,6)]decane-3,5-dione; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride; 4,7-epoxyisobenzofuran-1,3-dione, hexahydro-, (3a-alpha, 4beta, 7beta, 7a-alpha)-; Exo-cis-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; Endothall anhydride; 3-(5-(4-(diphenylamino)phenyl)-[2,2-bithiophen]-5-yl)cyclohex-2-enone; EXO-7-OXA-BICYCLO(2.2.1)-HEPTANE-2,3-DICARBOXYLIC ANHYDRIDE; exo-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride; norcantharidin, (3aalpha,4beta,7beta,7aalpha)-isomer; 3,6-Endoxohexahydrophthalic anhydride, exo isomer; 4,10-dioxatricyclo[5.2.1.0<2,6>]decane-3,5-dione; 4,10-Dioxa-tricyclo[5.2.1.02,6]decane-3,5-dione; 4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-; hexahydro-4,7-epoxy-2-benzofuran-1,3-dione; Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; 3,6-Endooxyphthalic anhydride, hexahydro-; Phthalic anhydride, hexahydro-3,6-endoxo-; 3,6-Endoxohexahydrophthalic anhydride; Phthalic anhydride,6-endoxo-; JAABVEXCGCXWRR-UHFFFAOYSA-N; sodium norcantharidate; 4,3-dione, hexahydro-; Norcantharidin, solid; DEMETHYL-CANTHARIDIN; (+/-)-Norcantharidin; (Rac)-Norcantharidin; Endothall anhydride; demethylcantharate; (±)-Norcantharidin; Spectrum5_001514; Spectrum2_001683; Spectrum3_001634; Spectrum4_000601; Norcantharadine; Isocantharidin; Norcantharidin; 3, hexahydro-; DivK1c_007000; Lopac0_000830; NCI60_001019; KBio1_001944; KBio2_004715; Tox21_500830; KBio3_002547; KBio2_002147; KBio2_007283; (+/-)-NCTD; NCTD; (Rac)-NCTD
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:197221
- PubChem: 93004
- Metlin: METLIN44424
- ChEMBL: CHEMBL8327
- Wikipedia: Norcantharidin
- MeSH: norcantharidin
- ChemIDplus: 0005442126
- CAS: 29745-04-8
- CAS: 51154-98-4
- CAS: 5442-12-6
- MoNA: BML81815
- medchemexpress: HY-N0585
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yingcong Wang, Sanfeng Dong, Ke Hu, Li Xu, Qilin Feng, Bo Li, Guangli Wang, Gege Chen, Bibo Zhang, Xinyan Jia, Zhijian Xu, Xuejie Gao, Hui Zhang, Yongsheng Xie, Meiling Lu, Shuaikang Chang, Dongliang Song, Xiaosong Wu, Qi Jia, Huabin Zhu, Jinfeng Zhou, Weiliang Zhu, Jumei Shi. The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13-MAPK-YWHAE signaling pathway.
Journal of translational medicine.
2023 Nov; 21(1):858. doi:
10.1186/s12967-023-04739-7. [PMID: 38012658] - Lijuan Ma, Xuetong Sun, Wenwen Ji, Bei Zhang, Jianting Li, Wenjuan Fu, Xiangying Zhang, Wenhui Qian, Enze Sheng, Dong Zhu. Supramolecular self-assembled AIE molecules are used in the search for target proteins in norcantharidin.
Analytica chimica acta.
2023 Jan; 1239(?):340642. doi:
10.1016/j.aca.2022.340642. [PMID: 36628744] - Bing-Tao Zhai, Jing Sun, Ya-Jun Shi, Xiao-Fei Zhang, Jun-Bo Zou, Jiang-Xue Cheng, Yu Fan, Dong-Yan Guo, Huan Tian. Review targeted drug delivery systems for norcantharidin in cancer therapy.
Journal of nanobiotechnology.
2022 Dec; 20(1):509. doi:
10.1186/s12951-022-01703-3. [PMID: 36463199] - Qian Liu, Henglai Sun, Xinyu Li, Huagang Sheng, Liqiao Zhu. Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227740. [PMID: 36431851] - Jia Wang, Xiange Huang, Hegen Li, Deyue Yan, Wei Huang. Two Zn(II) coordination polymers with anticancer drug norcantharidin as ligands for cancer chemotherapy.
Dalton transactions (Cambridge, England : 2003).
