doxylamine (BioDeep_00000229714)

   

human metabolite


代谢物信息卡片


doxylamine

化学式: C17H22N2O (270.1732042)
中文名称: 多西拉敏
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C
InChI: InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3018
D002491 - Central Nervous System Agents

同义名列表

1 个代谢物同义名

doxylamine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jiu-Qiang Xiong, Pengfei Cui, Shaoguo Ru, Sanjay P Govindwar, Mayur B Kurade, Min Jang, Sang-Hyoun Kim, Byong-Hun Jeon. Unravelling metabolism and microbial community of a phytobed co-planted with Typha angustifolia and Ipomoea aquatica for biodegradation of doxylamine from wastewater. Journal of hazardous materials. 2021 01; 401(?):123404. doi: 10.1016/j.jhazmat.2020.123404. [PMID: 32659588]
  • Sophie Allard, Pierre-Marie Allard, Isabelle Morel, Thomas Gicquel. Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3-MeO-PCP, doxylamine, and chlormequat. Drug testing and analysis. 2019 May; 11(5):669-677. doi: 10.1002/dta.2550. [PMID: 30468699]
  • Eun Kim, Yoon Hee Choi, Ji Yeon Lim, Jaehee Lee, Duk Hee Lee. The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion. The American journal of emergency medicine. 2018 Jul; 36(7):1170-1173. doi: 10.1016/j.ajem.2017.11.058. [PMID: 29196111]
  • Mark Allison, Cecilia Hale. A Phase I Study of the Pharmacokinetics and Pharmacodynamics of Intranasal Doxylamine in Subjects with Chronic Intermittent Sleep Impairment. Drugs in R&D. 2018 Jun; 18(2):129-136. doi: 10.1007/s40268-018-0232-1. [PMID: 29671128]
  • Jessica L Knittel, Shawn P Vorce, Barry Levine, Rhome L Hughes, Thomas Z Bosy. Multidrug toxicity involving sumatriptan. Journal of analytical toxicology. 2015 Jan; 39(1):75-9. doi: 10.1093/jat/bku120. [PMID: 25324526]
  • Ilan Matok, Shannon Clark, Steve Caritis, Menachem Miodovnik, Jason G Umans, Gary Hankins, Donald R Mattison, Gideon Koren. Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. Journal of clinical pharmacology. 2014 Dec; 54(12):1429-33. doi: 10.1002/jcph.369. [PMID: 25052410]
  • Daniela Remane, Diana Wetzel, Frank T Peters. Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for screening of urine specimens for 100 analytes relevant in drug-facilitated crime (DFC). Analytical and bioanalytical chemistry. 2014 Jul; 406(18):4411-24. doi: 10.1007/s00216-014-7841-5. [PMID: 24817357]
  • Krishneeta C Kashyap, Lisa M Nissen, Simon S Smith, Greg Kyle. Management of over-the-counter insomnia complaints in Australian community pharmacies: a standardized patient study. The International journal of pharmacy practice. 2014 Apr; 22(2):125-34. doi: 10.1111/ijpp.12052. [PMID: 23947610]
  • Guhan Balan, Gary A Thompson, Roger Gibb, Lijuan Li, David Hull, Molly Seeck. Doxylamine pharmacokinetics following single dose oral administration in children ages 2-17 years. Journal of clinical pharmacology. 2013 Nov; 53(11):1177-85. doi: 10.1002/jcph.137. [PMID: 23868556]
  • Arlan L Rosenbloom. Sudden death of a young woman attributed to diabetic ketoacidosis. Journal of forensic and legal medicine. 2013 Nov; 20(8):1063-5. doi: 10.1016/j.jflm.2013.09.028. [PMID: 24237820]
  • Sebastián Videla, Jesús Cebrecos, Mounia Lahjou, France Wagner, Pascal Guibord, Zhengguo Xu, Anna Cabot, Mercedes Encabo, Gregorio Encina, Eric Sicard, Artur Sans. Pharmacokinetic dose proportionality between two strengths (12.5 mg and 25 mg) of doxylamine hydrogen succinate film-coated tablets in fasting state: a single-dose, randomized, two-period crossover study in healthy volunteers. Drugs in R&D. 2013 Jun; 13(2):129-35. doi: 10.1007/s40268-013-0015-7. [PMID: 23633146]
