Ratic (BioDeep_00000229727)

   

human metabolite


代谢物信息卡片


Ranitidine

化学式: C13H22N4O3S (314.1413)
中文名称: 雷尼替丁
谱图信息: 最多检出来源 Homo sapiens(general) 1.35%

分子结构信息

SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
InChI: InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+

描述信息

A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 196

同义名列表

3 个代谢物同义名

Ranitidine; ZANTAC; Ratic



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Saba Safari, Seifollah Bahramikia, Omid Dezfoulian. Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems. Inflammopharmacology. 2023 Jul; ?(?):. doi: 10.1007/s10787-023-01284-z. [PMID: 37405588]
  • Yunqiu Zhang, Fengling Rao, Xianxi Zhang, Hucai Zhang, Fengqin Chang, Abdukader Abdukayum, Zhong Jin, Guangzhi Hu. Ultrasmall nitrogen-doped Cu0·92Co2·08O4 nanocrystal-decorated cerium dioxide nanoparticles for fast and complete degradation of ranitidine via permonosulfate activation. Chemosphere. 2023 Jun; 327(?):138527. doi: 10.1016/j.chemosphere.2023.138527. [PMID: 37003436]
  • Sahar Idris, Anuradha Mishra, Mohammad Khushtar. Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. Chinese journal of integrative medicine. 2023 Apr; ?(?):. doi: 10.1007/s11655-023-3734-9. [PMID: 37079159]
  • Yajuan Bi, Xue Wang, Lifeng Han, Yiqing Tian, Tongwei Bo, Caiyu Li, Bowen Shi, Chunshan Gui, Youcai Zhang. Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation. Journal of natural products. 2023 01; 86(1):191-198. doi: 10.1021/acs.jnatprod.2c00927. [PMID: 36563333]
  • A A Al-Zubaidy, A M Khalil. Gastroprotective Effect of Capparis spinosa on Indomethacin-induced Gastric Ulcer in Rats. Archives of Razi Institute. 2022 Aug; 77(4):1429-1437. doi: 10.22092/ari.2022.357514.2053. [PMID: 36883165]
  • Ping Zhu, Xusheng Pan, Yilin Shen, Xiang Huang, Fang Yu, Deli Wu, Qingge Feng, John Zhou, Xiaowei Li. Biodegradation and potential effect of ranitidine during aerobic composting of human feces. Chemosphere. 2022 Jun; 296(?):134062. doi: 10.1016/j.chemosphere.2022.134062. [PMID: 35202670]
  • Jordan Williams, Vishal Siramshetty, Ðắc-Trung Nguyễn, Elias Carvalho Padilha, Md Kabir, Kyeong-Ri Yu, Amy Q Wang, Tongan Zhao, Misha Itkin, Paul Shinn, Ewy A Mathé, Xin Xu, Pranav Shah. Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability. Bioorganic & medicinal chemistry. 2022 02; 56(?):116588. doi: 10.1016/j.bmc.2021.116588. [PMID: 35030421]
  • Mette Nørgaard, Ina Trolle Andersen, Uffe Heide-Jørgensen, Rune Erichsen, Judy R Rees, Margaret R Karagas, Henrik Toft Sørensen. Ranitidine and Risk of Bladder and Kidney Cancer: A Population-Based Cohort Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 01; 31(1):45-50. doi: 10.1158/1055-9965.epi-21-0737. [PMID: 34649959]
  • Naif Al-Gabri, Gehad M Elnagar, Sultan A M Saghir, Amina El-Shaibany, Sultan F Alnomasy, Ziyad M Althafar, Nesreen M I M Elkomy, Mahmoud M Elaasser, Maisa Siddiq Abdoh, Mohammed Yosri. Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats. BioMed research international. 2022; 2022(?):9246785. doi: 10.1155/2022/9246785. [PMID: 35111849]
  • Shaheen Perveen, Shahnaz Gauhar, Rabia Ismail Yousuf, Huma Ali, Farya Zafar, Anab Fatima Sheikh. Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human volunteers of Karachi, Pakistan. PloS one. 2022; 17(5):e0267791. doi: 10.1371/journal.pone.0267791. [PMID: 35609024]
  • Mohammad Beiranvand, Seifollah Bahramikia, Omid Dezfoulian. Evaluation of antioxidant and anti-ulcerogenic effects of Eremurus persicus (Jaub & Spach) Boiss leaf hydroalcoholic extract on ethanol-induced gastric ulcer in rats. Inflammopharmacology. 2021 Oct; 29(5):1503-1518. doi: 10.1007/s10787-021-00868-x. [PMID: 34435283]