2022 Apr; 51(14):5624-5634. doi:
10.1039/d2dt00300g. [PMID: 35319055] - Xinglu Chen, Xiangsheng Cai, Dianpeng Zheng, Xiuya Huang, Ying Chen, Tanggang Deng, Lijun Mo, Hongwei Li, Jinlong Li, Sansan Chen. Norcantharidin counteracts acquired everolimus resistance in renal cell carcinoma by dual inhibition of mammalian target of rapamycin complex 1 and complex 2 pathways in Vitro.
Anti-cancer drugs.
2022 01; 33(1):e94-e102. doi:
10.1097/cad.0000000000001147. [PMID: 34261913] - Zijun Yan, Kun Yang, Xiang Tang, Yunfeng Bi, Yuzhen Ding, Mengyue Deng, Die Xia, Yunqi Zhao, Tong Chen. Norcantharidin Nanostructured Lipid Carrier (NCTD-NLC) Suppresses the Viability of Human Hepatocellular Carcinoma HepG2 Cells and Accelerates the Apoptosis.
Journal of immunology research.
2022; 2022(?):3851604. doi:
10.1155/2022/3851604. [PMID: 35497873] - Shuaishuai Huang, Gulimire Tuergong, Hangjie Zhu, Xue Wang, Guobin Weng, Yu Ren. Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells.
Acta pharmaceutica (Zagreb, Croatia).
2021 Jun; 71(2):267-278. doi:
10.2478/acph-2021-0012. [PMID: 33151174] - Leyi Liang, Ling Zhao, Ying Wang, Yan Wang. Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells.
Molecular pharmaceutics.
2021 03; 18(3):1003-1013. doi:
10.1021/acs.molpharmaceut.0c00976. [PMID: 33527831] - Han-Wen Luo, Dan-Dan Yin, Zheng Xiao, Lu Wen, Ying-Jun Liao, Cheng-Yuan Tang, Dong Zeng, Heng-Ting Xiao, Ying Li. Anti-renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac-mediated C-terminal phosphorylation of Smad3.
Chemical biology & drug design.
2021 02; 97(2):293-304. doi:
10.1111/cbdd.13781. [PMID: 32896083] - Jiao Tian, Zheng Xiao, Ju Wei, Yi Shan, Dong Zeng, Yilin Tao, Xi Fang, Chengyuan Tang, Xiaojun Chen, Ying Li. NCTD Prevents Renal Interstitial Fibrosis via Targeting Sp1/lncRNA Gm26669 Axis.
International journal of biological sciences.
2021; 17(12):3118-3132. doi:
10.7150/ijbs.59195. [PMID: 34421354] - Jianbo Zhou, Yali Ren, Lu Tan, Xiaominting Song, Miao Wang, Yuzhi Li, Zhixing Cao, Chuanjie Guo. Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110755. doi:
10.1016/j.biopha.2020.110755. [PMID: 33152920] - Dong Zeng, Zheng Xiao, Qianqian Xu, Hanwen Luo, Lu Wen, Chengyuan Tang, Yi Shan, Jiao Tian, Ju Wei, Ying Li. Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Life sciences.
2020 Nov; 260(?):118488. doi:
10.1016/j.lfs.2020.118488. [PMID: 32979359] - Ying Jiang, Xiaolin Liu, Xinyi Tan, Ye Hou, Wanxiao Sun, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang. In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting.
AAPS PharmSciTech.
2020 Oct; 21(7):277. doi:
10.1208/s12249-020-01829-3. [PMID: 33033942] - Minchen Liu, Jue Tu, Yi Feng, Jiquan Zhang, Jing Wu. Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma.
Journal of nanobiotechnology.
2020 Aug; 18(1):114. doi:
10.1186/s12951-020-00677-4. [PMID: 32811502] - Shiqiang Zhang, Yun Yang, Yunwei Hua, Chen Hu, Yi Zhong. NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Molecular medicine reports.
2020 08; 22(2):774-782. doi:
10.3892/mmr.2020.11151. [PMID: 32468032] - Zheng Xiao, Lu Wen, Dong Zeng, Dandan Yin, Xun Zhou, Chengyuan Tang, Ying Li. Protein Phosphatase 2A Inhibiting β-Catenin Phosphorylation Contributes Critically to the Anti-renal Interstitial Fibrotic Effect of Norcantharidin.
Inflammation.
2020 Jun; 43(3):878-891. doi:
10.1007/s10753-019-01173-0. [PMID: 31940108] - Jinhua Chi, Zhiwen Jiang, Xiaotong Chen, Yanfei Peng, Wanshun Liu, Baosan Han, Baoqin Han. Studies on anti-hepatocarcinoma effect, pharmacokinetics and tissue distribution of carboxymethyl chitosan based norcantharidin conjugates.