  • Sebastián Videla, Mounia Lahjou, Pascal Guibord, Zhengguo Xu, Carles Tolrà, Gregorio Encina, Eric Sicard, Artur Sans. Food effects on the pharmacokinetics of doxylamine hydrogen succinate 25 mg film-coated tablets: a single-dose, randomized, two-period crossover study in healthy volunteers. Drugs in R&D. 2012 Dec; 12(4):217-25. doi: 10.2165/11641640-000000000-00000. [PMID: 23230999]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • J L Donato, F Koizumi, A S Pereira, G D Mendes, G De Nucci. Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 899(?):46-56. doi: 10.1016/j.jchromb.2012.05.001. [PMID: 22651995]
  • Warren C Rodrigues, Catherine Castro, Philip Catbagan, Christine Moore, Guohong Wang. Immunoassay screening of diphenhydramine (Benadryl®) in urine and blood using a newly developed assay. Journal of analytical toxicology. 2012 Mar; 36(2):123-9. doi: 10.1093/jat/bkr015. [PMID: 22337782]
  • Derong Zhu, Xia Li, Jinying Sun, Tianyan You. Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection. Talanta. 2012 Jan; 88(?):265-71. doi: 10.1016/j.talanta.2011.10.040. [PMID: 22265497]
  • Han Joon Kim, Sang Hoon Oh, Chun Song Youn, Jung Hee Wee, Ji Hoon Kim, Won Jung Jeong, Soo Hyun Kim, Seung Hee Jeong, Kyu Nam Park. The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose. The American journal of emergency medicine. 2011 Oct; 29(8):903-7. doi: 10.1016/j.ajem.2010.10.032. [PMID: 21159475]
  • Peng C Tan, Siti Z Omar. Contemporary approaches to hyperemesis during pregnancy. Current opinion in obstetrics & gynecology. 2011 Apr; 23(2):87-93. doi: 10.1097/gco.0b013e328342d208. [PMID: 21297474]
  • Robert L Brent, Mildred S Christian, Robert M Diener. Evaluation of the reproductive and developmental risks of caffeine. Birth defects research. Part B, Developmental and reproductive toxicology. 2011 Apr; 92(2):152-87. doi: 10.1002/bdrb.20288. [PMID: 21370398]
  • Shawn P Vorce, Barry Levine, Pamela C McDonough, Marilyn R Past. An overdose death involving the insufflation of extended-release oxymorphone tablets. Journal of analytical toxicology. 2010 Oct; 34(8):521-6. doi: 10.1093/jat/34.8.521. [PMID: 21819798]
  • Nancy C Brahm, Lynn L Yeager, Mark D Fox, Kevin C Farmer, Tony A Palmer. Commonly prescribed medications and potential false-positive urine drug screens. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Aug; 67(16):1344-50. doi: 10.2146/ajhp090477. [PMID: 20689123]
  • Tianxiu Qian, Zongwei Cai. Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts. Chinese medicine. 2010 May; 5(?):19. doi: 10.1186/1749-8546-5-19. [PMID: 20504301]
  • Amber J Dickson, Shawn P Vorce, Barry Levine, Marilyn R Past. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. Journal of analytical toxicology. 2010 Apr; 34(3):162-8. doi: 10.1093/jat/34.3.162. [PMID: 20406541]
  • Marjorie Chèze, Aurélie Muckensturm, Guillaume Hoizey, Gilbert Pépin, Marc Deveaux. A tendency for re-offending in drug-facilitated crime. Forensic science international. 2010 Mar; 196(1-3):14-7. doi: 10.1016/j.forsciint.2009.12.037. [PMID: 20116946]
  • Eun-jung Lee, Sun-cheun Kim, In-kwan Hwang, Hee-jin Yang, Youn-shin Kim, Myun-soo Han, Moon-sik Yang, Yang-han Lee. The identification of ingested dandelion juice in gastric contents of a deceased person by direct sequencing and GC-MS methods. Journal of forensic sciences. 2009 May; 54(3):721-7. doi: 10.1111/j.1556-4029.2009.01019.x. [PMID: 19432748]
  • Husnain Syed, Sumit Som, Nazia Khan, Wael Faltas. Doxylamine toxicity: seizure, rhabdomyolysis and false positive urine drug screen for methadone. BMJ case reports. 2009; 2009(?):. doi: 10.1136/bcr.09.2008.0879. [PMID: 21686586]