  • Jeffry Florian, Murali K Matta, Ryan DePalma, Victoria Gershuny, Vikram Patel, Cheng-Hui Hsiao, Robbert Zusterzeel, Rodney Rouse, Kristin Prentice, Colleen Gosa Nalepinski, Insook Kim, Sojeong Yi, Liang Zhao, Miyoung Yoon, Susan Selaya, David Keire, Joyce Korvick, David G Strauss. Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial. JAMA. 2021 07; 326(3):240-249. doi: 10.1001/jama.2021.9199. [PMID: 34180947]
  • Mukta Gupta, Monica Gulati, Bhupinder Kapoor, Bimlesh Kumar, Rakesh Kumar, Rajan Kumar, Navneet Khurana, Reena Gupta, Naresh Singh. Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats. Journal of ethnopharmacology. 2021 Jul; 275(?):114115. doi: 10.1016/j.jep.2021.114115. [PMID: 33852947]
  • Omnia A El-Naem, Christine M El-Maraghy. A validated liquid chromatography-tandem mass spectrometric method for the determination of co-administered ranitidine and metronidazole in plasma of human volunteers. Analytical methods : advancing methods and applications. 2021 06; 13(23):2586-2595. doi: 10.1039/d1ay00284h. [PMID: 34019061]
  • Michele Rossi, Michela Freschi, Luciana de Camargo Nascente, Alessandra Salerno, Sarah de Melo Viana Teixeira, Florian Nachon, Fabien Chantegreil, Ondrej Soukup, Lukáš Prchal, Marco Malaguti, Christian Bergamini, Manuela Bartolini, Cristina Angeloni, Silvana Hrelia, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi. Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. Journal of medicinal chemistry. 2021 04; 64(8):4972-4990. doi: 10.1021/acs.jmedchem.1c00048. [PMID: 33829779]
  • Luis Eduardo Serrano-Mora, María L Zambrano-Zaragoza, Néstor Mendoza-Muñoz, Gerardo Leyva-Gómez, Zaida Urbán-Morlán, David Quintanar-Guerrero. Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials. Molecules (Basel, Switzerland). 2021 Apr; 26(7):. doi: 10.3390/molecules26072093. [PMID: 33917445]
  • Pierre Ekobena, Anton Ivanyuk, Françoise Livio. [Pharmacovigilance update]. Revue medicale suisse. 2021 Jan; 17(720-1):80-84. doi: NULL. [PMID: 33443836]
  • Prosper A Dabiré, Youssoufou Ouédraogo, Abel A Somé, Stanislas Sawadogo, Issaka Ouédraogo, Edith M Ilboudo, Raymond G Belemtougri. Relaxant Effects of the Aqueous Extract of Excoecaria grahamii (Euphorbiaceae) Leaves on Uterine Horn Contractility in Wistar Rats. BioMed research international. 2021; 2021(?):6618565. doi: 10.1155/2021/6618565. [PMID: 33928151]
  • Magdalena Gómez-Mateos, Francisco Arrebola, María Concepción Navarro, María Carmen Romero, José María González, Adela Valero. Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model. Digestive diseases and sciences. 2021 01; 66(1):105-113. doi: 10.1007/s10620-020-06144-2. [PMID: 32107679]
  • Shuofeng Yuan, Runming Wang, Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Tianfan Cheng, Kenn Ka-Heng Chik, Zi-Wei Ye, Suyu Wang, Andrew Chak-Yiu Lee, Lijian Jin, Hongyan Li, Dong-Yan Jin, Kwok-Yung Yuen, Hongzhe Sun. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nature microbiology. 2020 11; 5(11):1439-1448. doi: 10.1038/s41564-020-00802-x. [PMID: 33028965]
  • Abdelsamed I Elshamy, Abdel Razik H Farrag, Iriny M Ayoub, Karam A Mahdy, Rehab F Taher, Abd El-Nasser G Ei Gendy, Tarik A Mohamed, Salim S Al-Rejaie, Yasser A Ei-Amier, Ahmed M Abd-EIGawad, Mohamed A Farag. UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184234. [PMID: 32942704]
  • Samuel N Uwaezuoke, Ikenna K Ndu, Chizoma I Eneh, Chikere A Anusiem, Adaeze C Ayuk. A short course of oral ranitidine as a novel treatment for toddler's diarrhea: a parallel-group randomized controlled trial. BMC pediatrics. 2020 08; 20(1):380. doi: 10.1186/s12887-020-02267-7. [PMID: 32781992]