Carbohydrate polymers.
2019 Dec; 226(?):115297. doi:
10.1016/j.carbpol.2019.115297. [PMID: 31582090] - Hengting Xiao, Yingjun Liao, Chengyuan Tang, Zheng Xiao, Hanwen Luo, Jun Li, Hong Liu, Lin Sun, Dong Zeng, Ying Li. RNA-Seq analysis of potential lncRNAs and genes for the anti-renal fibrotic effect of norcantharidin.
Journal of cellular biochemistry.
2019 10; 120(10):17354-17367. doi:
10.1002/jcb.28999. [PMID: 31104327] - Yi-Fan Li, Hong Sun, Na Xi, Yalin Zhang. Effects of Cantharidin and Norcantharidin on Larval Feeding and Adult Oviposition Preferences of the Diamondback Moth (Lepidoptera: Plutellidae).
Journal of economic entomology.
2019 08; 112(4):1634-1637. doi:
10.1093/jee/toz049. [PMID: 30924494] - Chi-Hyun Ahn, Kyoung-Ok Hong, Bohwan Jin, WonWoo Lee, Yun Chan Jung, Hakmo Lee, Ji-Ae Shin, Sung-Dae Cho, Seong Doo Hong. Contribution of p38 MAPK Pathway to Norcantharidin-Induced Programmed Cell Death in Human Oral Squamous Cell Carcinoma.
International journal of molecular sciences.
2019 Jul; 20(14):. doi:
10.3390/ijms20143487. [PMID: 31315217] - Li-Juan Zhao, Nan Si, Bo Gao, Xiao-Lu Wei, Yan-Li Wang, Hai-Yu Zhao, Bao-Lin Bian. [Lipid metabolism study of sodium norcantharidate in LO2 hepatocytes based on lipidomics].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jan; 44(1):158-166. doi:
10.19540/j.cnki.cjcmm.20180925.002. [PMID: 30868827] - Yunfei Li, Yajuan Xiao, Hsuan-Pei Lin, Derek Reichel, Younsoo Bae, Eun Y Lee, Yiguo Jiang, Xuefei Huang, Chengfeng Yang, Zhishan Wang. In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.
Biomaterials.
2019 01; 188(?):160-172. doi:
10.1016/j.biomaterials.2018.10.019. [PMID: 30352320] - Kun Ye, Qiao-Yu Wei, Teng-Xiang Long, Hong-Guang He, Yun-Feng Huang, Li-Jia Xiong, Jiao Lan, Yi-Yun Huang, Zhi-Feng Gong, Xiao-Mei Peng, Qiu-Xia Wu. Norcantharidin Enhances High Concentrations of Fetal Bovine Serum-Induced Apoptosis in Human Mesangial Cells by Regulating the Mitogen-Activated Protein Kinase Signaling Pathway.
Kidney & blood pressure research.
2019; 44(6):1339-1351. doi:
10.1159/000502524. [PMID: 31661692] - Hassan Yasoob, Rashid Ahmed Khan, Muhammed Naveed, Maryam Rashid, Yalin Zhang. Biological Evaluation of Endothall, a Dicarboxylic Acid Analog of Norcantharidin, and Cantharidin on Oriental Leafworm, Spodoptera litura (Lepidoptera: Noctuidae).
Journal of economic entomology.
2018 12; 111(6):2706-2716. doi:
10.1093/jee/toy245. [PMID: 30169799] - Xiao-Ping Zhang, Lu-Lu Luo, Yong-Qi Liu, Xue-Song Liu, Fang-Yu An, Shao-Bo Sun, Xiao-Rong Xie, Guang-Qin Geng, Xue-Juan Chen, Zhen-Dong Li. Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine.
Journal of cancer research and therapeutics.
2018 Dec; 14(Supplement):S1035-S1040. doi:
10.4103/0973-1482.192852. [PMID: 30539842] - Shulong Jiang, Mengying Li, Ying Hu, Zhenhai Zhang, Huixia Lv. Multifunctional self-assembled micelles of galactosamine-hyaluronic acid-vitamin E succinate for targeting delivery of norcantharidin to hepatic carcinoma.
Carbohydrate polymers.
2018 Oct; 197(?):194-203. doi:
10.1016/j.carbpol.2018.05.090. [PMID: 30007605] - Dan Jin, Yan Wu, Cuijie Shao, Yong Gao, Deqiang Wang, Jiwei Guo. Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway.
Oncology reports.