  • Vincent Ioos, Vincent Das, Eric Maury, Jean-Luc Baudel, Jérôme Guéchot, Bertrand Guidet, Georges Offenstadt. A thyrotoxicosis outbreak due to dietary pills in Paris. Therapeutics and clinical risk management. 2008 Dec; 4(6):1375-9. doi: 10.2147/tcrm.s4110. [PMID: 19337445]
  • Matthew P Juhascik, Adam Negrusz, Diana Faugno, Linda Ledray, Pam Greene, Alice Lindner, Barbara Haner, R E Gaensslen. An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities. Journal of forensic sciences. 2007 Nov; 52(6):1396-400. doi: 10.1111/j.1556-4029.2007.00583.x. [PMID: 18093069]
  • Young-Il Jo, Jong-Oh Song, Jung-Hwan Park, Soon-Young Koh, Seung-Min Lee, Tae-Ho Seo, Jong-Ho Lee. Risk factors for rhabdomyolysis following doxylamine overdose. Human & experimental toxicology. 2007 Aug; 26(8):617-21. doi: 10.1177/0960327107077507. [PMID: 17884948]
  • Brett A Wagner, Lynn M Teesch, Garry R Buettner, Bradley E Britigan, C Patrick Burns, Krzysztof J Reszka. Inactivation of anthracyclines by serum heme proteins. Chemical research in toxicology. 2007 Jun; 20(6):920-6. doi: 10.1021/tx700002f. [PMID: 17497896]
  • A V Kireeva, A B Vozheva, S M Bakhtina, S V Volchenko, V N Kuklin. [Chemicotoxicological evaluation of doxylamine]. Sudebno-meditsinskaia ekspertiza. 2007 May; 50(3):22-5. doi: NULL. [PMID: 17598444]
  • M A Martínez-Gómez, M M Carril-Avilés, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis. Journal of chromatography. A. 2007 Apr; 1147(2):261-9. doi: 10.1016/j.chroma.2007.02.054. [PMID: 17339039]
  • Young Soon Cho, Hoon Lim, Seung Ho Kim. Comparison of lactated Ringer's solution and 0.9\% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication. Emergency medicine journal : EMJ. 2007 Apr; 24(4):276-80. doi: 10.1136/emj.2006.043265. [PMID: 17384382]
  • M Elisa Capella-Peiró, Alessandra Bossi, Josep Esteve-Romero. Optimization by factorial design of a capillary zone electrophoresis method for the simultaneous separation of antihistamines. Analytical biochemistry. 2006 May; 352(1):41-9. doi: 10.1016/j.ab.2005.12.028. [PMID: 16549055]
  • A F Fartushnyĭ, A P Sukhin, A I Gerasimenko, V V Shevchenko, E A Sborshchik. [Detection of reladorm and donormil in forensic-medical examination of cadavers]. Sudebno-meditsinskaia ekspertiza. 2005 Mar; 48(2):38-41. doi: NULL. [PMID: 15881142]
  • Kelly M Mahar Doan, Stephen A Wring, Larry J Shampine, Kelly H Jordan, James P Bishop, John Kratz, Eric Yang, Cosette J Serabjit-Singh, Kimberly K Adkison, Joseph W Polli. Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding. Pharmacology. 2004 Oct; 72(2):92-8. doi: 10.1159/000079137. [PMID: 15331914]
  • Iván Oliva, Ma Eva González-Trujano, Jesús Arrieta, Roberto Enciso-Rodríguez, Andrés Navarrete. Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice. Phytotherapy research : PTR. 2004 Apr; 18(4):290-6. doi: 10.1002/ptr.1389. [PMID: 15162363]
  • Uday Khosla, Kelly S Ruel, Daniel P Hunt. Antihistamine-induced rhabdomyolysis. Southern medical journal. 2003 Oct; 96(10):1023-6. doi: 10.1097/01.smj.0000076461.67623.e4. [PMID: 14570348]
  • Andries Pelser, Douw G Müller, Jeanetta du Plessis, Jan L du Preez, Colleen Goosen. Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration in rats. Biopharmaceutics & drug disposition. 2002 Sep; 23(6):239-44. doi: 10.1002/bdd.314. [PMID: 12214324]
  • Yang Deok Lee, Soo Teik Lee. Acute pancreatitis and acute renal failure complicating doxylamine succinate intoxication. Veterinary and human toxicology. 2002 Jun; 44(3):165-6. doi: NULL. [PMID: 12046971]
  • T Grobosch, U Lemm-Ahlers. Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction. Journal of analytical toxicology. 2002 Apr; 26(3):181-6. doi: 10.1093/jat/26.3.181. [PMID: 11991536]
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