  • Jessica M Sanches-Lopes, Graziele C Ferreira, Lucas C Pinheiro, Rafael Kemp, Jose E Tanus-Santos. Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite. Biochemical pharmacology. 2020 07; 177(?):113940. doi: 10.1016/j.bcp.2020.113940. [PMID: 32224135]
  • Chunyue Yu, Zeqi Su, Yicong Li, Yadong Li, Kaige Liu, Fuhao Chu, Ting Liu, Runhua Chen, Xia Ding. Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jun; 126(?):110036. doi: 10.1016/j.biopha.2020.110036. [PMID: 32172061]
  • Yang-Dan Liu, Gui-Zhong Xin, Wei Li, Feng-Jie Liu, Zhong-Ping Yao, Xin Di. A novel liquid-liquid-solid microextraction strategy for bio-sample preparation by in situ self-assembly of zeolitic imidazolate framework 8 on hollow fiber membrane. Analytica chimica acta. 2020 Jan; 1095(?):118-128. doi: 10.1016/j.aca.2019.10.037. [PMID: 31864612]
  • Monireh Karami, Yadollah Yamini, Yousef Abdossalami Asl. On-chip ion pair-based dispersive liquid-liquid extraction for quantitative determination of histamine H2 receptor antagonist drugs in human urine. Talanta. 2020 Jan; 206(?):120235. doi: 10.1016/j.talanta.2019.120235. [PMID: 31514880]
  • Junfeng Liu, Lingyun Lai, Jiajia Lin, Jiajia Zheng, Xiaoli Nie, Xiaoye Zhu, Jun Xue, Te Liu. Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota. International journal of biological sciences. 2020; 16(5):790-802. doi: 10.7150/ijbs.40934. [PMID: 32071549]
  • João Paulo Bizarro Lopes, Luana Silva, Marco Antonio Ceschi, Diogo Seibert Lüdtke, Aline Rigon Zimmer, Thais Carine Ruaro, Rafael Ferreira Dantas, Cristiane Martins Cardoso de Salles, Floriano Paes Silva-Jr, Mario Roberto Senger, Gisele Barbosa, Lídia Moreira Lima, Isabella Alvim Guedes, Laurent Emmanuel Dardenne. Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. MedChemComm. 2019 Dec; 10(12):2089-2101. doi: 10.1039/c9md00358d. [PMID: 32904099]
  • Alejandra Orona-Ortiz, Luis Medina-Torres, Josué A Velázquez-Moyado, Elizabeth A Pineda-Peña, José Luis Balderas-López, María Josefa Bernad-Bernad, José Carlos Tavares Carvalho, Andrés Navarrete. Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model. Scientific reports. 2019 11; 9(1):16622. doi: 10.1038/s41598-019-53089-2. [PMID: 31719599]
  • Maryam Naeimi, Hamidreza Kianifar, Zahra Memariani, Mohammad Kamalinejad, Ali Bijani, Roshanak Saghebi, Narjes Gorji. Comparison of the efficacy of ranitidine and quince syrup on gastroesophageal reflux disease in children. Complementary therapies in medicine. 2019 Aug; 45(?):215-221. doi: 10.1016/j.ctim.2019.06.007. [PMID: 31331564]
  • Abdelgawad A Fahmi, Mariam Abdur-Rahman, Asmaa F Aboul Naser, Manal A Hamed, Howaida I Abd-Alla, Mohamed I Nasr. Pulicaria crispa mitigates gastric ulcer induced by ethanol in rats: role of treatment and auto healing. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2019 May; 24(3):286-294. doi: 10.1080/1354750x.2018.1556340. [PMID: 30512969]
  • Yan Fei Fang, Wen Li Xu, Lan Wang, Qing Wu Lian, Li Feng Qiu, Hui Zhou, Shu Jie Chen. Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats. BioMed research international. 2019; 2019(?):4605748. doi: 10.1155/2019/4605748. [PMID: 31111054]
  • Agnieszka Matuszewska, Beata Nowak, Diana Jędrzejuk, Marcin Landwójtowicz, Ewa Sadanowicz, Tomasz Sozański, Joanna Kwiatkowska, Małgorzata Pieśniewska, Marek Bolanowski, Adam Szeląg. Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats. Pharmacological reports : PR. 2018 Oct; 70(5):951-954. doi: NULL. [PMID: 30103175]