2018 Aug; 40(2):609-620. doi:
10.3892/or.2018.6486. [PMID: 29901163] - Hainan Shao, Na Xi, Yalin Zhang. Microemulsion formulation of a new biopesticide to control the diamondback moth (Lepidoptera: Plutellidae).
Scientific reports.
2018 Jul; 8(1):10565. doi:
10.1038/s41598-018-28626-0. [PMID: 30002386] - Hong-Bo Shen, Ze-Jun Huo, Yun-Jing Bai, Xiao-Juan He, Chang-Hong Li, Yu-Kun Zhao, Qing-Qing Guo. Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats.
Chinese journal of integrative medicine.
2018 Apr; 24(4):278-283. doi:
10.1007/s11655-017-2792-2. [PMID: 29264841] - Zhenghai Zhang, Lei Yang, Jian Hou, Xiaojing Xia, Jing Wang, Qing Ning, Shulong Jiang. Promising positive liver targeting delivery system based on arabinogalactan-anchored polymeric micelles of norcantharidin.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup3):S630-S640. doi:
10.1080/21691401.2018.1505742. [PMID: 30449176] - Zhiwen Jiang, Jinhua Chi, Baoqin Han, Wanshun Liu. Preparation and pharmacological evaluation of norcantharidin-conjugated carboxymethyl chitosan in mice bearing hepatocellular carcinoma.
Carbohydrate polymers.
2017 Oct; 174(?):282-290. doi:
10.1016/j.carbpol.2017.06.072. [PMID: 28821069] - Dan Wang, Chendong Yang, Zhuien Wang, Yi Yang, Defang Li, Xiaojie Ding, Wenjuan Xu, Qiusheng Zheng. Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation.
Scientific reports.
2017 08; 7(1):9373. doi:
10.1038/s41598-017-09668-2. [PMID: 28839202] - Liya Zeng, Yalin Zhang. Development, optimization and in vitro evaluation of norcantharidin loadedself-nanoemulsifying drug delivery systems (NCTD-SNEDDS).
Pharmaceutical development and technology.
2017 May; 22(3):399-408. doi:
10.1080/10837450.2016.1219915. [PMID: 27487261] - Qiao-Yan Zhang, Xiao-Qiang Yue, Yi-Ping Jiang, Ting Han, Hai-Liang Xin. FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Scientific reports.
2017 03; 7(1):396. doi:
10.1038/s41598-017-00313-6. [PMID: 28341836] - Zeping Han, Baoxia Li, Juanjuan Wang, Xiangqiang Zhang, Zhenhua Li, Liting Dai, Mingrong Cao, Jianwei Jiang. Norcantharidin Inhibits SK-N-SH Neuroblastoma Cell Growth by Induction of Autophagy and Apoptosis.
Technology in cancer research & treatment.
2017 02; 16(1):33-44. doi:
10.1177/1533034615624583. [PMID: 26755751] - Hong-Wei Han, Han-Yue Qiu, Cui Hu, Wen-Xue Sun, Rong-Wu Yang, Jin-Liang Qi, Xiao-Ming Wang, Gui-Hua Lu, Yong-Hua Yang. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.
Bioorganic & medicinal chemistry letters.
2016 07; 26(14):3237-3242. doi:
10.1016/j.bmcl.2016.05.063. [PMID: 27262599] - Debasish Chattopadhyay, Mark R Swingle, Edward A Salter, Eric Wood, Brandon D'Arcy, Catherine Zivanov, Kevin Abney, Alla Musiyenko, Scott F Rusin, Arminja Kettenbach, Larry Yet, Chad E Schroeder, Jennifer E Golden, Wade H Dunham, Anne-Claude Gingras, Surajit Banerjee, David Forbes, Andrzej Wierzbicki, Richard E Honkanen. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochemical pharmacology.
2016 06; 109(?):14-26. doi:
10.1016/j.bcp.2016.03.011. [PMID: 27002182] - Min-Chen Liu, Xiao-Qiong Ma, Yong Xu, Li-Hua Peng, Min Han, Jian-Qing Gao. Liquid chromatography-tandem mass spectrometry evaluation of the pharmacokinetics of a diacid metabolite of norcantharidin loaded in folic acid-targeted liposomes in mice.
Journal of pharmaceutical and biomedical analysis.
2016 Feb; 119(?):76-83. doi:
10.1016/j.jpba.2015.11.017. [PMID: 26658337] - Deyue Yan, Lin-Kai Ni, Ho-Lun Chen, Li-Chou Chen, Yau-Hung Chen, Chien-Chung Cheng. Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo.
Bioorganic & medicinal chemistry letters.