  • Afsaneh Shakeri, Mohammad Hashem Hashempur, Mahdieh Mojibian, Fatemeh Aliasl, Soodabeh Bioos, Fatemeh Nejatbakhsh. A comparative study of ranitidine and quince (Cydonia oblonga mill) sauce on gastroesophageal reflux disease (GERD) in pregnancy: a randomised, open-label, active-controlled clinical trial. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2018 Oct; 38(7):899-905. doi: 10.1080/01443615.2018.1431210. [PMID: 29553843]
  • Agnieszka Matuszewska, Beata Nowak, Diana Jędrzejuk, Marcin Landwójtowicz, Ewa Sadanowicz, Tomasz Sozański, Joanna Kwiatkowska, Małgorzata Pieśniewska, Marek Bolanowski, Adam Szeląg. Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats. Pharmacological reports : PR. 2018 Sep; 70(5):951-954. doi: NULL. [PMID: 32002959]
  • Kristin E Follman, Marilyn E Morris. Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study. Drug metabolism and disposition: the biological fate of chemicals. 2018 05; 46(5):758-769. doi: 10.1124/dmd.117.079558. [PMID: 29490902]
  • Florence Ranchon, Nicolas Vantard, Emilie Henin, Emmanuel Bachy, Clémentine Sarkozy, Lionel Karlin, Fadhela Bouafia-Sauvy, Aurore Gouraud, Verane Schwiertz, Estelle Bourbon, Amandine Baudouin, Anne Gaelle Caffin, Thierry Vial, Gilles Salles, Catherine Rioufol. Delayed methotrexate elimination: Incidence, interaction with antacid drugs, and clinical consequences?. Hematological oncology. 2018 Apr; 36(2):399-406. doi: 10.1002/hon.2479. [PMID: 28983943]
  • Xitong Zhang, Yue Zhang, Han Han, Jun Yang, Benliang Xu, Bing Wang, Tong Zhang. Formulation Optimization of Gastro-Retention Tablets of Paeonol and Efficacy in Treatment of Experimental Gastric Ulcer. Chemical & pharmaceutical bulletin. 2017 Aug; 65(8):706-713. doi: 10.1248/cpb.c16-00993. [PMID: 28529239]
  • Walaa Arafa Keshk, Samer Mahmoud Zahran, Mohamed Alaa Katary, Darin Abd-Elaziz Ali. Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer. Chemico-biological interactions. 2017 Aug; 273(?):266-272. doi: 10.1016/j.cbi.2017.06.022. [PMID: 28648817]
  • Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar. Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution. Chemico-biological interactions. 2017 Jun; 272(?):53-64. doi: 10.1016/j.cbi.2017.04.006. [PMID: 28400101]
  • Chad Gregory Kahl, Crystal Deas. Exercise-Induced Anaphylaxis in an Air Force Aviator Taking a HMG-CoA Reductase Inhibitor: A Case Report and Review of the Presentation, Diagnoses, and Treatment. Military medicine. 2017 05; 182(5):e1816-e1819. doi: 10.7205/milmed-d-16-00247. [PMID: 29087932]
  • Vanessa Cristina Oliveira de Lima, Richele Janaína de Araújo Machado, Norberto Kássio Vieira Monteiro, Ibson Lucas de Lyra, Christina da Silva Camillo, Alexandre Coelho Serquiz, Adeliana Silva de Oliveira, Fabíola Patrícia da Silva Rufino, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes Dos Santos, Ana Heloneida de Araújo Morais. Gastroprotective and antielastase effects of protein inhibitors from Erythrina velutina seeds in an experimental ulcer model. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2017 04; 95(2):243-250. doi: 10.1139/bcb-2016-0034. [PMID: 28177773]
  • H K Knych, S D Stanley, R M Arthur, D S McKemie. Disposition of the anti-ulcer medications ranitidine, cimetidine, and omeprazole following administration of multiple doses to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2017 Jan; 40(1):92-96. doi: 10.1111/jvp.12328. [PMID: 27292271]
  • Mladena Lalic-Popovic, Jovana Paunkovic, Zorica Grujic, Svetlana Golocorbin-Kon, Velibor Vasovic, Hani Al-Salami, Momir Mikov. The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine. Placenta. 2016 12; 48(?):144-150. doi: 10.1016/j.placenta.2016.11.001. [PMID: 27871467]
  • Ismael Lares Asseff, Graciela Benitez Gaucin, Hugo Juárez Olguín, Jose Antonio Godinez Nájera, Alejandra Toledo López, Gabriela Pérez Guillé, Fausto Zamura Torres. Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux. BMC pediatrics. 2016 07; 16(?):90. doi: 10.1186/s12887-016-0630-x. [PMID: 27412521]
  • Francisco Afonso-Pereira, Sudaxshina Murdan, Joao Sousa, Francisco Veiga, Abdul W Basit. Sex differences in excipient effects: Enhancement in ranitidine bioavailability in the presence of polyethylene glycol in male, but not female, rats. International journal of pharmaceutics. 2016 Jun; 506(1-2):237-41. doi: 10.1016/j.ijpharm.2016.04.022. [PMID: 27085641]
  • Hyung-Woo Doh, Charles L Stebbins, Hyun-Min Choi, Joonsung Park, Hosung Nho, Jong-Kyung Kim. Histamine H2 receptor blockade augments blood pressure responses to acute submaximal exercise in males. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2016 Jun; 41(6):605-10. doi: 10.1139/apnm-2015-0450. [PMID: 27191340]
  • Teng Zeng, William A Mitch. Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine. Carcinogenesis. 2016 06; 37(6):625-634. doi: 10.1093/carcin/bgw034. [PMID: 26992900]
  • Sung Kweon Cho, Jae-Yong Chung. The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment. International journal of clinical pharmacology and therapeutics. 2016 Apr; 54(4):253-62. doi: 10.5414/cp202473. [PMID: 26784938]
  • Salwa R Elshaboury, Niveen A Mohamed, Sameh Ahmed, Shereen Farrag. An Efficient Ion-Pair Liquid Chromatographic Method for the Determination of Some H2 Receptor Antagonists. Journal of chromatographic science. 2016 Mar; 54(3):419-28. doi: 10.1093/chromsci/bmv159. [PMID: 26538490]
  • Jae Gwang Park, Seung Cheol Kim, Yun Hwan Kim, Woo Seok Yang, Yong Kim, Sungyoul Hong, Kyung-Hee Kim, Byong Chul Yoo, Shi Hyung Kim, Jong-Hoon Kim, Jae Youl Cho. Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid. Mediators of inflammation. 2016; 2016(?):1903849. doi: 10.1155/2016/1903849. [PMID: 27057092]
  • Sachin Manocha, Dushyant Lal, Subramanian Venkataraman. ADMINISTRATION OF H2 BLOCKERS IN NSAID INDUCED GASTROPATHY IN RATS: effect on histopathological changes in gastric, hepatic and renal tissues. Arquivos de gastroenterologia. 2016 Jan; 53(1):36-43. doi: 10.1590/s0004-28032016000100008. [PMID: 27281503]
  • Flora Chang, Ann M O'Hare, Yinghui Miao, Michael A Steinman. Use of Renally Inappropriate Medications in Older Veterans: A National Study. Journal of the American Geriatrics Society. 2015 Nov; 63(11):2290-7. doi: 10.1111/jgs.13790. [PMID: 26503124]
  • Jayaraman Megala, Arumugam Geetha. Effect of Pithecellobium dulce (Roxb.) Benth. fruit extract on cysteamine induced duodenal ulcer in rats. Indian journal of experimental biology. 2015 Oct; 53(10):657-64. doi: . [PMID: 26665296]
  • Heidemarie Kletzl, Mylene Giraudon, Patricia Sanwald Ducray, Markus Abt, Marta Hamilton, Bert L Lum. Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: omeprazole and ranitidine. Anti-cancer drugs. 2015 Jun; 26(5):565-72. doi: 10.1097/cad.0000000000000212. [PMID: 25643050]
  • Erik Sjögren, David Dahlgren, Carl Roos, Hans Lennernäs. Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data. Molecular pharmaceutics. 2015 Jun; 12(6):2026-39. doi: 10.1021/mp500834v. [PMID: 25919764]
  • Eleonora Veglia, Cristina Grange, Alessandro Pini, Aldo Moggio, Cecilia Lanzi, Giovanni Camussi, Paul L Chazot, Arianna Carolina Rosa. Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2015 Apr; 64(3-4):261-70. doi: 10.1007/s00011-015-0807-z. [PMID: 25725698]
  • Li Liu, Sarah E Wheeler, Jacqueline A Rymer, Darla Lower, Jayne Zona, Octavia M Peck Palmer, Kenichi Tamama. Ranitidine interference with standard amphetamine immunoassay. Clinica chimica acta; international journal of clinical chemistry. 2015 Jan; 438(?):307-8. doi: 10.1016/j.cca.2014.09.012. [PMID: 25242739]