2016 Feb; 26(3):774-777. doi:
10.1016/j.bmcl.2015.12.099. [PMID: 26764188] - Min-Chen Liu, Lin Liu, Xia-Rong Wang, Wu-Ping Shuai, Ying Hu, Min Han, Jian-Qing Gao. Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.
International journal of nanomedicine.
2016; 11(?):1395-412. doi:
10.2147/ijn.s96862. [PMID: 27110110] - Yang Wang, Wenbo Sun, Shunqing Zha, Huan Wang, Yalin Zhang. Synthesis and Biological Evaluation of Norcantharidin Derivatives Possessing an Aromatic Amine Moiety as Antifungal Agents.
Molecules (Basel, Switzerland).
2015 Dec; 20(12):21464-80. doi:
10.3390/molecules201219782. [PMID: 26633341] - Wen-Jie Wang, Meng-Yao Wu, Meng Shen, Qiaoming Zhi, Ze-Yi Liu, Fei-Ran Gong, Min Tao, Wei Li. Cantharidin and norcantharidin impair stemness of pancreatic cancer cells by repressing the β-catenin pathway and strengthen the cytotoxicity of gemcitabine and erlotinib.
International journal of oncology.
2015 Nov; 47(5):1912-22. doi:
10.3892/ijo.2015.3156. [PMID: 26398277] - Yong Wang, Min Xu, Zhen-Hai Di, Jian Zhang, Xue-Qun Mao, Hai-Bo Sun. Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro.
Journal of cancer research and therapeutics.
2015 Oct; 11(4):818-22. doi:
10.4103/0973-1482.146126. [PMID: 26881524] - Dan Zheng, Qi-Ming Sha, Jian-Qing Wang, Zheng-Mei Liu, Xiu-Fang Wan, Guo-Chuan Wang, Ya-Li Zhang, Guo-Zhen Yang. [Effect of Norcantharidin on Hematopoietic Function in Leucopenia Model Rat Induced by Cyclophosphamide].
Zhongguo shi yan xue ye xue za zhi.
2015 Jun; 23(3):826-31. doi:
10.7534/j.issn.1009-2137.2015.03.043. [PMID: 26117044] - Wen-Ji Song, Qiu-Yue Lin, Wen-Jiao Jiang, Fang-Yuan Du, Qing-Yuan Qi, Qiong Wei. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with norcantharidin and benzimidazole derivatives.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 137(?):122-8. doi:
10.1016/j.saa.2014.08.069. [PMID: 25218220] - Jinlong Ma, Huan Teng, Juan Wang, Yu Zhang, Tianyang Ren, Xing Tang, Cuifang Cai. A highly stable norcantharidin loaded lipid microspheres: preparation, biodistribution and targeting evaluation.
International journal of pharmaceutics.
2014 Oct; 473(1-2):475-84. doi:
10.1016/j.ijpharm.2014.07.047. [PMID: 25089504] - Xiaohui Wang, Zhimin Gu, Gongquan Li, Shufeng Zhang, Zhenjie Cao, Zhanfeng Yang, Guangzhi Liu. Norcantharidin enhances ABT-263-mediated anticancer activity in neuroblastoma cells by upregulation of Noxa.
Oncology reports.
2014 Aug; 32(2):716-22. doi:
10.3892/or.2014.3228. [PMID: 24891300] - Minchen Liu, Xiaoqiong Ma, Zhexiu Jin, Wuchao Li, Manman Guo, Fanzhu Li. Determination and pharmacokinetic study of the diacid metabolite of norcantharidin in beagle plasma by use of liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2013 Nov; 405(28):9273-83. doi:
10.1007/s00216-013-7300-8. [PMID: 24096565] - Xiaofen Xu, Yanggong Li, Feihu Wang, Li Lv, Jieying Liu, Mingna Li, Aijie Guo, Jinjun Jiang, Yuanyuan Shen, Shengrong Guo. Synthesis, in vitro and in vivo evaluation of new norcantharidin-conjugated hydroxypropyltrimethyl ammonium chloride chitosan derivatives as polymer therapeutics.
International journal of pharmaceutics.
2013 Sep; 453(2):610-9. doi:
10.1016/j.ijpharm.2013.05.052. [PMID: 23742972] - Liu-Mei Shou, Qiong-Yan Zhang, Wei Li, Xin Xie, Kai Chen, Lian Lian, Zhen-Yu Li, Fei-Ran Gong, Ke-Sheng Dai, Yi-Xiang Mao, Min Tao. Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin.
Oncology reports.
2013 Sep; 30(3):1059-66. doi:
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