  • C I N'Da, A Petzer, J P Petzer. The inhibition of acetylcholinesterase by dantrolene and ondansetron. Drug research. 2015 Jan; 65(1):46-51. doi: 10.1055/s-0034-1372612. [PMID: 24764253]
  • Quaid Nadri, Mohammed Mahdi Althaf. Granulomatous tubulointerstitial nephritis secondary to omeprazole. BMJ case reports. 2014 Oct; 2014(?):. doi: 10.1136/bcr-2014-203842. [PMID: 25323274]
  • Milena Marsoni, Fabrizio De Mattia, Massimo Labra, Antonia Bruno, Marcella Bracale, Candida Vannini. Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants. Ecotoxicology and environmental safety. 2014 10; 108(?):52-7. doi: 10.1016/j.ecoenv.2014.05.029. [PMID: 25042244]
  • Sandro Boland, Jo Alen, Arnaud Bourin, Karolien Castermans, Nicki Boumans, Laura Panitti, Jessica Vanormelingen, Dirk Leysen, Olivier Defert. Novel Roflumilast analogs as soft PDE4 inhibitors. Bioorganic & medicinal chemistry letters. 2014 Sep; 24(18):4594-4597. doi: 10.1016/j.bmcl.2014.07.016. [PMID: 25149511]
  • Susanne Johansson, Jessica Read, Stuart Oliver, Mark Steinberg, Yan Li, Eleanor Lisbon, David Mathews, Philip T Leese, Paul Martin. Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine. Clinical pharmacokinetics. 2014 Sep; 53(9):837-47. doi: 10.1007/s40262-014-0161-2. [PMID: 25117183]
  • Ana Oliveira, Dora Pinho, António Albino-Teixeira, Rui Medeiros, Ricardo Jorge Dinis-Oliveira, Félix Carvalho. Morphine glucuronidation increases its analgesic effect in guinea pigs. Life sciences. 2014 Jul; 109(2):104-10. doi: 10.1016/j.lfs.2014.06.010. [PMID: 24968302]
  • A Khanal, G M Peterson, R L Castelino, M D Jose. Renal drug dosing recommendations: evaluation of product information for brands of the same drug. Internal medicine journal. 2014 Jun; 44(6):591-6. doi: 10.1111/imj.12446. [PMID: 24946814]
  • André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry. 2014 Apr; 57(7):3005-10. doi: 10.1021/jm401963n. [PMID: 24601604]
  • Natalia Alonso, Federico Monczor, Emiliana Echeverría, Carlos Davio, Carina Shayo, Natalia Fernández. Signal transduction mechanism of biased ligands at histamine H2 receptors. The Biochemical journal. 2014 Apr; 459(1):117-26. doi: 10.1042/bj20131226. [PMID: 24417223]
  • B Rezaei, H Lotfi-Forushani, A A Ensafi. Modified Au nanoparticles-imprinted sol-gel, multiwall carbon nanotubes pencil graphite electrode used as a sensor for ranitidine determination. Materials science & engineering. C, Materials for biological applications. 2014 Apr; 37(?):113-9. doi: 10.1016/j.msec.2013.12.036. [PMID: 24582230]
  • Andy Rorie, Whitney S Goldner, Elizabeth Lyden, Jill A Poole. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014 Apr; 112(4):376-82. doi: 10.1016/j.anai.2014.01.010. [PMID: 24507460]
  • G A J van Boekel, C H H Kerkhofs, F van de Logt, L B Hilbrands. Proton pump inhibitors do not increase the risk of acute rejection. The Netherlands journal of medicine. 2014 Feb; 72(2):86-90. doi: NULL. [PMID: 24659591]
  • Joanna Folwarczna, Aleksandra Janas, Maria Pytlik, Leszek Śliwiński, Marek Wiercigroch, Anna Brzęczek. Modifications of histamine receptor signaling affect bone mechanical properties in rats. Pharmacological reports : PR. 2014 Feb; 66(1):93-9. doi: 10.1016/j.pharep.2013.08.010. [PMID: 24905313]
  • Sayed H Seif el-Din, Naglaa M El-Lakkany, Mona A Mohamed, Manal M Hamed, Olov Sterner, Sanaa S Botros. Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice. Pharmaceutical biology. 2014 Feb; 52(2):144-50. doi: 10.3109/13880209.2013.818041. [PMID: 24047470]
  • Peter N Morcos, Sebastian A Moreira, Mercidita T Navarro, Núria Bech, Amanda Quatkemeyer, Patrick F Smith, Barbara J Brennan. Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers. The Journal of pharmacy and pharmacology. 2014 Jan; 66(1):23-31. doi: 10.1111/jphp.12151. [PMID: 24117531]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Alexander Kogan, Robert Aitchison, Dania S Lees, Ciro Louis Landoli, Kristoffer Dayrit, Morris Kharasch, Ernest Wang. 61-year-old man with sudden onset of gross hematuria: a case report. American journal of therapeutics. 2014 Jan; 21(1):e7-8. doi: 10.1097/mjt.0b013e31825fa0e6. [PMID: 23344100]
  • Yong Du, Weichun Zhao, Leilei Lu, Jiayan Zheng, Xishi Hu, Zhehan Yu, Lixin Zhu. Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α (TNF-α) and endothelin-1 (ET-1). Asian Pacific journal of tropical biomedicine. 2013 Dec; 3(12):925-30. doi: 10.1016/s2221-1691(13)60180-x. [PMID: 24093781]
  • H M S Qodriyah, A Y Asmadi. Eurycoma longifolia in Radix for the treatment of ethanol-induced gastric lesion in rats. Pakistan journal of biological sciences : PJBS. 2013 Dec; 16(23):1815-8. doi: 10.3923/pjbs.2013.1815.1818. [PMID: 24506055]
  • J F Hilton, D Tu, L Seymour, F A Shepherd, P A Bradbury. An evaluation of the possible interaction of gastric acid suppressing medication and the EGFR tyrosine kinase inhibitor erlotinib. Lung cancer (Amsterdam, Netherlands). 2013 Oct; 82(1):136-42. doi: 10.1016/j.lungcan.2013.06.008. [PMID: 23910908]
  • Bing Yan, Jun Shi, Li-Juan Xiu, Xuan Liu, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Xiu-Xia Yuan, Yin-Cheng Zhang, Yong-Jin Li, Pin-Kang Wei, Zhi-Feng Qin. Xiaotan Tongfu granules contribute to the prevention of stress ulcers. World journal of gastroenterology. 2013 Sep; 19(33):5473-84. doi: 10.3748/wjg.v19.i33.5473. [PMID: 24023490]
  • Marslin Gregory, B Divya, Revina Ann Mary, M M Hipolith Viji, V K Kalaichelvan, V Palanivel. Anti-ulcer activity of Ficus religiosa leaf ethanolic extract. Asian Pacific journal of tropical biomedicine. 2013 Jul; 3(7):554-6. doi: 10.1016/s2221-1691(13)60112-4. [PMID: 23836366]
  • Ahmed F Hawwa, Paul M Westwood, Paul S Collier, Jeffrey S Millership, Shirish Yakkundi, Gillian Thurley, Mike D Shields, Anthony J Nunn, Henry L Halliday, James C McElnay. Prophylactic ranitidine treatment in critically ill children--a population pharmacokinetic study. British journal of clinical pharmacology. 2013 May; 75(5):1265-76. doi: 10.1111/j.1365-2125.2012.04473.x. [PMID: 23016949]
  • Ken Grime, Stuart W Paine. Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. Drug metabolism and disposition: the biological fate of chemicals. 2013 Feb; 41(2):372-8. doi: 10.1124/dmd.112.049312. [PMID: 23139379]
  • Nageh A El-Mahdy, Alaa E El-Sisi, Bedair I Dewidar, Karima I El-Desouky. Histamine protects against the acute phase of experimentally-induced hepatic ischemia/re-perfusion. Journal of immunotoxicology. 2013 Jan; 10(1):9-16. doi: 10.3109/1547691x.2012.684158. [PMID: 22793375]
  • Masoud Alirezaei, Omid Dezfoulian, Shima Neamati, Marzyeh Rashidipour, Nader Tanideh, Arash Kheradmand. Oleuropein prevents ethanol-induced gastric ulcers via elevation of antioxidant enzyme activities in rats. Journal of physiology and biochemistry. 2012 Dec; 68(4):583-92. doi: 10.1007/s13105-012-0177-8. [PMID: 22581435]
  • D U Owu, C R Nwokocha, A O Obembe, A D Essien, D E Ikpi, E E Osim. Effect of Gongronema latifolium ethanol leaf extract on gastric acid secretion and cytoprotection in streptozotocin-induced diabetic rats. The West Indian medical journal. 2012 Dec; 61(9):853-60. doi: 10.7727/wimj.2011.040. [PMID: 24020223]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sawpheeyah Nima, Srirat Kasiwong, Wibool Ridtitid, Niwan Thaenmanee, Sirima Mahattanadul. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. Journal of ethnopharmacology. 2012 Jul; 142(2):354-61. doi: 10.1016/j.jep.2012.04.044. [PMID: 22580040]
  • M Boyce, O David, K Darwin, T Mitchell, A Johnston, S Warrington. Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects. Alimentary pharmacology & therapeutics. 2012 Jul; 36(2):181-9. doi: 10.1111/j.1365-2036.2012.05143.x. [PMID: 22607579]
  • Hejab Imteyaz, Wikrom Karnsakul, Michael A Levine, Patricia E Burrows, Jane Benson, Stephanie Hsu, Kathleen B Schwarz. Unusual case of hypothyroidism in an infant with hepatic hemangioma. Journal of pediatric gastroenterology and nutrition. 2012 May; 54(5):692-5. doi: 10.1097/mpg.0b013e31822a3221. [PMID: 21716131]
  • Sevgi Tatar Ulu, Muzaffer Tuncel. A sensitive and rapid determination of ranitidine in human plasma by HPLC with fluorescence detection and its application for a pharmacokinetic study. Journal of chromatographic science. 2012 Apr; 50(4):301-6. doi: 10.1093/chromsci/bms003. [PMID: 22345389]
  • Hyun Jung Jin, Jeong-Eun Kim, Young-Min Ye, Yoon-Seok Chang, Hae-Sim Park. Ranitidine-induced anaphylaxis with detection of serum specific IgE to ranitidine and human serum albumin conjugates. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2012 Mar; 108(3):210-2. doi: 10.1016/j.anai.2011.12.015. [PMID: 22374210]
  • Jose Enrique Montoya, Herdee Gloriane Luna, Nunilon G Vergara, Jose Roberto Amparo, Gloria R Cristal-Luna. Incidence of infusion-related reaction to monoclonal antibody rituximab: a national kidney and transplant institute experience. Annals of the Academy of Medicine, Singapore. 2012 Mar; 41(3):125-6. doi: NULL. [PMID: 22538739]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Z Zabidi, W N Wan Zainulddin, S S Mamat, S Shamsahal Din, F H Kamisan, F Yahya, N A Ismail, R Rodzi, H Hassan, N Mohtarrudin, M N Somchit, Z A Zakaria. Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2012; 21(5):501-3. doi: 10.1159/000337406. [PMID: 22517296]
  • Travis T Wager, Betty A Pettersen, Anne W Schmidt, Douglas K Spracklin, Scot Mente, Todd W Butler, Harry Howard, Daniel J Lettiere, David M Rubitski, Diane F Wong, Frank M Nedza, Frederick R Nelson, Hans Rollema, Jeffrey W Raggon, Jiri Aubrecht, Jody K Freeman, John M Marcek, Julie Cianfrogna, Karen W Cook, Larry C James, Linda A Chatman, Philip A Iredale, Michael J Banker, Michael L Homiski, Jennifer B Munzner, Rama Y Chandrasekaran. Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764). Journal of medicinal chemistry. 2011 Nov; 54(21):7602-20. doi: 10.1021/jm200939b. [PMID: 21928839]
  • Yin-Xia Chang, Yue-Qin Qiu, Li-Ming Du, Chang-Feng Li, Min Guo. Determination of ranitidine, nizatidine, and cimetidine by a sensitive fluorescent probe. The Analyst. 2011 Oct; 136(20):4168-73. doi: 10.1039/c1an15078b. [PMID: 21858296]
  • Ghada M Mansour, Ehab H Nashaat. Role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum. Archives of gynecology and obstetrics. 2011 Oct; 284(4):843-7. doi: 10.1007/s00404-010-1759-8. [PMID: 21079980]
  • Sunil K Jaiswal, Chandana V Rao, Brijesh Sharma, Pritee Mishra, Sanjib Das, Mukesh K Dubey. Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. Journal of ethnopharmacology. 2011 Sep; 137(1):341-4. doi: 10.1016/j.jep.2011.05.028. [PMID: 21658440]
  • D Yuvraj Singh, N Kamta Prasad. Double liposomes mediated dual drug targeting for treatment of Helicobacter pylori infections. Die Pharmazie. 2011 May; 66(5):368-73. doi: ". [PMID: 21699071]